@unpublished{WohlgemuthMitric2020,
  author    = {Wohlgemuth, Matthias and Mitric, Roland},
  title     = {Excitation energy transport in DNA modelled by multi-chromophoric field-induced surface hopping},
  series = {Physical Chemistry Chemical Physics},
  journal   = {Physical Chemistry Chemical Physics},
  edition   = {submitted version},
  doi       = {10.1039/D0CP02255A},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-209467},
  year      = {2020},
  abstract  = {Absorption of ultraviolet light is known as a major source of carcinogenic mutations of DNA. The underlying processes of excitation energy dissipation are yet not fully understood. In this work we provide a new and generally applicable route for studying the excitation energy transport in multi-chromophoric complexes at an atomistic level. The surface-hopping approach in the frame of the extended Frenkel exciton model combined with QM/MM techniques allowed us to simulate the photodynamics of the alternating (dAdT)10 : (dAdT)10 double-stranded DNA. In accordance with recent experiments, we find that the excited state decay is multiexponential, involving a long and a short component which are due to two distinct mechanisms: formation of long-lived delocalized excitonic and charge transfer states vs. ultrafast decaying localized states resembling those of the bare nucleobases. Our simulations explain all stages of the ultrafast photodynamics including initial photoexcitation, dynamical evolution out of the Franck-Condon region, excimer formation and nonradiative relaxation to the ground state.},
  language  = {en}
}
@unpublished{HumeniukBužančićHocheetal.2020,
  author    = {Humeniuk, Alexander and Bužančić, Margarita and Hoche, Joscha and Cerezo, Javier and Mitric, Roland and Santoro, Fabrizio and Bonačić-Koutecky, Vlasta},
  title     = {Predicting fluorescence quantum yields for molecules in solution: A critical assessment of the harmonic approximation and the choice of the lineshape function},
  series = {The Journal of Chemical Physics},
  journal   = {The Journal of Chemical Physics},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-199305},
  year      = {2020},
  abstract  = {For the rational design of new fluorophores, reliable predictions of fluorescence quantum yields from first principles would be of great help. However, efficient computational approaches for predicting transition rates usually assume that the vibrational structure is harmonic. While the harmonic approximation has been used successfully to predict vibrationally resolved spectra and radiative rates, its reliability for non-radiative rates is much more questionable. Since non-adiabatic transitions convert large amounts of electronic energy into vibrational energy, the highly excited final vibrational states deviate greatly from harmonic oscillator eigenfunctions. We employ a time-dependent formalism to compute radiative and non-radiative rates for transitions and study the dependence on model parameters. For several coumarin dyes we compare different adiabatic and vertical harmonic models (AS, ASF, AH, VG, VGF, VH), in order to dissect the importance of displacements, frequency changes and Duschinsky rotations. In addition we analyze the effect of different broadening functions (Gaussian, Lorentzian or Voigt). Moreover, to assess the qualitative influence of anharmonicity on the internal conversion rate, we develop a simplified anharmonic model. We adress the reliability of these models considering the potential errors introduced by the harmonic approximation and the phenomenological width of the broadening function.},
  language  = {en}
}
@unpublished{TitovHumeniukMitric2020,
  author    = {Titov, Evgenii and Humeniuk, Alexander and Mitric, Roland},
  title     = {Comparison of moving and fixed basis sets for nonadiabatic quantum dynamics at conical intersections},
  series = {Chemical Physics},
  journal   = {Chemical Physics},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-199225},
  year      = {2020},
  abstract  = {We assess the performance of two different types of basis sets for nonadiabatic quantum dynamics at conical intersections. The basis sets of both types are generated using Ehrenfest trajectories of nuclear coherent states. These trajectories can either serve as a moving (time-dependent) basis or be employed to sample a fixed (time-independent) basis. We demonstrate on the example of two-state two-dimensional and three-state five-dimensional models that both basis set types can yield highly accurate results for population transfer at intersections, as compared with reference quantum dynamics. The details of wave packet evolutions are discussed for the case of the two-dimensional model. The fixed basis is found to be superior to the moving one in reproducing nonlocal spreading and maintaining correct shape of the wave packet upon time evolution. Moreover, for the models considered, the fixed basis set outperforms the moving one in terms of computational efficiency.},
  language  = {en}
}
@phdthesis{Redlich2020,
  author    = {Redlich, Sarah},
  title     = {Opportunities and obstacles of ecological intensification: Biological pest control in arable cropping systems},
  doi       = {10.25972/OPUS-17122},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171228},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2020},
  abstract  = {Modern agriculture is the basis of human existence, a blessing, but also a curse. It provides nourishment and well-being to the ever-growing human population, yet destroys biodiversity-mediated processes that underpin productivity: ecosystem services such as water filtration, pollination and biological pest control. Ecological intensification is a promising alternative to conventional farming, and aims to sustain yield and ecosystem health by actively managing biodiversity and essential ecosystem services. Here, I investigate opportunities and obstacles for ecological intensification. My research focuses on 1) the relative importance of soil, management and landscape variables for biodiversity and wheat yield (Chapter II); 2) the influence of multi-scale landscape-level crop diversity on biological pest control in wheat (Chapter III) and 3) on overall and functional bird diversity (Chapter IV). I conclude 4) by introducing a guide that helps scientists to increase research impact by acknowledging the role of stakeholder engagement for the successful implementation of ecological intensification (Chapter V). Ecological intensification relies on the identification of natural pathways that are able to sustain current yields. Here, we crossed an observational field study of arthropod pests and natural enemies in 28 real-life wheat systems with an orthogonal on-field insecticide-fertilizer experiment. Using path analysis, we quantified the effect of 34 factors (soil characteristics, recent and historic crop management, landscape heterogeneity) that directly or indirectly (via predator-prey interactions) contribute to winter wheat yield. Reduced soil preparation and high crop rotation diversity enhanced crop productivity independent of external agrochemical inputs. Concurrently, biological control by arthropod natural enemies could be restored by decreasing average field sizes on the landscape scale, extending crop rotations and reducing soil disturbance. Furthermore, reductions in agrochemical inputs decreased pest abundances, thereby facilitating yield quality. Landscape-level crop diversity is a promising tool for ecological intensification. However, biodiversity enhancement via diversification measures does not always translate into agricultural benefits due to antagonistic species interactions (intraguild predation). Additionally, positive effects of crop diversity on biological control may be masked by inappropriate study scales or correlations with other landscape variables (e.g. seminatural habitat). Therefore, the multiscale and context-dependent impact of crop diversity on biodiversity and ecosystem services is ambiguous. In 18 winter wheat fields along a crop diversity gradient, insect- and bird-mediated pest control was assessed using a natural enemy exclusion experiment with cereal grain aphids. Although birds did not influence the strength of insect-mediated pest control, crop diversity (rather than seminatural habitat cover) enhanced aphid regulation by up to 33\%, particularly on