@article{SasseSchilligDierolfetal.2011,
  author    = {Sasse, Christoph and Schillig, Rebecca and Dierolf, Franziska and Weyler, Michael and Schneider, Sabrina and Mogavero, Selene and Rogers, David P. and Morschh{\"a}user, Joachim},
  title     = {The Transcription Factor Ndt80 Does Not Contribute to Mrr1-, Tac1-, and Upc2-Mediated Fluconazole Resistance in Candida albicans},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-69201},
  year      = {2011},
  abstract  = {The pathogenic yeast Candida albicans can develop resistance to the widely used antifungal agent fluconazole, which inhibits ergosterol biosynthesis, by the overexpression of genes encoding multidrug efflux pumps or ergosterol biosynthesis enzymes. Zinc cluster transcription factors play a central role in the transcriptional regulation of drug resistance. Mrr1 regulates the expression of the major facilitator MDR1, Tac1 controls the expression of the ABC transporters CDR1 and CDR2, and Upc2 regulates ergosterol biosynthesis (ERG) genes. Gain-of-function mutations in these transcription factors result in constitutive overexpression of their target genes and are responsible for fluconazole resistance in many clinical C. albicans isolates. The transcription factor Ndt80 contributes to the drug-induced upregulation of CDR1 and ERG genes and also binds to the MDR1 and CDR2 promoters, suggesting that it is an important component of all major transcriptional mechanisms of fluconazole resistance. However, we found that Ndt80 is not required for the induction of MDR1 and CDR2 expression by inducing chemicals. CDR2 was even partially derepressed in ndt80D mutants, indicating that Ndt80 is a repressor of CDR2 expression. Hyperactive forms of Mrr1, Tac1, and Upc2 promoted overexpression of MDR1, CDR1/CDR2, and ERG11, respectively, with the same efficiency in the presence and absence of Ndt80. Mrr1- and Tac1-mediated fluconazole resistance was even slightly enhanced in ndt80D mutants compared to wild-type cells. These results demonstrate that Ndt80 is dispensable for the constitutive overexpression of Mrr1, Tac1, and Upc2 target genes and the increased fluconazole resistance of strains that have acquired activating mutations in these transcription factors.},
  subject      = {Candida albicans},
  language  = {en}
}
@article{SchneiderKoerkelWeinert1989,
  author    = {Schneider, Wolfgang and K{\"o}rkel, Joachim and Weinert, Franz E.},
  title     = {Domain-Specific Knowledge and Memory Performance: A Comparison of High- and Low-Aptitude Children},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62107},
  year      = {1989},
  abstract  = {Two studies compared memory performance and text comprehension of groups that were equivalent on domain-specific knowledge but differed in overall aptitude, to investigate whether prior knowledge about a particular domain or overall aptitude level was more important when the task was to acquire and use new information in the domain of interest. Both studies dealt with third-, fifth-, and seventh-grade soccer experts' and novices' memory and comprehension of a story dealing with a soccer game. Several measures of memory performance, memory monitoring, and text comprehension were used. Levels of soccer knowledge and of overall aptitude were varied in a factorial design. Neither study detected significant differences between high-aptitude and low-aptitude experts, regardless of their ages. Low aptitude experts outperformed high-aptitude novices on all memory and comprehension measures. The results indicate that domain-specific knowledge can compensate for low overall aptitude on domain-related cognitive tasks.},
  subject      = {Psychologie},
  language  = {en}
}
@article{SchneiderKoerkel1989,
  author    = {Schneider, Wolfgang and K{\"o}rkel, Joachim},
  title     = {The knowledge base and text recall: Evidence from a short-term longitudinal study},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62093},
  year      = {1989},
  abstract  = {In a short-term longitudinal study, we investigated how domain-specific knowledge in soccer influences the amount of text recall and comprehension in elementary school and junior high school children of high and low overall aptitudes. Both level of soccer knowledge and overall aptitude were varied in a factorial design. Third, fifth, and seventh grade children were given several measures of text recall and comprehension and were retested on these measures about 1 year later. Performance was more a function of soccer knowledge than of aptitude level.},
