@article{FreibergMatlachGrehnetal.2013,
  author    = {Freiberg, Florentina Joyce and Matlach, Juliane and Grehn, Franz and Karl, Sabine and Klink, Thomas},
  title     = {Postoperative subconjunctival bevacizumab injection as an adjunct to 5-fluorouracil in the management of scarring after trabeculectomy},
  series = {Clinical Ophthalmology},
  journal   = {Clinical Ophthalmology},
  doi       = {10.2147/OPTH.S41750},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-96546},
  year      = {2013},
  abstract  = {Purpose: Scarring after glaucoma filtering surgery remains the most frequent cause for bleb failure. The aim of this study was to assess if the postoperative injection of bevacizumab reduces the number of postoperative subconjunctival 5-fluorouracil (5-FU) injections. Further, the effect of bevacizumab as an adjunct to 5-FU on the intraocular pressure (IOP) outcome, bleb morphology, postoperative medications, and complications was evaluated. Methods: Glaucoma patients (N = 61) who underwent trabeculectomy with mitomycin C were analyzed retrospectively (follow-up period of 25 ± 19 months). Surgery was performed exclusively by one experienced glaucoma specialist using a standardized technique. Patients in group 1 received subconjunctival applications of 5-FU postoperatively. Patients in group 2 received 5-FU and subconjunctival injection of bevacizumab. Results: Group 1 had 6.4 ± 3.3 (0-15) (mean ± standard deviation and range, respectively) 5-FU injections. Group 2 had 4.0 ± 2.8 (0-12) (mean ± standard deviation and range, respectively) 5-FU injections. The added injection of bevacizumab significantly reduced the mean number of 5-FU injections by 2.4 ± 3.08 (P ≤ 0.005). There was no significantly lower IOP in group 2 when compared to group 1. A significant reduction in vascularization and in cork screw vessels could be found in both groups (P < 0.0001, 7 days to last 5-FU), yet there was no difference between the two groups at the last follow-up. Postoperative complications were significantly higher for both groups when more 5-FU injections were applied. (P = 0.008). No significant difference in best corrected visual acuity (P = 0.852) and visual field testing (P = 0.610) between preoperative to last follow-up could be found between the two groups. Conclusion: The postoperative injection of bevacizumab reduced the number of subconjunctival 5-FU injections significantly by 2.4 injections. A significant difference in postoperative IOP reduction, bleb morphology, and postoperative medication was not detected.},
  language  = {en}
}
@article{KlinkSauerKoerberetal.2015,
  author    = {Klink, Thomas and Sauer, Johannes and K{\"o}rber, Norbert J and Grehn, Franz and Much, Martin M and Thederan, Luisa and Matlach, Juliane and Salgado, Josefina Parente},
  title     = {Quality of life following glaucoma surgery: canaloplasty versus trabeculectomy},
  series = {Clinical Ophthalmology},
  volume    = {9},
  journal   = {Clinical Ophthalmology},
  doi       = {10.2147/OPTH.S72357},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-149520},
  pages     = {7-16},
  year      = {2015},
  abstract  = {Purpose: To evaluate quality of life (QoL) with a new questionnaire after canaloplasty (CP) and trabeculectomy (TE). Patients and methods: We assessed outcomes of surgery, rate of revision surgeries, patients' mood, and influence of postoperative care on QoL, surgery interference with daily activities, and postsurgical complaints. Patients completed the QoL questionnaire 24 months after surgery. Results: Patients who underwent CP (n=175) were compared to TE patients (n=152). In the CP group, 57\% of patients expressed high satisfaction, while 41\% of patients in the TE group said they were highly satisfied. The satisfaction difference was statistically significant (P=0.034). Significantly fewer second surgeries were needed after CP (8\% CP versus 35\% TE, P<0.001). Patients were more positive in the CP group (54\% CP versus 37\% TE, P<0.009). Stress related to postoperative care was lower in the CP group compared to the TE group (14\% versus 46\%). Difficulties with activities of daily living, such as reading, were much lower or even nonexistent after CP, and complaints like eye burning or stinging were significantly lower in the CP group. Conclusions: Compared with TE, CP is associated with less QoL impairment and higher patient satisfaction after surgery. However, long-term data on intraocular pressure reduction after surgery are needed to confirm long-term patient satisfaction with this surgery.},
  language  = {en}
}
@article{KlinkSauerKoerberetal.2014,
  author    = {Klink, Thomas and Sauer, Johannes and K{\"o}rber, Norbert J. and Grehn, Franz and Much, Martin M. and Thederan, Luisa and Matlach, Juliane and Salgado, Josefina Parente},
  title     = {Quality of life following glaucoma surgery: canaloplasty versus trabeculectomy},
  doi       = {10.2147/OPTH.S72357},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-113596},
  year      = {2014},
  abstract  = {Purpose: To evaluate quality of life (QoL) with a new questionnaire after canaloplasty (CP) and trabeculectomy (TE). Patients and methods: We assessed outcomes of surgery, rate of revision surgeries, patients' mood, and influence of postoperative care on QoL, surgery interference with daily activities, and postsurgical complaints. Patients completed the QoL questionnaire 24 months after surgery. Results: Patients who underwent CP (n=175) were compared to TE patients (n=152). In the CP group, 57\% of patients expressed high satisfaction, while 41\% of patients in the TE group said they were highly satisfied. The satisfaction difference was statistically significant (P=0.034). Significantly fewer second surgeries were needed after CP (8\% CP versus 35\% TE, P<0.001). Patients were more positive in the CP group (54\% CP versus 37\% TE, P<0.009). Stress related to postoperative care was lower in the CP group compared to the TE group (14\% versus 46\%). Difficulties with activities of daily living, such as reading, were much lower or even nonexistent after CP, and complaints like eye burning or stinging were significantly lower in the CP group. Conclusions: Compared with TE, CP is associated with less QoL impairment and higher patient satisfaction after surgery. However, long-term data on intraocular pressure reduction after surgery are needed to confirm long-term patient satisfaction with this surgery.},
  language  = {en}
}