small spatial scales. Crop diversification, an important Greening measure in the European Common Agricultural Policy, can improve biological control, and could lower dependence on insecticides, if the functional identity of crops is taken into account. Simple measures such as 'effective number of crop types' help in science communication. Although avian pest control did not respond to landscape-level crop diversity, birds may still benefit from increased crop resources in the landscape, depending on their functional grouping (feeding guild, conservation status, habitat preference, nesting behaviour). Observational studies of bird functional diversity on 14 wheat study fields showed that non-crop landscape heterogeneity rather than crop diversity played a key role in determining the richness of all birds. Insect-feeding, non-farmland and non-threatened birds increased across multiple spatial scales (up to 3000 m). Only crop-nesting farmland birds declined in heterogeneous landscapes. Thus, crop diversification may be less suitable for conserving avian diversity, but abundant species benefit from overall habitat heterogeneity. Specialist farmland birds may require more targeted management approaches. Identifying ecological pathways that favour biodiversity and ecosystem services provides opportunities for ecological intensification that increase the likelihood of balancing conservation and productivity goals. However, change towards a more sustainable agriculture will be slow to come if research findings are not implemented on a global scale. During dissemination activities within the EU project Liberation, I gathered information on the advantages and shortcomings of ecological intensification and its implementation. Here, I introduce a guide ('TREE') aimed at scientists that want to increase the impact of their research. TREE emphasizes the need to engage with stakeholders throughout the planning and research process, and actively seek and promote science dissemination and knowledge implementation. This idea requires scientists to leave their comfort zone and consider socioeconomic, practical and legal aspects often ignored in classical research. Ecological intensification is a valuable instrument for sustainable agriculture. Here, I identified new pathways that facilitate ecological intensification. Soil quality, disturbance levels and spatial or temporal crop diversification showed strong positive correlations with natural enemies, biological pest control and yield, thereby lowering the dependence on agrochemical inputs. Differences between functional groups caused opposing, scale-specific responses to landscape variables. Opposed to our predictions, birds did not disturb insect-mediated pest control in our study system, nor did avian richness relate to landscape-level crop diversity. However, dominant functional bird groups increased with non-crop landscape heterogeneity. These findings highlight the value of combining different on-field and landscape approaches to ecological intensification. Concurrently, the success of ecological intensification can be increased by involving stakeholders throughout the research process. This increases the quality of science and reduces the chance of experiencing unscalable obstacles to implementation.},
  language  = {en}
}
@article{RonaldHoebartner2020,
  author    = {Ronald, Micura and H{\"o}bartner, Claudia},
  title     = {Fundamental studies of functional nucleic acids: aptamers, riboswitches, ribozymes and DNAzymes},
  series = {Chemical Society Reviews},
  journal   = {Chemical Society Reviews},
  edition   = {Advance Article},
  doi       = {10.1039/D0CS00617C},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-212133},
  year      = {2020},
  abstract  = {This review aims at juxtaposing common versus distinct structural and functional strategies that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently discovered systems, we begin our analysis with small-molecule binding aptamers, with emphasis on in vitro-selected fluorogenic RNA aptamers and their different modes of ligand binding and fluorescence activation. Fundamental insights are much needed to advance RNA imaging probes for detection of exo- and endogenous RNA and for RNA process tracking. Secondly, we discuss the latest gene expression-regulating mRNA riboswitches that respond to the alarmone ppGpp, to PRPP, to NAD+, to adenosine and cytidine diphosphates, and to precursors of thiamine biosynthesis (HMP-PP), and we outline new subclasses of SAM and tetrahydrofolate-binding RNA regulators. Many riboswitches bind protein enzyme cofactors that, in principle, can catalyse a chemical reaction. For RNA, however, only one system (glmS ribozyme) has been identified in Nature thus far that utilizes a small molecule - glucosamine-6-phosphate - to participate directly in reaction catalysis (phosphodiester cleavage). We wonder why that is the case and what is to be done to reveal such likely existing cellular activities that could be more diverse than currently imagined. Thirdly, this brings us to the four latest small nucleolytic ribozymes termed twister, twister-sister, pistol, and hatchet as well as to in vitro selected DNA and RNA enzymes that promote new chemistry, mainly by exploiting their ability for RNA labelling and nucleoside modification recognition. Enormous progress in understanding the strategies of nucleic acids catalysts has been made by providing thorough structural fundaments (e.g. first structure of a DNAzyme, structures of ribozyme transition state mimics) in combination with functional assays and atomic mutagenesis.},
  language  = {en}
}
@article{MezaChinchaLindnerSchindleretal.2020,
  author    = {Meza-Chincha, Ana-Lucia and Lindner, Joachim O. and Schindler, Dorothee and Schmidt, David and Krause, Ana-Maria and R{\"o}hr, Merle I. S. and Mitrić, Roland and W{\"u}rthner, Frank},
  title     = {Impact of substituents on molecular properties and catalytic activities of trinuclear Ru macrocycles in water oxidation},
  issn      = {2041-6539},
  doi       = {10.1039/d0sc01097a},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-204653},
  year      = {2020},
  abstract  = {Herein we report a broad series of new trinuclear supramolecular Ru(bda) macrocycles bearing different substituents at the axial or equatorial ligands which enabled investigation of substituent effects on the catalytic activities in chemical and photocatalytic water oxidation. Our detailed investigations revealed that the activities of these functionalized macrocycles in water oxidation are significantly affected by the position at which the substituents were introduced. Interestingly, this effect could not be explained based on the redox properties of the catalysts since these are not markedly influenced by the functionalization of the ligands. Instead, detailed investigations by X-ray crystal structure analysis and theoretical simulations showed that conformational changes imparted by the substituents are responsible for the variation of catalytic activities of the Ru macrocycles. For the first time, macrocyclic structure of this class of water oxidation catalysts is unequivocally confirmed and experimental indication for a hydrogen-bonded water network present in the cavity of the macrocycles is provided by crystal structure analysis. We ascribe the high catalytic efficiency of our Ru(bda) macrocycles to cooperative proton abstractions facilitated by such a network of preorganized water molecules in their cavity, which is reminiscent of catalytic activities of enzymes at active sites.},
  language  = {en}
}
@unpublished{HermannArrowsmithTrujilloGonzalezetal.2020,
  author    = {Hermann, Alexander and Arrowsmith, Merle and Trujillo-Gonzalez, Daniel and Jim{\´e}nez-Halla, J. Oscar C. and Vargas, Alfredo and Braunschweig, Holger},
  title     = {Trapping of a Borirane Intermediate in the Reductive Coupling of an Arylborane to a Diborene},
  series = {Journal of the American Chemical Society},
  journal   = {Journal of the American Chemical Society},
  doi       = {10.1021/jacs.0c02306},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-203140},
  year      = {2020},
