@article{WalterGrussNeidlingeretal.2020,
  author    = {Walter, Steffen and Gruss, Sascha and Neidlinger, Jana and Stross, Isabelle and Hann, Alexander and Wagner, Martin and Seufferlein, Thomas and Walter, Benjamin},
  title     = {Evaluation of an Objective Measurement Tool for Stress Level Reduction by Individually Chosen Music During Colonoscopy—Results From the Study "ColoRelaxTone"},
  series = {Frontiers in Medicine},
  volume    = {7},
  journal   = {Frontiers in Medicine},
  doi       = {10.3389/fmed.2020.00525},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-212337},
  year      = {2020},
  abstract  = {Background and Aims: Colonoscopy as standard procedure in endoscopy is often perceived as uncomfortable for patients. Patient's anxiety is therefore a significant issue, which often lead to avoidance of participation of relevant examinations as CRC-screening. Non-pharmacological anxiety management interventions such as music might contribute to relaxation in the phase prior and during endoscopy. Although music's anxiolytic effects have been reported previously, no objective measurement of stress level reduction has been reported yet. Focus of this study was to evaluate the objective measurement of the state of relaxation in patients undergoing colonoscopy. Methods: Prospective study (n = 196) performed at one endoscopic high-volume center. Standard colonoscopy was performed in control group. Interventional group received additionally self-chosen music over earphones. Facial Electromyography (fEMG) activity was obtained. Clinician Satisfaction with Sedation Instrument (CSSI) and Patients Satisfaction with Sedation Instrument (PSSI) was answered by colonoscopists and patients, respectively. Overall satisfaction with music accompanied colonoscopy was obtained if applicable. Results: Mean difference measured by fEMG via musculus zygomaticus major indicated a significantly lower stress level in the music group [7.700(±5.560) μV vs. 4.820(±3.330) μV; p = 0.001]. Clinician satisfaction was significantly higher with patients listening to music [82.69(±15.04) vs. 87.3(±15.02) pts.; p = 0.001]. Patient's satisfaction was higher but did not differ significantly. Conclusions: We conclude that self-chosen music contributes objectively to a reduced stress level for patients and therefore subjectively perceived satisfaction for endoscopists. Therefore, music should be considered as a non-pharmacological treatment method of distress reduction especially in the beginning of endoscopic procedures.},
  language  = {en}
}
@article{WatermannMeyerWagneretal.2023,
  author    = {Watermann, Christoph and Meyer, Malin Tordis and Wagner, Steffen and Wittekindt, Claus and Klussmann, Jens Peter and Erguen, Sueleyman and Baumgart-Vogt, Eveline and Karnati, Srikanth},
  title     = {Peroxisomes are highly abundant and heterogeneous in human parotid glands},
  series = {International Journal of Molecular Sciences},
  volume    = {24},
  journal   = {International Journal of Molecular Sciences},
  number    = {5},
  issn      = {1422-0067},
  doi       = {10.3390/ijms24054783},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-311079},
  year      = {2023},
  abstract  = {The parotid gland is one of the major salivary glands producing a serous secretion, and it plays an essential role in the digestive and immune systems. Knowledge of peroxisomes in the human parotid gland is minimal; furthermore, the peroxisomal compartment and its enzyme composition in the different cell types of the human parotid gland have never been subjected to a detailed investigation. Therefore, we performed a comprehensive analysis of peroxisomes in the human parotid gland's striated duct and acinar cells. We combined biochemical techniques with various light and electron microscopy techniques to determine the localization of parotid secretory proteins and different peroxisomal marker proteins in parotid gland tissue. Moreover, we analyzed the mRNA of numerous gene encoding proteins localized in peroxisomes using real-time quantitative PCR. The results confirm the presence of peroxisomes in all striated duct and acinar cells of the human parotid gland. Immunofluorescence analyses for various peroxisomal proteins showed a higher abundance and more intense staining in striated duct cells compared to acinar cells. Moreover, human parotid glands comprise high quantities of catalase and other antioxidative enzymes in discrete subcellular regions, suggesting their role in protection against oxidative stress. This study provides the first thorough description of parotid peroxisomes in different parotid cell types of healthy human tissue.},
  language  = {en}
}
@article{MeyerWatermannDreyeretal.2021,
  author    = {Meyer, Malin Tordis and Watermann, Christoph and Dreyer, Thomas and Wagner, Steffen and Wittekindt, Claus and Klussmann, Jens Peter and Erg{\"u}n, S{\"u}leyman and Baumgart-Vogt, Eveline and Karnati, Srikanth},
  title     = {Differential expression of peroxisomal proteins in distinct types of parotid gland tumors},
  series = {International Journal of Molecular Sciences},
  volume    = {22},
  journal   = {International Journal of Molecular Sciences},
  number    = {15},
  issn      = {1422-0067},
  doi       = {10.3390/ijms22157872},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-261047},
  year      = {2021},
