@article{GinzkeyEickerMargetetal.2013,
  author    = {Ginzkey, Christian and Eicker, Sven and Marget, Matthias and Krause, J{\"o}rg and Brecht, Stefan and Westphal, Manfred and Hugo, Heinz-Hermann and Mehdorn, Maximilian and Steinmann, J{\"o}rg and Hamel, Wolfgang},
  title     = {Incomplete tumour control following DNA vaccination against rat gliomas expressing a model antigen},
  series = {Acta Neurochirurgica},
  volume    = {155},
  journal   = {Acta Neurochirurgica},
  number    = {1},
  doi       = {10.1007/s00701-012-1526-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-126775},
  pages     = {51-59},
  year      = {2013},
  abstract  = {Background Vaccination against tumour-associated antigens is one approach to elicit anti-tumour responses. We investigated the effect of polynucleotide (DNA) vaccination using a model antigen (E. coli lacZ) in a syngeneic gliosarcoma model (9L). Methods Fisher 344 rats were vaccinated thrice by intramuscular injection of a lacZ-encoding or a control plasmid in weekly intervals. One week after the last vaccination, lacZ-expressing 9L cells were implanted into the striatum. Results After 3 weeks, in lacZ-vaccinated animals the tumours were significantly smaller than in control-vaccinated animals. In cytotoxic T cell assays lysis rates of >50 \% could only be observed in a few of the lacZ-vaccinated animals. This response was directed against lacZ-expressing and parental 9L cells but not against syngeneic MADB 106 adenocarcinoma cells. In Elispot assays interferon-γ production was observed upon stimulation with 9LlacZ and 9L wild-type but not MADB 106 cells. This response was higher for lacZ-immunized animals. All animals revealed dense infiltrates with CD8+ lymphocytes and, to a lesser extent, with NK cells. CD25-staining indicated cells possibly associated with the maintenance of peripheral tolerance to self-antigens. All tumours were densely infiltrated by microglia consisting mostly of ramified cells. Only focal accumulation of macrophage-like cells expressing ED1, a marker for phagocytic activity, was observed. Conclusion Prophylactic DNA vaccination resulted in effective but incomplete suppression of brain tumour formation. Mechanisms other than cytotoxic T cell responses as measured in the generally used in vitro assays appear to play a role in tumour suppression.},
  language  = {en}
}
@article{DechHolzwarthAsametal.2021,
  author    = {Dech, Stefan and Holzwarth, Stefanie and Asam, Sarah and Andresen, Thorsten and Bachmann, Martin and Boettcher, Martin and Dietz, Andreas and Eisfelder, Christina and Frey, Corinne and Gesell, Gerhard and Gessner, Ursula and Hirner, Andreas and Hofmann, Matthias and Kirches, Grit and Klein, Doris and Klein, Igor and Kraus, Tanja and Krause, Detmar and Plank, Simon and Popp, Thomas and Reinermann, Sophie and Reiners, Philipp and Roessler, Sebastian and Ruppert, Thomas and Scherbachenko, Alexander and Vignesh, Ranjitha and Wolfmueller, Meinhard and Zwenzner, Hendrik and Kuenzer, Claudia},
  title     = {Potential and challenges of harmonizing 40 years of AVHRR data: the TIMELINE experience},
  series = {Remote Sensing},
  volume    = {13},
  journal   = {Remote Sensing},
  number    = {18},
  issn      = {2072-4292},
  doi       = {10.3390/rs13183618},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-246134},
  year      = {2021},
