@article{FergerRogerKoesteretal.2022,
  author    = {Ferger, Matthias and Roger, Chantal and K{\"o}ster, Eva and Rauch, Florian and Lorenzen, Sabine and Krummenacher, Ivo and Friedrich, Alexandra and Košćak, Marta and Nestić, Davor and Braunschweig, Holger and Lambert, Christoph and Piantanida, Ivo and Marder, Todd B.},
  title     = {Electron-Rich EDOT Linkers in Tetracationic bis-Triarylborane Chromophores: Influence on Water Stability, Biomacromolecule Sensing, and Photoinduced Cytotoxicity},
  series = {Chemistry - A European Journal},
  volume    = {28},
  journal   = {Chemistry - A European Journal},
  number    = {48},
  doi       = {10.1002/chem.202201130},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-287241},
  year      = {2022},
  abstract  = {Three novel tetracationic bis-triarylboranes with 3,4-ethylenedioxythiophene (EDOT) linkers, and their neutral precursors, showed significant red-shifted absorption and emission compared to their thiophene-containing analogues, with one of the EDOT-derivatives emitting in the NIR region. Only the EDOT-linked trixylylborane tetracation was stable in aqueous solution, indicating that direct attachment of a thiophene or even 3-methylthiophene to the boron atom is insufficient to provide hydrolytic stability in aqueous solution. Further comparative analysis of the EDOT-linked trixylylborane tetracation and its bis-thiophene analogue revealed efficient photo-induced singlet oxygen production, with the consequent biological implications. Thus, both analogues bind strongly to ds-DNA and BSA, very efficiently enter living human cells, accumulate in several different cytoplasmic organelles with no toxic effect but, under intense visible light irradiation, they exhibit almost instantaneous and very strong cytotoxic effects, presumably attributed to singlet oxygen production. Thus, both compounds are intriguing theranostic agents, whose intracellular and probably intra-tissue location can be monitored by strong fluorescence, allowing switching on of the strong bioactivity by well-focused visible light.},
  language  = {en}
}
@article{VoigtThieleWetzkeetal.2021,
  author    = {Voigt, Gesche M. and Thiele, Dominik and Wetzke, Martin and Weidemann, J{\"u}rgen and Parpatt, Patricia-Maria and Welte, Tobias and Seidenberg, J{\"u}rgen and Vogelberg, Christian and Koster, Holger and Rohde, Gernot G. U. and H{\"a}rtel, Christoph and Hansen, Gesine and Kopp, Matthias V.},
  title     = {Interobserver agreement in interpretation of chest radiographs for pediatric community acquired pneumonia: Findings of the pedCAPNETZ-cohort},
  series = {Pediatric Pulmonology},
  volume    = {56},
  journal   = {Pediatric Pulmonology},
  number    = {8},
  doi       = {10.1002/ppul.25528},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-244705},
  pages     = {2676 -- 2685},
  year      = {2021},
  abstract  = {Although chest radiograph (CXR) is commonly used in diagnosing pediatric community acquired pneumonia (pCAP), limited data on interobserver agreement among radiologists exist. PedCAPNETZ is a prospective, observational, and multicenter study on pCAP. N = 233 CXR from patients with clinical diagnosis of pCAP were retrieved and n = 12 CXR without pathological findings were added. All CXR were interpreted by a radiologist at the site of recruitment and by two external, blinded pediatric radiologists. To evaluate interobserver agreement, the reporting of presence or absence of pCAP in CXR was analyzed, and prevalence and bias-adjusted kappa (PABAK) statistical testing was applied. Overall, n = 190 (82\%) of CXR were confirmed as pCAP by two external pediatric radiologists. Compared with patients with pCAP negative CXR, patients with CXR-confirmed pCAP displayed higher C-reactive protein levels and a longer duration of symptoms before enrollment (p < .007). Further parameters, that is, age, respiratory rate, and oxygen saturation showed no significant difference. The interobserver agreement between the onsite radiologists and each of the two independent pediatric radiologists for the presence of pCAP was poor to fair (69\%; PABAK = 0.39\% and 76\%; PABAK = 0.53, respectively). The concordance between the external radiologists was fair (81\%; PABAK = 0.62). With regard to typical CXR findings for pCAP, chance corrected interrater agreement was highest for pleural effusions, infiltrates, and consolidations and lowest for interstitial patterns and peribronchial thickening. Our data show a poor interobserver agreement in the CXR-based diagnosis of pCAP and emphasized the need for harmonized interpretation standards.},
  language  = {en}
}