@unpublished{Nassourou2011, author = {Nassourou, Mohamadou}, title = {Computer-based Textual Documents Collation System for Reconstructing the Original Text from Automatically Identified Base Text and Ranked Witnesses}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-65749}, year = {2011}, abstract = {Given a collection of diverging documents about some lost original text, any person interested in the text would try reconstructing it from the diverging documents. Whether it is eclecticism, stemmatics, or copy-text, one is expected to explicitly or indirectly select one of the documents as a starting point or as a base text, which could be emended through comparison with remaining documents, so that a text that could be designated as the original document is generated. Unfortunately the process of giving priority to one of the documents also known as witnesses is a subjective approach. In fact even Cladistics, which could be considered as a computer-based approach of implementing stemmatics, does not present or recommend users to select a certain witness as a starting point for the process of reconstructing the original document. In this study, a computational method using a rule-based Bayesian classifier is used, to assist text scholars in their attempts of reconstructing a non-existing document from some available witnesses. The method developed in this study consists of selecting a base text successively and collating it with remaining documents. Each completed collation cycle stores the selected base text and its closest witness, along with a weighted score of their similarities and differences. At the end of the collation process, a witness selected more often by majority of base texts is considered as the probable base text of the collection. Witnesses' scores are weighted using a weighting system, based on effects of types of textual modifications on the process of reconstructing original documents. Users have the possibility to select between baseless and base text collation. If a base text is selected, the task is reduced to ranking the witnesses with respect to the base text, otherwise a base text as well as ranking of the witnesses with respect to the base text are computed and displayed on a bar diagram. Additionally this study includes a recursive algorithm for automatically reconstructing the original text from the identified base text and ranked witnesses.}, subject = {Textvergleich}, language = {en} } @unpublished{Nassourou2011, author = {Nassourou, Mohamadou}, title = {Philosophical and Computational Approaches for Estimating and Visualizing Months of Revelations of Quranic Chapters}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-65784}, year = {2011}, abstract = {The question of why the Quran structure does not follow its chronology of revelation is a recurring one. Some Islamic scholars such as [1] have answered the question using hadiths, as well as other philosophical reasons based on internal evidences of the Quran itself. Unfortunately till today many are still wondering about this issue. Muslims believe that the Quran is a summary and a copy of the content of a preserved tablet called Lawhul-Mahfuz located in the heaven. Logically speaking, this suggests that the arrangement of the verses and chapters is expected to be similar to that of the Lawhul-Mahfuz. As for the arrangement of the verses in each chapter, there is unanimity that it was carried out by the Prophet himself under the guidance of Angel Gabriel with the recommendation of God. But concerning the ordering of the chapters, there are reports about some divergences [3] among the Prophet's companions as to which chapter should precede which one. This paper argues that Quranic chapters might have been arranged according to months and seasons of revelation. In fact, based on some verses of the Quran, it is defendable that the Lawhul-Mahfuz itself is understood to have been structured in terms of the months of the year. In this study, philosophical and mathematical arguments for computing chapters' months of revelation are discussed, and the result is displayed on an interactive scatter plot.}, subject = {Text Mining}, language = {en} } @article{NaseemDandekar2012, author = {Naseem, Muhammad and Dandekar, Thomas}, title = {The Role of Auxin-Cytokinin Antagonism in Plant-Pathogen Interactions}, series = {PLOS Pathogens}, volume = {8}, journal = {PLOS Pathogens}, number = {11}, doi = {10.1371/journal.ppat.1003026}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-131901}, pages = {e1003026}, year = {2012}, abstract = {No abstract available.}, language = {en} } @article{NaglerNaegeleGillietal.2018, author = {Nagler, Matthias and N{\"a}gele, Thomas and Gilli, Christian and Fragner, Lena and Korte, Arthur and Platzer, Alexander and Farlow, Ashley and Nordborg, Magnus and Weckwerth, Wolfram}, title = {Eco-Metabolomics and Metabolic Modeling: Making the Leap From Model Systems in the Lab to Native Populations in the Field}, series = {Frontiers in Plant Science}, volume = {9}, journal = {Frontiers in Plant Science}, number = {1556}, issn = {1664-462X}, doi = {10.3389/fpls.2018.01556}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-189560}, year = {2018}, abstract = {Experimental high-throughput analysis of molecular networks is a central approach to characterize the adaptation of plant metabolism to the environment. However, recent studies have demonstrated that it is hardly possible to predict in situ metabolic phenotypes from experiments under controlled conditions, such as growth chambers or greenhouses. This is particularly due to the high molecular variance of in situ samples induced by environmental fluctuations. An approach of functional metabolome interpretation of field samples would be desirable in order to be able to identify and trace back the impact of environmental changes on plant metabolism. To test the applicability of metabolomics studies for a characterization of plant populations in the field, we have identified and analyzed in situ samples of nearby grown natural populations of Arabidopsis thaliana in Austria. A. thaliana is the primary molecular biological model system in plant biology with one of the best functionally annotated genomes representing a reference system for all other plant genome projects. The genomes of these novel natural populations were sequenced and phylogenetically compared to a comprehensive genome database of A. thaliana ecotypes. Experimental results on primary and secondary metabolite profiling and genotypic variation were functionally integrated by a data mining strategy, which combines statistical output of metabolomics data with genome-derived biochemical pathway reconstruction and metabolic modeling. Correlations of biochemical model predictions and population-specific genetic variation indicated varying strategies of metabolic regulation on a population level which enabled the direct comparison, differentiation, and prediction of metabolic adaptation of the same species to different habitats. These differences were most pronounced at organic and amino acid metabolism as well as at the interface of primary and secondary metabolism and allowed for the direct classification of population-specific metabolic phenotypes within geographically contiguous sampling sites.}, language = {en} } @article{MuellerLeppichGeissetal.2023, author = {M{\"u}ller, Konstantin and Leppich, Robert and Geiß, Christian and Borst, Vanessa and Pelizari, Patrick Aravena and Kounev, Samuel and Taubenb{\"o}ck, Hannes}, title = {Deep neural network regression for normalized digital surface model generation with Sentinel-2 imagery}, series = {IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing}, volume = {16}, journal = {IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing}, issn = {1939-1404}, doi = {10.1109/JSTARS.2023.3297710}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-349424}, pages = {8508-8519}, year = {2023}, abstract = {In recent history, normalized digital surface models (nDSMs) have been constantly gaining importance as a means to solve large-scale geographic problems. High-resolution surface models are precious, as they can provide detailed information for a specific area. However, measurements with a high resolution are time consuming and costly. Only a few approaches exist to create high-resolution nDSMs for extensive areas. This article explores approaches to extract high-resolution nDSMs from low-resolution Sentinel-2 data, allowing us to derive large-scale models. We thereby utilize the advantages of Sentinel 2 being open access, having global coverage, and providing steady updates through a high repetition rate. Several deep learning models are trained to overcome the gap in producing high-resolution surface maps from low-resolution input data. With U-Net as a base architecture, we extend the capabilities of our model by integrating tailored multiscale encoders with differently sized kernels in the convolution as well as conformed self-attention inside the skip connection gates. Using pixelwise regression, our U-Net base models can achieve a mean height error of approximately 2 m. Moreover, through our enhancements to the model architecture, we reduce the model error by more than 7\%.}, language = {en} } @phdthesis{Maeder2008, author = {M{\"a}der, Andreas}, title = {Performance Models for UMTS 3.5G Mobile Wireless Systems}, doi = {10.25972/OPUS-2766}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-32525}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2008}, abstract = {Mobile telecommunication systems of the 3.5th generation (3.5G) constitute a first step towards the requirements of an all-IP world. As the denotation suggests, 3.5G systems are not completely new designed from scratch. Instead, they are evolved from existing 3G systems like UMTS or cdma2000. 3.5G systems are primarily designed and optimized for packet-switched best-effort traffic, but they are also intended to increase system capacity by exploiting available radio resources more efficiently. Systems based on cdma2000 are enhanced with 1xEV-DO (EV-DO: evolution, data-optimized). In the UMTS domain, the 3G partnership project (3GPP) specified the High Speed Packet Access (HSPA) family, consisting of High Speed Downlink Packet Access (HSDPA) and its counterpart High Speed Uplink Packet Access (HSUPA) or Enhanced Uplink. The focus of this monograph is on HSPA systems, although the operation principles of other 3.5G systems are similar. One of the main contributions of our work are performance models which allow a holistic view on the system. The models consider user traffic on flow-level, such that only on significant changes of the system state a recalculation of parameters like bandwidth is necessary. The impact of lower layers is captured by stochastic models. This approach combines accurate modeling and the ability to cope with computational complexity. Adopting this approach to HSDPA, we develop a new physical layer abstraction model that takes radio resources, scheduling discipline, radio propagation and mobile device capabilities into account. Together with models for the calculation of network-wide interference and transmit powers, a discrete-event simulation and an analytical model based on a queuing-theoretical approach are proposed. For the Enhanced Uplink, we develop analytical models considering independent and correlated other-cell interference.}, subject = {Mobilfunk}, language = {en} } @phdthesis{Milbrandt2007, author = {Milbrandt, Jens}, title = {Performance Evaluation of Efficient Resource Management Concepts for Next Generation IP Networks}, doi = {10.25972/OPUS-1991}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-23332}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2007}, abstract = {Next generation networks (NGNs) must integrate the services of current circuit-switched telephone networks and packet-switched data networks. This convergence towards a unified communication infrastructure necessitates from the high capital expenditures (CAPEX) and operational expenditures (OPEX) due to the coexistence of separate networks for voice and data. In the end, NGNs must offer the same services as these legacy networks and, therefore, they must provide a low-cost packet-switched solution with real-time transport capabilities for telephony and multimedia applications. In addition, NGNs must be fault-tolerant to guarantee user satisfaction and to support business-critical processes also in case of network failures. A key technology for the operation of NGNs is the Internet Protocol (IP) which evolved to a common and well accepted standard for networking in the Internet during the last 25 years. There are two basically different approaches to achieve QoS in IP networks. With capacity overprovisioning (CO), an IP network is equipped with sufficient bandwidth such that network congestion becomes very unlikely and QoS is maintained most of the time. The second option to achieve QoS in IP networks is admission control (AC). AC represents a network-inherent intelligence that admits real-time traffic flows to a single link or an entire network only if enough resources are available such that the requirements on packet loss and delay can be met. Otherwise, the request of a new flow is blocked. This work focuses on resource management and control mechanisms for NGNs, in particular on AC and associated bandwidth allocation methods. The first contribution consists of a new