  subject      = {Psychologie},
  language  = {en}
}
@article{SchneiderKoerkelWeinert1987,
  author    = {Schneider, Wolfgang and K{\"o}rkel, Joachim and Weinert, Franz E.},
  title     = {The effects of intelligence, self-concept, and attributional style on metamemory and memory behaviour},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62050},
  year      = {1987},
  abstract  = {No abstract available},
  subject      = {Psychologie},
  language  = {en}
}
@phdthesis{Schneider1991,
  author    = {Schneider, Joachim},
  title     = {Heinrich Deichsler und die N{\"u}rnberger Chronistik des 15. Jahrhunderts},
  isbn      = {3-88226-503-5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-35483},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1991},
  abstract  = {Ein Kennzeichen der sp{\"a}tmittelalterlichen Stadtchronistik ist das Auftreten von Autoren und Lesern aus neuen, bis dahin illiteraten sozialen Schichten. Zur Erforschung dieser Geschichtsschreibung liefert die Arbeit von Joachim Schneider am Beispiel N{\"u}rnberg mit seinen kodikologischen und rezeptionsgeschichtlichen, aber auch seinen modernen sozial- und mentalit{\"a}tsgeschichtlichen Fragestellungen einen wichtigen Beitrag. Im Zentrum der Untersuchung steht die Chronik des Bierbrauers und Aufsehers {\"u}ber das Bettelwesen, Heinrich Deichsler. Nach eingehender Analyse von Materialgewinnung und Arbeitstechniken Deichslers ist das Bild, das die N{\"u}rnberger um 1500 von ihrer Vergangenheit hatten, ein weiterer Schwerpunkt dieses Werkes. Schneider vergleicht dazu die Deichslersche Chronik mit anderen N{\"u}rnberger historiographischen Texten. Insbesondere geht es dabei um die Gemeinsamkeiten und Unterschiede zwischen b{\"u}rgerlicher und offizi{\"o}ser Geschichtsbetrachtung. Zwei f{\"u}r die Stadt zentrale Geschichts{\"u}berlieferungen stehen im Vordergrund: Die Erwerbung und Behauptung der Reichskleinodien sowie der Aufstand von 1348/49. Ein weiteres Kapitel der Arbeit liefert anhand der Zeitungen, Urkunden u.{\"A}., die Deichsler in seine Chronik als Inserte einf{\"u}gte, einen Beitrag zu den noch wenig erforschten Anf{\"a}ngen des Zeitungswesens. Deichslers selbst{\"a}ndige Chronistik f{\"u}hrt schließlich mitten in das N{\"u}rnberger Alltagsleben um 1500. Auch hier zeigen sich bei Themen und Darstellungsweise bezeichnende Unterschiede zu anderen N{\"u}rnberger Chroniken, die aus sozial h{\"o}herem Milieu stammen. Schneiders Untersuchung beschreibt nicht nur chronistische Techniken, Geschichtsbild und Mentalit{\"a}t eines bemerkenswert fleißigen Mittelschicht-Chronisten, es entsteht vielmehr ein Panorama der reichen sp{\"a}tmittelalterlichen N{\"u}rnberger Geschichtsschreibung und damit der Geschichte dieser Stadt selbst in ihren großen und kleinen Ereignissen - einer Stadt, die gerade damals ihre wohl gr{\"o}ßte Zeit erlebte.},
  subject      = {Deichsler},
  language  = {de}
}
@article{SchneiderKoerkelVogel1987,
  author    = {Schneider, Wolfgang and K{\"o}rkel, Joachim and Vogel, Klaus},
  title     = {Zusammenh{\"a}nge zwischen Metaged{\"a}chtnis, strategischem Verhalten und Ged{\"a}chtnisleistungen im Grundschulalter: Eine entwicklungspsychologische Studie},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87368},
  year      = {1987},
  abstract  = {In der vorliegenden Studie wurde die Frage gepr{\"u}ft, inwieweit Schulanf{\"a}nger im Vergleich zu fortgeschrittenen Grundsch{\"u}lern tats{\"a}chlich nur wenig dar{\"u}ber wissen, welche Strategien in freien Reproduktionsaufgaben (son-recall) voneilhaft sind. Zu diesem Zweck wurde das Metaged{\"a}chtnis von Zweit- und Vienkl{\"a}ßlern, also ihr Wissen um die Vorteile unterschiedlicher Sortier- und Lernstrategien, mit ihrem Lernverhalten bzw. ihrem Leistungsverm{\"o}gen in unterschiedlichen Varianten der sort-recall-Aufgabe verglichen. Diese Prozedur gestattete es, die Bewertung unterschiedlicher Strategien direkt mit ihrer jeweiligen Wirksamkeit zu vergleichen. Die an je 32 Zweit- und Viertkl{\"a}ßlern gewonnenen Befunde: lassen sich insgesamt so interpretieren, daß die j{\"u}ngeren Kinder kaum etwas {\"u}ber angemessene Verhaltensweisen bei freien Reproduktionsaufgaben wissen; sie ziehen perzeptuelle Organisationsstrategien konzeptuellen (taxonomischen) Organisationsstrategien vor, profitieren tats{\"a}chlich jedoch signifikant mehr von konzeptuellen Strategien. Demgegen{\"u}ber verf{\"u}gten die: Vienkl{\"a}ßler in der Regel {\"u}ber angemessenes Metaged{\"a}chtnis: sie sch{\"a}tzten taxonomische Strategien nicht nur h{\"o}her ein, sondern profitierten auch de facto deutlich mehr von solchen Techniken. Die Befunde k{\"o}nnen insgesamt als Best{\"a}tigung der in der neueren Literatur verbreiteten Annahme gewertet werden, daß sich das Wissen um Ged{\"a}chtnisanforderungen bei sort-recall-Aufgaben erst gegen Ende: der Grundschulzeit herausbildet.},
