@article{KristDornquastReinholdetal.2021,
  author    = {Krist, Lilian and Dornquast, Christina and Reinhold, Thomas and Icke, Katja and Danquah, Ina and Willich, Stefan N. and Becher, Heiko and Keil, Thomas},
  title     = {Predictors of changes in physical activity and sedentary behavior during the COVID-19 pandemic in a Turkish migrant cohort in Germany},
  series = {International Journal of Environmental Research and Public Health},
  volume    = {18},
  journal   = {International Journal of Environmental Research and Public Health},
  number    = {18},
  issn      = {1660-4601},
  doi       = {10.3390/ijerph18189682},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-246176},
  year      = {2021},
  abstract  = {The new coronavirus (COVID-19) pandemic and the resulting response measures have led to severe limitations of people's exercise possibilities with diminished physical activity (PA) and increased sedentary behavior (SB). Since for migrant groups in Germany, no data is available, this study aimed to investigate factors associated with changes in PA and SB in a sample of Turkish descent. Participants of a prospective cohort study (adults of Turkish descent, living in Berlin, Germany) completed a questionnaire regarding COVID-19 related topics including PA and SB since February 2020. Changes in PA and SB were described, and sociodemographic, migrant-related, and health-related predictors of PA decrease and SB increase were determined using multivariable regression analyses. Of 106 participants, 69\% reported a decline of PA, 36\% reported an increase in SB. PA decrease and SB increase seemed to be associated with inactivity before the pandemic as well as with the female sex. SB increase appeared to be additionally associated with educational level and BMI. The COVID-19 pandemic and the response measures had persistent detrimental effects on this migrant population. Since sufficient PA before the pandemic had the strongest association with maintaining PA and SB during the crisis, the German government and public health professionals should prioritize PA promotion in this vulnerable group.},
  language  = {en}
}
@article{KristDornquastReinholdetal.2020,
  author    = {Krist, Lilian and Dornquast, Christina and Reinhold, Thomas and Becher, Heiko and Icke, Katja and Danquah, Ina and Willich, Stefan N. and Keil, Thomas},
  title     = {Physical activity trajectories among persons of Turkish descent living in Germany — a cohort study},
  series = {International Journal of Environmental Research and Public Health},
  volume    = {17},
  journal   = {International Journal of Environmental Research and Public Health},
  number    = {17},
  issn      = {1660-4601},
  doi       = {10.3390/ijerph17176349},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-211221},
  year      = {2020},
  abstract  = {Physical activity (PA) behavior is increasingly described as trajectories taking changes over a longer period into account. Little is known, however, about predictors of those trajectories among migrant populations. Therefore, the aim of the present cohort study was to describe changes of PA over six years and to explore migration-related and other predictors for different PA trajectories in adults of Turkish descent living in Berlin. At baseline (2011/2012) and after six years, sociodemographics, health behavior, and medical information were assessed. Four PA trajectories were defined using data of weekly PA from baseline and follow-up: "inactive", "decreasing", "increasing", and "stable active". Multivariable regression analyses were performed in order to determine predictors for the "stable active" trajectory, and results were presented as adjusted odds ratios (aOR) with 95\% confidence intervals (95\%CI). In this analysis, 197 people (60.9\% women, mean age ± standard deviation 49.9 ± 12.8 years) were included. A total of 77.7\% were first-generation migrants, and 50.5\% had Turkish citizenship. The four PA trajectories differed regarding citizenship, preferred questionnaire language, and marital status. "Stable active" trajectory membership was predicted by educational level (high vs. low: aOR 4.20, 95\%CI [1.10; 16.00]), citizenship (German or dual vs. Turkish only: 3.60 [1.20; 10.86]), preferred questionnaire language (German vs. Turkish: 3.35 [1.05; 10.66]), and BMI (overweight vs. normal weight: 0.28 [0.08; 0.99]). In our study, migration-related factors only partially predicted trajectory membership, however, persons with citizenship of their country of origin and/or with poor language skills should be particularly considered when planning PA prevention programs.},
  language  = {en}
}
@article{ForchertPotapovaPanettaetal.2022,
  author    = {Forchert, Leandra and Potapova, Ekaterina and Panetta, Valentina and Dramburg, Stephanie and Perna, Serena and Posa, Daniela and Resch-Marat, Yvonne and Lupinek, Christian and Rohrbach, Alexander and Grabenhenrich, Linus and Icke, Katja and Bauer, Carl-Peter and Hoffman, Ute and Forster, Johannes and Zepp, Fred and Schuster, Antje and Wahn, Ulrich and Keil, Thomas and Lau, Susanne and Vrtala, Susanne and Valenta, Rudolf and Matricardi, Paolo Maria},
  title     = {Der p 23-specific IgE response throughout childhood and its association with allergic disease: A birth cohort study},
  series = {Pediatric Allergy and Immunology},
  volume    = {33},
  journal   = {Pediatric Allergy and Immunology},
  number    = {7},
  doi       = {10.1111/pai.13829},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-287181},
  year      = {2022},