link-oriented AC method called experience-based admission control (EBAC) which is a hybrid approach dealing with the problems inherent to conventional AC mechanisms like parameter-based or measurement-based AC (PBAC/MBAC). PBAC provides good QoS but suffers from poor resource utilization and, vice versa, MBAC uses resources efficiently but is susceptible to QoS violations. Hence, EBAC aims at increasing the resource efficiency while maintaining the QoS which increases the revenues of ISPs and postpones their CAPEX for infrastructure upgrades. To show the advantages of EBAC, we first review today's AC approaches and then develop the concept of EBAC. EBAC is a simple mechanism that safely overbooks the capacity of a single link to increase its resource utilization. We evaluate the performance of EBAC by its simulation under various traffic conditions. The second contribution concerns dynamic resource allocation in transport networks which implement a specific network admission control (NAC) architecture. In general, the performance of different NAC systems may be evaluated by conventional methods such as call blocking analysis which has often been applied in the context of multi-service asynchronous transfer mode (ATM) networks. However, to yield more practical results than abstract blocking probabilities, we propose a new method to compare different AC approaches by their respective bandwidth requirements. To present our new method for comparing different AC systems, we first give an overview of network resource management (NRM) in general. Then we present the concept of adaptive bandwidth allocation (ABA) in capacity tunnels and illustrate the analytical performance evaluation framework to compare different AC systems by their capacity requirements. Different network characteristics influence the performance of ABA. Therefore, the impact of various traffic demand models and tunnel implementations, and the influence of resilience requirements is investigated. In conclusion, the resources in NGNs must be exclusively dedicated to admitted traffic to guarantee QoS. For that purpose, robust and efficient concepts for NRM are required to control the requested bandwidth with regard to the available transmission capacity. Sophisticated AC will be a key function for NRM in NGNs and, therefore, efficient resource management concepts like experience-based admission control and adaptive bandwidth allocation for admission-controlled capacity tunnels, as presented in this work are appealing for NGN solutions.}, subject = {Ressourcenmanagement}, language = {en} } @techreport{Metzger2020, type = {Working Paper}, author = {Metzger, Florian}, title = {Crowdsensed QoE for the community - a concept to make QoE assessment accessible}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-203748}, pages = {7}, year = {2020}, abstract = {In recent years several community testbeds as well as participatory sensing platforms have successfully established themselves to provide open data to everyone interested. Each of them with a specific goal in mind, ranging from collecting radio coverage data up to environmental and radiation data. Such data can be used by the community in their decision making, whether to subscribe to a specific mobile phone service that provides good coverage in an area or in finding a sunny and warm region for the summer holidays. However, the existing platforms are usually limiting themselves to directly measurable network QoS. If such a crowdsourced data set provides more in-depth derived measures, this would enable an even better decision making. A community-driven crowdsensing platform that derives spatial application-layer user experience from resource-friendly bandwidth estimates would be such a case, video streaming services come to mind as a prime example. In this paper we present a concept for such a system based on an initial prototype that eases the collection of data necessary to determine mobile-specific QoE at large scale. In addition we reason why the simple quality metric proposed here can hold its own.}, subject = {Quality of Experience}, language = {en} } @article{MergetKoetschanHackletal.2012, author = {Merget, Benjamin and Koetschan, Christian and Hackl, Thomas and F{\"o}rster, Frank and Dandekar, Thomas and M{\"u}ller, Tobias and Schultz, J{\"o}rg and Wolf, Matthias}, title = {The ITS2 Database}, series = {Journal of Visual Expression}, volume = {61}, journal = {Journal of Visual Expression}, number = {e3806}, doi = {10.3791/3806}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-124600}, year = {2012}, abstract = {The internal transcribed spacer 2 (ITS2) has been used as a phylogenetic marker for more than two decades. As ITS2 research mainly focused on the very variable ITS2 sequence, it confined this marker to low-level phylogenetics only. However, the combination of the ITS2 sequence and its highly conserved secondary structure improves the phylogenetic resolution1 and allows phylogenetic inference at multiple taxonomic ranks, including species delimitation. The ITS2 Database presents an exhaustive dataset of internal transcribed spacer 2 sequences from NCBI GenBank accurately reannotated. Following an annotation by profile Hidden Markov Models (HMMs), the secondary structure of each sequence is predicted. First, it is tested whether a minimum energy based fold (direct fold) results in a correct, four helix conformation. If this is not the case, the structure is predicted by homology modeling. In homology modeling, an already known secondary structure is transferred to another ITS2 sequence, whose secondary structure was not able to fold correctly in a direct fold. The ITS2 Database is not only a database for storage and retrieval of ITS2 sequence-structures. It also provides several tools to process your own ITS2 sequences, including annotation, structural prediction, motif detection and BLAST search on the combined sequence-structure information. Moreover, it integrates trimmed versions of 4SALE and ProfDistS for multiple sequence-structure alignment calculation and Neighbor Joining tree reconstruction. Together they form a coherent analysis pipeline from an initial set of sequences to a phylogeny based on sequence and secondary structure. In a nutshell, this workbench simplifies first phylogenetic analyses to only a few mouse-clicks, while additionally providing tools and data for comprehensive large-scale analyses.}, language = {en} } @phdthesis{Menth2004, author = {Menth, Michael}, title = {Efficient admission control and routing for resilient communication networks}, doi = {10.25972/OPUS-846}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-9949}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2004}, abstract = {This work is subdivided into two main areas: resilient admission control and resilient routing. The work gives an overview of the state of the art of quality of service mechanisms in communication networks and proposes a categorization of admission control (AC) methods. These approaches are investigated regarding performance, more precisely, regarding the potential resource utilization by dimensioning the capacity for a network with a given topology, traffic matrix, and a required flow blocking probability. In case of a failure, the affected traffic is rerouted over backup paths which increases the traffic rate on the respective links. To guarantee the effectiveness of admission control also in failure scenarios, the increased traffic rate must be taken into account for capacity dimensioning and leads to resilient AC. Capacity dimensioning is not feasible for existing networks with already given link capacities. For the application of resilient NAC in this case, the size of distributed AC budgets must be adapted according to the traffic matrix in such a way that the maximum blocking probability for all flows is minimized and that the capacity of all links is not exceeded by the admissible traffic rate in any failure scenario. Several algorithms for the solution of that problem are presented and compared regarding their efficiency and fairness. A prototype for resilient AC was implemented in the laboratories of Siemens AG in Munich within the scope of the project KING. Resilience requires additional capacity on the backup paths for failure scenarios. The amount of this backup capacity depends on the routing and can be minimized by routing optimization. New protection switching mechanisms are presented that deviate the traffic quickly around outage locations. They are simple and can be implemented, e.g, by MPLS technology. The Self-Protecting Multi-Path (SPM) is a multi-path consisting of disjoint partial paths. The traffic is distributed over all faultless partial paths according to an optimized load balancing function both in the working case and in failure scenarios. Performance studies show that the network topology and the traffic matrix also influence the amount of required backup capacity significantly. The example of the COST-239 network illustrates that conventional shortest path routing may need 50\% more capacity than the optimized SPM if all single link and node failures are protected.}, subject = {Kommunikation}, language = {en} } @techreport{MazighBeausencourtBodeetal.2023, type = {Working Paper}, author = {Mazigh, Sadok Mehdi and Beausencourt, Marcel and Bode, Max Julius and Scheffler, Thomas}, title = {Using P4-INT on Tofino for Measuring Device Performance Characteristics in a Network Lab}, series = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, journal = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, doi = {10.25972/OPUS-32208}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-322084}, pages = {4}, year = {2023}, abstract = {This paper presents a prototypical implementation of the In-band Network Telemetry (INT) specification in P4 and demonstrates a use case, where a Tofino Switch is used to measure device and network performance in a lab setting. This work is based on research activities in the area of P4 data plane programming conducted at the network lab of HTW Berlin.}, language = {en} } @techreport{MartinoDeutschmannHielscheretal.2023, type = {Working Paper}, author = {Martino, Luigi and Deutschmann, J{\"o}rg and Hielscher, Kai-Steffen and German, Reinhard}, title = {Towards a 5G Satellite Communication Framework for V2X}, series = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, journal = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, doi = {10.25972/OPUS-32214}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-322148}, pages = {5}, year = {2023}, abstract = {In recent years, satellite communication has been expanding its field of application in the world of computer networks. This paper aims to provide an overview of how a typical scenario involving 5G Non-Terrestrial Networks (NTNs) for vehicle to everything (V2X) applications is characterized. In particular, a first implementation of a system that integrates them together will be described. Such a framework will later be used to evaluate the performance of applications such as Vehicle Monitoring (VM), Remote Driving (RD), Voice Over IP (VoIP), and others. Different configuration scenarios such as Low Earth Orbit and Geostationary Orbit will be considered.}, language = {en} } @phdthesis{Martin2008, author = {Martin, R{\"u}diger}, title = {Resilience, Provisioning, and Control for the Network of the Future}, doi = {10.25972/OPUS-2504}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-28497}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2008}, abstract = {The Internet sees an ongoing transformation process from a single best-effort service network into a multi-service network. In addition to traditional applications like e-mail,WWW-traffic, or file transfer, future generation networks (FGNs) will carry services with real-time constraints and stringent availability and reliability requirements like Voice over IP (VoIP), video conferencing, virtual private networks (VPNs) for finance, other real-time business applications, tele-medicine, or tele-robotics. Hence, quality of service (QoS) guarantees and resilience to failures are crucial characteristics of an FGN architecture. At the same time, network operations must be efficient. This necessitates sophisticated mechanisms for the provisioning and the control of future communication infrastructures. In this work we investigate such echanisms for resilient FGNs. There are many aspects of the provisioning and control of resilient FGNs such as traffic matrix estimation, traffic characterization, traffic forecasting, mechanisms for QoS enforcement also during failure cases, resilient routing, or calability concerns for future routing and addressing mechanisms. In this work we focus on three important aspects for which performance analysis can deliver substantial insights: load balancing for multipath Internet routing, fast resilience concepts, and advanced dimensioning techniques for resilient networks. Routing in modern communication networks is often based on multipath structures, e.g., equal-cost multipath routing (ECMP) in IP networks, to facilitate traffic engineering and resiliency. When multipath routing is applied, load balancing algorithms distribute the traffic over available paths towards the destination according to pre-configured distribution values. State-of-the-art load balancing algorithms operate either on the packet or the flow level. Packet level mechanisms achieve highly accurate