@article{GuggenbergerBleyVogtetal.2022,
  author    = {Guggenberger, Konstanze V. and Bley, Thorsten A. and Vogt, Marius L. and Urbach, Horst and Meckel, Stephan},
  title     = {High-Resolution Black Blood Vessel Wall Imaging in COVID-19 Encephalopathy-Is it Really Endotheliitis?},
  series = {Clinical Neuroradiology},
  volume    = {32},
  journal   = {Clinical Neuroradiology},
  number    = {1},
  doi       = {10.1007/s00062-021-01109-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-264794},
  pages     = {295-296},
  year      = {2022},
  abstract  = {No abstract available.},
  language  = {en}
}
@article{GuggenbergerTorreLudwigetal.2022,
  author    = {Guggenberger, Konstanze Viktoria and Torre, Giulia Dalla and Ludwig, Ute and Vogel, Patrick and Weng, Andreas Max and Vogt, Marius Lothar and Fr{\"o}hlich, Matthias and Schmalzing, Marc and Raithel, Esther and Forman, Christoph and Urbach, Horst and Meckel, Stephan and Bley, Thorsten Alexander},
  title     = {Vasa vasorum of proximal cerebral arteries after dural crossing - potential imaging confounder in diagnosing intracranial vasculitis in elderly subjects on black-blood MRI},
  series = {European Radiology},
  volume    = {32},
  journal   = {European Radiology},
  number    = {2},
  issn      = {1432-1084},
  doi       = {10.1007/s00330-021-08181-5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-266524},
  pages     = {1276-1284},
  year      = {2022},
  abstract  = {Objectives Vessel wall enhancement (VWE) may be commonly seen on MRI images of asymptomatic subjects. This study aimed to characterize the VWE of the proximal internal carotid (ICA) and vertebral arteries (VA) in a non-vasculitic elderly patient cohort. Methods Cranial MRI scans at 3 Tesla were performed in 43 patients (aged ≥ 50 years) with known malignancy for exclusion of cerebral metastases. For vessel wall imaging (VWI), a high-resolution compressed-sensing black-blood 3D T1-weighted fast (turbo) spin echo sequence (T1 CS-SPACE prototype) was applied post gadolinium with an isotropic resolution of 0.55 mm. Bilateral proximal intradural ICA and VA segments were evaluated for presence, morphology, and longitudinal extension of VWE. Results Concentric VWE of the proximal intradural ICA was found in 13 (30\%) patients, and of the proximal intradural VA in 39 (91\%) patients. Mean longitudinal extension of VWE after dural entry was 13 mm in the VA and 2 mm in the ICA. In 14 of 39 patients (36\%) with proximal intradural VWE, morphology of VWE was suggestive of the mere presence of vasa vasorum. In 25 patients (64 \%), morphology indicated atherosclerotic lesions in addition to vasa vasorum. Conclusions Vasa vasorum may account for concentric VWE within the proximal 2 mm of the ICA and 13 mm of the VA after dural entry in elderly subjects. Concentric VWE in these locations should not be confused with large artery vasculitis. Distal to these segments, VWE may be more likely related to pathologic conditions such as vasculitis.},
  language  = {en}
}
@article{GuggenbergerVogtSongetal.2023,
  author    = {Guggenberger, Konstanze V. and Vogt, Marius L. and Song, Jae W. and Weng, Andreas M. and Fr{\"o}hlich, Matthias and Schmalzing, Marc and Venhoff, Nils and Hillenkamp, Jost and Pham, Mirko and Meckel, Stephan and Bley, Thorsten A.},
  title     = {Intraorbital findings in giant cell arteritis on black blood MRI},
  series = {European Radiology},
  volume    = {33},
  journal   = {European Radiology},
  number    = {4},
  doi       = {10.1007/s00330-022-09256-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324978},
  pages     = {2529-2535},
  year      = {2023},
  abstract  = {Objective Blindness is a feared complication of giant cell arteritis (GCA). However, the spectrum of pathologic orbital imaging findings on magnetic resonance imaging (MRI) in GCA is not well understood. In this study, we assess inflammatory changes of intraorbital structures on black blood MRI (BB-MRI) in patients with GCA compared to age-matched controls. Methods In this multicenter case-control study, 106 subjects underwent BB-MRI. Fifty-six patients with clinically or histologically diagnosed GCA and 50 age-matched controls without clinical or laboratory evidence of vasculitis were included. All individuals were imaged on a 3-T MR scanner with a post-contrast compressed-sensing (CS) T1-weighted sampling perfection with application-optimized contrasts using different flip angle evolution (SPACE) BB-MRI sequence. Imaging results were correlated with available clinical symptoms. Results Eighteen of 56 GCA patients (32\%) showed inflammatory changes of at least one of the intraorbital structures. The most common finding was enhancement of at least one of the optic nerve sheaths (N = 13, 72\%). Vessel wall enhancement of the ophthalmic artery was unilateral in 8 and bilateral in 3 patients. Enhancement of the optic nerve was observed in one patient. There was no significant correlation between imaging features of inflammation and clinically reported orbital symptoms (p = 0.10). None of the age-matched control patients showed any inflammatory changes of intraorbital structures. Conclusions BB-MRI revealed inflammatory findings in the orbits in up to 32\% of patients with GCA. Optic nerve sheath enhancement was the most common intraorbital inflammatory change on BB-MRI. MRI findings were independent of clinically reported orbital symptoms. Key Points • Up to 32\% of GCA patients shows signs of inflammation of intraorbital structures on BB-MRI. • Enhancement of the optic nerve sheath is the most common intraorbital finding in GCA patients on BB-MRI. • Features of inflammation of intraorbital structures are independent of clinically reported symptoms.},
  language  = {en}
}