  abstract  = {The reductive coupling of an NHC-stabilized aryldibromoborane yields a mixture of trans- and cis-diborenes in which the aryl groups are coplanar with the diborene core. Under dilute reduction conditions two diastereomers of a borirane-borane intermediate are isolated, which upon further reduction give rise to the aforementioned diborene mixture. DFT calculations suggest a mechanism proceeding via nucleophilic attack of a dicoordinate borylene intermediate on the aryl ring and subsequent intramolecular B-B bond formation.},
  language  = {en}
}
@unpublished{ScheitlGhaemMaghamiLenzetal.2020,
  author    = {Scheitl, Carolin P.M. and Ghaem Maghami, Mohammad and Lenz, Ann-Kathrin and H{\"o}bartner, Claudia},
  title     = {Site-specific RNA methylation by a methyltransferase ribozyme},
  series = {Nature},
  journal   = {Nature},
  doi       = {10.1038/s41586-020-2854-z},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218687},
  year      = {2020},
  abstract  = {Nearly all classes of coding and non-coding RNA undergo post-transcriptional modification including RNA methylation. Methylated nucleotides belong to the evolutionarily most conserved features of tRNA and rRNA.1,2 Many contemporary methyltransferases use the universal cofactor S-adenosylmethionine (SAM) as methyl group donor. This and other nucleotide-derived cofactors are considered as evolutionary leftovers from an RNA World, in which ribozymes may have catalysed essential metabolic reactions beyond self-replication.3 Chemically diverse ribozymes seem to have been lost in Nature, but may be reconstructed in the laboratory by in vitro selection. Here, we report a methyltransferase ribozyme that catalyses the site-specific installation of 1-methyladenosine (m1A) in a substrate RNA, utilizing O6-methylguanine (m6G) as a small-molecule cofactor. The ribozyme shows a broad RNA sequence scope, as exemplified by site-specific adenosine methylation in tRNAs. This finding provides fundamental insights into RNA's catalytic abilities, serves a synthetic tool to install m1A in RNA, and may pave the way to in vitro evolution of other methyltransferase and demethylase ribozymes.},
  language  = {en}
}
@article{ZhouRascheKortuemetal.2020,
  author    = {Zhou, Xiang and Rasche, Leo and Kort{\"u}m, K. Martin and Danhof, Sophia and Hudecek, Michael and Einsele, Hermann},
  title     = {Toxicities of Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma: An Overview of Experience From Clinical Trials, Pathophysiology, and Management Strategies},
  series = {Frontiers in Immunology},
  volume    = {11},
  journal   = {Frontiers in Immunology},
  issn      = {1664-3224},
  doi       = {10.3389/fimmu.2020.620312},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-219911},
  year      = {2020},
  abstract  = {In the last few years, monoclonal antibodies (mAbs) such as elotuzumab and daratutumab have brought the treatment of multiple myeloma (MM) into the new era of immunotherapy. More recently, chimeric antigen receptor (CAR) modified T cell, a novel cellular immunotherapy, has been developed for treatment of relapsed/refractory (RR) MM, and early phase clinical trials have shown promising efficacy of CAR T cell therapy. Many patients with end stage RRMM regard CAR T cell therapy as their "last chance" and a "hope of cure". However, severe adverse events (AEs) and even toxic death related to CAR T cell therapy have been observed. The management of AEs related to CAR T cell therapy represents a new challenge, as the pathophysiology is not fully understood and there is still no well-established standard of management. With regard to CAR T cell associated toxicities in MM, in this review, we will provide an overview of experience from clinical trials, pathophysiology, and management strategies.},
  language  = {en}
}
@article{StennettJayaramanBrueckneretal.2020,
  author    = {Stennett, Tom E. and Jayaraman, Arumugam and Br{\"u}ckner, Tobias and Schneider, Lea and Braunschweig, Holger},
  title     = {Hydrophosphination of boron-boron multiple bonds},
  series = {Chemical Science},
  volume    = {11},
  journal   = {Chemical Science},
  doi       = {10.1039/c9sc05908c},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-240681},
  pages     = {1335-1341},
  year      = {2020},
  abstract  = {Five compounds containing boron-boron multiple bonds are shown to undergo hydrophosphination reactions with diphenylphosphine in the absence of a catalyst. With diborenes, the products obtained are highly dependent on the substitution pattern at the boron atoms, with both 1,1- and 1,2- hydrophosphinations observed. With a symmetrical diboryne, 1,2-hydrophosphination yields a hydro(phosphino)diborene. The different mechanistic pathways for the hydrophosphination of diborenes are rationalised with the aid of density functional theory calculations.},
  language  = {en}
}
@unpublished{SchmidtFantuzziArrowsmithetal.2020,
  author    = {Schmidt, Uwe and Fantuzzi, Felipe and Arrowsmith, Merle and Hermann, Alexander and Prieschl, Dominic and Rempel, Anna and Engels, Bernd and Braunschweig, Holger},
  title     = {Tuneable reduction of cymantrenylboranes to diborenes or borylene-derived boratafulvenes},
  series = {Chemical Communications},
  journal   = {Chemical Communications},
  doi       = {10.1039/D0CC06398C},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-222149},
  year      = {2020},
  abstract  = {Whereas the reduction of N-heterocyclic carbene (NHC)-stabilised cymantrenyldibromoboranes, (NHC)BBr\(_2\)Cym, in benzene results in formation of the corresponding diborenes (NHC)\(_2\)B\(_2\)Cym\(_2\), a change of solvent to THF yields a borylene of the form (NHC)\(_2\)BCym, stabilised through its boratafulvene resonance form.},
  language  = {en}
}
@article{LiuLegareSeufertetal.2020,
  author    = {Liu, Siyuan and L{\´e}gar{\´e}, Marc-Andr{\´e} and Seufert, Jens and Prieschl, Dominic and Rempel, Anna and Englert, Lukas and Dellermann, Theresa and Paprocki, Valerie and Stoy, Andreas and Braunschweig, Holger},
  title     = {2,2′-Bipyridyl as a Redox-Active Borylene Abstraction Agent},
  series = {Inorganic Chemistry},
  volume    = {59},
  journal   = {Inorganic Chemistry},
  number    = {15},
  doi       = {10.1021/acs.inorgchem.0c01383},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-215595},
  pages     = {10866-10873},
  year      = {2020},
  abstract  = {2,2′-Bipyridyl is shown to spontaneously abstract a borylene fragment (R-B:) from various hypovalent boron compounds. This process is a redox reaction in which the bipyridine is reduced and becomes a dianionic substituent bound to boron through its two nitrogen atoms. Various transition metal-borylene complexes and diboranes, as a well as a diborene, take part in this reaction. In the latter case, our results show an intriguing example of the homolytic cleavage of a B═B double bond.},
  language  = {en}
}
@article{TylekBlumHrynevichetal.2020,
  author    = {Tylek, Tina and Blum, Carina and Hrynevich, Andrei and Schlegelmilch, Katrin and Schilling, Tatjana and Dalton, Paul D and Groll, J{\"u}rgen},
  title     = {Precisely defined fiber scaffolds with 40 μm porosity induce elongation driven M2-like polarization of human macrophages},
  series = {Biofabrication},
  volume    = {12},
  journal   = {Biofabrication},
  number    = {2},
  doi       = {10.1088/1758-5090/ab5f4e},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-254012},
  year      = {2020},
  abstract  = {Macrophages are key players of the innate immune system that can roughly be divided into the pro-inflammatory M1 type and the anti-inflammatory, pro-healing M2 type. While a transient initial pro-inflammatory state is helpful, a prolonged inflammation deteriorates a proper healing and subsequent regeneration. One promising strategy to drive macrophage polarization by biomaterials is precise control over biomaterial geometry. For regenerative approaches, it is of particular interest to identify geometrical parameters that direct human macrophage polarization. For this purpose, we advanced melt electrowriting (MEW) towards the fabrication of fibrous scaffolds with box-shaped pores and precise inter-fiber spacing from 100 μm down to only 40 μm. These scaffolds facilitate primary human macrophage elongation accompanied by differentiation towards the M2 type, which was most pronounced for the smallest pore size of 40 μm. These new findings can be important in helping to design new biomaterials with an enhanced positive impact on tissue regeneration.},
  language  = {en}
}
@article{GrimmWeberKittelSchneideretal.2020,