traffic distributions, but are known to have negative effects on the performance of transport protocols and should not be applied. Flow level mechanisms avoid performance degradations, but at the expense of reduced accuracy. These inaccuracies may have unpredictable effects on link capacity requirements and complicate resource management. Thus, it is important to exactly understand the accuracy and dynamics of load balancing algorithms in order to be able to exercise better network control. Knowing about their weaknesses, it is also important to look for alternatives and to assess their applicability in different networking scenarios. This is the first aspect of this work. Component failures are inevitable during the operation of communication networks and lead to routing disruptions if no special precautions are taken. In case of a failure, the robust shortest-path routing of the Internet reconverges after some time to a state where all nodes are again reachable - provided physical connectivity still exists. But stringent availability and reliability criteria of new services make a fast reaction to failures obligatory for resilient FGNs. This led to the development of fast reroute (FRR) concepts for MPLS and IP routing. The operations of MPLS-FRR have already been standardized. Still, the standards leave some degrees of freedom for the resilient path layout and it is important to understand the tradeoffs between different options for the path layout to efficiently provision resilient FGNs. In contrast, the standardization for IP-FRR is an ongoing process. The applicability and possible combinations of different concepts still are open issues. IP-FRR also facilitates a comprehensive resilience framework for IP routing covering all steps of the failure recovery cycle. These points constitute another aspect of this work. Finally, communication networks are usually over-provisioned, i.e., they have much more capacity installed than actually required during normal operation. This is a precaution for various challenges such as network element failures. An alternative to this capacity overprovisioning (CO) approach is admission control (AC). AC blocks new flows in case of imminent overload due to unanticipated events to protect the QoS for already admitted flows. On the one hand, CO is generally viewed as a simple mechanism, AC as a more complex mechanism that complicates the network control plane and raises interoperability issues. On the other hand, AC appears more cost-efficient than CO. To obtain advanced provisioning methods for resilient FGNs, it is important to find suitable models for irregular events, such as failures and different sources of overload, and to incorporate them into capacity dimensioning methods. This allows for a fair comparison between CO and AC in various situations and yields a better understanding of the strengths and weaknesses of both concepts. Such an advanced capacity dimensioning method for resilient FGNs represents the third aspect of this work.}, subject = {Backbone-Netz}, language = {en} } @article{MandelHoernleinIflandetal.2011, author = {Mandel, Alexander and H{\"o}rnlein, Alexander and Ifland, Marianus and L{\"u}neburg, Edeltraud and Deckert, J{\"u}rgen and Puppe, Frank}, title = {Aufwandsanalyse f{\"u}r computerunterst{\"u}tzte Multiple-Choice Papierklausuren}, series = {GMS Journal for Medical Education}, volume = {28}, journal = {GMS Journal for Medical Education}, number = {4}, doi = {10.3205/zma000767}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-134386}, pages = {1-15, Doc55}, year = {2011}, abstract = {Introduction: Multiple-choice-examinations are still fundamental for assessment in medical degree programs. In addition to content related research, the optimization of the technical procedure is an important question. Medical examiners face three options: paper-based examinations with or without computer support or completely electronic examinations. Critical aspects are the effort for formatting, the logistic effort during the actual examination, quality, promptness and effort of the correction, the time for making the documents available for inspection by the students, and the statistical analysis of the examination results. Methods: Since three semesters a computer program for input and formatting of MC-questions in medical and other paper-based examinations is used and continuously improved at Wuerzburg University. In the winter semester (WS) 2009/10 eleven, in the summer semester (SS) 2010 twelve and in WS 2010/11 thirteen medical examinations were accomplished with the program and automatically evaluated. For the last two semesters the remaining manual workload was recorded. Results: The cost of the formatting and the subsequent analysis including adjustments of the analysis of an average examination with about 140 participants and about 35 questions was 5-7 hours for exams without complications in the winter semester 2009/2010, about 2 hours in SS 2010 and about 1.5 hours in the winter semester 2010/11. Including exams with complications, the average time was about 3 hours per exam in SS 2010 and 2.67 hours for the WS 10/11. Discussion: For conventional multiple-choice exams the computer-based formatting and evaluation of paper-based exams offers a significant time reduction for lecturers in comparison with the manual correction of paper-based exams and compared to purely electronically conducted exams it needs a much simpler technological infrastructure and fewer staff during the exam."}, language = {de} } @article{MaiwaldBruschkeSchneideretal.2023, author = {Maiwald, Ferdinand and Bruschke, Jonas and Schneider, Danilo and Wacker, Markus and Niebling, Florian}, title = {Giving historical photographs a new perspective: introducing camera orientation parameters as new metadata in a large-scale 4D application}, series = {Remote Sensing}, volume = {15}, journal = {Remote Sensing}, number = {7}, issn = {2072-4292}, doi = {10.3390/rs15071879}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-311103}, year = {2023}, abstract = {The ongoing digitization of historical photographs in archives allows investigating the quality, quantity, and distribution of these images. However, the exact interior and exterior camera orientations of these photographs are usually lost during the digitization process. The proposed method uses content-based image retrieval (CBIR) to filter exterior images of single buildings in combination with metadata information. The retrieved photographs are automatically processed in an adapted structure-from-motion (SfM) pipeline to determine the camera parameters. In an interactive georeferencing process, the calculated camera positions are transferred into a global coordinate system. As all image and camera data are efficiently stored in the proposed 4D database, they can be conveniently accessed afterward to georeference newly digitized images by using photogrammetric triangulation and spatial resection. The results show that the CBIR and the subsequent SfM are robust methods for various kinds of buildings and different quantity of data. The absolute accuracy of the camera positions after georeferencing lies in the range of a few meters likely introduced by the inaccurate LOD2 models used for transformation. The proposed photogrammetric method, the database structure, and the 4D visualization interface enable adding historical urban photographs and 3D models from other locations.}, language = {en} } @article{MadeiraGromerLatoschiketal.2021, author = {Madeira, Octavia and Gromer, Daniel and Latoschik, Marc Erich and Pauli, Paul}, title = {Effects of Acrophobic Fear and Trait Anxiety on Human Behavior in a Virtual Elevated Plus-Maze}, series = {Frontiers in Virtual Reality}, volume = {2}, journal = {Frontiers in Virtual Reality}, doi = {10.3389/frvir.2021.635048}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-258709}, year = {2021}, abstract = {The Elevated Plus-Maze (EPM) is a well-established apparatus to measure anxiety in rodents, i.e., animals exhibiting an increased relative time spent in the closed vs. the open arms are considered anxious. To examine whether such anxiety-modulated behaviors are conserved in humans, we re-translated this paradigm to a human setting using virtual reality in a Cave Automatic Virtual Environment (CAVE) system. In two studies, we examined whether the EPM exploration behavior of humans is modulated by their trait anxiety and also assessed the individuals' levels of acrophobia (fear of height), claustrophobia (fear of confined spaces), sensation seeking, and the reported anxiety when on the maze. First, we constructed an exact virtual copy of the animal EPM adjusted to human proportions. In analogy to animal EPM studies, participants (N = 30) freely explored the EPM for 5 min. In the second study (N = 61), we redesigned the EPM to make it more human-adapted and to differentiate influences of trait anxiety and acrophobia by introducing various floor textures and lower walls of closed arms to the height of standard handrails. In the first experiment, hierarchical regression analyses of exploration behavior revealed the expected association between open arm avoidance and Trait Anxiety, an even stronger association with acrophobic fear. In the second study, results revealed that acrophobia was associated with avoidance of open arms with mesh-floor texture, whereas for trait anxiety, claustrophobia, and sensation seeking, no effect was detected. Also, subjects' fear rating was moderated by all psychometrics but trait anxiety. In sum, both studies consistently indicate that humans show no general open arm avoidance analogous to rodents and that human EPM behavior is modulated strongest by acrophobic fear, whereas trait anxiety plays a subordinate role. Thus, we conclude that the criteria for cross-species validity are met insufficiently in this case. Despite the exploratory nature, our studies provide in-depth insights into human exploration behavior on the virtual EPM.}, language = {en} } @phdthesis{Loeffler2021, author = {L{\"o}ffler, Andre}, title = {Constrained Graph Layouts: Vertices on the Outer Face and on the Integer Grid}, edition = {1. Auflage}, publisher = {W{\"u}rzburg University Press}, address = {W{\"u}rzburg}, isbn = {978-3-95826-146-4}, doi = {10.25972/WUP-978-3-95826-147-1}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-215746}, school = {W{\"u}rzburg University Press}, pages = {viii, 161}, year = {2021}, abstract = {Constraining graph layouts - that is, restricting the placement of vertices and the routing of edges to obey certain constraints - is common practice in graph drawing. In this book, we discuss algorithmic results on two different restriction types: placing vertices on the outer face and on the integer grid. For the first type, we look into the outer k-planar and outer k-quasi-planar graphs, as well as giving a linear-time algorithm to recognize full and closed outer k-planar graphs Monadic Second-order Logic. For the second type, we consider the problem of transferring a given planar drawing onto the integer grid while perserving the original drawings topology; we also generalize a variant of Cauchy's rigidity theorem for orthogonal polyhedra of genus 0 to those of arbitrary genus.}, subject = {Graphenzeichnen}, language = {en} } @article{LugrinLatoschikHabeletal.2016, author = {Lugrin, Jean-Luc and Latoschik, Marc Erich and Habel, Michael and Roth, Daniel and Seufert, Christian and Grafe, Silke}, title = {Breaking Bad Behaviors: A New Tool for Learning Classroom Management Using Virtual Reality}, series = {Frontiers in ICT}, volume = {3}, journal = {Frontiers in ICT}, number = {26}, doi = {10.3389/fict.2016.00026}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-147945}, year = {2016}, abstract = {This article presents an immersive virtual reality (VR) system for training classroom management skills, with a specific focus on learning to manage disruptive student behavior in face-to-face, one-to-many teaching scenarios. The core of the system is a real-time 3D virtual simulation of a classroom populated by twenty-four semi-autonomous virtual students. The system has been designed as a companion tool for classroom management seminars in a syllabus for primary and secondary school teachers. This will allow lecturers to link theory with practice using the medium of VR. The system is therefore designed for two users: a trainee teacher and an instructor supervising the training session. The teacher is immersed in a real-time 3D simulation of a classroom by means of a head-mounted display and headphone. The instructor operates a graphical desktop console, which renders a view of the class and the teacher whose avatar movements are captured by a marker less tracking system. This console includes a 2D graphics menu with convenient behavior and feedback control mechanisms to provide human-guided training sessions. The system is built using low-cost consumer hardware and software. Its architecture and technical design are described in detail. A first evaluation confirms its conformance to critical usability requirements (i.e., safety and comfort, believability, simplicity, acceptability, extensibility, affordability, and mobility). Our initial results are promising and constitute the necessary first step toward a possible investigation of the efficiency and effectiveness of such a system in terms of learning outcomes and experience.