@phdthesis{Heuer2007,
  author    = {Heuer, Stefan Matthias},
  title     = {Der Einfluss proinflammatorischer Cytokine (TNF-alpha und IL-1 beta) auf die Mechanik und Energetik in humanem Myokard},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-27584},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2007},
  abstract  = {Die proinflammatorischen Cytokine TNF-alpha und IL-1 beta werden im Myokard bei akuter und chronischer Herzinsuffizienz sezerniert. Ihr negativer Einfluß auf Inotropie und Kontraktions{\"o}konomie des Myokards wurde in zahlreichen In-Vitro und Tiermodellen nachgewiesen. Bisherige Versuche einer therapeutischen Intervention in klinischen Studien waren trotz guter Erfolge in Tiermodellen bislang erfolglos. Um diese Diskrepanz zu untersuchen wurden erstmals Messungen der Kontraktilit{\"a}t und Kontraktions{\"o}konomie an humanem Myokard durchgef{\"u}hrt. Weiterhin wurden Untersuchungen bez{\"u}glich der postulierten Signaltransduktion mittels der Sphingomyelinaseaktivit{\"a}t Ergebnisse Sowohl TNF-alpha; als auch IL-1\&\#61538; zeigen {\"u}bereinstimmend mit In-Vitro Versuchen an nicht-humanem Myokard eine deutlich Minderung der Kontraktilit{\"a}t und Steigerung des kontraktionsabh{\"a}ngigen Sauerstoffverbrauchs. IL-beta f{\"u}hrt dar{\"u}ber hinaus zu einer erh{\"o}hten diastolischen Kraft. Die Relaxationsgeschwindigkeit wird nicht beeintr{\"a}chtigt. Glutathion vermindert diese Effekte in 10 molarer Konzentration fast vollst{\"a}ndig. Eine Steigerung der Aktivit{\"a}t der neutralen oder sauren Sphingomyelinase kann nicht als Bestandteil der Signaltransduktion best{\"a}tigt werden. Schlussfolgerung Alleinig auf TNF-alpha zielende Therapieans{\"a}tze inhibieren die negativen Einfl{\"u}sse von Cytokinen im isch{\"a}mischen und postisch{\"a}mischen Myokard nicht ausreichend. Glutathionapplikation kann TNF-alpha und IL-beta Effekte auf das Myokard inhibieren.},
  subject      = {Tumor-Nekrose-Faktor <alpha>},
  language  = {de}
}
@article{LevitisGouldvan PraagGauetal.2021,
  author    = {Levitis, Elizabeth and Gould van Praag, Cassandra D and Gau, R{\´e}mi and Heunis, Stephan and DuPre, Elizabeth and Kiar, Gregory and Bottenhorn, Katherine L and Glatard, Tristan and Nikolaidis, Aki and Whitaker, Kirstie Jane and Mancini, Matteo and Niso, Guiomar and Afyouni, Soroosh and Alonso-Ortiz, Eva and Appelhoff, Stefan and Arnatkeviciute, Aurina and Atay, Selim Melvin and Auer, Tibor and Baracchini, Giulia and Bayer, Johanna M M and Beauvais, Michael J S and Bijsterbosch, Janine D and Bilgin, Isil P and Bollmann, Saskia and Bollmann, Steffen and Botvinik-Nezer, Rotem and Bright, Molly G and Calhoun, Vince D and Chen, Xiao and Chopra, Sidhant and Chuan-Peng, Hu and Close, Thomas G and Cookson, Savannah L and Craddock, R Cameron and De La Vega, Alejandro and De Leener, Benjamin and Demeter, Damion V and Di Maio, Paola and Dickie, Erin W and Eickhoff, Simon B and Esteban, Oscar and Finc, Karolina and Frigo, Matteo and Ganesan, Saampras and Ganz, Melanie and Garner, Kelly G and Garza-Villarreal, Eduardo A and Gonzalez-Escamilla, Gabriel and Goswami, Rohit and Griffiths, John D and Grootswagers, Tijl and Guay, Samuel and Guest, Olivia and Handwerker, Daniel A and Herholz, Peer and Heuer, Katja and Huijser, Dorien C and Iacovella, Vittorio and Joseph, Michael J E and Karakuzu, Agah and Keator, David B and Kobeleva, Xenia and Kumar, Manoj and Laird, Angela R and Larson-Prior, Linda J and Lautarescu, Alexandra and Lazari, Alberto and Legarreta, Jon Haitz and Li, Xue-Ying and Lv, Jinglei and Mansour L., Sina and Meunier, David and Moraczewski, Dustin and Nandi, Tulika and Nastase, Samuel A and Nau, Matthias and Noble, Stephanie and Norgaard, Martin and Obungoloch, Johnes and Oostenveld, Robert and Orchard, Edwina R and Pinho, Ana Lu{\´i}sa and Poldrack, Russell A and Qiu, Anqi and Raamana, Pradeep Reddy and Rokem, Ariel and Rutherford, Saige and Sharan, Malvika and Shaw, Thomas B and Syeda, Warda T and Testerman, Meghan M and Toro, Roberto and Valk, Sofie L and Van Den Bossche, Sofie and Varoquaux, Ga{\"e}l and V{\´a}ša, František and Veldsman, Michele and Vohryzek, Jakub and Wagner, Adina S and Walsh, Reubs J and White, Tonya and Wong, Fu-Te and Xie, Xihe and Yan, Chao-Gan and Yang, Yu-Fang and Yee, Yohan and Zanitti, Gaston E and Van Gulick, Ana E and Duff, Eugene and Maumet, Camille},
  title     = {Centering inclusivity in the design of online conferences—An OHBM-Open Science perspective},
  series = {GigaScience},
  volume    = {10},
  journal   = {GigaScience},
  doi       = {10.1093/gigascience/giab051},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-371574},
  pages     = {1-14},
  year      = {2021},
  abstract  = {As the global health crisis unfolded, many academic conferences moved online in 2020. This move has been hailed as a positive step towards inclusivity in its attenuation of economic, physical, and legal barriers and effectively enabled many individuals from groups that have traditionally been underrepresented to join and participate. A number of studies have outlined how moving online made it possible to gather a more global community and has increased opportunities for individuals with various constraints, e.g., caregiving responsibilities. Yet, the mere existence of online conferences is no guarantee that everyone can attend and participate meaningfully. In fact, many elements of an online conference are still significant barriers to truly diverse participation: the tools used can be inaccessible for some individuals; the scheduling choices can favour some geographical locations; the set-up of the conference can provide more visibility to well-established researchers and reduce opportunities for early-career researchers. While acknowledging the benefits of an online setting, especially for individuals who have traditionally been underrepresented or excluded, we recognize that fostering social justice requires inclusivity to actively be centered in every aspect of online conference design. Here, we draw from the literature and from our own experiences to identify practices that purposefully encourage a diverse community to attend, participate in, and lead online conferences. Reflecting on how to design more inclusive online events is especially important as multiple scientific organizations have announced that they will continue offering an online version of their event when in-person conferences can resume.},
  language  = {en}
}