  abstract  = {Earth Observation satellite data allows for the monitoring of the surface of our planet at predefined intervals covering large areas. However, there is only one medium resolution sensor family in orbit that enables an observation time span of 40 and more years at a daily repeat interval. This is the AVHRR sensor family. If we want to investigate the long-term impacts of climate change on our environment, we can only do so based on data that remains available for several decades. If we then want to investigate processes with respect to climate change, we need very high temporal resolution enabling the generation of long-term time series and the derivation of related statistical parameters such as mean, variability, anomalies, and trends. The challenges to generating a well calibrated and harmonized 40-year-long time series based on AVHRR sensor data flown on 14 different platforms are enormous. However, only extremely thorough pre-processing and harmonization ensures that trends found in the data are real trends and not sensor-related (or other) artefacts. The generation of European-wide time series as a basis for the derivation of a multitude of parameters is therefore an extremely challenging task, the details of which are presented in this paper.},
  language  = {en}
}
@article{KimLiessStolteetal.2021,
  author    = {Kim, Jin Hong and Liess, Andreas and Stolte, Matthias and Krause, Ana-Maria and Stepanenko, Vladimir and Zhong, Chuwei and Bialas, David and Spano, Frank and W{\"u}rthner, Frank},
  title     = {An Efficient Narrowband Near-Infrared at 1040 nm Organic Photodetector Realized by Intermolecular Charge Transfer Mediated Coupling Based on a Squaraine Dye},
  series = {Advanced Materials},
  volume    = {33},
  journal   = {Advanced Materials},
  number    = {26},
  doi       = {10.1002/adma.202100582},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-256374},
  year      = {2021},
  abstract  = {A highly sensitive short-wave infrared (SWIR, λ > 1000 nm) organic photodiode (OPD) is described based on a well-organized nanocrystalline bulk-heterojunction (BHJ) active layer composed of a dicyanovinyl-functionalized squaraine dye (SQ-H) donor material in combination with PC\(_{61}\)BM. Through thermal annealing, dipolar SQ-H chromophores self-assemble in a nanoscale structure with intermolecular charge transfer mediated coupling, resulting in a redshifted and narrow absorption band at 1040 nm as well as enhanced charge carrier mobility. The optimized OPD exhibits an external quantum efficiency (EQE) of 12.3\% and a full-width at half-maximum of only 85 nm (815 cm\(^{-1}\)) at 1050 nm under 0 V, which is the first efficient SWIR OPD based on J-type aggregates. Photoplethysmography application for heart-rate monitoring is successfully demonstrated on flexible substrates without applying reverse bias, indicating the potential of OPDs based on short-range coupled dye aggregates for low-power operating wearable applications.},
  language  = {en}
}
@article{BochSpiessHeinzetal.2019,
  author    = {Boch, Tobias and Spiess, Birgit and Heinz, Werner and Cornely, Oliver A. and Schwerdtfeger, Rainer and Hahn, Joachim and Krause, Stefan W. and Duerken, Matthias and Bertz, Hartmut and Reuter, Stefan and Kiehl, Michael and Claus, Bernd and Deckert, Peter Markus and Hofmann, Wolf-Karsten and Buchheidt, Dieter and Reinwald, Mark},
  title     = {Aspergillus specific nested PCR from the site of infection is superior to testing concurrent blood samples in immunocompromised patients with suspected invasive aspergillosis},
  series = {Mycoses},
  volume    = {62},
  journal   = {Mycoses},
  number    = {11},
  doi       = {10.1111/myc.12983},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214065},
  pages     = {1035 -- 1042},
  year      = {2019},
