@article{GuptaMinochaThapaetal.2022, author = {Gupta, Shishir K. and Minocha, Rashmi and Thapa, Prithivi Jung and Srivastava, Mugdha and Dandekar, Thomas}, title = {Role of the pangolin in origin of SARS-CoV-2: an evolutionary perspective}, series = {International Journal of Molecular Sciences}, volume = {23}, journal = {International Journal of Molecular Sciences}, number = {16}, issn = {1422-0067}, doi = {10.3390/ijms23169115}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-285995}, year = {2022}, abstract = {After the recent emergence of SARS-CoV-2 infection, unanswered questions remain related to its evolutionary history, path of transmission or divergence and role of recombination. There is emerging evidence on amino acid substitutions occurring in key residues of the receptor-binding domain of the spike glycoprotein in coronavirus isolates from bat and pangolins. In this article, we summarize our current knowledge on the origin of SARS-CoV-2. We also analyze the host ACE2-interacting residues of the receptor-binding domain of spike glycoprotein in SARS-CoV-2 isolates from bats, and compare it to pangolin SARS-CoV-2 isolates collected from Guangdong province (GD Pangolin-CoV) and Guangxi autonomous regions (GX Pangolin-CoV) of South China. Based on our comparative analysis, we support the view that the Guangdong Pangolins are the intermediate hosts that adapted the SARS-CoV-2 and represented a significant evolutionary link in the path of transmission of SARS-CoV-2 virus. We also discuss the role of intermediate hosts in the origin of Omicron.}, language = {en} } @phdthesis{Bleier2023, author = {Bleier, Michael}, title = {Underwater Laser Scanning - Refractive Calibration, Self-calibration and Mapping for 3D Reconstruction}, isbn = {978-3-945459-45-4}, doi = {10.25972/OPUS-32269}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-322693}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2023}, abstract = {There is great interest in affordable, precise and reliable metrology underwater: Archaeologists want to document artifacts in situ with high detail. In marine research, biologists require the tools to monitor coral growth and geologists need recordings to model sediment transport. Furthermore, for offshore construction projects, maintenance and inspection millimeter-accurate measurements of defects and offshore structures are essential. While the process of digitizing individual objects and complete sites on land is well understood and standard methods, such as Structure from Motion or terrestrial laser scanning, are regularly applied, precise underwater surveying with high resolution is still a complex and difficult task. Applying optical scanning techniques in water is challenging due to reduced visibility caused by turbidity and light absorption. However, optical underwater scanners provide significant advantages in terms of achievable resolution and accuracy compared to acoustic systems. This thesis proposes an underwater laser scanning system and the algorithms for creating dense and accurate 3D scans in water. It is based on laser triangulation and the main optical components are an underwater camera and a cross-line laser projector. The prototype is configured with a motorized yaw axis for capturing scans from a tripod. Alternatively, it is mounted to a moving platform for mobile mapping. The main focus lies on the refractive calibration of the underwater camera and laser projector, the image processing and 3D reconstruction. For highest accuracy, the refraction at the individual media interfaces must be taken into account. This is addressed by an optimization-based calibration framework using a physical-geometric camera model derived from an analytical formulation of a ray-tracing projection model. In addition to scanning underwater structures, this work presents the 3D acquisition of semi-submerged structures and the correction of refraction effects. As in-situ calibration in water is complex and time-consuming, the challenge of transferring an in-air scanner calibration to water without re-calibration is investigated, as well as self-calibration techniques for structured light. The system was successfully deployed in various configurations for both static scanning and mobile mapping. An evaluation of the calibration and 3D reconstruction using reference objects and a comparison of free-form surfaces in clear water demonstrate the high accuracy potential in the range of one millimeter to less than one centimeter, depending on the measurement distance. Mobile underwater mapping and motion compensation based on visual-inertial odometry is demonstrated using a new optical underwater scanner based on fringe projection. Continuous registration of individual scans allows the acquisition of 3D models from an underwater vehicle. RGB images captured in parallel are used to create 3D point clouds of underwater scenes in full color. 3D maps are useful to the operator during the remote control of underwater vehicles and provide the building blocks to enable offshore inspection and surveying tasks. The advancing automation of the measurement technology will allow non-experts to use it, significantly reduce acquisition time and increase accuracy, making underwater metrology more cost-effective.