  subject      = {Metaged{\"a}chtnis},
  language  = {de}
}
@incollection{KoerkelSchneider1992,
  author    = {K{\"o}rkel, Joachim and Schneider, Wolfgang},
  title     = {Domain-specific versus metacognitive knowledge effects on text recall and comprehension},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86647},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1992},
  abstract  = {No abstract available.},
  subject      = {Unterricht},
  language  = {en}
}
@article{BartmannFischerHuebneretal.2021,
  author    = {Bartmann, Catharina and Fischer, Leah-Maria and H{\"u}bner, Theresa and M{\"u}ller-Reiter, Max and W{\"o}ckel, Achim and McNeill, Rhiannon V. and Schlaiss, Tanja and Kittel-Schneider, Sarah and K{\"a}mmerer, Ulrike and Diessner, Joachim},
  title     = {The effects of the COVID-19 pandemic on psychological stress in breast cancer patients},
  series = {BMC Cancer},
  volume    = {21},
  journal   = {BMC Cancer},
  doi       = {10.1186/s12885-021-09012-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-265802},
  year      = {2021},
  abstract  = {Background: The majority of breast cancer patients are severely psychologically affected by breast cancer diagnosis and subsequent therapeutic procedures. The COVID-19 pandemic and associated restrictions on public life have additionally caused significant psychological distress for much of the population. It is therefore plausible that breast cancer patients might be particularly susceptible to the additional psychological stress caused by the pandemic, increasing suffering. In this study we therefore aimed to assess the level of psychological distress currently experienced by a defined group of breast cancer patients in our breast cancer centre, compared to distress levels preCOVID-19 pandemic. Methods: Female breast cancer patients of all ages receiving either adjuvant, neoadjuvant, or palliative therapies were recruited for the study. All patients were screened for current or previous COVID-19 infection. The participants completed a self-designed COVID-19 pandemic questionnaire, the Stress and Coping Inventory (SCI), the National Comprehensive Cancer Network (R) (NCCN (R)) Distress Thermometer (DT), the European Organization for Research and Treatment of Cancer (EORTC) QLQ C30, and the BR23. Results: Eighty-two breast cancer patients were included. Therapy status and social demographic factors did not have a significant effect on the distress caused by the COVID-19 pandemic. The results of the DT pre and during COVID-19 pandemic did not differ significantly. Using the self-designed COVID-19 pandemic questionnaire, we detected three distinct subgroups demonstrating different levels of concerns in relation to SARS-CoV-2. The subgroup with the highest levels of concern reported significantly decreased life quality, related parameters and symptoms. Conclusions: This monocentric study demonstrated that the COVID-19 pandemic significantly affected psychological health in a subpopulation of breast cancer patients. The application of a self-created "COVID-19 pandemic questionnaire"could potentially be used to help identify breast cancer patients who are susceptible to increased psychological distress due to the COVID-19 pandemic, and therefore may need additional intensive psychological support.},
  language  = {en}
}
@inproceedings{SchneiderKoerkelWeinert1990,
  author    = {Schneider, Wolfgang and K{\"o}rkel, Joachim and Weinert, Franz E.},
  title     = {Expert knowledge, general abilities, and text processing},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87175},
  year      = {1990},
  abstract  = {No abstract available.},
  subject      = {Kognitive Entwicklung},
  language  = {en}
}
@incollection{SchneiderKoerkelWeinert1990,