  author    = {Grimm, Oliver and Weber, Heike and Kittel-Schneider, Sarah and Kranz, Thorsten M. and Jacob, Christian P. and Lesch, Klaus-Peter and Reif, Andreas},
  title     = {Impulsivity and Venturesomeness in an Adult ADHD Sample: Relation to Personality, Comorbidity, and Polygenic Risk},
  series = {Frontiers in Psychiatry},
  volume    = {11},
  journal   = {Frontiers in Psychiatry},
  issn      = {1664-0640},
  doi       = {10.3389/fpsyt.2020.557160},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-219751},
  year      = {2020},
  abstract  = {While impulsivity is a basic feature of attention-deficit/hyperactivity disorder (ADHD), no study explored the effect of different components of the Impulsiveness (Imp) and Venturesomeness (Vent) scale (IV7) on psychiatric comorbidities and an ADHD polygenic risk score (PRS). We used the IV7 self-report scale in an adult ADHD sample of 903 patients, 70\% suffering from additional comorbid disorders, and in a subsample of 435 genotyped patients. Venturesomeness, unlike immediate Impulsivity, is not specific to ADHD. We consequently analyzed the influence of Imp and Vent also in the context of a PRS on psychiatric comorbidities of ADHD. Vent shows a distinctly different distribution of comorbidities, e.g., less anxiety and depression. PRS showed no effect on different ADHD comorbidities, but correlated with childhood hyperactivity. In a complementary analysis using principal component analysis with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition ADHD criteria, revised NEO Personality Inventory, Imp, Vent, and PRS, we identified three ADHD subtypes. These are an impulsive-neurotic type, an adventurous-hyperactive type with a stronger genetic component, and an anxious-inattentive type. Our study thus suggests the importance of adventurousness and the differential consideration of impulsivity in ADHD. The genetic risk is distributed differently between these subtypes, which underlines the importance of clinically motivated subtyping. Impulsivity subtyping might give insights into the organization of comorbid disorders in ADHD and different genetic background.},
  language  = {en}
}
@article{EwingDellermannAngelWongetal.2020,
  author    = {Ewing, William C. and Dellermann, Theresa and Angel Wong, Y. T. and Mattock, James D. and Vargas, Alfredo and Bryce, David L. and Dewhurst, Rian D. and Braunschweig, Holger},
  title     = {\(\pi\)-Complexes of Diborynes with Main Group Atoms},
  series = {Chemistry - An Asian Journal},
  volume    = {15},
  journal   = {Chemistry - An Asian Journal},
  number    = {10},
  doi       = {10.1002/asia.202000185},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214677},
  pages     = {1553 -- 1557},
  year      = {2020},
  abstract  = {We present herein an in-depth study of complexes in which a molecule containing a boron-boron triple bond is bound to tellurate cations. The analysis allows the description of these salts as true π complexes between the B-B triple bond and the tellurium center. These complexes thus extend the well-known Dewar-Chatt-Duncanson model of bonding to compounds made up solely of p block elements. Structural, spectroscopic and computational evidence is offered to argue that a set of recently reported heterocycles consisting of phenyltellurium cations complexed to diborynes bear all the hallmarks of \(\pi\)-complexes in the \(\pi\)-complex/metallacycle continuum envisioned by Joseph Chatt. Described as such, these compounds are unique in representing the extreme of a metal-free continuum with conventional unsaturated three-membered rings (cyclopropenes, azirenes, borirenes) occupying the opposite end.},
  language  = {en}
}
@article{BeerHelfrichFoerster2020,
  author    = {Beer, Katharina and Helfrich-F{\"o}rster, Charlotte},
  title     = {Model and Non-model Insects in Chronobiology},
  series = {Frontiers in Behavioral Neuroscience},
  volume    = {14},
  journal   = {Frontiers in Behavioral Neuroscience},
  issn      = {1662-5153},
  doi       = {10.3389/fnbeh.2020.601676},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218721},
  year      = {2020},
  abstract  = {The fruit fly Drosophila melanogaster is an established model organism in chronobiology, because genetic manipulation and breeding in the laboratory are easy. The circadian clock neuroanatomy in D. melanogaster is one of the best-known clock networks in insects and basic circadian behavior has been characterized in detail in this insect. Another model in chronobiology is the honey bee Apis mellifera, of which diurnal foraging behavior has been described already in the early twentieth century. A. mellifera hallmarks the research on the interplay between the clock and sociality and complex behaviors like sun compass navigation and time-place-learning. Nevertheless, there are aspects of clock structure and function, like for example the role of the clock in photoperiodism and diapause, which can be only insufficiently investigated in these two models. Unlike high-latitude flies such as Chymomyza costata or D. ezoana, cosmopolitan D. melanogaster flies do not display a photoperiodic diapause. Similarly, A. mellifera bees do not go into "real" diapause, but most solitary bee species exhibit an obligatory diapause. Furthermore, sociality evolved in different Hymenoptera independently, wherefore it might be misleading to study the social clock only in one social insect. Consequently, additional research on non-model insects is required to understand the circadian clock in Diptera and Hymenoptera. In this review, we introduce the two chronobiology model insects D. melanogaster and A. mellifera, compare them with other insects and show their advantages and limitations as general models for insect circadian clocks.},
  language  = {en}
}
@article{KramerBangertSchilling2020,
  author    = {Kramer, Alexander and Bangert, Philip and Schilling, Klaus},
  title     = {UWE-4: First Electric Propulsion on a 1U CubeSat — In-Orbit Experiments and Characterization},
  series = {Aerospace},
  volume    = {7},
  journal   = {Aerospace},
  number    = {7},
  doi       = {10.3390/aerospace7070098},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-236124},
  year      = {2020},
  abstract  = {The electric propulsion system NanoFEEP was integrated and tested in orbit on the UWE-4 satellite, which marks the first successful demonstration of an electric propulsion system on board a 1U CubeSat. In-orbit characterization measurements of the heating process of the propellant and the power consumption of the propulsion system at different thrust levels are presented. Furthermore, an analysis of the thrust vector direction based on its effect on the attitude of the spacecraft is described. The employed heater liquefies the propellant for a duration of 30 min per orbit and consumes 103 ± 4 mW. During this time, the respective thruster can be activated. The propulsion system including one thruster head, its corresponding heater, the neutralizer and the digital components of the power processing unit consume 8.5 ± 0.1 mW ⋅μ A\(^{-1}\) + 184 ± 8.5 mW and scales with the emitter current. The estimated thrust directions of two thruster heads are at angles of 15.7 ± 7.6∘ and 13.2 ± 5.5∘ relative to their mounting direction in the CubeSat structure. In light of the very limited power on a 1U CubeSat, the NanoFEEP propulsion system renders a very viable option. The heater of subsequent NanoFEEP thrusters was already improved, such that the system can be activated during the whole orbit period.},
  language  = {en}
}
@article{SanchezMaldonadoMonizDiezterHorstetal.2020,
  author    = {S{\´a}nchez-Maldonado, Jose Manuel and Mo{\~n}iz-D{\´i}ez, Ana and ter Horst, Rob and Campa, Daniele and Cabrera-Serrano, Antonio Jos{\´e} and Mart{\´i}nez-Bueno, Manuel and Garrido-Collado, Mar{\´i}a del Pilar and Hern{\´a}ndez-Mohedo, Francisca and Fern{\´a}ndez-Puerta, Laura and L{\´o}pez-Nevot, Miguel {\´A}ngel and Cunha, Cristina and Gonz{\´a}lez-Sierra, Pedro Antonio and Springer, Jan and Lackner, Michaela and Alcazar-Fuoli, Laura and Fianchi, Luana and Aguado, Jos{\´e} Mar{\´i}a and Pagano, Livio and L{\´o}pez-Fern{\´a}ndez, Elisa and Clavero, Esther and Potenza, Leonardo and Luppi, Mario and Moratalla, Lucia and Solano, Carlos and Sampedro, Antonio and Cuenca-Estrella, Manuel and Lass-Fl{\"o}rl, Cornelia and Canzian, Federico and Loeffler, Juergen and Li, Yang and Einsele, Hermann and Netea, Mihai G. and V{\´a}zquez, Lourdes and Carvalho, Agostinho and Jurado, Manuel and Sainz, Juan},
