@article{MontesCobosLiFischeretal.2015,
  author    = {Montes-Cobos, Elena and Li, Xiao and Fischer, Henrike J. and Sasse, Andr{\´e} and K{\"u}gler, Sebastian and Didi{\´e}, Michael and Toischer, Karl and Fassnacht, Martin and Dressel, Ralf and Reichardt, Holger M.},
  title     = {Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload},
  series = {PLoS One},
  volume    = {10},
  journal   = {PLoS One},
  number    = {11},
  doi       = {10.1371/journal.pone.0143954},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-137575},
  pages     = {e0143954},
  year      = {2015},
  abstract  = {Mineralocorticoid receptor (MR) inactivation in mice results in early postnatal lethality. Therefore we generated mice in which MR expression can be silenced during adulthood by administration of doxycycline (Dox). Using a lentiviral approach, we obtained two lines of transgenic mice harboring a construct that allows for regulatable MR inactivation by RNAi and concomitant expression of eGFP. MR mRNA levels in heart and kidney of inducible MR knock-down mice were unaltered in the absence of Dox, confirming the tightness of the system. In contrast, two weeks after Dox administration MR expression was significantly diminished in a variety of tissues. In the kidney, this resulted in lower mRNA levels of selected target genes, which was accompanied by strongly increased serum aldosterone and plasma renin levels as well as by elevated sodium excretion. In the healthy heart, gene expression and the amount of collagen were unchanged despite MR levels being significantly reduced. After transverse aortic constriction, however, cardiac hypertrophy and progressive heart failure were attenuated by MR silencing, fibrosis was unaffected and mRNA levels of a subset of genes reduced. Taken together, we believe that this mouse model is a useful tool to investigate the role of the MR in pathophysiological processes.},
  language  = {en}
}
@article{ReppenhagenBeckerKugleretal.2023,
  author    = {Reppenhagen, Stephan and Becker, Roland and Kugler, Andreas and John, Dominik and Kopf, Sebastian and Anetzberger, Hermann},
  title     = {Hand dominance is not of significance in performing fundamental arthroscopic skills simulation training tasks},
  series = {Arthroscopy, Sports Medicine, and Rehabilitation},
  volume    = {5},
  journal   = {Arthroscopy, Sports Medicine, and Rehabilitation},
  number    = {5},
  issn      = {2666-061X},
  doi       = {10.1016/j.asmr.2023.100767},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-350432},
  year      = {2023},
  abstract  = {Purpose To compare the performance of the dominant and nondominant hand during fundamental arthroscopic simulator training. Methods Surgical trainees who participated in a 2-day simulator training course between 2021 and 2023 were classified, according to their arthroscopic experience in beginners and competents. Only right-handed individuals with complete data sets were included in the study. Ambidexterity was trained using a box trainer (Fundamentals of Arthroscopic Surgery Training, Virtamed AG, Schlieren, Switzerland).Two tasks, periscoping for learning camera guidance and triangulation for additional instrument handling, were performed 4 times with the camera in the dominant hand and then in the nondominant hand. For each task, exercise time, camera path length, and instrument path length were recorded and analyzed. Results Out of 94 participants 74 right-handed individuals (22 females, 52 males) were classified to novices (n = 43, less than 10 independently performed arthroscopies) and competents (n = 31, more than 10 independently performed arthroscopies). Competents performed significantly better than novices. No significant difference was found after changing the guiding hand for the camera from the dominant to the nondominant hand regarding the camera path length and the instrument path length. Notably, tasks were performed even faster when using the camera in the nondominant hand. Conclusions Our data demonstrate that the learned manual skills during basic arthroscopic training are quickly transferred to the contralateral side. In consequence, additional fundamental skills training for camera guidance and instrument handling of the nondominant hand are not necessary. Clinical Relevance For skillful arthroscopy, camera guidance and instrument handing must be equally mastered with both hands. It is important to understand how hand dominance may affect learning during arthroscopic simulator training.},
  language  = {en}
}