  author    = {Schneider, Wolfgang and K{\"o}rkel, Joachim and Weinert, Franz E.},
  title     = {Expert Knowledge, General Abilities, and Text Processing},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86548},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1990},
  abstract  = {No abstract available.},
  subject      = {Textverarbeitung <Psycholinguistik>},
  language  = {en}
}
@incollection{KnopfKoerkelSchneideretal.1986,
  author    = {Knopf, Monika and K{\"o}rkel, Joachim and Schneider, Wolfgang and Weinert, Franz E.},
  title     = {Human memory as a faculty versus human memory as a set of specific abilities: Evidence from a life-span approach},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87394},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1986},
  abstract  = {No abstract available.},
  subject      = {Ged{\"a}chtnis},
  language  = {en}
}
@article{GabrielJirůHillmannKraftetal.2020,
  author    = {Gabriel, Katharina M. A. and J{\´i}rů-Hillmann, Steffi and Kraft, Peter and Selig, Udo and R{\"u}cker, Victoria and M{\"u}hler, Johannes and D{\"o}tter, Klaus and Keidel, Matthias and Soda, Hassan and Rascher, Alexandra and Schneider, Rolf and Pfau, Mathias and Hoffmann, Roy and Stenzel, Joachim and Benghebrid, Mohamed and Goebel, Tobias and Doerck, Sebastian and Kramer, Daniela and Haeusler, Karl Georg and Volkmann, Jens and Heuschmann, Peter U. and Fluri, Felix},
  title     = {Two years' experience of implementing a comprehensive telemedical stroke network comprising in mainly rural region: the Transregional Network for Stroke Intervention with Telemedicine (TRANSIT-Stroke)},
  series = {BMC Neurology},
  volume    = {20},
  journal   = {BMC Neurology},
  doi       = {10.1186/s12883-020-01676-6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-229214},
  year      = {2020},
  abstract  = {Background Telemedicine improves the quality of acute stroke care in rural regions with limited access to specialized stroke care. We report the first 2 years' experience of implementing a comprehensive telemedical stroke network comprising all levels of stroke care in a defined region. Methods The TRANSIT-Stroke network covers a mainly rural region in north-western Bavaria (Germany). All hospitals providing acute stroke care in this region participate in TRANSIT-Stroke, including four hospitals with a supra-regional certified stroke unit (SU) care (level III), three of those providing teleconsultation to two hospitals with a regional certified SU (level II) and five hospitals without specialized SU care (level I). For a two-year-period (01/2015 to 12/2016), data of eight of these hospitals were available; 13 evidence-based quality indicators (QIs) related to processes during hospitalisation were evaluated quarterly and compared according to predefined target values between level-I- and level-II/III-hospitals. Results Overall, 7881 patients were included (mean age 74.6 years +/- 12.8; 48.4\% female). In level-II/III-hospitals adherence of all QIs to predefined targets was high ab initio. In level-I-hospitals, three patterns of QI-development were observed: a) high adherence ab initio (31\%), mainly in secondary stroke prevention; b) improvement over time (44\%), predominantly related to stroke specific diagnosis and in-hospital organization; c) no clear time trends (25\%). Overall, 10 out of 13 QIs reached predefined target values of quality of care at the end of the observation period. Conclusion The implementation of the comprehensive TRANSIT-Stroke network resulted in an improvement of quality of care in level-I-hospitals.},
  language  = {en}
}
@article{HuebnerWolfgangTheisetal.2022,
  author    = {H{\"u}bner, Theresa and Wolfgang, Tanja and Theis, Ann-Catrin and Steber, Magdalena and Wiedenmann, Lea and W{\"o}ckel, Achim and Diessner, Joachim and Hein, Grit and Gr{\"u}ndahl, Marthe and K{\"a}mmerer, Ulrike and Kittel-Schneider, Sarah and Bartmann, Catharina},
  title     = {The impact of the COVID-19 pandemic on stress and other psychological factors in pregnant women giving birth during the first wave of the pandemic},
  series = {Reproductive Health},
  volume    = {19},
  journal   = {Reproductive Health},
  number    = {1},
  doi       = {10.1186/s12978-022-01493-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-300189},
  year      = {2022},