  title     = {Polymorphisms within the TNFSF4 and MAPKAPK2 loci influence the risk of developing invasive aspergillosis: a two-stage case control study in the context of the aspBIOmics consortium},
  series = {Journal of Fungi},
  volume    = {7},
  journal   = {Journal of Fungi},
  number    = {1},
  issn      = {2309-608X},
  doi       = {10.3390/jof7010004},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220107},
  year      = {2020},
  abstract  = {Here, we assessed whether 36 single nucleotide polymorphisms (SNPs) within the TNFSF4 and MAPKAPK2 loci influence the risk of developing invasive aspergillosis (IA). We conducted a two-stage case control study including 911 high-risk patients diagnosed with hematological malignancies that were ascertained through the aspBIOmics consortium. The meta-analysis of the discovery and replication populations revealed that carriers of the TNFSF4\(_{rs7526628T/T}\) genotype had a significantly increased risk of developing IA (p = 0.00022). We also found that carriers of the TNFSF4\(_{rs7526628T}\) allele showed decreased serum levels of TNFSF14 protein (p = 0.0027), and that their macrophages had a decreased fungicidal activity (p = 0.048). In addition, we observed that each copy of the MAPKAPK2\(_{rs12137965G}\) allele increased the risk of IA by 60\% (p = 0.0017), whereas each copy of the MAPKAPK2\(_{rs17013271T}\) allele was estimated to decrease the risk of developing the disease (p = 0.0029). Mechanistically, we found that carriers of the risk MAPKAPK2\(_{rs12137965G}\) allele showed increased numbers of CD38+IgM-IgD- plasmablasts in blood (p = 0.00086), whereas those harboring two copies of the allele had decreased serum concentrations of thymic stromal lymphopoietin (p = 0.00097). Finally, we also found that carriers of the protective MAPKAPK2\(_{rs17013271T}\) allele had decreased numbers of CD27-IgM-IgD- B cells (p = 0.00087) and significantly lower numbers of CD14+ and CD14+CD16- cells (p = 0.00018 and 0.00023). Altogether, these results suggest a role of the TNFSF4 and MAPKAPK2 genes in determining IA risk.},
  language  = {en}
}
@article{PalladinoChiocchettiFranketal.2020,
  author    = {Palladino, Viola Stella and Chiocchetti, Andreas G. and Frank, Lukas and Haslinger, Denise and McNeill, Rhiannon and Radtke, Franziska and Till, Andreas and Haupt, Simone and Br{\"u}stle, Oliver and G{\"u}nther, Katharina and Edenhofer, Frank and Hoffmann, Per and Reif, Andreas and Kittel-Schneider, Sarah},
  title     = {Energy metabolism disturbances in cell models of PARK2 CNV carriers with ADHD},
  series = {Journal of Clinical Medicine},
  volume    = {9},
  journal   = {Journal of Clinical Medicine},
  number    = {12},
  issn      = {2077-0383},
  doi       = {10.3390/jcm9124092},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220074},
  year      = {2020},
  abstract  = {The main goal of the present study was the identification of cellular phenotypes in attention-deficit-/hyperactivity disorder (ADHD) patient-derived cellular models from carriers of rare copy number variants (CNVs) in the PARK2 locus that have been previously associated with ADHD. Human-derived fibroblasts (HDF) were cultured and human-induced pluripotent stem cells (hiPSC) were reprogrammed and differentiated into dopaminergic neuronal cells (mDANs). A series of assays in baseline condition and in different stress paradigms (nutrient deprivation, carbonyl cyanide m-chlorophenyl hydrazine (CCCP)) focusing on mitochondrial function and energy metabolism (ATP production, basal oxygen consumption rates, reactive oxygen species (ROS) abundance) were performed and changes in mitochondrial network morphology evaluated. We found changes in PARK2 CNV deletion and duplication carriers with ADHD in PARK2 gene and protein expression, ATP production and basal oxygen consumption rates compared to healthy and ADHD wildtype control cell lines, partly differing between HDF and mDANs and to some extent enhanced in stress paradigms. The generation of ROS was not influenced by the genotype. Our preliminary work suggests an energy impairment in HDF and mDAN cells of PARK2 CNV deletion and duplication carriers with ADHD. The energy impairment could be associated with the role of PARK2 dysregulation in mitochondrial dynamics.},
  language  = {en}
}
@article{BaaderKianiBrunkhorstKanaanetal.2020,
  author    = {Baader, Anna and Kiani, Behnaz and Brunkhorst-Kanaan, Nathalie and Kittel-Schneider, Sarah and Reif, Andreas and Grimm, Oliver},
  title     = {A within-sample comparison of two innovative neuropsychological tests for assessing ADHD},
  series = {Brain Sciences},
  volume    = {11},
  journal   = {Brain Sciences},
  number    = {1},
  issn      = {2076-3425},
  doi       = {10.3390/brainsci11010036},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-220089},
  year      = {2020},
  abstract  = {New innovative neuropsychological tests in attention deficit hyperactivity disorder ADHD have been proposed as objective measures for diagnosis and therapy. The current study aims to investigate two different commercial continuous performance tests (CPT) in a head-to-head comparison regarding their comparability and their link with clinical parameters. The CPTs were evaluated in a clinical sample of 29 adult patients presenting in an ADHD outpatient clinic. Correlational analyses were performed between neuropsychological data, clinical rating scales, and a personality-based measure. Though inattention was found to positively correlate between the two tests (r = 0.49, p = 0.01), no association with clinical measures and inattention was found for both tests. While hyperactivity did not correlate between both tests, current ADHD symptoms were positively associated with Nesplora Aquarium's motor activity (r = 0.52 to 0.61, p < 0.05) and the Qb-Test's hyperactivity (r = 0.52 to 0.71, p < 0.05). Conclusively, the overall comparability of the tests was limited and correlation with clinical parameters was low. While our study shows some interesting correlation between clinical symptoms and sub-scales of these tests, usage in clinical practice is not recommended.},
  language  = {en}
}
@article{VeniaminovaCespuglioChernukhaetal.2020,
  author    = {Veniaminova, Ekaterina and Cespuglio, Raymond and Chernukha, Irina and Schmitt-Boehrer, Angelika G. and Morozov, Sergey and Kalueff, Allan V. and Kuznetsova, Oxana and Anthony, Daniel C. and Lesch, Klaus-Peter and Strekalova, Tatyana},
  title     = {Metabolic, Molecular, and Behavioral Effects of Western Diet in Serotonin Transporter-Deficient Mice: Rescue by Heterozygosity?},
  series = {Frontiers in Neuroscience},
  volume    = {14},
  journal   = {Frontiers in Neuroscience},
  issn      = {1662-453X},
  doi       = {10.3389/fnins.2020.00024},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-199813},
  year      = {2020},
  abstract  = {Reduced function of the serotonin transporter (SERT) is associated with increased susceptibility to anxiety and depression and with type-2 diabetes, which is especially true in older women. Preference for a "Western diet" (WD), enriched with saturated fat, cholesterol, and sugars, may aggravate these conditions. In previous studies, decreased glucose tolerance, central and peripheral inflammation, dyslipidemia, emotional, cognitive, and social abnormalities were reported in WD-fed young female mice. We investigated the metabolic, molecular, and behavioral changes associated with a 3-week-long dietary regime of either the WD or control diet in 12-month-old female mice with three different Sert genotypes: homozygous (Slc6a4) gene knockout (Sert\(^{-/-}\): KO), heterozygous (Sert\(^{+/-}\): HET), or wild-type mice (Sert\(^{+/+}\): WT). In the WT-WD and KO-WD groups, but not in HET-WD-fed mice, most of changes induced by the WD paralleled those found in the younger mice, including brain overexpression of inflammatory marker Toll-like receptor 4 (Tlr4) and impaired hippocampus-dependent performance in the marble test. However, the 12-month-old female mice became obese. Control diet KO mice exhibited impaired hippocampal-dependent behaviors, increased brain expression of the serotonin receptors Htr2c and Htr1b, as well as increased Tlr4 and mitochondrial regulator, peroxisome proliferator-activated receptor gamma-coactivator-1a (Ppargc1a). Paradoxically, these, and other changes, were reversed in KO-WD mutants, suggesting a complex interplay between Sert deficiency and metabolic factors as well as potential compensatory molecular mechanisms that might be disrupted by the WD exposure. Most, but not all, of the changes in gene expression in the brain and liver of KO mice were not exhibited by the HET mice fed with either diet. Some of the WD-induced changes were similar in the KO-WD and HET-WD-fed mice, but the latter displayed a "rescued" phenotype in terms of diet-induced abnormalities in glucose tolerance, neuroinflammation, and hippocampus-dependent performance. Thus, complete versus partial Sert inactivation in aged mice results in distinct metabolic, molecular, and behavioral consequences in response to the WD. Our findings show that Sert\(^{+/-}\) mice are resilient to certain environmental challenges and support the concept of heterosis as evolutionary adaptive mechanism.},
