@phdthesis{Kieser2008,
  author    = {Kieser, Stephanie Beatrix},
  title     = {Effekt eines 6-monatigen Trainings auf die k{\"o}rperliche Leistungsf{\"a}higkeit von Jugendlichen und jungen Erwachsenen mit Mukoviszidose},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-26530},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2008},
  abstract  = {K{\"o}rperliche Aktivit{\"a}t ist ein wichtiges Element im Leben von Patienten mit Cystischer Fibrose. Die k{\"o}rperliche Fitness gilt zur Zeit als einer der besten Pr{\"a}diktoren f{\"u}r die Langzeit-Mortalit{\"a}t bei Patienten mit CF. Bisherige Studien f{\"u}hrten ausschließlich {\"u}berwachtes Training durch. Ziel dieser Arbeit war es zu {\"u}berpr{\"u}fen, ob ein un{\"u}berwachtes regelm{\"a}ßiges k{\"o}rperliches Heimtraining bei Mukoviszidosepatienten {\"u}ber 6 Monate durchf{\"u}hrbar ist und eine Verbesserung der k{\"o}rperlichen Leistungsf{\"a}higkeit erm{\"o}glicht. Es wurden 48 Patienten in Trainingsgruppe (n=23) und Kontrollgruppe (n=25) randomisiert. Die Untersuchungen ergaben im Verlauf eine signifikante Verbesserung der maximalen Sauerstoffaufnahme (VO2 max;p=0.0017) und der maximalen Leistungsf{\"a}higkeit (W:p=0.0293) bei der Trainingsgruppe im Vergleich zur Kontrollgruppe. Es wurde nachgewiesen, dass un{\"u}berwachtes k{\"o}rperliches Training bei CF-Patienten einen Leistungszuwachs bringt und damit Konsequenzen f{\"u}r ihre Lebensqualit{\"a}t und Lebenserwartung hat.},
  subject      = {Mukoviszidose},
  language  = {de}
}
@article{HebestreitSchmidKieseretal.2014,
  author    = {Hebestreit, Helge and Schmid, Kerstin and Kieser, Stephanie and Junge, Sibylle and Ballmann, Manfred and Roth, Kristina and Hebestreit, Alexandra and Schenk, Thomas and Schindler, Christian and Posselt, Hans-Georg and Kriemler, Susi},
  title     = {Quality of life is associated with physical activity and fitness in cystic fibrosis},
  doi       = {10.1186/1471-2466-14-26},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-110508},
  year      = {2014},
  abstract  = {Background Health-related and disease-specific quality of life (HRQoL) has been increasingly valued as relevant clinical parameter in cystic fibrosis (CF) clinical care and clinical trials. HRQoL measures should assess - among other domains - daily functioning from a patient's perspective. However, validation studies for the most frequently used HRQoL questionnaire in CF, the Cystic Fibrosis Questionnaire (CFQ), have not included measures of physical activity or fitness. The objective of this study was, therefore, to determine the cross-sectional and longitudinal relationships between HRQoL, physical activity and fitness in patients with CF. Methods Baseline (n = 76) and 6-month follow-up data (n = 70) from patients with CF (age ≥12 years, FEV1 ≥35\%) were analysed. Patients participated in two multi-centre exercise intervention studies with identical assessment methodology. Outcome variables included HRQoL (German revised multi-dimensional disease-specific CFQ (CFQ-R)), body composition, pulmonary function, physical activity, short-term muscle power, and aerobic fitness by peak oxygen uptake and aerobic power. Results Peak oxygen uptake was positively related to 7 of 13 HRQoL scales cross-sectionally (r = 0.30-0.46). Muscle power (r = 0.25-0.32) and peak aerobic power (r = 0.24-0.35) were positively related to 4 scales each, and reported physical activity to 1 scale (r = 0.29). Changes in HRQoL-scores were directly and significantly related to changes in reported activity (r = 0.35-0.39), peak aerobic power (r = 0.31-0.34), and peak oxygen uptake (r = 0.26-0.37) in 3 scales each. Established associates of HRQoL such as FEV1 or body mass index correlated positively with fewer scales (all 0.24 < r < 0.55). Conclusions HRQoL was associated with physical fitness, especially aerobic fitness, and to a lesser extent with reported physical activity. These findings underline the importance of physical fitness for HRQoL in CF and provide an additional rationale for exercise testing in this population.},
  language  = {en}
}