@article{SchickBaarBrunoetal.2015,
  author    = {Schick, Martin Alexander and Baar, Wolfgang and Bruno, Raphael Romano and Wollborn, Jakob and Held, Christopher and Schneider, Reinhard and Flemming, Sven and Schlegel, Nicolas and Roewer, Norbert and Neuhaus, Winfried and Wunder, Christian},
  title     = {Balanced hydroxyethylstarch (HES 130/0.4) impairs kidney function in-vivo without inflammation},
  series = {PLoS One},
  volume    = {10},
  journal   = {PLoS One},
  number    = {9},
  doi       = {10.1371/journal.pone.0137247},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-126068},
  pages     = {e0137247},
  year      = {2015},
  abstract  = {Volume therapy is a standard procedure in daily perioperative care, and there is an ongoing discussion about the benefits of colloid resuscitation with hydroxyethylstarch (HES). In sepsis HES should be avoided due to a higher risk for acute kidney injury (AKI). Results of the usage of HES in patients without sepsis are controversial. Therefore we conducted an animal study to evaluate the impact of 6\% HES 130/0.4 on kidney integrity with sepsis or under healthy conditions Sepsis was induced by standardized Colon Ascendens Stent Peritonitis (sCASP). sCASP-group as well as control group (C) remained untreated for 24 h. After 18 h sCASP+HES group (sCASP+VOL) and control+HES (C+VOL) received 50 ml/KG balanced 6\% HES (VOL) 130/0.4 over 6h. After 24h kidney function was measured via Inulin- and PAH-Clearance in re-anesthetized rats, and serum urea, creatinine (crea), cystatin C and Neutrophil gelatinase-associated lipocalin (NGAL) as well as histopathology were analysed. In vitro human proximal tubule cells (PTC) were cultured +/- lipopolysaccharid (LPS) and with 0.1-4.0\% VOL. Cell viability was measured with XTT-, cell toxicity with LDH-test. sCASP induced severe septic AKI demonstrated divergent results regarding renal function by clearance or creatinine measure focusing on VOL. Soleley HES (C+VOL) deteriorated renal function without sCASP. Histopathology revealed significantly derangements in all HES groups compared to control. In vitro LPS did not worsen the HES induced reduction of cell viability in PTC cells. For the first time, we demonstrated, that application of 50 ml/KG 6\% HES 130/0.4 over 6 hours induced AKI without inflammation in vivo. Severity of sCASP induced septic AKI might be no longer susceptible to the way of volume expansion},
  language  = {en}
}
@incollection{Held1990,
  author    = {Held, Winfried},
  title     = {K{\"u}nstliche Beleuchtung und Architektur},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39125},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1990},
  abstract  = {No abstract available},
  subject      = {Griechenland <Altertum> / Beleuchtung / Architektur},
  language  = {de}
}
@incollection{Held1993,
  author    = {Held, Winfried},
  title     = {Heiligtum und Wohnhaus : ein Beitrag zur Topographie des klassischen Milet},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39133},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1993},
  abstract  = {No abstract available},
  subject      = {Klassische Arch{\"a}ologie},
  language  = {de}
}
@incollection{HeldRumscheid1994,
  author    = {Held, Winfried and Rumscheid, Frank},
  title     = {Erinnerungen an Mozakis. Eine neugefundene Stockwerkstele aus dem bithynischen Tarsos},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39148},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Klassische Arch{\"a}ologie},
  language  = {de}
}