@article{VainioValtonenHeberetal.2013,
  author    = {Vainio, Rami and Valtonen, Eino and Heber, Bernd and Malandraki, Olga E. and Papaioannou, Athanasios and Klein, Karl-Ludwig and Afanasiev, Alexander and Agueda, Neus and Aurass, Henry and Battarbee, Markus and Braune, Stephan and Dr{\"o}ge, Wolfgang and Ganse, Urs and Hamadache, Clarisse and Heynderickx, Daniel and Huttunen-Heikinmaa, Kalle and Kiener, J{\"u}rgen and Kilian, Patrick and Kopp, Andreas and Kouloumvakos, Athanasios and Maisala, Sami and Mishev, Alexander and Miteva, Rosita and Nindos, Alexander and Oittinen, Tero and Raukunen, Osku and Riihonen, Esa and Rodriguez-Gasen, Rosa and Saloniemi, Oskari and Sanahuja, Blai and Scherer, Renate and Spanier, Felix and Tatischeff, Vincent and Tziotziou, Kostas and Usoskin, Ilya G. and Vilmer, Nicole},
  title     = {The first SEPServer event catalogue similar to ~68-MeV solar proton events observed at 1 AU in 1996-2010},
  series = {Journal of Space Weather and Space Climate},
  volume    = {3},
  journal   = {Journal of Space Weather and Space Climate},
  number    = {A12},
  issn      = {2115-7251},
  doi       = {10.1051/swsc/2013030},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-122847},
  year      = {2013},
  abstract  = {SEPServer is a three-year collaborative project funded by the seventh framework programme (FP7-SPACE) of the European Union. The objective of the project is to provide access to state-of-the-art observations and analysis tools for the scientific community on solar energetic particle (SEP) events and related electromagnetic (EM) emissions. The project will eventually lead to better understanding of the particle acceleration and transport processes at the Sun and in the inner heliosphere. These processes lead to SEP events that form one of the key elements of space weather. In this paper we present the first results from the systematic analysis work performed on the following datasets: SOHO/ERNE, SOHO/EPHIN, ACE/EPAM, Wind/WAVES and GOES X-rays. A catalogue of SEP events at 1 AU, with complete coverage over solar cycle 23, based on high-energy (similar to 68-MeV) protons from SOHO/ERNE and electron recordings of the events by SOHO/EPHIN and ACE/EPAM are presented. A total of 115 energetic particle events have been identified and analysed using velocity dispersion analysis (VDA) for protons and time-shifting analysis (TSA) for electrons and protons in order to infer the SEP release times at the Sun. EM observations during the times of the SEP event onset have been gathered and compared to the release time estimates of particles. Data from those events that occurred during the European day-time, i.e., those that also have observations from ground-based observatories included in SEPServer, are listed and a preliminary analysis of their associations is presented. We find that VDA results for protons can be a useful tool for the analysis of proton release times, but if the derived proton path length is out of a range of 1 AU < s less than or similar to 3 AU, the result of the analysis may be compromised, as indicated by the anti-correlation of the derived path length and release time delay from the associated X-ray flare. The average path length derived from VDA is about 1.9 times the nominal length of the spiral magnetic field line. This implies that the path length of first-arriving MeV to deka-MeV protons is affected by interplanetary scattering. TSA of near-relativistic electrons results in a release time that shows significant scatter with respect to the EM emissions but with a trend of being delayed more with increasing distance between the flare and the nominal footpoint of the Earth-connected field line.},
  language  = {en}
}
@article{GuggenbergerTorreLudwigetal.2022,
  author    = {Guggenberger, Konstanze Viktoria and Torre, Giulia Dalla and Ludwig, Ute and Vogel, Patrick and Weng, Andreas Max and Vogt, Marius Lothar and Fr{\"o}hlich, Matthias and Schmalzing, Marc and Raithel, Esther and Forman, Christoph and Urbach, Horst and Meckel, Stephan and Bley, Thorsten Alexander},
  title     = {Vasa vasorum of proximal cerebral arteries after dural crossing - potential imaging confounder in diagnosing intracranial vasculitis in elderly subjects on black-blood MRI},
  series = {European Radiology},
  volume    = {32},
  journal   = {European Radiology},
  number    = {2},
  issn      = {1432-1084},
  doi       = {10.1007/s00330-021-08181-5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-266524},
  pages     = {1276-1284},
  year      = {2022},