  language  = {en}
}
@article{FrischholzBerberichBoecketal.2020,
  author    = {Frischholz, Sebastian and Berberich, Oliver and B{\"o}ck, Thomas and Meffert, Rainer H. and Blunk, Torsten},
  title     = {Resveratrol counteracts IL-1β-mediated impairment of extracellular matrix deposition in 3D articular chondrocyte constructs},
  series = {Journal of Tissue Engineering and Regenerative Medicine},
  volume    = {14},
  journal   = {Journal of Tissue Engineering and Regenerative Medicine},
  number    = {7},
  doi       = {10.1002/term.3031},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-215471},
  pages     = {897 -- 908},
  year      = {2020},
  abstract  = {When aiming at cell-based therapies in osteoarthritis (OA), proinflammatory conditions mediated by cytokines such as IL-1β need to be considered. In recent studies, the phytoalexin resveratrol (RSV) has exhibited potent anti-inflammatory properties. However, long-term effects on 3D cartilaginous constructs under inflammatory conditions with regard to tissue quality, especially extracellular matrix (ECM) composition, have remained unexplored. Therefore, we employed long-term model cultures for cell-based therapies in an in vitro OA environment and evaluated effects of RSV. Pellet constructs made from expanded porcine articular chondrocytes were cultured with either IL-1β (1-10 ng/ml) or RSV (50 μM) alone, or a cotreatment with both agents. Treatments were applied for 14 days, either directly after pellet formation or after a preculture period of 7 days. Culture with IL-1β (10 ng/ml) decreased pellet size and DNA amount and severely compromised glycosaminoglycan (GAG) and collagen content. Cotreatment with RSV distinctly counteracted the proinflammatory catabolism and led to partial rescue of the ECM composition in both culture systems, with especially strong effects on GAG. Marked MMP13 expression was detected in IL-1β-treated pellets, but none upon RSV cotreatment. Expression of collagen type I was increased upon IL-1β treatment and still observed when adding RSV, whereas collagen type X, indicating hypertrophy, was detected exclusively in pellets treated with RSV alone. In conclusion, RSV can counteract IL-1β-mediated degradation and distinctly improve cartilaginous ECM deposition in 3D long-term inflammatory cultures. Nevertheless, potential hypertrophic effects should be taken into account when considering RSV as cotreatment for articular cartilage repair techniques.},
  language  = {en}
}
@article{SteinmetzgerBaeuerleinHoebartner2020,
  author    = {Steinmetzger, Christian and B{\"a}uerlein, Carmen and H{\"o}bartner, Claudia},
  title     = {Supramolecular fluorescence resonance energy transfer in nucleobase-modified fluorogenic RNA aptamers},
  series = {Angewandte Chemie, International Edition},
  volume    = {59},
  journal   = {Angewandte Chemie, International Edition},
  doi       = {10.1002/anie.201916707},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-203084},
  pages     = {6760-6764},
  year      = {2020},
  abstract  = {RNA aptamers form compact tertiary structures and bind their ligands in specific binding sites. Fluorescence-based strategies reveal information on structure and dynamics of RNA aptamers. Here we report the incorporation of the universal emissive nucleobase analog 4-cyanoindole into the fluorogenic RNA aptamer Chili, and its application as a donor for supramolecular FRET to bound ligands DMHBI+ or DMHBO+. The photophysical properties of the new nucleobase-ligand-FRET pair revealed structural restraints for the overall RNA aptamer organization and identified nucleotide positions suitable for FRET-based readout of ligand binding. This strategy is generally suitable for binding site mapping and may also be applied for responsive aptamer devices.},
  language  = {en}
}
@article{ConstantinescuPascaZimtaetal.2020,
  author    = {Constantinescu, Catalin and Pasca, Sergiu and Zimta, Alina-Andreea and Tat, Tiberiu and Rus, Ioana and Teodorescu, Patric and Iluta, Sabina and Tanase, Alina and Colita, Anca and Sigurjonsson, Olafur and Einsele, Hermann and Tomuleasa, Ciprian},
  title     = {Overview of the side-effects of FDA- and/or EMA-approved targeted therapies for the treatment of hematological malignancies},
  series = {Journal of Clinical Medicine},
  volume    = {9},
  journal   = {Journal of Clinical Medicine},
  number    = {9},
  issn      = {2077-0383},
  doi       = {10.3390/jcm9092903},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-213020},
  year      = {2020},
  abstract  = {In the last decade there has been tremendous effort in offering better therapeutic management strategies to patients with hematologic malignancies. These efforts have ranged from biological to clinical approaches and resulted in the rapid development of new approaches. The main "problem" that comes with the high influx of newly approved drugs, which not only influences hematologists that frequently work with these drugs but also affects other healthcare professionals that work with hematologists in patient management, including intensive care unit (ICU) physicians, is they have to keep up within their specialty and, in addition, with the side-effects that can occur when encountering hematology-specific therapies. Nonetheless, there are few people that have an in-depth understanding of a specialty outside theirs. Thus, this manuscript offers an overview of the most common side-effects caused by therapies used in hematology nowadays, or that are currently being investigated in clinical trials, with the purpose to serve as an aid to other specialties. Nevertheless, because of the high amount of information on this subject, each chapter will offer an overview of the side-effects of a drug class with each reference of the section being intended as further reading.},
  language  = {en}
}
@article{MuellerHummersHillermannetal.2020,
  author    = {M{\"u}ller, Frank and Hummers, Eva and Hillermann, Nele and Dopfer, Christian and Jablonka, Alexandra and Friede, Tim and Simmenroth, Anne and Wetzke, Martin},
  title     = {Factors influencing the frequency of airway infections in underage refugees: a retrospective, cross sectional study},
  series = {International Journal of Environmental Research and Public Health},
  volume    = {17},
  journal   = {International Journal of Environmental Research and Public Health},
  number    = {18},
  issn      = {1660-4601},
  doi       = {10.3390/ijerph17186823},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-213134},
  year      = {2020},
  abstract  = {Background: Infections are a leading cause of refugee morbidity. Recent data on the rate of airway infections and factors influencing their spread in refugee reception centers is scarce. Methods: A retrospective, cross-sectional study of de-identified medical records with a focus on respiratory infections in underage refugees was conducted at two large German refugee reception centers. Results: In total, medical data from n = 10,431 refugees over an observational period of n = 819 days was analyzed. Among pediatric patients (n = 4289), 55.3\% presented at least once to the on-site medical ward with an acute respiratory infection or signs thereof. In 38.4\% of pediatric consultations, acute airway infections or signs thereof were present. Airway infections spiked during colder months and were significantly more prevalent amongst preschool and resettled children. Their frequency displayed a positive correlation with the number of refugees housed at the reception centers. Conclusions: We show that respiratory infections are a leading cause for morbidity in young refugees and that their rate is influenced age, season, status, and residential density. This illustrates the need to protect refugee children from contracting airway infections which may also reduce the spread of coronavirus disease 2019 (COVID-19) during the current pandemic.},
