@article{RogowskiLehmannGeroulaPrejbiszetal.2018, author = {Rogowski-Lehmann, Natalie and Geroula, Aikaterini and Prejbisz, Aleksander and Timmers, Henri J. L. M. and Megerle, Felix and Robledo, Mercedes and Fassnacht, Martin and Fliedner, Stephanie M. J. and Reincke, Martin and Stell, Anthony and Januszewicz, Andrzej and Lenders, Jacques W. M. and Eisenhofer, Graeme and Beuschlein, Felix}, title = {Missed clinical clues in patients with pheochromocytoma/paraganglioma discovered by imaging}, series = {Endocrine Connections}, volume = {7}, journal = {Endocrine Connections}, number = {11}, doi = {10.1530/EC-18-0318}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-226481}, pages = {1168-1177}, year = {2018}, abstract = {Background: Pheochromocytomas and paragangliomas (PPGLs) are rare but potentially harmful tumors that can vary in their clinical presentation. Tumors may be found due to signs and symptoms, as part of a hereditary syndrome or following an imaging procedure. Objective: To investigate potential differences in clinical presentation between PPGLs discovered by imaging (iPPGLs), symptomatic cases (sPPGLs) and those diagnosed during follow-up because of earlier disease/known hereditary mutations (fPPGL). Design: Prospective study protocol, which has enrolled patients from six European centers with confirmed PPGLs. Data were analyzed from 235 patients (37 iPPGLs, 36 sPPGLs, 27\% fPPGLs) and compared for tumor volume, biochemical profile, mutation status, presence of metastases and self-reported symptoms. iPPGL patients were diagnosed at a significantly higher age than fPPGLs (P<0.001), found to have larger tumors (P=0.003) and higher metanephrine and normetanephrine levels at diagnosis (P=0.021). Significantly lower than in sPPGL, there was a relevant number of self-reported symptoms in iPPGL (2.9 vs 4.3 symptoms, P< 0.001). In 16.2\% of iPPGL, mutations in susceptibility genes were detected, although this proportion was lower than that in fPPGL (60.9\%) and sPPGL (21.5\%). Patients with PPGLs detected by imaging were older, have higher tumor volume and more excessive hormonal secretion in comparison to those found as part of a surveillance program. Presence of typical symptoms indicates that in a relevant proportion of those patients, the PPGL diagnosis had been delayed. Precis: Pheochromocytoma/paraganglioma discovered by imaging are often symptomatic and carry a significant proportion of germline mutations in susceptibility genes.}, subject = {Biochemical-Diagnosis}, language = {en} } @phdthesis{Lehmann2021, author = {Lehmann, Martin}, title = {Postoperative Ver{\"a}nderungen der regionalen Ventilation unter Spontanatmung bei Patienten nach Lungenresektion}, doi = {10.25972/OPUS-22221}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-222214}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2021}, abstract = {Hintergrund: Die pulmonale elektrische Impedanztomographie (EIT) stellt die regionale Ventilation der Lunge dar. Ziel dieser Studie war es, die postoperative Umverteilung der regionalen Ventilation nach lungenchirurgischen Eingriffen in Abh{\"a}ngigkeit von der Operationsseite und deren Zusammenhang mit der forcierten Vitalkapazit{\"a}t zu untersuchen. Methoden: In dieser Beobachtungsstudie wurden Patienten untersucht, die sich rechts- und linksseitig offenen und videothorakoskopischen Eingriffen unterzogen. Es wurden Messungen mit EIT und Spirometrie durchgef{\"u}hrt. Jeweils 13 links- und 13 rechtsseitig operierte erwachsene Patienten, wurden pr{\"a}operativ, sowie am dritten postoperativen Tag untersucht. Der Center of Ventilation (COV) innerhalb einer 32 x 32 Matrix wurde aus den EIT-Daten berechnet. COVx (links/rechts) wurde zu COVx' (ipsilateral/kontralateral) mit invertiertem Vektor der perioperativen Ver{\"a}nderung bei rechtsseitiger Operation modifiziert, um den Effekt der Zeit und der Seite der Operation in beiden Gruppen mit Two-way ANOVA f{\"u}r wiederholte Messungen zu testen. Ergebnisse: Die perioperative Verschiebung von COVx' war abh{\"a}ngig von der Operationsseite (p=0,007) und war um -1,97 Matrixpunkte (p<0,001) bei rechtsseitiger und -0,61 Matrixpunkte (p=0,425) bei linksseitiger Operation von der Operationsseite weg gerichtet. Die forcierte Vitalkapazit{\"a}t (\%vom Soll) verringerte sich von 94 (83-109) \% [Median (Perzentile)] (linksseitig) und 89 (80-97) \% (rechtsseitig) auf 61 (59-66) \% bzw. 62 (40-72) \% (p<0,05) und korrelierte mit COVx' f{\"u}r beide Gruppen. Schlussfolgerung: Nur nach rechtsseitiger Lungenoperation konnte die EIT eine reduzierte Ventilation auf der Seite der Operation zeigen, w{\"a}hrend die Vitalkapazit{\"a}t in beiden Gruppen deutlich reduziert war.