@article{PoepplerLuebtowSchlauersbachetal.2019,
  author    = {P{\"o}ppler, Ann-Christin and L{\"u}btow, Michael M. and Schlauersbach, Jonas and Wiest, Johannes and Meinel, Lorenz and Luxenhofer, Robert},
  title     = {Strukturmodell von Polymermizellen in Abh{\"a}ngigkeit von der Curcumin-Beladung mithilfe von Festk{\"o}rper-NMR-Spektroskopie},
  series = {Angewandte Chemie},
  volume    = {131},
  journal   = {Angewandte Chemie},
  number    = {51},
  doi       = {10.1002/ange.201908914},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-212513},
  pages     = {18712-18718},
  year      = {2019},
  abstract  = {Detaillierte Einblicke in die Struktur von mit Wirkstoffen beladenen Polymermizellen sind rar, aber wichtig um gezielt optimierte Transportsysteme entwickeln zu k{\"o}nnen. Wir konnten beobachten, dass eine Erh{\"o}hung der Curcumin-Beladung von Triblockcopolymeren auf Basis von Poly(2-oxazolinen) und Poly(2-oxazinen) schlechtere Aufl{\"o}sungseigenschaften nach sich zieht. Mitthilfe von Festk{\"o}rper-NMR-Spektroskopie und komplement{\"a}ren Techniken ist es m{\"o}glich, ein ladungsabh{\"a}ngiges Strukturmodell auf molekularer Ebene zu erstellen, das eine Erkl{\"a}rung f{\"u}r die beobachteten Unterschiede liefert. Dabei belegen die {\"A}nderungen der chemischen Verschiebungen und Kreuzsignale in 2D-NMR-Experimenten die Beteiligung des hydrophoben Polymerblocks an der Koordination der Curcumin-Molek{\"u}le, w{\"a}hrend bei h{\"o}herer Beladung auch eine zunehmende Wechselwirkung mit dem hydrophilen Polymerblock beobachtet wird. Letztere k{\"o}nnte elementar f{\"u}r die Stabilisierung von ultrahochbeladenen Polymermizellen sowie das Design von verbesserten Wirkstofftransportsystemen sein.},
  language  = {de}
}
@article{KadeTandonWeichholdetal.2021,
  author    = {Kade, Juliane C. and Tandon, Biranche and Weichhold, Jan and Pisignano, Dario and Persano, Luana and Luxenhofer, Robert and Dalton, Paul D.},
  title     = {Melt electrowriting of poly(vinylidene fluoride-co-trifluoroethylene)},
  series = {Polymer International},
  volume    = {70},
  journal   = {Polymer International},
  number    = {12},
  doi       = {10.1002/pi.6272},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-257654},
  pages     = {1725-1732},
  year      = {2021},
  abstract  = {Poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-co-TrFE)) is an electroactive polymer with growing interest for applications in biomedical materials and flexible electronics. In this study, a solvent-free additive manufacturing technique called melt electrowriting (MEW) has been utilized to fabricate well-defined microperiodic structures of the copolymer (P(VDF-co-TrFE)). MEW of the highly viscous polymer melt was initiated using a heated collector at temperatures above 120 °C and required remarkably slow collector speeds below 100 mm min\(^{-1}\). The fiber surface morphology was affected by the collector speed and an increase in β-phase was observed for scaffolds compared to the unprocessed powder. Videography shows vibrations of the P(VDF-co-TrFE) jet previously unseen during MEW, probably due to repeated charge buildup and discharge. Furthermore, piezo-force microscopy measurements demonstrated the electromechanical response of MEW-fabricated fibers. This research therefore achieves the melt electrohydrodynamic processing of fibers with micrometer resolution into defined structures with an important electroactive polymer.},
  language  = {en}
}
@article{PoepplerLuebtowSchlauersbachetal.2019,
  author    = {P{\"o}ppler, Ann-Christin and L{\"u}btow, Michael M. and Schlauersbach, Jonas and Wiest, Johannes and Meinel, Lorenz and Luxenhofer, Robert},
  title     = {Loading dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid-State NMR Spectroscopy},
  series = {Angewandte Chemie International Edition},
  volume    = {58},
  journal   = {Angewandte Chemie International Edition},
  number    = {51},
  doi       = {10.1002/anie.201908914},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-206705},
  pages     = {18540-18546},
  year      = {2019},
  abstract  = {Detailed insight into the internal structure of drug-loaded polymeric micelles is scarce, but important for developing optimized delivery systems. We observed that an increase in the curcumin loading of triblock copolymers based on poly(2-oxazolines) and poly(2-oxazines) results in poorer dissolution properties. Using solid-state NMR spectroscopy and complementary tools we propose a loading-dependent structural model on the molecular level that provides an explanation for these pronounced differences. Changes in the chemical shifts and cross-peaks in 2D NMR experiments give evidence for the involvement of the hydrophobic polymer block in the curcumin coordination at low loadings, while at higher loadings an increase in the interaction with the hydrophilic polymer blocks is observed. The involvement of the hydrophilic compartment may be critical for ultrahigh-loaded polymer micelles and can help to rationalize specific polymer modifications to improve the performance of similar drug delivery systems.},
  language  = {en}
}