@phdthesis{FreiherrvonRotenhan2022,
  author    = {Freiherr von Rotenhan, Stefan},
  title     = {Herstellung und Charakterisierung von anti-CD40- und anti-41BB-Fusionsproteinen mit PDL1-abh{\"a}ngiger agonistischer Aktivit{\"a}t},
  doi       = {10.25972/OPUS-28879},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-288794},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2022},
  abstract  = {In this work, bispecific antibodies were produced by coupling TNFR-specific antibodies with checkpoint inhibitors, tested for their functionality and compared with each other. This combination should enable a targeted TNFR activation in tumor tissue, where a high PDL1 expression is frequent and therefore the formation of oligomeric transactivating (TNFSF3-TNFRSF3)2 complexes should only occur there by binding to PDL1-expressing cells. These receptor-ligand complexes are a prerequisite for the agonistic activity of the antibodies.},
  subject      = {Immun-Checkpoint},
  language  = {de}
}