}, language = {en} } @article{LopezArreguinMontenegro2019, author = {Lopez-Arreguin, A. J. R. and Montenegro, S.}, title = {Improving engineering models of terramechanics for planetary exploration}, series = {Results in Engineering}, volume = {3}, journal = {Results in Engineering}, doi = {10.1016/j.rineng.2019.100027}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-202490}, pages = {100027}, year = {2019}, abstract = {This short letter proposes more consolidated explicit solutions for the forces and torques acting on typical rover wheels, that can be used as a method to determine their average mobility characteristics in planetary soils. The closed loop solutions stand in one of the verified methods, but at difference of the previous, observables are decoupled requiring a less amount of physical parameters to measure. As a result, we show that with knowledge of terrain properties, wheel driving performance rely in a single observable only. Because of their generality, the formulated equations established here can have further implications in autonomy and control of rovers or planetary soil characterization.}, language = {en} } @article{LohWamserPoigneeetal.2022, author = {Loh, Frank and Wamser, Florian and Poign{\´e}e, Fabian and Geißler, Stefan and Hoßfeld, Tobias}, title = {YouTube Dataset on Mobile Streaming for Internet Traffic Modeling and Streaming Analysis}, series = {Scientific Data}, volume = {9}, journal = {Scientific Data}, number = {1}, doi = {10.1038/s41597-022-01418-y}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-300240}, year = {2022}, abstract = {Around 4.9 billion Internet users worldwide watch billions of hours of online video every day. As a result, streaming is by far the predominant type of traffic in communication networks. According to Google statistics, three out of five video views come from mobile devices. Thus, in view of the continuous technological advances in end devices and increasing mobile use, datasets for mobile streaming are indispensable in research but only sparsely dealt with in literature so far. With this public dataset, we provide 1,081 hours of time-synchronous video measurements at network, transport, and application layer with the native YouTube streaming client on mobile devices. The dataset includes 80 network scenarios with 171 different individual bandwidth settings measured in 5,181 runs with limited bandwidth, 1,939 runs with emulated 3 G/4 G traces, and 4,022 runs with pre-defined bandwidth changes. This corresponds to 332 GB video payload. We present the most relevant quality indicators for scientific use, i.e., initial playback delay, streaming video quality, adaptive video quality changes, video rebuffering events, and streaming phases.}, language = {en} } @techreport{LohRaffeckGeissleretal.2023, type = {Working Paper}, author = {Loh, Frank and Raffeck, Simon and Geißler, Stefan and Hoßfeld, Tobias}, title = {Paving the Way for an Energy Efficient and Sustainable Future Internet of Things}, series = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, journal = {KuVS Fachgespr{\"a}ch - W{\"u}rzburg Workshop on Modeling, Analysis and Simulation of Next-Generation Communication Networks 2023 (WueWoWAS'23)}, doi = {10.25972/OPUS-32216}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-322161}, pages = {4}, year = {2023}, abstract = {In this work, we describe the network from data collection to data processing and storage as a system based on different layers. We outline the different layers and highlight major tasks and dependencies with regard to energy consumption and energy efficiency. With this view, we can outwork challenges and questions a future system architect must answer to provide a more sustainable, green, resource friendly, and energy efficient application or system. Therefore, all system layers must be considered individually but also altogether for future IoT solutions. This requires, in particular, novel sustainability metrics in addition to current Quality of Service and Quality of Experience metrics to provide a high power, user satisfying, and sustainable network.}, language = {en} } @article{LohPoigneeWamseretal.2021, author = {Loh, Frank and Poign{\´e}e, Fabian and Wamser, Florian and Leidinger, Ferdinand and Hoßfeld, Tobias}, title = {Uplink vs. Downlink: Machine Learning-Based Quality Prediction for HTTP Adaptive Video Streaming}, series = {Sensors}, volume = {21}, journal = {Sensors}, number = {12}, issn = {1424-8220}, doi = {10.3390/s21124172}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-241121}, year = {2021}, abstract = {Streaming video is responsible for the bulk of Internet traffic these days. For this reason, Internet providers and network operators try to make predictions and assessments about the streaming quality for an end user. Current monitoring solutions are based on a variety of different machine learning approaches. The challenge for providers and operators nowadays is that existing approaches require large amounts of data. In this work, the most relevant quality of experience metrics, i.e., the initial playback delay, the video streaming quality, video quality changes, and video rebuffering events, are examined using a voluminous data set of more than 13,000 YouTube video streaming runs that were collected with the native YouTube mobile app. Three Machine Learning models are developed and compared to estimate playback behavior based on uplink request information. The main focus has been on developing a lightweight approach using as few features and as little data as possible, while maintaining state-of-the-art performance.}, language = {en} } @article{LohMehlingHossfeld2022, author = {Loh, Frank and Mehling, Noah and Hoßfeld, Tobias}, title = {Towards LoRaWAN without data loss: studying the performance of different channel access approaches}, series = {Sensors}, volume = {22}, journal = {Sensors}, number = {2}, issn = {1424-8220}, doi = {10.3390/s22020691}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-302418}, year = {2022}, abstract = {The Long Range Wide Area Network (LoRaWAN) is one of the fastest growing Internet of Things (IoT) access protocols. It operates in the license free 868 MHz band and gives everyone the possibility to create their own small sensor networks. The drawback of this technology is often unscheduled or random channel access, which leads to message collisions and potential data loss. For that reason, recent literature studies alternative approaches for LoRaWAN channel access. In this work, state-of-the-art random channel access is compared with alternative approaches from the literature by means of collision probability. Furthermore, a time scheduled channel access methodology is presented to completely avoid collisions in LoRaWAN. For this approach, an exhaustive simulation study was conducted and the performance was evaluated with random access cross-traffic. In a general theoretical analysis the limits of the time scheduled approach are discussed to comply with duty cycle regulations in LoRaWAN.}, language = {en} } @techreport{LohGeisslerHossfeld2022, type = {Working Paper}, author = {Loh, Frank and Geißler, Stefan and Hoßfeld, Tobias}, title = {LoRaWAN Network Planning in Smart Environments: Towards Reliability, Scalability, and Cost Reduction}, series = {W{\"u}rzburg Workshop on Next-Generation Communication Networks (WueWoWas'22)}, journal = {W{\"u}rzburg Workshop on Next-Generation Communication Networks (WueWoWas'22)}, doi = {10.25972/OPUS-28082}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-280829}, pages = {4}, year = {2022}, abstract = {The goal in this work is to present a guidance for LoRaWAN planning to improve overall reliability for message transmissions and scalability. At the end, the cost component is discussed. Therefore, a five step approach is presented that helps to plan a LoRaWAN deployment step by step: Based on the device locations, an initial gateway placement is suggested followed by in-depth frequency and channel access planning. After an initial planning phase, updates for channel access and the initial gateway planning is suggested that should also be done periodically during network operation. Since current gateway placement approaches are only studied with random channel access, there is a lot of potential in the cell planning phase. Furthermore, the performance of different channel access approaches is highly related on network load, and thus cell size and sensor density. Last, the influence of different cell planning ideas on expected costs are discussed.}, subject = {Datennetz}, language = {en} } @article{LodaKrebsDanhofetal.2019, author = {Loda, Sophia and Krebs, Jonathan and Danhof, Sophia and Schreder, Martin and Solimando, Antonio G. and Strifler, Susanne and Rasche, Leo and Kort{\"u}m, Martin and Kerscher, Alexander and Knop, Stefan and Puppe, Frank and Einsele, Hermann and Bittrich, Max}, title = {Exploration of artificial intelligence use with ARIES in multiple myeloma research}, series = {Journal of Clinical Medicine}, volume = {8}, journal = {Journal of Clinical Medicine}, number = {7}, issn = {2077-0383}, doi = {10.3390/jcm8070999}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-197231}, pages = {999}, year = {2019}, abstract = {Background: Natural language processing (NLP) is a powerful tool supporting the generation of Real-World Evidence (RWE). There is no NLP system that enables the extensive querying of parameters specific to multiple myeloma (MM) out of unstructured medical reports. We therefore created a MM-specific ontology to accelerate the information extraction (IE) out of unstructured text. Methods: Our MM ontology consists of extensive MM-specific and hierarchically structured attributes and values. We implemented "A Rule-based Information Extraction System" (ARIES) that uses this ontology. We evaluated ARIES on 200 randomly selected medical reports of patients diagnosed with MM. Results: Our system achieved a high F1-Score of 0.92 on the evaluation dataset with a precision of 0.87 and recall of 0.98. Conclusions: Our rule-based IE system enables the comprehensive querying of medical reports. The IE accelerates the extraction of data and enables clinicians to faster generate RWE on hematological issues. RWE helps clinicians to make decisions in an evidence-based manner. Our tool easily accelerates the integration of research evidence into everyday clinical practice.}, language = {en} } @article{LinsenmannMaerzDufneretal.2021, author = {Linsenmann, Thomas and M{\"a}rz, Alexander and Dufner, Vera and Stetter, Christian and Weiland, Judith and Westermaier, Thomas}, title = {Optimization of radiation settings for angiography using 3D fluoroscopy for imaging of intracranial aneurysms}, series = {Computer Assisted Surgery}, volume = {26}, journal = {Computer Assisted Surgery}, number = {1}, doi = {10.1080/24699322.2021.1894240}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-259251}, pages = {22-30}, year = {2021}, abstract = {Mobile 3D fluoroscopes have become increasingly available in neurosurgical operating rooms. We recently reported its use for imaging cerebral vascular malformations and aneurysms. This study was conducted to evaluate various radiation settings for the imaging of cerebral aneurysms before and after surgical occlusion. Eighteen patients with cerebral aneurysms with the indication for surgical clipping were included in this prospective analysis. Before surgery the patients were randomized into one of three different scan protocols according (default settings of the 3D fluoroscope): Group 1: 110 kV, 80 mA (enhanced cranial mode), group 2: 120 kV, 64 mA (lumbar spine mode), group 3: 120 kV, 25 mA (head/neck settings). Prior to surgery, a rotational fluoroscopy scan (duration 24 s) was performed without contrast agent followed by another scan with 50 ml of intravenous iodine contrast agent. The image files of both scans were transferred to an Apple PowerMac(R) workstation, subtracted and reconstructed using OsiriX(R) MD 10.0 software. The procedure was repeated after clip placement. The image quality regarding preoperative aneurysm configuration and postoperative assessment of aneurysm occlusion and vessel patency was analyzed by 2 independent reviewers using a 6-grade scale. This technique quickly supplies images of adequate quality to depict intracranial aneurysms and distal vessel patency after aneurysm clipping. Regarding these features, a further optimization to our previous protocol seems possible lowering the voltage and increasing tube current. For quick intraoperative assessment, image subtraction seems not necessary. Thus, a native scan without a contrast agent is not necessary. Further optimization may be possible using a different contrast injection protocol.