  language  = {en}
}
@article{FerianecFueloepJežovičovaetal.2020,
  author    = {Ferianec, Vladim{\´i}r and F{\"u}l{\"o}p, Matej and Ježovičov{\´a}, Miriam and Radošinsk{\´a}, Jana and Husseinov{\´a}, Marta and Feriancov{\´a}, Michaela and Radošinsk{\´a}, Dominika and Baranč{\´i}k, Miroslav and Muchov{\´a}, Jana and Hȍgger, Petra and Ďuračkov{\´a}, Zdeňka},
  title     = {The oak-wood extract Robuvit\(^®\) improves recovery and oxidative stress after hysterectomy: a randomized, double-blind, placebo-controlled pilot study},
  series = {Nutrients},
  volume    = {12},
  journal   = {Nutrients},
  number    = {4},
  issn      = {2072-6643},
  doi       = {10.3390/nu12040913},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-203265},
  year      = {2020},
  abstract  = {Hysterectomy has a variety of medical indications and improves pre-operative symptoms but might compromise the quality of life during recovery due to symptoms such as fatigue, headache, nausea, depression, or pain. The aim of the present study was to determine the effect of a standardized extract from French oak wood (Quercus robur) containing at least 40\% polyphenols of the ellagitannins class, Robuvit\(^®\), on convalescence and oxidative stress of women after hysterectomy. Recovery status was monitored with the SF-36 questionnaire. The supplementation with Robuvit\(^®\) (300 mg/day) during 4 weeks significantly improved general and mental health, while under placebo some items significantly deteriorated. Oxidative stress and enhancement of MMP-9 activity was significantly reduced by Robuvit\(^®\) versus placebo. After 8 weeks of intervention, the patients' condition improved independently of the intervention. Our results suggest that the use of Robuvit\(^®\) as a natural supplement relieves post-operative symptoms of patients after hysterectomy and reduces oxidative stress. The study was registered with ID ISRCTN 11457040 (13/09/2019).},
  language  = {en}
}
@article{ButtStempfleListeretal.2020,
  author    = {Butt, Elke and Stempfle, Katrin and Lister, Lorenz and Wolf, Felix and Kraft, Marcella and Herrmann, Andreas B. and Viciano, Cristina Perpina and Weber, Christian and Hochhaus, Andreas and Ernst, Thomas and Hoffmann, Carsten and Zernecke, Alma and Frietsch, Jochen J.},
  title     = {Phosphorylation-dependent differences in CXCR4-LASP1-AKT1 interaction between breast cancer and chronic myeloid leukemia},
  series = {Cells},
  volume    = {9},
  journal   = {Cells},
  number    = {2},
  issn      = {2073-4409},
  doi       = {10.3390/cells9020444},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-200638},
  year      = {2020},
  abstract  = {The serine/threonine protein kinase AKT1 is a downstream target of the chemokine receptor 4 (CXCR4), and both proteins play a central role in the modulation of diverse cellular processes, including proliferation and cell survival. While in chronic myeloid leukemia (CML) the CXCR4 is downregulated, thereby promoting the mobilization of progenitor cells into blood, the receptor is highly expressed in breast cancer cells, favoring the migratory capacity of these cells. Recently, the LIM and SH3 domain protein 1 (LASP1) has been described as a novel CXCR4 binding partner and as a promoter of the PI3K/AKT pathway. In this study, we uncovered a direct binding of LASP1, phosphorylated at S146, to both CXCR4 and AKT1, as shown by immunoprecipitation assays, pull-down experiments, and immunohistochemistry data. In contrast, phosphorylation of LASP1 at Y171 abrogated these interactions, suggesting that both LASP1 phospho-forms interact. Finally, findings demonstrating different phosphorylation patterns of LASP1 in breast cancer and chronic myeloid leukemia may have implications for CXCR4 function and tyrosine kinase inhibitor treatment.},
  language  = {en}
}
@article{UnnikrishnanSchleicherShahetal.2020,
  author    = {Unnikrishnan, Vishnu and Schleicher, Miro and Shah, Yash and Jamaludeen, Noor and Pryss, Ruediger and Schobel, Johannes and Kraft, Robin and Schlee, Winfried and Spiliopoulou, Myra},
  title     = {The effect of non-personalised tips on the continued use of self-monitoring mHealth applications},
  series = {Brain Sciences},
  volume    = {10},
  journal   = {Brain Sciences},
  number    = {12},
  issn      = {2076-3425},
  doi       = {10.3390/brainsci10120924},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-219435},
  year      = {2020},
  abstract  = {Chronic tinnitus, the perception of a phantom sound in the absence of corresponding stimulus, is a condition known to affect patients' quality of life. Recent advances in mHealth have enabled patients to maintain a 'disease journal' of ecologically-valid momentary assessments, improving patients' own awareness of their disease while also providing clinicians valuable data for research. In this study, we investigate the effect of non-personalised tips on patients' perception of tinnitus, and on their continued use of the application. The data collected from the study involved three groups of patients that used the app for 16 weeks. Groups A \& Y were exposed to feedback from the start of the study, while group B only received tips for the second half of the study. Groups A and Y were run by different supervisors and also differed in the number of hospital visits during the study. Users of Group A and B underwent assessment at baseline, mid-study, post-study and follow-up, while users of group Y were only assessed at baseline and post-study. It is seen that the users in group B use the app for longer, and also more often during the day. The answers of the users to the Ecological Momentary Assessments are seen to form clusters where the degree to which the tinnitus distress depends on tinnitus loudness varies. Additionally, cluster-level models were able to predict new unseen data with better accuracy than a single global model. This strengthens the argument that the discovered clusters really do reflect underlying patterns in disease expression.},
  language  = {en}
}
@article{HerrmannEngelkeEbertetal.2020,
  author    = {Herrmann, Marietta and Engelke, Klaus and Ebert, Regina and M{\"u}ller-Deubert, Sigrid and Rudert, Maximilian and Ziouti, Fani and Jundt, Franziska and Felsenberg, Dieter and Jakob, Franz},
  title     = {Interactions between muscle and bone — Where physics meets biology},
  series = {Biomolecules},
  volume    = {10},
  journal   = {Biomolecules},
  number    = {3},
  issn      = {2218-273X},
  doi       = {10.3390/biom10030432},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-203399},
  year      = {2020},
  abstract  = {Muscle and bone interact via physical forces and secreted osteokines and myokines. Physical forces are generated through gravity, locomotion, exercise, and external devices. Cells sense mechanical strain via adhesion molecules and translate it into biochemical responses, modulating the basic mechanisms of cellular biology such as lineage commitment, tissue formation, and maturation. This may result in the initiation of bone formation, muscle hypertrophy, and the enhanced production of extracellular matrix constituents, adhesion molecules, and cytoskeletal elements. Bone and muscle mass, resistance to strain, and the stiffness of matrix, cells, and tissues are enhanced, influencing fracture resistance and muscle power. This propagates a dynamic and continuous reciprocity of physicochemical interaction. Secreted growth and differentiation factors are important effectors of mutual interaction. The acute effects of exercise induce the secretion of exosomes with cargo molecules that are capable of mediating the endocrine effects between muscle, bone, and the organism. Long-term changes induce adaptations of the respective tissue secretome that maintain adequate homeostatic conditions. Lessons from unloading, microgravity, and disuse teach us that gratuitous tissue is removed or reorganized while immobility and inflammation trigger muscle and bone marrow fatty infiltration and propagate degenerative diseases such as sarcopenia and osteoporosis. Ongoing research will certainly find new therapeutic targets for prevention and treatment.},