  abstract  = {Objectives Vessel wall enhancement (VWE) may be commonly seen on MRI images of asymptomatic subjects. This study aimed to characterize the VWE of the proximal internal carotid (ICA) and vertebral arteries (VA) in a non-vasculitic elderly patient cohort. Methods Cranial MRI scans at 3 Tesla were performed in 43 patients (aged ≥ 50 years) with known malignancy for exclusion of cerebral metastases. For vessel wall imaging (VWI), a high-resolution compressed-sensing black-blood 3D T1-weighted fast (turbo) spin echo sequence (T1 CS-SPACE prototype) was applied post gadolinium with an isotropic resolution of 0.55 mm. Bilateral proximal intradural ICA and VA segments were evaluated for presence, morphology, and longitudinal extension of VWE. Results Concentric VWE of the proximal intradural ICA was found in 13 (30\%) patients, and of the proximal intradural VA in 39 (91\%) patients. Mean longitudinal extension of VWE after dural entry was 13 mm in the VA and 2 mm in the ICA. In 14 of 39 patients (36\%) with proximal intradural VWE, morphology of VWE was suggestive of the mere presence of vasa vasorum. In 25 patients (64 \%), morphology indicated atherosclerotic lesions in addition to vasa vasorum. Conclusions Vasa vasorum may account for concentric VWE within the proximal 2 mm of the ICA and 13 mm of the VA after dural entry in elderly subjects. Concentric VWE in these locations should not be confused with large artery vasculitis. Distal to these segments, VWE may be more likely related to pathologic conditions such as vasculitis.},
  language  = {en}
}
@article{WagnerDrouetTeschnerWolschkeetal.2021,
  author    = {Wagner-Drouet, Eva and Teschner, Daniel and Wolschke, Christine and Sch{\"a}fer-Eckart, Kerstin and G{\"a}rtner, Johannes and Mielke, Stephan and Schreder, Martin and Kobbe, Guido and Hilgendorf, Inken and Klein, Stefan and Verbeek, Mareike and Ditschkowski, Markus and Koch, Martina and Lindemann, Monika and Schmidt, Traudel and Rascle, Anne and Barabas, Sascha and Deml, Ludwig and Wagner, Ralf and Wolff, Daniel},
  title     = {Comparison of cytomegalovirus-specific immune cell response to proteins versus peptides using an IFN-γ ELISpot assay after hematopoietic stem cell transplantation},
  series = {Diagnostics},
  volume    = {11},
  journal   = {Diagnostics},
  number    = {2},
  issn      = {2075-4418},
  doi       = {10.3390/diagnostics11020312},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-228843},
  year      = {2021},
  abstract  = {Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality following hematopoietic stem cell transplantation (HSCT). Measuring CMV-specific cellular immunity may improve the risk stratification and management of patients. IFN-γ ELISpot assays, based on the stimulation of peripheral blood mononuclear cells with CMV pp65 and IE-1 proteins or peptides, have been validated in clinical settings. However, it remains unclear to which extend the T-cell response to synthetic peptides reflect that mediated by full-length proteins processed by antigen-presenting cells. We compared the stimulating ability of pp65 and IE-1 proteins and corresponding overlapping peptides in 16 HSCT recipients using a standardized IFN-γ ELISpot assay. Paired qualitative test results showed an overall 74.4\% concordance. Discordant results were mainly due to low-response tests, with one exception. One patient with early CMV reactivation and graft-versus-host disease, sustained CMV DNAemia and high CD8\(^+\) counts showed successive negative protein-based ELISpot results but a high and sustained response to IE-1 peptides. Our results suggest that the response to exogenous proteins, which involves their uptake and processing by antigen-presenting cells, more closely reflects the physiological response to CMV infection, while the response to exogenous peptides may lead to artificial in vitro T-cell responses, especially in strongly immunosuppressed patients.},
  language  = {en}
}
@article{BruchhagenJarickMewisetal.2018,
  author    = {Bruchhagen, Christin and Jarick, Marcel and Mewis, Carolin and Hertlein, Tobias and Niemann, Silke and Ohlsen, Knut and Peters, Georg and Planz, Oliver and Ludwig, Stephan and Ehrhardt, Christina},
  title     = {Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound},
  series = {Scientific Reports},
  volume    = {8},
  journal   = {Scientific Reports},
  doi       = {10.1038/s41598-018-27445-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-221648},
  year      = {2018},
  abstract  = {Influenza virus (IV) infections cause severe respiratory illnesses that can be complicated by bacterial super-infections. Previously, we identified the cellular Raf-MEK-ERK cascade as a promising antiviral target. Inhibitors of MEK, such as CI-1040, showed potent antiviral activity. However, it remained unclear if this inhibitor and its active form, ATR-002, might sensitize host cells to either IV or secondary bacterial infections. To address these questions, we studied the anti-pathogen activity of ATR-002 in comparison to CI-1040, particularly, its impact on Staphylococcus aureus (S. aureus), which is a major cause of IV super-infections. We analysed IV and S. aureus titres in vitro during super-infection in the presence and absence of the drugs and characterized the direct impact of ATR-002 on bacterial growth and phenotypic changes. Importantly, neither CI-1040 nor ATR-002 treatment led to increased bacterial titres during super-infection, indicating that the drug does not sensitize cells for bacterial infection. In contrast, we rather observed reduced bacterial titres in presence of ATR-002. Surprisingly, ATR-002 also led to reduced bacterial growth in suspension cultures, reduced stress- and antibiotic tolerance without resistance induction. Our data identified for the first time that a particular MEK-inhibitor metabolite exhibits direct antibacterial activity, which is likely due to interference with the bacterial PknB kinase/Stp phosphatase signalling system.},
  language  = {en}
}