}, language = {en} } @article{LimanMayFetteetal.2023, author = {Liman, Leon and May, Bernd and Fette, Georg and Krebs, Jonathan and Puppe, Frank}, title = {Using a clinical data warehouse to calculate and present key metrics for the radiology department: implementation and performance evaluation}, series = {JMIR Medical Informatics}, volume = {11}, journal = {JMIR Medical Informatics}, issn = {2291-9694}, doi = {10.2196/41808}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-349411}, year = {2023}, abstract = {Background: Due to the importance of radiologic examinations, such as X-rays or computed tomography scans, for many clinical diagnoses, the optimal use of the radiology department is 1 of the primary goals of many hospitals. Objective: This study aims to calculate the key metrics of this use by creating a radiology data warehouse solution, where data from radiology information systems (RISs) can be imported and then queried using a query language as well as a graphical user interface (GUI). Methods: Using a simple configuration file, the developed system allowed for the processing of radiology data exported from any kind of RIS into a Microsoft Excel, comma-separated value (CSV), or JavaScript Object Notation (JSON) file. These data were then imported into a clinical data warehouse. Additional values based on the radiology data were calculated during this import process by implementing 1 of several provided interfaces. Afterward, the query language and GUI of the data warehouse were used to configure and calculate reports on these data. For the most common types of requested reports, a web interface was created to view their numbers as graphics. Results: The tool was successfully tested with the data of 4 different German hospitals from 2018 to 2021, with a total of 1,436,111 examinations. The user feedback was good, since all their queries could be answered if the available data were sufficient. The initial processing of the radiology data for using them with the clinical data warehouse took (depending on the amount of data provided by each hospital) between 7 minutes and 1 hour 11 minutes. Calculating 3 reports of different complexities on the data of each hospital was possible in 1-3 seconds for reports with up to 200 individual calculations and in up to 1.5 minutes for reports with up to 8200 individual calculations. Conclusions: A system was developed with the main advantage of being generic concerning the export of different RISs as well as concerning the configuration of queries for various reports. The queries could be configured easily using the GUI of the data warehouse, and their results could be exported into the standard formats Excel and CSV for further processing.}, language = {en} } @article{LiGuanGaoetal.2020, author = {Li, Ningbo and Guan, Lianwu and Gao, Yanbin and Du, Shitong and Wu, Menghao and Guang, Xingxing and Cong, Xiaodan}, title = {Indoor and outdoor low-cost seamless integrated navigation system based on the integration of INS/GNSS/LIDAR system}, series = {Remote Sensing}, volume = {12}, journal = {Remote Sensing}, number = {19}, issn = {2072-4292}, doi = {10.3390/rs12193271}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-216229}, year = {2020}, abstract = {Global Navigation Satellite System (GNSS) provides accurate positioning data for vehicular navigation in open outdoor environment. In an indoor environment, Light Detection and Ranging (LIDAR) Simultaneous Localization and Mapping (SLAM) establishes a two-dimensional map and provides positioning data. However, LIDAR can only provide relative positioning data and it cannot directly provide the latitude and longitude of the current position. As a consequence, GNSS/Inertial Navigation System (INS) integrated navigation could be employed in outdoors, while the indoors part makes use of INS/LIDAR integrated navigation and the corresponding switching navigation will make the indoor and outdoor positioning consistent. In addition, when the vehicle enters the garage, the GNSS signal will be blurred for a while and then disappeared. Ambiguous GNSS satellite signals will lead to the continuous distortion or overall drift of the positioning trajectory in the indoor condition. Therefore, an INS/LIDAR seamless integrated navigation algorithm and a switching algorithm based on vehicle navigation system are designed. According to the experimental data, the positioning accuracy of the INS/LIDAR navigation algorithm in the simulated environmental experiment is 50\% higher than that of the Dead Reckoning (DR) algorithm. Besides, the switching algorithm developed based on the INS/LIDAR integrated navigation algorithm can achieve 80\% success rate in navigation mode switching.}, language = {en} } @techreport{LhamoNguyenFitzek2022, type = {Working Paper}, author = {Lhamo, Osel and Nguyen, Giang T. and Fitzek, Frank H. P.}, title = {Virtual Queues for QoS Compliance of Haptic Data Streams in Teleoperation}, series = {W{\"u}rzburg Workshop on Next-Generation Communication Networks (WueWoWas'22)}, journal = {W{\"u}rzburg Workshop on Next-Generation Communication Networks (WueWoWas'22)}, doi = {10.25972/OPUS-28076}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-280762}, pages = {4}, year = {2022}, abstract = {Tactile Internet aims at allowing perceived real-time interactions between humans and machines. This requires satisfying a stringent latency requirement of haptic data streams whose data rates vary drastically as the results of perceptual codecs. This introduces a complex problem for the underlying network infrastructure to fulfill the pre-defined level of Quality of Service (QoS). However, novel networking hardware with data plane programming capability allows processing packets differently and opens up a new opportunity. For example, a dynamic and network-aware resource management strategy can help satisfy the QoS requirements of different priority flows without wasting precious bandwidth. This paper introduces virtual queues for service differentiation between different types of traffic streams, leveraging protocol independent switch architecture (PISA). We propose coordinating the management of all the queues and dynamically adapting their sizes to minimize packet loss and delay due to network congestion and ensure QoS compliance.}, subject = {Datennetz}, language = {en} } @article{LeschKoenigKounevetal.2022, author = {Lesch, Veronika and K{\"o}nig, Maximilian and Kounev, Samuel and Stein, Anthony and Krupitzer, Christian}, title = {Tackling the rich vehicle routing problem with nature-inspired algorithms}, series = {Applied Intelligence}, volume = {52}, journal = {Applied Intelligence}, issn = {1573-7497}, doi = {10.1007/s10489-021-03035-5}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-268942}, pages = {9476-9500}, year = {2022}, abstract = {In the last decades, the classical Vehicle Routing Problem (VRP), i.e., assigning a set of orders to vehicles and planning their routes has been intensively researched. As only the assignment of order to vehicles and their routes is already an NP-complete problem, the application of these algorithms in practice often fails to take into account the constraints and restrictions that apply in real-world applications, the so called rich VRP (rVRP) and are limited to single aspects. In this work, we incorporate the main relevant real-world constraints and requirements. We propose a two-stage strategy and a Timeline algorithm for time windows and pause times, and apply a Genetic Algorithm (GA) and Ant Colony Optimization (ACO) individually to the problem to find optimal solutions. Our evaluation of eight different problem instances against four state-of-the-art algorithms shows that our approach handles all given constraints in a reasonable time.}, language = {en} } @phdthesis{Lehrieder2013, author = {Lehrieder, Frank}, title = {Performance Evaluation and Optimization of Content Distribution using Overlay Networks}, doi = {10.25972/OPUS-6420}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-76018}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2013}, abstract = {The work presents a performance evaluation and optimization of so-called overlay networks for content distribution in the Internet. Chapter 1 describes the importance which have such networks in today's Internet, for example, for the transmission of video content. The focus of this work is on overlay networks based on the peer-to-peer principle. These are characterized by the fact that users who download content, also contribute to the distribution process by sharing parts of the data to other users. This enables efficient content distribution because each user not only consumes resources in the system, but also provides its own resources. Chapter 2 of the monograph contains a detailed description of the functionality of today's most popular overlay network BitTorrent. It explains the various components and their interaction. This is followed by an illustration of why such overlay networks for Internet service providers (ISPs) are problematic. The reason lies in the large amount of inter-ISP traffic that is produced by these overlay networks. Since this inter-ISP traffic leads to high costs for ISPs, they try to reduce it by improved mechanisms for overlay networks. One optimization approach is the use of topology awareness within the overlay networks. It provides users of the overlay networks with information about the underlying physical network topology. This allows them to avoid inter-ISP traffic by exchanging data preferrentially with other users that are connected to the same ISP. Another approach to save inter-ISP traffic is caching. In this case the ISP provides additional computers in its network, called caches, which store copies of popular content. The users of this ISP can then obtain such content from the cache. This prevents that the content must be retrieved from locations outside of the ISP's network, and saves costly inter-ISP traffic in this way. In the third chapter of the thesis, the results of a comprehensive measurement study of overlay networks, which can be found in today's Internet, are presented. After a short description of the measurement methodology, the results of the measurements are described. These results contain data on a variety of characteristics of current P2P overlay networks in the Internet. These include the popularity of content, i.e., how many users are interested in specific content, the evolution of the popularity and the size of the files. The distribution of users within the Internet is investigated in detail. Special attention is given to the number of users that exchange a particular file within the same ISP. On the basis of these measurement results, an estimation of the traffic savings that can achieved by topology awareness is derived. This new estimation is of scientific and practical importance, since it is not limited to individual ISPs and files, but considers the whole Internet and the total amount of data exchanged in overlay networks. Finally, the characteristics of regional content are considered, in which the popularity is limited to certain parts of the Internet. This is for example the case of videos in German, Italian or French language. Chapter 4 of the thesis is devoted to the optimization of overlay networks for content distribution through caching. It presents a deterministic flow model that describes the influence of caches. On the basis of this model, it derives an estimate of the inter-ISP traffic that is generated by an overlay network, and which part can be saved by caches. The results show that the influence of the cache depends on the structure of the overlay networks, and that caches can also lead to an increase in inter-ISP traffic under certain circumstances. The described model is thus an important tool for ISPs to decide for which overlay networks caches are useful and to dimension them. Chapter 5 summarizes the content of the work and emphasizes the importance of the findings. In addition, it explains how the findings can be applied to the optimization of future overlay networks. Special attention is given to the growing importance of video-on-demand and real-time video transmissions.}, subject = {Leistungsbewertung}, language = {en} } @techreport{LeGrossmannKrieger2022, type = {Working Paper}, author = {Le, Duy Thanh and Großmann, Marcel and Krieger, Udo R.}, title = {Cloudless Resource Monitoring in a Fog Computing System Enabled by an SDN/NFV Infrastructure}, series = {W{\"u}rzburg Workshop on Next-Generation Communication Networks (WueWoWas'22)}, journal = {W{\"u}rzburg Workshop on Next-Generation Communication Networks (WueWoWas'22)}, doi = {10.25972/OPUS-28072}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-280723}, pages = {4}, year = {2022}, abstract = {Today's advanced Internet-of-Things applications raise technical challenges on cloud, edge, and fog computing. The design of an efficient, virtualized, context-aware, self-configuring orchestration system of a fog computing system constitutes a major development effort within this very innovative area of research. In this paper we describe the architecture and relevant implementation aspects of a cloudless resource monitoring system interworking with an SDN/NFV infrastructure. It realizes the basic monitoring component of the fundamental MAPE-K principles employed in autonomic computing. Here we present the hierarchical layering and functionality within the underlying fog nodes to generate a working prototype of an intelligent, self-managed orchestrator for advanced IoT applications and services. The latter system has the capability to monitor automatically various performance aspects of the resource allocation among multiple hosts of a fog computing system interconnected by SDN.