  abstract  = {Background The onset of mental illness such as depression and anxiety disorders in pregnancy and postpartum period is common. The coronavirus induced disease 2019 (COVID-19) pandemic and the resulting public policy responses represent an exceptional situation worldwide and there are hints for adverse psychosocial impact, hence, the study of psychological effects of the pandemic in women during hospitalization for delivery and in the postpartum period is highly relevant. Methods Patients who gave birth during the first wave of the COVID-19 pandemic in Germany (March to June 2020) at the Department of Obstetrics and Gynecology, University of W{\"u}rzburg, Germany, were recruited at hospital admission for delivery. Biosamples were collected for analysis of SARS-CoV-2 infection and various stress hormones and interleukin-6 (IL-6). In addition to sociodemographic and medical obstetric data, survey questionnaires in relation to concerns about and fear of COVID-19, depression, stress, anxiety, loneliness, maternal self-efficacy and the mother-child bonding were administered at T1 (delivery stay) and T2 (3-6 months postpartum). Results In total, all 94 recruited patients had a moderate concern of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at T1 with a significant rise at T2. This concern correlated with low to low-medium general psychosocial stress levels and stress symptoms, and the women showed a significant increase of active coping from T1 to T2. Anxiety levels were low and the Edinburgh Postnatal Depression Scale showed a medium score of 5 with a significant (T1), but only week correlation with the concerns about SARS-CoV-2. In contrast to the overall good maternal bonding without correlation to SARS-CoV-2 concern, the maternal self-efficiency correlated negatively with the obstetric impairment caused by the COVID-19 pandemic. Conclusion Obstetric patients` concerns regarding SARS-CoV-2 and the accompanying pandemic increased during the course of the pandemic correlating positively with stress and depression. Of note is the increase in active coping over time and the overall good mother-child-bonding. Maternal self-efficacy was affected in part by the restrictions of the pandemic.},
  language  = {en}
}
@article{SchischlevskijCordtsGuentheretal.2021,
  author    = {Schischlevskij, Pavel and Cordts, Isabell and G{\"u}nther, Ren{\´e} and Stolte, Benjamin and Zeller, Daniel and Schr{\"o}ter, Carsten and Weyen, Ute and Regensburger, Martin and Wolf, Joachim and Schneider, Ilka and Hermann, Andreas and Metelmann, Moritz and Kohl, Zacharias and Linker, Ralf A. and Koch, Jan Christoph and Stendel, Claudia and M{\"u}schen, Lars H. and Osmanovic, Alma and Binz, Camilla and Klopstock, Thomas and Dorst, Johannes and Ludolph, Albert C. and Boentert, Matthias and Hagenacker, Tim and Deschauer, Marcus and Lingor, Paul and Petri, Susanne and Schreiber-Katz, Olivia},
  title     = {Informal caregiving in amyotrophic lateral sclerosis (ALS): a high caregiver burden and drastic consequences on caregivers' lives},
  series = {Brain Sciences},
  volume    = {11},
  journal   = {Brain Sciences},
  number    = {6},
  issn      = {2076-3425},
  doi       = {10.3390/brainsci11060748},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-240981},
  year      = {2021},
  abstract  = {Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes progressive autonomy loss and need for care. This does not only affect patients themselves, but also the patients' informal caregivers (CGs) in their health, personal and professional lives. The big efforts of this multi-center study were not only to evaluate the caregivers' burden and to identify its predictors, but it also should provide a specific understanding of the needs of ALS patients' CGs and fill the gap of knowledge on their personal and work lives. Using standardized questionnaires, primary data from patients and their main informal CGs (n = 249) were collected. Patients' functional status and disease severity were evaluated using the Barthel Index, the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) and the King's Stages for ALS. The caregivers' burden was recorded by the Zarit Burden Interview (ZBI). Comorbid anxiety and depression of caregivers were assessed by the Hospital Anxiety and Depression Scale. Additionally, the EuroQol Five Dimension Five Level Scale evaluated their health-related quality of life. The