}, subject = {Impedanztomografie}, language = {de} } @article{BellingerWehrmannRohdeetal.2023, author = {Bellinger, Daniel and Wehrmann, Kristin and Rohde, Anna and Schuppert, Maria and St{\"o}rk, Stefan and Flohr-Jost, Michael and Gall, Dominik and Pauli, Paul and Deckert, J{\"u}rgen and Herrmann, Martin J. and Erhardt-Lehmann, Angelika}, title = {The application of virtual reality exposure versus relaxation training in music performance anxiety: a randomized controlled study}, series = {BMC Psychiatry}, volume = {23}, journal = {BMC Psychiatry}, doi = {10.1186/s12888-023-05040-z}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-357833}, year = {2023}, abstract = {Background Performance anxiety is the most frequently reported anxiety disorder among professional musicians. Typical symptoms are - on a physical level - the consequences of an increase in sympathetic tone with cardiac stress, such as acceleration of heartbeat, increase in blood pressure, increased respiratory rate and tremor up to nausea or flush reactions. These symptoms can cause emotional distress, a reduced musical and artistical performance up to an impaired functioning. While anxiety disorders are preferably treated using cognitive-behavioral therapy with exposure, this approach is rather difficult for treating music performance anxiety since the presence of a public or professional jury is required and not easily available. The use of virtual reality (VR) could therefore display an alternative. So far, no therapy studies on music performance anxiety applying virtual reality exposure therapy have investigated the therapy outcome including cardiovascular changes as outcome parameters. Methods This mono-center, prospective, randomized and controlled clinical trial has a pre-post design with a follow-up period of 6 months. 46 professional and semi-professional musicians will be recruited and allocated randomly to an VR exposure group or a control group receiving progressive muscle relaxation training. Both groups will be treated over 4 single sessions. Music performance anxiety will be diagnosed based on a clinical interview using ICD-10 and DSM-5 criteria for specific phobia or social anxiety. A behavioral assessment test is conducted three times (pre, post, follow-up) in VR through an audition in a concert hall. Primary outcomes are the changes in music performance anxiety measured by the German B{\"u}hnenangstfragebogen and the cardiovascular reactivity reflected by heart rate variability (HRV). Secondary outcomes are changes in blood pressure, stress parameters such as cortisol in the blood and saliva, neuropeptides, and DNA-methylation. Discussion The trial investigates the effect of VR exposure in musicians with performance anxiety compared to a relaxation technique on anxiety symptoms and corresponding cardiovascular parameters. We expect a reduction of anxiety but also a consecutive improvement of HRV with cardiovascular protective effects. Trial registration This study was registered on clinicaltrials.gov. (ClinicalTrials.gov Number: NCT05735860)}, language = {en} } @article{LambovHensiekPoeppleretal.2020, author = {Lambov, Martin and Hensiek, Nicola and P{\"o}ppler, Ann-Christin and Lehmann, Matthias}, title = {Columnar Liquid Crystals from Star-Shaped Conjugated Mesogens as Nano-Reservoirs for Small Acceptors}, series = {ChemPlusChem}, volume = {85}, journal = {ChemPlusChem}, number = {10}, doi = {10.1002/cplu.202000341}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218014}, pages = {2219 -- 2229}, year = {2020}, abstract = {Shape-persistent conjugated mesogens with oligothiophene arms of different lengths have been synthesized. Such mesogens possess free intrinsic space between their conjugated arms. They form columnar liquid-crystalline phases, in which the void is filled by dense helical packing in the neat phase similar to an oligo(phenylene vinylene) derivative of equal size. The void can also be compensated by the inclusion of the small acceptor molecule 2,4,7-trinitrofluorenone. In solution, the acceptor interacts with the core as the largest π-surface, while in the solid material, it is incorporated between the arms and sandwiched by the star-shaped neighbours along the columnar assemblies. The TNF acceptors are not nanosegregated from the star-shaped donors, thus the liquid crystal structure converts to a nano-reservoir for TNF (endo-receptor). These host-guest arrangements are confirmed by comprehensive X-ray scattering experiments and solid-state NMR spectroscopy. This results in ordered columnar hexagonal phases at high temperatures, which change to helical columnar mesophases or to columnar soft crystals at room temperature.