}, subject = {Datennetz}, language = {en} } @article{LatoschikWienrich2022, author = {Latoschik, Marc Erich and Wienrich, Carolin}, title = {Congruence and plausibility, not presence: pivotal conditions for XR experiences and effects, a novel approach}, series = {Frontiers in Virtual Reality}, volume = {3}, journal = {Frontiers in Virtual Reality}, issn = {2673-4192}, doi = {10.3389/frvir.2022.694433}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-284787}, year = {2022}, abstract = {Presence is often considered the most important quale describing the subjective feeling of being in a computer-generated and/or computer-mediated virtual environment. The identification and separation of orthogonal presence components, i.e., the place illusion and the plausibility illusion, has been an accepted theoretical model describing Virtual Reality (VR) experiences for some time. This perspective article challenges this presence-oriented VR theory. First, we argue that a place illusion cannot be the major construct to describe the much wider scope of virtual, augmented, and mixed reality (VR, AR, MR: or XR for short). Second, we argue that there is no plausibility illusion but merely plausibility, and we derive the place illusion caused by the congruent and plausible generation of spatial cues and similarly for all the current model's so-defined illusions. Finally, we propose congruence and plausibility to become the central essential conditions in a novel theoretical model describing XR experiences and effects.}, language = {en} } @article{LandeckAlvarezIgarzabalUnruhetal.2022, author = {Landeck, Maximilian and Alvarez Igarz{\´a}bal, Federico and Unruh, Fabian and Habenicht, Hannah and Khoshnoud, Shiva and Wittmann, Marc and Lugrin, Jean-Luc and Latoschik, Marc Erich}, title = {Journey through a virtual tunnel: Simulated motion and its effects on the experience of time}, series = {Frontiers in Virtual Reality}, volume = {3}, journal = {Frontiers in Virtual Reality}, issn = {2673-4192}, doi = {10.3389/frvir.2022.1059971}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-301519}, year = {2022}, abstract = {This paper examines the relationship between time and motion perception in virtual environments. Previous work has shown that the perception of motion can affect the perception of time. We developed a virtual environment that simulates motion in a tunnel and measured its effects on the estimation of the duration of time, the speed at which perceived time passes, and the illusion of self-motion, also known as vection. When large areas of the visual field move in the same direction, vection can occur; observers often perceive this as self-motion rather than motion of the environment. To generate different levels of vection and investigate its effects on time perception, we developed an abstract procedural tunnel generator. The generator can simulate different speeds and densities of tunnel sections (visibly distinguishable sections that form the virtual tunnel), as well as the degree of embodiment of the user avatar (with or without virtual hands). We exposed participants to various tunnel simulations with different durations, speeds, and densities in a remote desktop and a virtual reality (VR) laboratory study. Time passed subjectively faster under high-speed and high-density conditions in both studies. The experience of self-motion was also stronger under high-speed and high-density conditions. Both studies revealed a significant correlation between the perceived passage of time and perceived self-motion. Subjects in the virtual reality study reported a stronger self-motion experience, a faster perceived passage of time, and shorter time estimates than subjects in the desktop study. Our results suggest that a virtual tunnel simulation can manipulate time perception in virtual reality. We will explore these results for the development of virtual reality applications for therapeutic approaches in our future work. This could be particularly useful in treating disorders like depression, autism, and schizophrenia, which are known to be associated with distortions in time perception. For example, the tunnel could be therapeutically applied by resetting patients' time perceptions by exposing them to the tunnel under different conditions, such as increasing or decreasing perceived time.}, language = {en} } @article{KunzLiangNillaetal.2016, author = {Kunz, Meik and Liang, Chunguang and Nilla, Santosh and Cecil, Alexander and Dandekar, Thomas}, title = {The drug-minded protein interaction database (DrumPID) for efficient target analysis and drug development}, series = {Database}, volume = {2016}, journal = {Database}, doi = {10.1093/database/baw041}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-147369}, pages = {baw041}, year = {2016}, abstract = {The drug-minded protein interaction database (DrumPID) has been designed to provide fast, tailored information on drugs and their protein networks including indications, protein targets and side-targets. Starting queries include compound, target and protein interactions and organism-specific protein families. Furthermore, drug name, chemical structures and their SMILES notation, affected proteins (potential drug targets), organisms as well as diseases can be queried including various combinations and refinement of searches. Drugs and protein interactions are analyzed in detail with reference to protein structures and catalytic domains, related compound structures as well as potential targets in other organisms. DrumPID considers drug functionality, compound similarity, target structure, interactome analysis and organismic range for a compound, useful for drug development, predicting drug side-effects and structure-activity relationships.}, language = {en} } @article{KuhnGrippFliederetal.2015, author = {Kuhn, Joachim and Gripp, Tatjana and Flieder, Tobias and Dittrich, Marcus and Hendig, Doris and Busse, Jessica and Knabbe, Cornelius and Birschmann, Ingvild}, title = {UPLC-MRM Mass Spectrometry Method for Measurement of the Coagulation Inhibitors Dabigatran and Rivaroxaban in Human Plasma and Its Comparison with Functional Assays}, series = {PLOS ONE}, volume = {10}, journal = {PLOS ONE}, number = {12}, doi = {10.1371/journal.pone.0145478}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-136023}, pages = {e0145478}, year = {2015}, abstract = {Introduction The fast, precise, and accurate measurement of the new generation of oral anticoagulants such as dabigatran and rivaroxaban in patients' plasma my provide important information in different clinical circumstances such as in the case of suspicion of overdose, when patients switch from existing oral anticoagulant, in patients with hepatic or renal impairment, by concomitant use of interaction drugs, or to assess anticoagulant concentration in patients' blood before major surgery. Methods Here, we describe a quick and precise method to measure the coagulation inhibitors dabigatran and rivaroxaban using ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry in multiple reactions monitoring (MRM) mode (UPLC-MRM MS). Internal standards (ISs) were added to the sample and after protein precipitation; the sample was separated on a reverse phase column. After ionization of the analytes the ions were detected using electrospray ionization-tandem mass spectrometry. Run time was 2.5 minutes per injection. Ion suppression was characterized by means of post-column infusion. Results The calibration curves of dabigatran and rivaroxaban were linear over the working range between 0.8 and 800 mu g/L (r > 0.99). Limits of detection (LOD) in the plasma matrix were 0.21 mu g/L for dabigatran and 0.34 mu g/L for rivaroxaban, and lower limits of quantification (LLOQ) in the plasma matrix were 0.46 mu g/L for dabigatran and 0.54 mu g/L for rivaroxaban. The intraassay coefficients of variation (CVs) for dabigatran and rivaroxaban were < 4\% and 6\%; respectively, the interassay CVs were < 6\% for dabigatran and < 9\% for rivaroxaban. Inaccuracy was < 5\% for both substances. The mean recovery was 104.5\% (range 83.8-113.0\%) for dabigatran and 87.0\%(range 73.6-105.4\%) for rivaroxaban. No significant ion suppressions were detected at the elution times of dabigatran or rivaroxaban. Both coagulation inhibitors were stable in citrate plasma at -20 degrees C, 4 degrees C and even at RT for at least one week. A method comparison between our UPLC-MRM MS method, the commercially available automated Direct Thrombin Inhibitor assay (DTI assay) for dabigatran measurement from CoaChrom Diagnostica, as well as the automated anti-Xa assay for rivaroxaban measurement from Chromogenix both performed by ACL-TOP showed a high degree of correlation. However, UPLC-MRM MS measurement of dabigatran and rivaroxaban has a much better selectivity than classical functional assays measuring activities of various coagulation factors which are susceptible to interference by other coagulant drugs. Conclusions Overall, we developed and validated a sensitive and specific UPLC-MRM MS assay for the quick and specific measurement of dabigatran and rivaroxaban in human plasma.}, language = {en} } @article{KrupitzerEberhardingerGerostathopoulosetal.2020, author = {Krupitzer, Christian and Eberhardinger, Benedikt and Gerostathopoulos, Ilias and Raibulet, Claudia}, title = {Introduction to the special issue "Applications in Self-Aware Computing Systems and their Evaluation"}, series = {Computers}, volume = {9}, journal = {Computers}, number = {1}, issn = {2073-431X}, doi = {10.3390/computers9010022}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-203439}, year = {2020}, abstract = {The joint 1st Workshop on Evaluations and Measurements in Self-Aware Computing Systems (EMSAC 2019) and Workshop on Self-Aware Computing (SeAC) was held as part of the FAS* conference alliance in conjunction with the 16th IEEE International Conference on Autonomic Computing (ICAC) and the 13th IEEE International Conference on Self-Adaptive and Self-Organizing Systems (SASO) in Ume{\aa}, Sweden on 20 June 2019. The goal of this one-day workshop was to bring together researchers and practitioners from academic environments and from the industry to share their solutions, ideas, visions, and doubts in self-aware computing systems in general and in the evaluation and measurements of such systems in particular. The workshop aimed to enable discussions, partnerships, and collaborations among the participants. This special issue follows the theme of the workshop. It contains extended versions of workshop presentations as well as additional contributions.}, language = {en} } @article{KruegerFriedrichFoersteretal.2012, author = {Krueger, Beate and Friedrich, Torben and F{\"o}rster, Frank and Bernhardt, J{\"o}rg and Gross, Roy and Dandekar, Thomas}, title = {Different evolutionary modifications as a guide to rewire two-component systems}, series = {Bioinformatics and Biology Insights}, volume = {6}, journal = {Bioinformatics and Biology Insights}, doi = {10.4137/BBI.S9356}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-123647}, pages = {97-128}, year = {2012}, abstract = {Two-component systems (TCS) are short signalling pathways generally occurring in prokaryotes. They frequently regulate prokaryotic stimulus responses and thus are also of interest for engineering in biotechnology and synthetic biology. The aim of this study is to better understand and describe rewiring of TCS while investigating different evolutionary scenarios. Based on large-scale screens of TCS in different organisms, this study gives detailed data, concrete alignments, and structure analysis on three general modification scenarios, where TCS were rewired for new responses and functions: (i) exchanges in the sequence within single TCS domains, (ii) exchange of whole TCS domains; (iii) addition of new components modulating TCS function. As a result, the replacement of stimulus and promotor cassettes to rewire TCS is well defined exploiting the alignments given here. The diverged TCS examples are non-trivial and the design is challenging. Designed connector proteins may also be useful to modify TCS in selected cases.}, language = {en} } @article{KrenzerMakowskiHekaloetal.2022, author = {Krenzer, Adrian and Makowski, Kevin and Hekalo, Amar and Fitting, Daniel and Troya, Joel and Zoller, Wolfram G. and Hann, Alexander and Puppe, Frank}, title = {Fast machine learning annotation in the medical domain: a semi-automated video annotation tool for gastroenterologists}, series = {BioMedical Engineering OnLine}, volume = {21}, journal = {BioMedical Engineering OnLine}, number = {1}, doi = {10.1186/s12938-022-01001-x}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-300231}, year = {2022}, abstract = {Background Machine learning, especially deep learning, is becoming more and more relevant in research and development in the medical domain. For all the supervised deep learning applications, data is the most critical factor in securing successful implementation and sustaining the progress of the machine learning model. Especially gastroenterological data, which often involves endoscopic videos, are cumbersome to annotate. Domain experts are needed to interpret and annotate the videos. To support those domain experts, we generated a framework. With this framework, instead of annotating every frame in the video sequence, experts are just performing key annotations at the beginning and the end of sequences with pathologies, e.g., visible polyps. Subsequently, non-expert annotators supported by machine learning add the missing annotations for the frames in-between. Methods In our framework, an expert reviews the video and annotates a few video frames to verify the object's annotations for the non-expert. In a second step, a non-expert has visual confirmation of the given object and can annotate all following and preceding frames with AI assistance. After the expert has finished, relevant frames will be selected and passed on to an AI model. This information allows the AI model to detect and mark the desired object on all following and preceding frames with an annotation. Therefore, the non-expert can adjust and modify the AI predictions and export the results, which can then be used to train the AI model. Results Using this framework, we were able to reduce workload of domain experts on average by a factor of 20 on our data. This is primarily due to the structure of the framework, which is designed to minimize the workload of the domain expert. Pairing this framework with a state-of-the-art semi-automated AI model enhances the annotation speed further. Through a prospective study with 10 participants, we show that semi-automated annotation using our tool doubles the annotation speed of non-expert annotators compared to a well-known state-of-the-art annotation tool. Conclusion In summary, we introduce a framework for fast expert annotation for gastroenterologists, which reduces the workload of the domain expert considerably while maintaining a very high annotation quality. The framework incorporates a semi-automated annotation system utilizing trained object detection models. The software and framework are open-source.