}, subject = {Selbstkalibrierung}, language = {en} } @techreport{GrossmannLe2023, type = {Working Paper}, author = {Großmann, Marcel and Le, Duy Thanh}, title = {Visualization of Network Emulation Enabled by Kathar{\´a}}, series = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, journal = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, doi = {10.25972/OPUS-32218}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-322189}, pages = {4}, year = {2023}, abstract = {In network research, reproducibility of experiments is not always easy to achieve. Infrastructures are cumbersome to set up or are not available due to vendor-specific devices. Emulators try to overcome those issues to a given extent and are available in different service models. Unfortunately, the usability of emulators requires time-consuming efforts and a deep understanding of their functionality. At first, we analyze to which extent currently available open-source emulators support network configurations and how user-friendly they are. With these insights, we describe, how an ease-to-use emulator is implemented and may run as a Network Emulator as a Service (NEaaS). Therefore, virtualization plays a major role in order to deploy a NEaaS based on Kathar{\´a}.}, language = {en} } @techreport{DworzakGrossmannLe2023, type = {Working Paper}, author = {Dworzak, Manuel and Großmann, Marcel and Le, Duy Thanh}, title = {Federated Learning for Service Placement in Fog and Edge Computing}, series = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, journal = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, doi = {10.25972/OPUS-32219}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-322193}, pages = {4}, year = {2023}, abstract = {Service orchestration requires enormous attention and is a struggle nowadays. Of course, virtualization provides a base level of abstraction for services to be deployable on a lot of infrastructures. With container virtualization, the trend to migrate applications to a micro-services level in order to be executable in Fog and Edge Computing environments increases manageability and maintenance efforts rapidly. Similarly, network virtualization adds effort to calibrate IP flows for Software-Defined Networks and eventually route it by means of Network Function Virtualization. Nevertheless, there are concepts like MAPE-K to support micro-service distribution in next-generation cloud and network environments. We want to explore, how a service distribution can be improved by adopting machine learning concepts for infrastructure or service changes. Therefore, we show how federated machine learning is integrated into a cloud-to-fog-continuum without burdening single nodes.}, language = {en} } @article{KoopmannStubbemannKapaetal.2021, author = {Koopmann, Tobias and Stubbemann, Maximilian and Kapa, Matthias and Paris, Michael and Buenstorf, Guido and Hanika, Tom and Hotho, Andreas and J{\"a}schke, Robert and Stumme, Gerd}, title = {Proximity dimensions and the emergence of collaboration: a HypTrails study on German AI research}, series = {Scientometrics}, volume = {126}, journal = {Scientometrics}, number = {12}, issn = {1588-2861}, doi = {10.1007/s11192-021-03922-1}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-269831}, pages = {9847-9868}, year = {2021}, abstract = {Creation and exchange of knowledge depends on collaboration. Recent work has suggested that the emergence of collaboration frequently relies on geographic proximity. However, being co-located tends to be associated with other dimensions of proximity, such as social ties or a shared organizational environment. To account for such factors, multiple dimensions of proximity have been proposed, including cognitive, institutional, organizational, social and geographical proximity. Since they strongly interrelate, disentangling these dimensions and their respective impact on collaboration is challenging. To address this issue, we propose various methods for measuring different dimensions of proximity. We then present an approach to compare and rank them with respect to the extent to which they indicate co-publications and co-inventions. We adapt the HypTrails approach, which was originally developed to explain human navigation, to co-author and co-inventor graphs. We evaluate this approach on a subset of the German research community, specifically academic authors and inventors active in research on artificial intelligence (AI). We find that social proximity and cognitive proximity are more important for the emergence of collaboration than geographic proximity.}, language = {en} } @article{FathyDarwishAbdelhamidetal.2022, author = {Fathy, Moustafa and Darwish, Mostafa A. and Abdelhamid, Al-Shaimaa M. and Alrashedy, Gehad M. and Othman, Othman Ali and Naseem, Muhammad and Dandekar, Thomas and Othman, Eman M.}, title = {Kinetin ameliorates cisplatin-induced hepatotoxicity and lymphotoxicity via attenuating oxidative damage, cell apoptosis and inflammation in rats}, series = {Biomedicines}, volume = {10}, journal = {Biomedicines}, number = {7}, issn = {2227-9059}, doi = {10.3390/biomedicines10071620}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-281686}, year = {2022}, abstract = {Though several previous studies reported the in vitro and in vivo antioxidant effect of kinetin (Kn), details on its action in cisplatin-induced toxicity are still scarce. In this study we evaluated, for the first time, the effects of kinetin in cisplatin (cp)- induced liver and lymphocyte toxicity in rats. Wistar male albino rats were divided into nine groups: (i) the control (C), (ii) groups 2,3 and 4, which received 0.25, 0.5 and 1 mg/kg kinetin for 10 days; (iii) the cisplatin (cp) group, which received a single intraperitoneal injection of CP (7.0 mg/kg); and (iv) groups 6, 7, 8 and 9, which received, for 10 days, 0.25, 0.5 and 1 mg/kg kinetin or 200 mg/kg vitamin C, respectively, and Cp on the fourth day. CP-injected rats showed a significant impairment in biochemical, oxidative stress and inflammatory parameters in hepatic tissue and lymphocytes. PCR showed a profound increase in caspase-3, and a significant decline in AKT gene expression. Intriguingly, Kn treatment restored the biochemical, redox status and inflammatory parameters. Hepatic AKT and caspase-3 expression as well as CD95 levels in lymphocytes were also restored. In conclusion, Kn mitigated oxidative imbalance, inflammation and apoptosis in CP-induced liver and lymphocyte toxicity; therefore, it can be considered as a promising therapy.