  abstract  = {Invasive aspergillosis (IA) is a severe complication in immunocompromised patients. Early diagnosis is crucial to decrease its high mortality, yet the diagnostic gold standard (histopathology and culture) is time-consuming and cannot offer early confirmation of IA. Detection of IA by polymerase chain reaction (PCR) shows promising potential. Various studies have analysed its diagnostic performance in different clinical settings, especially addressing optimal specimen selection. However, direct comparison of different types of specimens in individual patients though essential, is rarely reported. We systematically assessed the diagnostic performance of an Aspergillus-specific nested PCR by investigating specimens from the site of infection and comparing it with concurrent blood samples in individual patients (pts) with IA. In a retrospective multicenter analysis PCR was performed on clinical specimens (n = 138) of immunocompromised high-risk pts (n = 133) from the site of infection together with concurrent blood samples. 38 pts were classified as proven/probable, 67 as possible and 28 as no IA according to 2008 European Organization for Research and Treatment of Cancer/Mycoses Study Group consensus definitions. A considerably superior performance of PCR from the site of infection was observed particularly in pts during antifungal prophylaxis (AFP)/antifungal therapy (AFT). Besides a specificity of 85\%, sensitivity varied markedly in BAL (64\%), CSF (100\%), tissue samples (67\%) as opposed to concurrent blood samples (8\%). Our results further emphasise the need for investigating clinical samples from the site of infection in case of suspected IA to further establish or rule out the diagnosis.},
  language  = {en}
}
@article{BoldStolteShoyamaetal.2022,
  author    = {Bold, Kevin and Stolte, Matthias and Shoyama, Kazutaka and Krause, Ana-Maria and Schmiedel, Alexander and Holzapfel, Marco and Lambert, Christoph and W{\"u}rthner, Frank},
  title     = {Macrocyclic Donor-Acceptor Dyads Composed of Oligothiophene Half-Cycles and Perylene Bisimides},
  series = {Chemistry - A European Journal},
  volume    = {28},
  journal   = {Chemistry - A European Journal},
  number    = {30},
  doi       = {10.1002/chem.202200355},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-276435},
  year      = {2022},
  abstract  = {A series of donor-acceptor (D-A) macrocyclic dyads consisting of an electron-poor perylene bisimide (PBI) π-scaffold bridged with electron-rich α-oligothiophenes bearing four, five, six and seven thiophene units between the two phenyl-imide substituents has been synthesized and characterized by steady-state UV/Vis absorption and fluorescence spectroscopy, cyclic and differential pulse voltammetry as well as transient absorption spectroscopy. Tying the oligothiophene strands in a conformationally fixed macrocyclic arrangement leads to a more rigid π-scaffold with vibronic fine structure in the respective absorption spectra. Electrochemical analysis disclosed charged state properties in solution which are strongly dependent on the degree of rigidification within the individual macrocycle. Investigation of the excited state dynamics revealed an oligothiophene bridge size-dependent fast charge transfer process for the macrocyclic dyads upon PBI subunit excitation.},
  language  = {en}
}
@article{FehskeBerningerAlmetal.2021,
  author    = {Fehske, Kai and Berninger, Markus T. and Alm, Lena and Hoffmann, Reinhard and Zellner, Johannes and K{\"o}sters, Clemens and Barzen, Stefan and Raschke, Michael J. and Izadpanah, Kaywan and Herbst, Elmar and Domnick, Christoph and Sch{\"u}ttrumpf, Jan Philipp and Krause, Matthias},
  title     = {Aktueller Versorgungsstandard von Patellafrakturen in Deutschland},
  series = {Der Unfallchirurg},
  volume    = {124},
  journal   = {Der Unfallchirurg},
  organization    = {Komitee Frakturen der Deutschen Kniegesellschaft (DKG)},
  issn      = {0177-5537},
  doi       = {10.1007/s00113-020-00939-8},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-235047},
  pages     = {832-838},
  year      = {2021},
