@article{JansenOhlendorfErhardetal.2013,
  author    = {Jansen, Nils and Ohlendorf, Birgit and Erhard, Arlette and Bruhn, Torsten and Bringmann, Gerhard and Imhoff, Johannes F.},
  title     = {Helicusin E, Isochromophilone X and Isochromophilone XI: New Chloroazaphilones Produced by the Fungus Bartalinia robillardoides Strain LF550},
  series = {Marine Drugs},
  volume    = {11},
  journal   = {Marine Drugs},
  number    = {3},
  doi       = {10.3390/md11030800},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-129649},
  pages     = {800-816},
  year      = {2013},
  abstract  = {Microbial studies of the Mediterranean sponge Tethya aurantium led to the isolation of the fungus Bartalinia robillardoides strain LF550. The strain produced a number of secondary metabolites belonging to the chloroazaphilones. This is the first report on the isolation of chloroazaphilones of a fungal strain belonging to the genus Bartalinia. Besides some known compounds (helicusin A (1) and deacetylsclerotiorin (2)), three new chloroazaphilones (helicusin E (3); isochromophilone X (4) and isochromophilone XI (5)) and one new pentaketide (bartanolide (6)) were isolated. The structure elucidations were based on spectroscopic analyses. All isolated compounds revealed different biological activity spectra against a test panel of four bacteria: three fungi; two tumor cell lines and two enzymes.},
  language  = {en}
}
@article{KunzLabesWieseetal.2014,
  author    = {Kunz, Anna Lena and Labes, Antje and Wiese, Jutta and Bruhn, Torsten and Bringmann, Gerhard and Imhoff, Johannes F.},
  title     = {Nature's Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain},
  series = {Marine Drugs},
  volume    = {12},
  journal   = {Marine Drugs},
  number    = {4},
  issn      = {1660-3397},
  doi       = {10.3390/md12041699},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-116816},
  pages     = {1699-1714},
  year      = {2014},
  abstract  = {Eight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I-K) also showed moderate activities against PDE 4B.},
  language  = {en}
}
@article{VillalobosWieseImhoffetal.2019,
  author    = {Villalobos, Alvaro S. and Wiese, Jutta and Imhoff, Johannes F. and Dorador, Cristina and Keller, Alexander and Hentschel, Ute},
  title     = {Systematic affiliation and genome analysis of Subtercola vilae DB165T with particular emphasis on cold adaptation of an isolate from a high-altitude cold volcano lake},
  series = {Microorganisms},
  volume    = {7},
  journal   = {Microorganisms},
  number    = {4},
  issn      = {2076-2607},
  doi       = {10.3390/microorganisms7040107},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-197394},
  year      = {2019},
  abstract  = {Among the Microbacteriaceae the species of Subtercola and Agreia form closely associated clusters. Phylogenetic analysis demonstrated three major phylogenetic branches of these species. One of these branches contains the two psychrophilic species Subtercola frigoramans and Subtercola vilae, together with a larger number of isolates from various cold environments. Genomic evidence supports the separation of Agreia and Subtercola species. In order to gain insight into the ability of S. vilae to adapt to life in this extreme environment, we analyzed the genome with a particular focus on properties related to possible adaptation to a cold environment. General properties of the genome are presented, including carbon and energy metabolism, as well as secondary metabolite production. The repertoire of genes in the genome of S. vilae DB165\(^T\) linked to adaptations to the harsh conditions found in Llullaillaco Volcano Lake includes several mechanisms to transcribe proteins under low temperatures, such as a high number of tRNAs and cold shock proteins. In addition, S. vilae DB165\(^T\) is capable of producing a number of proteins to cope with oxidative stress, which is of particular relevance at low temperature environments, in which reactive oxygen species are more abundant. Most important, it obtains capacities to produce cryo-protectants, and to combat against ice crystal formation, it produces ice-binding proteins. Two new ice-binding proteins were identified which are unique to S. vilae DB165\(^T\). These results indicate that S. vilae has the capacity to employ different mechanisms to live under the extreme and cold conditions prevalent in Llullaillaco Volcano Lake.},
  language  = {en}
}
@article{ImhoffRahnKuenzeletal.2020,
  author    = {Imhoff, Johannes F. and Rahn, Tanja and K{\"u}nzel, Sven and Keller, Alexander and Neulinger, Sven C.},
  title     = {Osmotic adaptation and compatible solute biosynthesis of phototrophic bacteria as revealed from genome analyses},
  series = {Microorganisms},
  volume    = {9},
  journal   = {Microorganisms},
  number    = {1},
  issn      = {2076-2607},
  doi       = {10.3390/microorganisms9010046},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220161},
  year      = {2020},
  abstract  = {Osmotic adaptation and accumulation of compatible solutes is a key process for life at high osmotic pressure and elevated salt concentrations. Most important solutes that can protect cell structures and metabolic processes at high salt concentrations are glycine betaine and ectoine. The genome analysis of more than 130 phototrophic bacteria shows that biosynthesis of glycine betaine is common among marine and halophilic phototrophic Proteobacteria and their chemotrophic relatives, as well as in representatives of Pirellulaceae and Actinobacteria, but are also found in halophilic Cyanobacteria and Chloroherpeton thalassium. This ability correlates well with the successful toleration of extreme salt concentrations. Freshwater bacteria in general lack the possibilities to synthesize and often also to take up these compounds. The biosynthesis of ectoine is found in the phylogenetic lines of phototrophic Alpha- and Gammaproteobacteria, most prominent in the Halorhodospira species and a number of Rhodobacteraceae. It is also common among Streptomycetes and Bacilli. The phylogeny of glycine-sarcosine methyltransferase (GMT) and diaminobutyrate-pyruvate aminotransferase (EctB) sequences correlate well with otherwise established phylogenetic groups. Most significantly, GMT sequences of cyanobacteria form two major phylogenetic branches and the branch of Halorhodospira species is distinct from all other Ectothiorhodospiraceae. A variety of transport systems for osmolytes are present in the studied bacteria.},
  language  = {en}
}