}, language = {en} } @article{KrenzerHeilFittingetal., author = {Krenzer, Adrian and Heil, Stefan and Fitting, Daniel and Matti, Safa and Zoller, Wolfram G. and Hann, Alexander and Puppe, Frank}, title = {Automated classification of polyps using deep learning architectures and few-shot learning}, series = {BMC Medical Imaging}, volume = {23}, journal = {BMC Medical Imaging}, doi = {10.1186/s12880-023-01007-4}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-357465}, abstract = {Background Colorectal cancer is a leading cause of cancer-related deaths worldwide. The best method to prevent CRC is a colonoscopy. However, not all colon polyps have the risk of becoming cancerous. Therefore, polyps are classified using different classification systems. After the classification, further treatment and procedures are based on the classification of the polyp. Nevertheless, classification is not easy. Therefore, we suggest two novel automated classifications system assisting gastroenterologists in classifying polyps based on the NICE and Paris classification. Methods We build two classification systems. One is classifying polyps based on their shape (Paris). The other classifies polyps based on their texture and surface patterns (NICE). A two-step process for the Paris classification is introduced: First, detecting and cropping the polyp on the image, and secondly, classifying the polyp based on the cropped area with a transformer network. For the NICE classification, we design a few-shot learning algorithm based on the Deep Metric Learning approach. The algorithm creates an embedding space for polyps, which allows classification from a few examples to account for the data scarcity of NICE annotated images in our database. Results For the Paris classification, we achieve an accuracy of 89.35 \%, surpassing all papers in the literature and establishing a new state-of-the-art and baseline accuracy for other publications on a public data set. For the NICE classification, we achieve a competitive accuracy of 81.13 \% and demonstrate thereby the viability of the few-shot learning paradigm in polyp classification in data-scarce environments. Additionally, we show different ablations of the algorithms. Finally, we further elaborate on the explainability of the system by showing heat maps of the neural network explaining neural activations. Conclusion Overall we introduce two polyp classification systems to assist gastroenterologists. We achieve state-of-the-art performance in the Paris classification and demonstrate the viability of the few-shot learning paradigm in the NICE classification, addressing the prevalent data scarcity issues faced in medical machine learning.}, language = {en} } @phdthesis{Krenzer2023, author = {Krenzer, Adrian}, title = {Machine learning to support physicians in endoscopic examinations with a focus on automatic polyp detection in images and videos}, doi = {10.25972/OPUS-31911}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-319119}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2023}, abstract = {Deep learning enables enormous progress in many computer vision-related tasks. Artificial Intel- ligence (AI) steadily yields new state-of-the-art results in the field of detection and classification. Thereby AI performance equals or exceeds human performance. Those achievements impacted many domains, including medical applications. One particular field of medical applications is gastroenterology. In gastroenterology, machine learning algorithms are used to assist examiners during interventions. One of the most critical concerns for gastroenterologists is the development of Colorectal Cancer (CRC), which is one of the leading causes of cancer-related deaths worldwide. Detecting polyps in screening colonoscopies is the essential procedure to prevent CRC. Thereby, the gastroenterologist uses an endoscope to screen the whole colon to find polyps during a colonoscopy. Polyps are mucosal growths that can vary in severity. This thesis supports gastroenterologists in their examinations with automated detection and clas- sification systems for polyps. The main contribution is a real-time polyp detection system. This system is ready to be installed in any gastroenterology practice worldwide using open-source soft- ware. The system achieves state-of-the-art detection results and is currently evaluated in a clinical trial in four different centers in Germany. The thesis presents two additional key contributions: One is a polyp detection system with ex- tended vision tested in an animal trial. Polyps often hide behind folds or in uninvestigated areas. Therefore, the polyp detection system with extended vision uses an endoscope assisted by two additional cameras to see behind those folds. If a polyp is detected, the endoscopist receives a vi- sual signal. While the detection system handles the additional two camera inputs, the endoscopist focuses on the main camera as usual. The second one are two polyp classification models, one for the classification based on shape (Paris) and the other on surface and texture (NBI International Colorectal Endoscopic (NICE) classification). Both classifications help the endoscopist with the treatment of and the decisions about the detected polyp. The key algorithms of the thesis achieve state-of-the-art performance. Outstandingly, the polyp detection system tested on a highly demanding video data set shows an F1 score of 90.25 \% while working in real-time. The results exceed all real-time systems in the literature. Furthermore, the first preliminary results of the clinical trial of the polyp detection system suggest a high Adenoma Detection Rate (ADR). In the preliminary study, all polyps were detected by the polyp detection system, and the system achieved a high usability score of 96.3 (max 100). The Paris classification model achieved an F1 score of 89.35 \% which is state-of-the-art. The NICE classification model achieved an F1 score of 81.13 \%. Furthermore, a large data set for polyp detection and classification was created during this thesis. Therefore a fast and robust annotation system called Fast Colonoscopy Annotation Tool (FastCAT) was developed. The system simplifies the annotation process for gastroenterologists. Thereby the i gastroenterologists only annotate key parts of the endoscopic video. Afterward, those video parts are pre-labeled by a polyp detection AI to speed up the process. After the AI has pre-labeled the frames, non-experts correct and finish the annotation. This annotation process is fast and ensures high quality. FastCAT reduces the overall workload of the gastroenterologist on average by a factor of 20 compared to an open-source state-of-art annotation tool.}, subject = {Deep Learning}, language = {en} } @article{KraftReichertPryss2021, author = {Kraft, Robin and Reichert, Manfred and Pryss, R{\"u}diger}, title = {Towards the interpretation of sound measurements from smartphones collected with mobile crowdsensing in the healthcare domain: an experiment with Android devices}, series = {Sensors}, volume = {22}, journal = {Sensors}, number = {1}, issn = {1424-8220}, doi = {10.3390/s22010170}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-252246}, year = {2021}, abstract = {The ubiquity of mobile devices fosters the combined use of ecological momentary assessments (EMA) and mobile crowdsensing (MCS) in the field of healthcare. This combination not only allows researchers to collect ecologically valid data, but also to use smartphone sensors to capture the context in which these data are collected. The TrackYourTinnitus (TYT) platform uses EMA to track users' individual subjective tinnitus perception and MCS to capture an objective environmental sound level while the EMA questionnaire is filled in. However, the sound level data cannot be used directly among the different smartphones used by TYT users, since uncalibrated raw values are stored. This work describes an approach towards making these values comparable. In the described setting, the evaluation of sensor measurements from different smartphone users becomes increasingly prevalent. Therefore, the shown approach can be also considered as a more general solution as it not only shows how it helped to interpret TYT sound level data, but may also stimulate other researchers, especially those who need to interpret sensor data in a similar setting. Altogether, the approach will show that measuring sound levels with mobile devices is possible in healthcare scenarios, but there are many challenges to ensuring that the measured values are interpretable.}, language = {en} } @article{KraftBirkReichertetal.2020, author = {Kraft, Robin and Birk, Ferdinand and Reichert, Manfred and Deshpande, Aniruddha and Schlee, Winfried and Langguth, Berthold and Baumeister, Harald and Probst, Thomas and Spiliopoulou, Myra and Pryss, R{\"u}diger}, title = {Efficient processing of geospatial mHealth data using a scalable crowdsensing platform}, series = {Sensors}, volume = {20}, journal = {Sensors}, number = {12}, issn = {1424-8220}, doi = {10.3390/s20123456}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-207826}, year = {2020}, abstract = {Smart sensors and smartphones are becoming increasingly prevalent. Both can be used to gather environmental data (e.g., noise). Importantly, these devices can be connected to each other as well as to the Internet to collect large amounts of sensor data, which leads to many new opportunities. In particular, mobile crowdsensing techniques can be used to capture phenomena of common interest. Especially valuable insights can be gained if the collected data are additionally related to the time and place of the measurements. However, many technical solutions still use monolithic backends that are not capable of processing crowdsensing data in a flexible, efficient, and scalable manner. In this work, an architectural design was conceived with the goal to manage geospatial data in challenging crowdsensing healthcare scenarios. It will be shown how the proposed approach can be used to provide users with an interactive map of environmental noise, allowing tinnitus patients and other health-conscious people to avoid locations with harmful sound levels. Technically, the shown approach combines cloud-native applications with Big Data and stream processing concepts. In general, the presented architectural design shall serve as a foundation to implement practical and scalable crowdsensing platforms for various healthcare scenarios beyond the addressed use case.}, language = {en} } @techreport{KounevBrosigHuber2014, author = {Kounev, Samuel and Brosig, Fabian and Huber, Nikolaus}, title = {The Descartes Modeling Language}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-104887}, pages = {91}, year = {2014}, abstract = {This technical report introduces the Descartes Modeling Language (DML), a new architecture-level modeling language for modeling Quality-of-Service (QoS) and resource management related aspects of modern dynamic IT systems, infrastructures and services. DML is designed to serve as a basis for self-aware resource management during operation ensuring that system QoS requirements are continuously satisfied while infrastructure resources are utilized as efficiently as possible.