}, language = {en} } @article{LehmannOehlerZuberetal.2020, author = {Lehmann, Martin and Oehler, Beatrice and Zuber, Jonas and Malzahn, Uwe and Walles, Thorsten and Muellenbach, Ralf M. and Roewer, Norbert and Kredel, Markus}, title = {Redistribution of pulmonary ventilation after lung surgery detected with electrical impedance tomography}, series = {Acta Anaesthesiologica Scandinavica}, volume = {64}, journal = {Acta Anaesthesiologica Scandinavica}, number = {4}, doi = {10.1111/aas.13525}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-213575}, pages = {517-525}, year = {2020}, abstract = {Background: Regional ventilation of the lung can be visualized by pulmonary electrical impedance tomography (EIT). The aim of this study was to examine the post-operative redistribution of regional ventilation after lung surgery dependent on the side of surgery and its association with forced vital capacity. Methods: In this prospective, observational cohort study 13 patients undergoing right and 13 patients undergoing left-sided open or video-thoracoscopic procedures have been investigated. Pre-operative measurements with EIT and spirometry were compared with data obtained 3 days post-operation. The center of ventilation (COV) within a 32 × 32 pixel matrix was calculated from EIT data. The transverse axis coordinate of COV, COVx (left/right), was modified to COVx′ (ipsilateral/contralateral). Thus, COVx′ shows a negative change if ventilation shifts contralateral independent of the side of surgery. This enabled testing with two-way ANOVA for repeated measurements (side, time). Results: The perioperative shift of COVx′ was dependent on the side of surgery (P = .007). Ventilation shifted away from the side of surgery after the right-sided surgery (COVx′-1.97 pixel matrix points, P < .001), but not after the left-sided surgery (COVx′-0.61, P = .425). The forced vital capacity (\%predicted) decreased from 94 (83-109)\% (median [quartiles]; [left-sided]) and 89 (80-97)\% (right-sided surgery) to 61 (59-66)\% and 62 (40-72)\% (P < .05), respectively. The perioperative changes in forced vital capacity (\%predicted) were weakly associated with the shift of COVx′. Conclusion: Only after right-sided lung surgery, EIT showed reduced ventilation on the side of surgery while vital capacity was markedly reduced in both groups.}, language = {en} } @article{LehmannBaumannLambovetal.2021, author = {Lehmann, Matthias and Baumann, Maximilian and Lambov, Martin and Eremin, Alexey}, title = {Parallel polar dimers in the columnar self-assembly of umbrella-shaped subphthalocyanine mesogens}, series = {Advanced Functional Materials}, volume = {31}, journal = {Advanced Functional Materials}, number = {38}, doi = {10.1002/adfm.202104217}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-256343}, year = {2021}, abstract = {The self-assembly of umbrella-shaped mesogens is explored with subphthalocyanine cores and oligo(thienyl) arms with different lengths in the light of their application as light-harvesting and photoconducting materials. While the shortest arm derivatives self-assemble in a conventional columnar phase with a single mesogen as a repeating unit, the more extended derivatives generate dimers that pile up into liquid crystalline columns. In contrast to the antiparallel arrangement known from single crystals, the present mesogens align as parallel dimers in polar columnar phases as confirmed by X-ray scattering, experimental densities, dielectric spectroscopy, second harmonic generation, alignment, and conductivity studies. UV-vis and fluorescence spectroscopies reveal a broad absorption in the visible range and only weak emission of the Q-band. Thus, these light-collecting molecules forming strongly polar columnar mesophases are attractive for application in the area of photoconductive materials.}, language = {en} }