caregivers' burden was high (mean ZBI = 26/88, 0 = no burden, ≥24 = highly burdened) and correlated with patients' functional status (r\(_p\) = -0.555, p < 0.001, n = 242). It was influenced by the CGs' own mental health issues due to caregiving (+11.36, 95\% CI [6.84; 15.87], p < 0.001), patients' wheelchair dependency (+9.30, 95\% CI [5.94; 12.66], p < 0.001) and was interrelated with the CGs' depression (r\(_p\) = 0.627, p < 0.001, n = 234), anxiety (r\(_p\) = 0.550, p < 0.001, n = 234), and poorer physical condition (r\(_p\) = -0.362, p < 0.001, n = 237). Moreover, female CGs showed symptoms of anxiety more often, which also correlated with the patients' impairment in daily routine (r\(_s\) = -0.280, p < 0.001, n = 169). As increasing disease severity, along with decreasing autonomy, was the main predictor of caregiver burden and showed to create relevant (negative) implications on CGs' lives, patient care and supportive therapies should address this issue. Moreover, in order to preserve the mental and physical health of the CGs, new concepts of care have to focus on both, on not only patients but also their CGs and gender-associated specific issues. As caregiving in ALS also significantly influences the socioeconomic status by restrictions in CGs' work lives and income, and the main reported needs being lack of psychological support and a high bureaucracy, the situation of CGs needs more attention. Apart from their own multi-disciplinary medical and psychological care, more support in care and patient management issues is required.},
  language  = {en}
}
@article{PeseschkianCordtsGuentheretal.2021,
  author    = {Peseschkian, Tara and Cordts, Isabell and G{\"u}nther, Ren{\´e} and Stolte, Benjamin and Zeller, Daniel and Schr{\"o}ter, Carsten and Weyen, Ute and Regensburger, Martin and Wolf, Joachim and Schneider, Ilka and Hermann, Andreas and Metelmann, Moritz and Kohl, Zacharias and Linker, Ralf A. and Koch, Jan Christoph and B{\"u}chner, Boriana and Weiland, Ulrike and Sch{\"o}nfelder, Erik and Heinrich, Felix and Osmanovic, Alma and Klopstock, Thomas and Dorst, Johannes and Ludolph, Albert C. and Boentert, Matthias and Hagenacker, Tim and Deschauer, Marcus and Lingor, Paul and Petri, Susanne and Schreiber-Katz, Olivia},
  title     = {A nation-wide, multi-center study on the quality of life of ALS patients in Germany},
  series = {Brain Sciences},
  volume    = {11},
  journal   = {Brain Sciences},
  number    = {3},
  issn      = {2076-3425},
  doi       = {10.3390/brainsci11030372},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-234147},
  year      = {2021},
  abstract  = {Improving quality of life (QoL) is central to amyotrophic lateral sclerosis (ALS) treatment. This Germany-wide, multicenter cross-sectional study analyses the impact of different symptom-specific treatments and ALS variants on QoL. Health-related QoL (HRQoL) in 325 ALS patients was assessed using the Amyotrophic Lateral Sclerosis Assessment Questionnaire 5 (ALSAQ-5) and EuroQol Five Dimension Five Level Scale (EQ-5D-5L), together with disease severity (captured by the revised ALS Functional Rating Scale (ALSFRS-R)) and the current care and therapies used by our cohort. At inclusion, the mean ALSAQ-5 total score was 56.93 (max. 100, best = 0) with a better QoL associated with a less severe disease status (β = -1.96 per increase of one point in the ALSFRS-R score, p < 0.001). "Limb-onset" ALS (lALS) was associated with a better QoL than "bulbar-onset" ALS (bALS) (mean ALSAQ-5 total score 55.46 versus 60.99, p = 0.040). Moreover, with the ALSFRS-R as a covariate, using a mobility aid (β = -7.60, p = 0.001), being tracheostomized (β = -14.80, p = 0.004) and using non-invasive ventilation (β = -5.71, p = 0.030) were associated with an improved QoL, compared to those at the same disease stage who did not use these aids. In contrast, antidepressant intake (β = 5.95, p = 0.007), and increasing age (β = 0.18, p = 0.023) were predictors of worse QoL. Our results showed that the ALSAQ-5 was better-suited for ALS patients than the EQ-5D-5L. Further, the early and symptom-specific clinical management and supply of assistive devices can significantly improve the individual HRQoL of ALS patients. Appropriate QoL questionnaires are needed to monitor the impact of treatment to provide the best possible and individualized care.},
  language  = {en}
}