}, subject = {Ressourcenmanagement}, language = {en} } @phdthesis{Kosub2001, author = {Kosub, Sven}, title = {Complexity and Partitions}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-2808}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2001}, abstract = {Computational complexity theory usually investigates the complexity of sets, i.e., the complexity of partitions into two parts. But often it is more appropriate to represent natural problems by partitions into more than two parts. A particularly interesting class of such problems consists of classification problems for relations. For instance, a binary relation R typically defines a partitioning of the set of all pairs (x,y) into four parts, classifiable according to the cases where R(x,y) and R(y,x) hold, only R(x,y) or only R(y,x) holds or even neither R(x,y) nor R(y,x) is true. By means of concrete classification problems such as Graph Embedding or Entailment (for propositional logic), this thesis systematically develops tools, in shape of the boolean hierarchy of NP-partitions and its refinements, for the qualitative analysis of the complexity of partitions generated by NP-relations. The Boolean hierarchy of NP-partitions is introduced as a generalization of the well-known and well-studied Boolean hierarchy (of sets) over NP. Whereas the latter hierarchy has a very simple structure, the situation is much more complicated for the case of partitions into at least three parts. To get an idea of this hierarchy, alternative descriptions of the partition classes are given in terms of finite, labeled lattices. Based on these characterizations the Embedding Conjecture is established providing the complete information on the structure of the hierarchy. This conjecture is supported by several results. A natural extension of the Boolean hierarchy of NP-partitions emerges from the lattice-characterization of its classes by considering partition classes generated by finite, labeled posets. It turns out that all significant ideas translate from the case of lattices. The induced refined Boolean hierarchy of NP-partitions enables us more accuratly capturing the complexity of certain relations (such as Graph Embedding) and a description of projectively closed partition classes.}, subject = {Partition }, language = {en} } @article{KoopmannStubbemannKapaetal.2021, author = {Koopmann, Tobias and Stubbemann, Maximilian and Kapa, Matthias and Paris, Michael and Buenstorf, Guido and Hanika, Tom and Hotho, Andreas and J{\"a}schke, Robert and Stumme, Gerd}, title = {Proximity dimensions and the emergence of collaboration: a HypTrails study on German AI research}, series = {Scientometrics}, volume = {126}, journal = {Scientometrics}, number = {12}, issn = {1588-2861}, doi = {10.1007/s11192-021-03922-1}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-269831}, pages = {9847-9868}, year = {2021}, abstract = {Creation and exchange of knowledge depends on collaboration. Recent work has suggested that the emergence of collaboration frequently relies on geographic proximity. However, being co-located tends to be associated with other dimensions of proximity, such as social ties or a shared organizational environment. To account for such factors, multiple dimensions of proximity have been proposed, including cognitive, institutional, organizational, social and geographical proximity. Since they strongly interrelate, disentangling these dimensions and their respective impact on collaboration is challenging. To address this issue, we propose various methods for measuring different dimensions of proximity. We then present an approach to compare and rank them with respect to the extent to which they indicate co-publications and co-inventions. We adapt the HypTrails approach, which was originally developed to explain human navigation, to co-author and co-inventor graphs. We evaluate this approach on a subset of the German research community, specifically academic authors and inventors active in research on artificial intelligence (AI). We find that social proximity and cognitive proximity are more important for the emergence of collaboration than geographic proximity.}, language = {en} } @phdthesis{Kluegl2000, author = {Kl{\"u}gl, Franziska}, title = {Aktivit{\"a}tsbasierte Verhaltensmodellierung und ihre Unterst{\"u}tzung bei Multiagentensimulationen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-2874}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2000}, abstract = {Durch Zusammenf{\"u}hrung traditioneller Methoden zur individuenbasierten Simulation und dem Konzept der Multiagentensysteme steht mit der Multiagentensimulation eine Methodik zur Verf{\"u}gung, die es erm{\"o}glicht, sowohl technisch als auch konzeptionell eine neue Ebene an Detaillierung bei Modellbildung und Simulation zu erreichen. Ein Modell beruht dabei auf dem Konzept einer Gesellschaft: Es besteht aus einer Menge interagierender, aber in ihren Entscheidungen autonomen Einheiten, den Agenten. Diese {\"a}ndern durch ihre Aktionen ihre Umwelt und reagieren ebenso auf die f{\"u}r sie wahrnehmbaren {\"A}nderungen in der Umwelt. Durch die Simulation jedes Agenten zusammen mit der Umwelt, in der er "lebt", wird die Dynamik im Gesamtsystem beobachtbar. In der vorliegenden Dissertation wurde ein Repr{\"a}sentationsschema f{\"u}r Multiagentensimulationen entwickelt werden, das es Fachexperten, wie zum Beispiel Biologen, erm{\"o}glicht, selbst{\"a}ndig ohne traditionelles Programmieren Multiagentenmodelle zu implementieren und mit diesen Experimente durchzuf{\"u}hren. Dieses deklarative Schema beruht auf zwei Basiskonzepten: Der K{\"o}rper eines Agenten besteht aus Zustandsvariablen. Das Verhalten des Agenten kann mit Regeln beschrieben werden. Ausgehend davon werden verschiedene Strukturierungsans{\"a}tze behandelt. Das wichtigste Konzept ist das der "Aktivit{\"a}t", einer Art "Verhaltenszustand": W{\"a}hrend der Agent in einer Aktivit{\"a}t A verweilt, f{\"u}hrt er die zugeh{\"o}rigen Aktionen aus und dies solange, bis eine Regel feuert, die diese Aktivit{\"a}t beendet und eine neue Aktivit{\"a}t ausw{\"a}hlt. Durch Indizierung dieser Regeln bei den zugeh{\"o}rigen Aktivit{\"a}ten und Einf{\"u}hrung von abstrakten Aktivit{\"a}ten entsteht ein Schema f{\"u}r eine vielf{\"a}ltig strukturierbare Verhaltensbeschreibung. Zu diesem Schema wurde ein Interpreter entwickelt, der ein derartig repr{\"a}sentiertes Modell ausf{\"u}hrt und so Simulationsexperimente mit dem Multiagentenmodell erlaubt. Auf dieser Basis wurde die Modellierungs- und Experimentierumgebung SeSAm ("Shell f{\"u}r Simulierte Agentensysteme") entwickelt. Sie verwendet vorhandene Konzepte aus dem visuellen Programmieren. Mit dieser Umgebung wurden Anwendungsmodelle aus verschiedenen Dom{\"a}nen realisiert: Neben abstrakten Spielbeispielen waren dies vor allem Fragestellungen zu sozialen Insekten, z.B. zum Verhalten von Ameisen, Bienen oder der Interaktion zwischen Bienenv{\"o}lkern und Milbenpopulationen.}, subject = {Agent }, language = {de} } @phdthesis{Kluge2004, author = {Kluge, Boris}, title = {Motion coordination for a mobile robot in dynamic environments}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-15508}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2004}, abstract = {Generating coordinated motion for a mobile robot operating in natural, continuously changing environments among moving obstacles such as humans is a complex task which requires the solution of various sub problems. In this thesis, we will cover the topics of perception and navigation in dynamic environments, as well as reasoning about the motion of the obstacles and of the robot itself. Perception is mainly considered for a laser range finder, and an according method for obstacle detection and tracking is proposed. Network optimization algorithms are used for data association in the tracking step, resulting in considerable robustness with respect to clutter by small objects. Navigation in general is accomplished using an adaptation of the velocity obstacle approach to the given vehicle kinematics, and cooperative motion coordination between the robot and a human guide is achieved using an appropriate selection rule for collision-free velocities. Next, the robot is enabled to compare its path to the path of a human guide using one of a collection of presented distance measures, which permits the detection of exceptional conditions. Furthermore, a taxonomy for the assessment of situations concerning the robot is presented, and following a summary of existing approaches to more intelligent and comprehensive perception, we propose a method for obstruction detection. Finally, a new approach to reflective navigation behaviors is described where the robot reasons about intelligent moving obstacles in its environment, which allows to adjust the character of the robot motion from regardful and defensive to more self-confident and aggressive behaviors.}, subject = {Bewegungsablauf}, language = {de} } @article{KlemzRote2022, author = {Klemz, Boris and Rote, G{\"u}nter}, title = {Linear-Time Algorithms for Maximum-Weight Induced Matchings and Minimum Chain Covers in Convex Bipartite Graphs}, series = {Algorithmica}, volume = {84}, journal = {Algorithmica}, number = {4}, issn = {1432-0541}, doi = {10.1007/s00453-021-00904-w}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-267876}, pages = {1064-1080}, year = {2022}, abstract = {A bipartite graph G=(U,V,E) is convex if the vertices in V can be linearly ordered such that for each vertex u∈U, the neighbors of u are consecutive in the ordering of V. An induced matching H of G is a matching for which no edge of E connects endpoints of two different edges of H. We show that in a convex bipartite graph with n vertices and m weighted edges, an induced matching of maximum total weight can be computed in O(n+m) time. An unweighted convex bipartite graph has a representation of size O(n) that records for each vertex u∈U the first and last neighbor in the ordering of V. Given such a compact representation, we compute an induced matching of maximum cardinality in O(n) time. In convex bipartite graphs, maximum-cardinality induced matchings are dual to minimum chain covers. A chain cover is a covering of the edge set by chain subgraphs, that is, subgraphs that do not contain induced matchings of more than one edge. Given a compact representation, we compute a representation of a minimum chain cover in O(n) time. If no compact representation is given, the cover can be computed in O(n+m) time. All of our algorithms achieve optimal linear running time for the respective problem and model, and they improve and generalize the previous results in several ways: The best algorithms for the unweighted problem versions had a running time of O(n\(^{2}\)) (Brandst{\"a}dt et al. in Theor. Comput. Sci. 381(1-3):260-265, 2007. https://doi.org/10.1016/j.tcs.2007.04.006). The weighted case has not been considered before.}, language = {en} } @phdthesis{Klein2014, author = {Klein, Dominik Werner}, title = {Design and Evaluation of Components for Future Internet Architectures}, issn = {1432-8801}, doi = {10.25972/OPUS-9313}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-93134}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2014}, abstract = {Die derzeitige Internetarchitektur wurde nicht in einem geplanten Prozess konzipiert und entwickelt, sondern hat vielmehr eine evolutionsartige Entwicklung hinter sich. Ausl{\"o}ser f{\"u}r die jeweiligen Evolutionsschritte waren dabei meist aufstrebende Anwendungen, welche neue Anforderungen an die zugrundeliegende Netzarchitektur gestellt haben. Um diese Anforderungen zu erf{\"u}llen, wurden h{\"a}ufig neuartige Dienste oder Protokolle spezifiziert und in die bestehende Architektur integriert. Dieser Prozess ist jedoch meist mit hohem Aufwand verbunden und daher sehr tr{\"a}ge, was die Entwicklung und Verbreitung innovativer Dienste beeintr{\"a}chtigt. Derzeitig diskutierte Konzepte wie Software-Defined Networking (SDN) oder Netzvirtualisierung (NV) werden als eine M{\"o}glichkeit angesehen, die Altlasten der bestehenden Internetarchitektur zu l{\"o}sen. Beiden Konzepten gemein ist die Idee, logische Netze {\"u}ber dem physikalischen Substrat zu betreiben. Diese logischen Netze sind hochdynamisch und k{\"o}nnen so flexibel an die Anforderungen der jeweiligen Anwendungen angepasst werden. Insbesondere erlaubt das Konzept der Virtualisierung intelligentere Netzknoten, was innovative neue Anwendungsf{\"a}lle erm{\"o}glicht. Ein h{\"a}ufig in diesem Zusammenhang diskutierter Anwendungsfall ist die Mobilit{\"a}t sowohl von Endger{\"a}ten als auch von Diensten an sich. Die Mobilit{\"a}t der Dienste wird hierbei ausgenutzt, um die Zugriffsverz{\"o}gerung oder die belegten Ressourcen im Netz zu reduzieren, indem die Dienste zum Beispiel in f{\"u}r den Nutzer geographisch nahe Datenzentren migriert werden. Neben den reinen Mechanismen bez{\"u}glich Dienst- und Endger{\"a}temobilit{\"a}t sind in diesem Zusammenhang auch geeignete {\"U}berwachungsl{\"o}sungen relevant, welche die vom Nutzer wahrgenommene Dienstg{\"u}te bewerten k{\"o}nnen. Diese L{\"o}sungen liefern wichtige Entscheidungshilfen f{\"u}r die Migration oder {\"u}berwachen m{\"o}gliche Effekte der Migration auf die erfahrene Dienstg{\"u}te beim Nutzer. Im Falle von Video Streaming erm{\"o}glicht ein solcher Anwendungsfall die flexible Anpassung der Streaming Topologie f{\"u}r mobile Nutzer, um so die Videoqualit{\"a}t unabh{\"a}ngig vom Zugangsnetz aufrechterhalten zu k{\"o}nnen. Im Rahmen dieser Doktorarbeit wird der beschriebene Anwendungsfall am Beispiel einer Video Streaming Anwendung n{\"a}her analysiert und auftretende Herausforderungen werden diskutiert. Des Weiteren werden L{\"o}sungsans{\"a}tze vorgestellt und bez{\"u}glich ihrer Effizienz ausgewertet. Im Detail besch{\"a}ftigt sich die Arbeit mit der Leistungsanalyse von Mechanismen f{\"u}r die Dienstmobilit{\"a}t und entwickelt eine Architektur zur Optimierung der Dienstmobilit{\"a}t. Im Bereich Endger{\"a}temobilit{\"a}t werden Verbesserungen entwickelt, welche die Latenz zwischen Endger{\"a}t und Dienst reduzieren oder die Konnektivit{\"a}t unabh{\"a}ngig vom Zugangsnetz gew{\"a}hrleisten. Im letzten Teilbereich wird eine L{\"o}sung zur {\"U}berwachung der Videoqualit{\"a}t im Netz entwickelt und bez{\"u}glich ihrer Genauigkeit analysiert.}, subject = {Leistungsbewertung}, language = {en} }