  abstract  = {Salivary gland cancers are rare but aggressive tumors that have poor prognosis and lack effective cure. Of those, parotid tumors constitute the majority. Functioning as metabolic machinery contributing to cellular redox balance, peroxisomes have emerged as crucial players in tumorigenesis. Studies on murine and human cells have examined the role of peroxisomes in carcinogenesis with conflicting results. These studies either examined the consequences of altered peroxisomal proliferators or compared their expression in healthy and neoplastic tissues. None, however, examined such differences exclusively in human parotid tissue or extended comparison to peroxisomal proteins and their associated gene expressions. Therefore, we examined differences in peroxisomal dynamics in parotid tumors of different morphologies. Using immunofluorescence and quantitative PCR, we compared the expression levels of key peroxisomal enzymes and proliferators in healthy and neoplastic parotid tissue samples. Three parotid tumor subtypes were examined: pleomorphic adenoma, mucoepidermoid carcinoma and acinic cell carcinoma. We observed higher expression of peroxisomal matrix proteins in neoplastic samples with exceptional down regulation of certain enzymes; however, the degree of expression varied between tumor subtypes. Our findings confirm previous experimental results on other organ tissues and suggest peroxisomes as possible therapeutic targets or markers in all or certain subtypes of parotid neoplasms.},
  language  = {en}
}
@article{LevitisGouldvan PraagGauetal.2021,
  author    = {Levitis, Elizabeth and Gould van Praag, Cassandra D and Gau, R{\´e}mi and Heunis, Stephan and DuPre, Elizabeth and Kiar, Gregory and Bottenhorn, Katherine L and Glatard, Tristan and Nikolaidis, Aki and Whitaker, Kirstie Jane and Mancini, Matteo and Niso, Guiomar and Afyouni, Soroosh and Alonso-Ortiz, Eva and Appelhoff, Stefan and Arnatkeviciute, Aurina and Atay, Selim Melvin and Auer, Tibor and Baracchini, Giulia and Bayer, Johanna M M and Beauvais, Michael J S and Bijsterbosch, Janine D and Bilgin, Isil P and Bollmann, Saskia and Bollmann, Steffen and Botvinik-Nezer, Rotem and Bright, Molly G and Calhoun, Vince D and Chen, Xiao and Chopra, Sidhant and Chuan-Peng, Hu and Close, Thomas G and Cookson, Savannah L and Craddock, R Cameron and De La Vega, Alejandro and De Leener, Benjamin and Demeter, Damion V and Di Maio, Paola and Dickie, Erin W and Eickhoff, Simon B and Esteban, Oscar and Finc, Karolina and Frigo, Matteo and Ganesan, Saampras and Ganz, Melanie and Garner, Kelly G and Garza-Villarreal, Eduardo A and Gonzalez-Escamilla, Gabriel and Goswami, Rohit and Griffiths, John D and Grootswagers, Tijl and Guay, Samuel and Guest, Olivia and Handwerker, Daniel A and Herholz, Peer and Heuer, Katja and Huijser, Dorien C and Iacovella, Vittorio and Joseph, Michael J E and Karakuzu, Agah and Keator, David B and Kobeleva, Xenia and Kumar, Manoj and Laird, Angela R and Larson-Prior, Linda J and Lautarescu, Alexandra and Lazari, Alberto and Legarreta, Jon Haitz and Li, Xue-Ying and Lv, Jinglei and Mansour L., Sina and Meunier, David and Moraczewski, Dustin and Nandi, Tulika and Nastase, Samuel A and Nau, Matthias and Noble, Stephanie and Norgaard, Martin and Obungoloch, Johnes and Oostenveld, Robert and Orchard, Edwina R and Pinho, Ana Lu{\´i}sa and Poldrack, Russell A and Qiu, Anqi and Raamana, Pradeep Reddy and Rokem, Ariel and Rutherford, Saige and Sharan, Malvika and Shaw, Thomas B and Syeda, Warda T and Testerman, Meghan M and Toro, Roberto and Valk, Sofie L and Van Den Bossche, Sofie and Varoquaux, Ga{\"e}l and V{\´a}ša, František and Veldsman, Michele and Vohryzek, Jakub and Wagner, Adina S and Walsh, Reubs J and White, Tonya and Wong, Fu-Te and Xie, Xihe and Yan, Chao-Gan and Yang, Yu-Fang and Yee, Yohan and Zanitti, Gaston E and Van Gulick, Ana E and Duff, Eugene and Maumet, Camille},
  title     = {Centering inclusivity in the design of online conferences—An OHBM-Open Science perspective},
  series = {GigaScience},
  volume    = {10},
  journal   = {GigaScience},
  doi       = {10.1093/gigascience/giab051},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-371574},
  pages     = {1-14},
  year      = {2021},
  abstract  = {As the global health crisis unfolded, many academic conferences moved online in 2020. This move has been hailed as a positive step towards inclusivity in its attenuation of economic, physical, and legal barriers and effectively enabled many individuals from groups that have traditionally been underrepresented to join and participate. A number of studies have outlined how moving online made it possible to gather a more global community and has increased opportunities for individuals with various constraints, e.g., caregiving responsibilities. Yet, the mere existence of online conferences is no guarantee that everyone can attend and participate meaningfully. In fact, many elements of an online conference are still significant barriers to truly diverse participation: the tools used can be inaccessible for some individuals; the scheduling choices can favour some geographical locations; the set-up of the conference can provide more visibility to well-established researchers and reduce opportunities for early-career researchers. While acknowledging the benefits of an online setting, especially for individuals who have traditionally been underrepresented or excluded, we recognize that fostering social justice requires inclusivity to actively be centered in every aspect of online conference design. Here, we draw from the literature and from our own experiences to identify practices that purposefully encourage a diverse community to attend, participate in, and lead online conferences. Reflecting on how to design more inclusive online events is especially important as multiple scientific organizations have announced that they will continue offering an online version of their event when in-person conferences can resume.},
  language  = {en}
}