  abstract  = {Background The Dermatophagoides pteronyssinus molecule Der p 23 is a major allergen whose clinical relevance has been shown in cross-sectional studies. We longitudinally analysed the trajectory of Der p 23-specific IgE antibody (sIgE) levels throughout childhood and youth, their early-life determinants and their clinical relevance for allergic rhinitis and asthma. Methods We obtained sera and clinical data of 191 participants of the German Multicentre Allergy Study, a prospective birth cohort. Serum samples from birth to 20 years of age with sIgE reactivity to Der p 23 in a customised semiquantitative microarray were newly analysed with a singleplex quantitative assay. Early mite exposure was assessed by measuring the average content of Der p 1 in house dust at 6 and 18 months. Results Der p 23-sIgE levels were detected at least once in 97/191 participants (51\%). Prevalence of Der p 23 sensitisation and mean sIgE levels increased until age 10 years, plateaued until age 13 years and were lowest at age 20 years. Asthma, allergic rhinitis (AR) and atopic dermatitis (AD) were more prevalent in Der p 23-sensitised children, including those with monomolecular but persistent sensitisation (11/97, 11\%). A higher exposure to mites in infancy and occurrence of AD before 5 years of age preceded the onset of Der p 23 sensitisation, which in turn preceded a higher incidence of asthma. Conclusions Der p 23 sensitisation peaks in late childhood and then decreases. It is preceded by early mite exposure and AD. Asthma and AR can occur in patients persistently sensitised to Der p 23 as the only mite allergen, suggesting the inclusion of molecular testing of Der p 23-sIgE for subjects with clinical suspicion of HDM allergy but without sIgE to other major D.pt. allergens.},
  language  = {en}
}
@article{RossbergKellerIckeetal.2020,
  author    = {Roßberg, Siri and Keller, Theresa and Icke, Katja and Siedmann, Valentina and Lau, Imke and Keil, Thomas and Lau, Susanne},
  title     = {Orally applied bacterial lysate in infants at risk for atopy does not prevent atopic dermatitis, allergic rhinitis, asthma or allergic sensitization at school age: Follow-up of a randomized trial},
  series = {Allergy},
  volume    = {75},
  journal   = {Allergy},
  number    = {8},
  doi       = {10.1111/all.14247},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-213456},
  pages     = {2020 -- 2025},
  year      = {2020},
  abstract  = {Background The allergy preventive effects of gut immune modulation by bacterial compounds are still not fully understood. Objective We sought to evaluate the effect of bacterial lysate applied orally from the second until seventh months of life on the prevalence of allergic diseases at school age. Methods In a randomized, placebo-controlled trial, 606 newborns with at least one allergic parent received orally a bacterial lysate consisting of heat-killed Gram-negative Escherichia coli Symbio and Gram-positive Enterococcus faecalis Symbio or placebo from week 5 until the end of month 7. A total of 402 children were followed until school age (6-11 years) for the assessment of current atopic dermatitis (AD), allergic rhinitis (AR), asthma and sensitization against aeroallergens. Results AD was diagnosed in 11.0\% (22/200) of children in the active and in 10.4\% (21/202) of children in the placebo group. AR was diagnosed in 35\% (70/200) of children in the active and in 38.1\% (77/202) children in the placebo group. Asthma was diagnosed in 9\% (18/199) of children in the active and in 6.6\% (13/197) of children in the placebo group. Sensitization occurred in 46.5\% (66/142) of participants in the active and 51.7\% (76/147) in the placebo group. Conclusion An oral bacterial lysate of heat-killed Gram-negative Escherichia coli and Gram-positive Enterococcus faecalis applied during the first 7 months of life did not influence the development of AD, asthma and AR at school age.},
  language  = {en}
}
@article{KristDornquastReinholdetal.2021,
  author    = {Krist, Lilian and Dornquast, Christina and Reinhold, Thomas and Becher, Heiko and J{\"o}ckel, Karl-Heinz and Schmidt, B{\"o}rge and Schramm, Sara and Icke, Katja and Danquah, Ina and Willich, Stefan N. and Keil, Thomas and Brand, Tilman},
  title     = {Association of acculturation status with longitudinal changes in health-related quality of life — results from a cohort study of adults with Turkish origin in Germany},
  series = {International Journal of Environmental Research and Public Health},
  volume    = {18},
  journal   = {International Journal of Environmental Research and Public Health},
  number    = {6},
  issn      = {1660-4601},
  doi       = {10.3390/ijerph18062827},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-234068},
  year      = {2021},
  abstract  = {Health-related quality of life (HRQL) among migrant populations can be associated with acculturation (i.e., the process of adopting, acquiring and adjusting to a new cultural environment). Since there is a lack of longitudinal studies, we aimed to describe HRQL changes among adults of Turkish descent living in Berlin and Essen, Germany, and their association with acculturation. Participants of a population-based study were recruited in 2012-2013 and reinvited six years later to complete a questionnaire. Acculturation was assessed at baseline using the Frankfurt acculturation scale (integration, assimilation, separation and marginalization). HRQL was assessed at baseline (SF-8) and at follow-up (SF-12) resulting in a physical (PCS) and mental (MCS) sum score. Associations with acculturation and HRQL were analyzed with linear regression models using a time-by-acculturation status interaction term. In the study 330 persons were included (65\% women, mean age ± standard deviation 43.3 ± 11.8 years). Over the 6 years, MCS decreased, while PCS remained stable. While cross-sectional analyses showed associations of acculturation status with both MCS and PCS, temporal changes including the time interaction term did not reveal associations of baseline acculturation status with HRQL. When investigating HRQL in acculturation, more longitudinal studies are needed to take changes in both HRQL and acculturation status into account.},
  language  = {en}
}