}, language = {en} } @techreport{MartinoDeutschmannHielscheretal.2023, type = {Working Paper}, author = {Martino, Luigi and Deutschmann, J{\"o}rg and Hielscher, Kai-Steffen and German, Reinhard}, title = {Towards a 5G Satellite Communication Framework for V2X}, series = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, journal = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, doi = {10.25972/OPUS-32214}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-322148}, pages = {5}, year = {2023}, abstract = {In recent years, satellite communication has been expanding its field of application in the world of computer networks. This paper aims to provide an overview of how a typical scenario involving 5G Non-Terrestrial Networks (NTNs) for vehicle to everything (V2X) applications is characterized. In particular, a first implementation of a system that integrates them together will be described. Such a framework will later be used to evaluate the performance of applications such as Vehicle Monitoring (VM), Remote Driving (RD), Voice Over IP (VoIP), and others. Different configuration scenarios such as Low Earth Orbit and Geostationary Orbit will be considered.}, language = {en} } @techreport{RauberBrechtelSchotten2023, type = {Working Paper}, author = {Rauber, Christof A. O. and Brechtel, Lukas and Schotten, Hans D.}, title = {JCAS-Enabled Sensing as a Service in 6th-Generation Mobile Communication Networks}, series = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, journal = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, doi = {10.25972/OPUS-32213}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-322135}, pages = {4}, year = {2023}, abstract = {The introduction of new types of frequency spectrum in 6G technology facilitates the convergence of conventional mobile communications and radar functions. Thus, the mobile network itself becomes a versatile sensor system. This enables mobile network operators to offer a sensing service in addition to conventional data and telephony services. The potential benefits are expected to accrue to various stakeholders, including individuals, the environment, and society in general. The paper discusses technological development, possible integration, and use cases, as well as future development areas.}, language = {en} } @techreport{LohRaffeckGeissleretal.2023, type = {Working Paper}, author = {Loh, Frank and Raffeck, Simon and Geißler, Stefan and Hoßfeld, Tobias}, title = {Paving the Way for an Energy Efficient and Sustainable Future Internet of Things}, series = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, journal = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, doi = {10.25972/OPUS-32216}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-322161}, pages = {4}, year = {2023}, abstract = {In this work, we describe the network from data collection to data processing and storage as a system based on different layers. We outline the different layers and highlight major tasks and dependencies with regard to energy consumption and energy efficiency. With this view, we can outwork challenges and questions a future system architect must answer to provide a more sustainable, green, resource friendly, and energy efficient application or system. Therefore, all system layers must be considered individually but also altogether for future IoT solutions. This requires, in particular, novel sustainability metrics in addition to current Quality of Service and Quality of Experience metrics to provide a high power, user satisfying, and sustainable network.}, language = {en} } @techreport{FundaKonheiserGermanetal.2023, type = {Working Paper}, author = {Funda, Christoph and Konheiser, Tobias and German, Reinhard and Hielscher, Kai-Steffen}, title = {How to Model and Predict the Scalability of a Hardware-In-The-Loop Test Bench for Data Re-Injection?}, series = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, journal = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, doi = {10.25972/OPUS-32215}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-322150}, pages = {4}, year = {2023}, abstract = {This paper describes a novel application of an empirical network calculus model based on measurements of a hardware-in-the-loop (HIL) test system. The aim is to predict the performance of a HIL test bench for open-loop re-injection in the context of scalability. HIL test benches are distributed computer systems including software, hardware, and networking devices. They are used to validate complex technical systems, but have not yet been system under study themselves. Our approach is to use measurements from the HIL system to create an empirical model for arrival and service curves. We predict the performance and design the previously unknown parameters of the HIL simulator with network calculus (NC), namely the buffer sizes and the minimum needed pre-buffer time for the playback buffer. We furthermore show, that it is possible to estimate the CPU load from arrival and service-curves based on the utilization theorem, and hence estimate the scalability of the HIL system in the context of the number of sensor streams.}, language = {en} }