@article{MasuWolfHoltmannetal.1993,
  author    = {Masu, Yasuo and Wolf, Eckhard and Holtmann, Bettina and Sendtner, Michael and Brem, Gottfried and Thoenen, Hans},
  title     = {Disruption of the CNTF gene results in motor neuron degeneration},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-33038},
  year      = {1993},
  abstract  = {CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a subpopulation of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determined motor neuron degeneration, its physiological function remained elusive. Here it is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength.},
  language  = {en}
}