@article{WackExnerWegeneretal.2020,
  author    = {Wack, Linda J. and Exner, Florian and Wegener, Sonja and Sauer, Otto A.},
  title     = {The impact of isocentric shifts on delivery accuracy during the irradiation of small cerebral targets — Quantification and possible corrections},
  series = {Journal of Applied Clinical Medical Physics},
  volume    = {21},
  journal   = {Journal of Applied Clinical Medical Physics},
  number    = {5},
  doi       = {10.1002/acm2.12854},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218146},
  pages     = {56-64},
  year      = {2020},
  abstract  = {Purpose To assess the impact of isocenter shifts due to linac gantry and table rotation during cranial stereotactic radiosurgery on D\(_{98}\), target volume coverage (TVC), conformity (CI), and gradient index (GI). Methods Winston-Lutz (WL) checks were performed on two Elekta Synergy linacs. A stereotactic quality assurance (QA) plan was applied to the ArcCHECK phantom to assess the impact of isocenter shift corrections on Gamma pass rates. These corrections included gantry sag, distance of collimator and couch axes to the gantry axis, and distance between cone-beam computed tomography (CBCT) isocenter and treatment beam (MV) isocenter. We applied the shifts via script to the treatment plan in Pinnacle 16.2. In a planning study, isocenter and mechanical rotation axis shifts of 0.25 to 2 mm were applied to stereotactic plans of spherical planning target volumes (PTVs) of various volumes. The shifts determined via WL measurements were applied to 16 patient plans with PTV sizes between 0.22 and 10.4 cm3. Results ArcCHECK measurements of a stereotactic treatment showed significant increases in Gamma pass rate for all three measurements (up to 3.8 percentage points) after correction of measured isocenter deviations. For spherical targets of 1 cm3, CI was most severely affected by increasing the distance of the CBCT isocenter (1.22 to 1.62). Gradient index increased with an isocenter-collimator axis distance of 1.5 mm (3.84 vs 4.62). D98 (normalized to reference) dropped to 0.85 (CBCT), 0.92 (table axis), 0.95 (collimator axis), and 0.98 (gantry sag), with similar but smaller changes for larger targets. Applying measured shifts to patient plans lead to relevant drops in D\(_{98}\) and TVC (7\%) for targets below 2 cm\(^3\) treated on linac 1. Conclusion Mechanical deviations during gantry, collimator, and table rotation may adversely affect the treatment of small stereotactic lesions. Adjustments of beam isocenters in the treatment planning system (TPS) can be used to both quantify their impact and for prospective correction of treatment plans.},
  language  = {en}
}