  abstract  = {Hintergrund Die Versorgung von Patellafrakturen ist technisch anspruchsvoll. Auch wenn die radiologischen Ergebnisse zumeist zufriedenstellend sind, deckt sich dies h{\"a}ufig nicht mit der subjektiven Einsch{\"a}tzung der Patienten. Die klassische Versorgung mittels Drahtzuggurtung weist einige Komplikationen auf. Die winkelstabile Plattenosteosynthese hat sich in den letzten Jahren biomechanisch als vorteilhaft erwiesen. Fragestellung Von wem werden Patellafrakturen in Deutschland versorgt? Wie sieht der aktuelle Versorgungsstandard aus? Haben sich „moderne" Osteosyntheseformen durchgesetzt? Was sind die h{\"a}ufigsten Komplikationen? Material und Methoden Die Mitglieder der Deutschen Gesellschaft f{\"u}r Orthop{\"a}die und Unfallchirurgie sowie der Deutschen Kniegesellschaft wurden aufgefordert, an einer Onlinebefragung teilzunehmen. Ergebnisse Insgesamt wurden 511 komplett ausgef{\"u}llte Fragebogen ausgewertet. Die Befragten sind zum gr{\"o}ßten Teil auf Unfallchirurgie spezialisiert (51,5 \%) und verf{\"u}gen {\"u}ber langj{\"a}hrige Berufserfahrung in Traumazentren. Die H{\"a}lfte der Operateure versorgt ≤5 Patellafrakturen j{\"a}hrlich. In knapp 40 \% der F{\"a}lle wird die pr{\"a}operative Bildgebung um eine Computertomographie erg{\"a}nzt. Die klassische Zuggurtung ist noch die bevorzugte Osteosyntheseform bei allen Frakturtypen (Querfraktur 52 \%, Mehrfragmentfrakturen 40 \%). Bei Mehrfragmentfrakturen entscheiden sich 30 \% der Operateure f{\"u}r eine winkelstabile Plattenosteosynthese. Bei Beteiligung des kaudalen Pols dient als zus{\"a}tzliche Sicherung die McLaughlin-Schlinge (60 \%). Diskussion Der Versorgungsstandard von Patellafrakturen in Deutschland entspricht weitgehend der aktualisierten S2e-Leitlinie. Nach wie vor wird die klassische Zuggurtungsosteosynthese als Verfahren der Wahl genutzt. Weitere klinische (Langzeit‑)Studien werden ben{\"o}tigt, um die Vorteile der winkelstabilen Plattenosteosynthese zu verifizieren.},
  language  = {de}
}
@article{DiehlSchmidLicataGoldhardtetal.2019,
  author    = {Diehl-Schmid, Janine and Licata, Abigail and Goldhardt, Oliver and F{\"o}rstl, Hans and Yakushew, Igor and Otto, Markus and Anderl-Straub, Sarah and Beer, Ambros and Ludolph, Albert Christian and Landwehrmeyer, Georg Bernhard and Levin, Johannes and Danek, Adrian and Fliessbach, Klaus and Spottke, Annika and Fassbender, Klaus and Lyros, Epameinondas and Prudlo, Johannes and Krause, Bernd Joachim and Volk, Alexander and Edbauer, Dieter and Schroeter, Matthias Leopold and Drzezga, Alexander and Kornhuber, Johannes and Lauer, Martin and Grimmer, Timo},
  title     = {FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations},
  series = {Translational Psychiatry},
  volume    = {9},
  journal   = {Translational Psychiatry},
  organization    = {FTLDc Study Group},
  doi       = {10.1038/s41398-019-0381-1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225308},
  year      = {2019},
  abstract  = {C9ORF72 mutations are the most common cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). MRI studies have investigated structural changes in C9ORF72-associated FTLD (C9FTLD) and provided first insights about a prominent involvement of the thalamus and the cerebellum. Our multicenter, 18F-fluorodeoxyglucose positron-emission tomography study of 22 mutation carriers with FTLD, 22 matched non-carriers with FTLD, and 23 cognitively healthy controls provided valuable insights into functional changes in C9FTLD: compared to non-carriers, mutation carriers showed a significant reduction of glucose metabolism in both thalami, underscoring the key role of the thalamus in C9FTLD. Thalamic metabolism did not correlate with disease severity, duration of disease, or the presence of psychotic symptoms. Against our expectations we could not demonstrate a cerebellar hypometabolism in carriers or non-carriers. Future imaging and neuropathological studies in large patient cohorts are required to further elucidate the central role of the thalamus in C9FTLD.},
  language  = {en}
}