  language  = {en}
}
@article{RodriguesLiesnerReutteretal.2020,
  author    = {Rodrigues, Johannes and Liesner, Marvin and Reutter, Mario and Mussel, Patrick and Hewig, Johannes},
  title     = {It's costly punishment, not altruistic: Low midfrontal theta and state anger predict punishment},
  series = {Psychophysiology},
  volume    = {57},
  journal   = {Psychophysiology},
  number    = {8},
  doi       = {10.1111/psyp.13557},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214696},
  year      = {2020},
  abstract  = {Punishment in economic games has been interpreted as "altruistic." However, it was shown that punishment is related to trait anger instead of trait altruism in a third-party dictator game if compensation is also available. Here, we investigated the influence of state anger on punishment and compensation in the third-party dictator game. Therefore, we used movie sequences for emotional priming, including the target states anger, happy, and neutral. We measured the Feedback-Related Negativity (FRN) and midfrontal theta band activation, to investigate an electro-cortical correlate of the processing of fair and unfair offers. Also, we assessed single-trial FRN and midfrontal theta band activation as a predictor for punishment and compensation. We found that punishment was linked to state anger. Midfrontal theta band activation, which has previously been linked to altruistic acts and cognitive control, predicted less punishment. Additionally, trait anger led to enhanced FRN for unfair offers. This led to the interpretation that the FRN depicts the evaluation of fairness, while midfrontal theta band activation captures an aspect of cognitive control and altruistic motivation. We conclude that we need to redefine "altruistic punishment" into "costly punishment," as no direct link of altruism and punishment is given. Additionally, midfrontal theta band activation complements the FRN and offers additional insights into complex responses and decision processes, especially as a single trial predictor. },
  language  = {en}
}
@article{WeissRodriguesPaeleckeetal.2020,
  author    = {Weiß, Martin and Rodrigues, Johannes and Paelecke, Marko and Hewig, Johannes},
  title     = {We, Them, and It: Dictator Game Offers Depend on Hierarchical Social Status, Artificial Intelligence, and Social Dominance},
  series = {Frontiers in Psychology},
  volume    = {11},
  journal   = {Frontiers in Psychology},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2020.541756},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218168},
  year      = {2020},
  abstract  = {We investigated the influence of social status on behavior in a modified dictator game (DG). Since the DG contains an inherent dominance gradient, we examined the relationship between dictator decisions and recipient status, which was operationalized by three social identities and an artificial intelligence (AI). Additionally, we examined the predictive value of social dominance orientation (SDO) on the behavior of dictators toward the different social and non-social hierarchical recipients. A multilevel model analysis showed that recipients with the same status as the dictator benefited the most and the artificial intelligence the least. Furthermore, SDO, regardless of social status, predicted behavior toward recipients in such a way that higher dominance was associated with lower dictator offers. In summary, participants treated other persons of higher and lower status equally, those of equal status better and, above all, an algorithm worst. The large proportion of female participants and the limited variance of SDO should be taken into account with regard to the results of individual differences in SDO.},
  language  = {en}
}
@article{KannBruennertHansenetal.2020,
  author    = {Kann, Simone and Bruennert, Daniela and Hansen, Jessica and Concha Mendoza, Gustavo Andr{\´e}s and Crespo Gonzalez, Jos{\´e} Jos{\´e} and Armenta Quintero, Cielo Leonor and Hanke, Miriam and Hagen, Ralf Matthias and Backhaus, Joy and Frickmann, Hagen},
  title     = {High prevalence of intestinal pathogens in Indigenous in Colombia},
  series = {Journal of Clinical Medicine},
  volume    = {9},
  journal   = {Journal of Clinical Medicine},
  number    = {9},
  issn      = {2077-0383},
  doi       = {10.3390/jcm9092786},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-211289},
  year      = {2020},
  abstract  = {Background: Intestinal infections remain a major public health burden in developing countries. Due to social, ecological, environmental, and cultural conditions, Indigenous peoples in Colombia are at particularly high risk. Materials: 137 stool samples were analyzed by microscopy and real-time-Polymerase Chain Reaction (RT-PCR), targeting protozoan parasites (Giardia intestinalis, Entamoeba histolytica, Cryptosporidium spp., and Cyclospora cayetanensis), bacteria (Campylobacter jejuni, Salmonella spp., Shigella ssp./enteroinvasive E. coli (EIEC), Yersinia spp., enterohemorrhagic E. coli (EHEC), enteropathogenic E. coli (EPEC), enterotoxin-producing E. coli (ETEC), enteroaggregative E. coli (EAEC), and Tropheryma whipplei), and helminths (Necator americanus, Strongyloides stercoralis, Ascaris lumbricoides, Ancylostoma spp., Trichuris. trichiura, Taenia spp., Hymenolepis nana, Enterobius vermicularis, and Schistosoma spp.). Microscopy found additional cases of helminth infections. Results: At least one pathogen was detected in 93\% of the samples. The overall results revealed protozoa in 79\%, helminths in 69\%, and bacteria in 41\%. G. intestinalis (48\%), Necator/hookworm (27\%), and EAEC (68\%) were the most common in each group. Noteworthy, T. whipplei was positive in 7\% and T. trichirua in 23\% of the samples. A significant association of one infection promoting the other was determined for G. intestinalis and C. jejuni, helminth infections, and EIEC. Conclusions: The results illustrate the high burden of gastrointestinal pathogens among Indigenous peoples compared to other developing countries. Countermeasures are urgently required.},
  language  = {en}
}
@article{MehdiDodePryssetal.2020,
  author    = {Mehdi, Muntazir and Dode, Albi and Pryss, R{\"u}diger and Schlee, Winfried and Reichert, Manfred and Hauck, Franz J.},
  title     = {Contemporary review of smartphone apps for tinnitus management and treatment},
  series = {Brain Sciences},
  volume    = {10},
  journal   = {Brain Sciences},
  number    = {11},
  issn      = {2076-3425},
  doi       = {10.3390/brainsci10110867},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-219367},
  year      = {2020},
  abstract  = {Tinnitus is a complex and heterogeneous psycho-physiological disorder responsible for causing a phantom ringing or buzzing sound albeit the absence of an external sound source. It has a direct influence on affecting the quality of life of its sufferers. Despite being around for a while, there has not been a cure for tinnitus, and the usual course of action for its treatment involves use of tinnitus retaining and sound therapy, or Cognitive Behavioral Therapy (CBT). One positive aspect about these therapies is that they can be administered face-to-face as well as delivered via internet or smartphone. Smartphones are especially helpful as they are highly personalized devices, and offer a well-established ecosystem of apps, accessible via respective marketplaces of differing mobile platforms. Note that current therapeutic treatments such as CBT have shown to be effective in suppressing the tinnitus symptoms when administered face-to-face, their effectiveness when being delivered using smartphones is not known so far. A quick search on the prominent market places of popular mobile platforms (Android and iOS) yielded roughly 250 smartphone apps offering tinnitus-related therapies and tinnitus management. As this number is expected to steadily increase due to high interest in smartphone app development, a contemporary review of such apps is crucial. In this paper, we aim to review scientific studies validating the smartphone apps, particularly to test their effectiveness in tinnitus management and treatment. We use the PRISMA guidelines for identification of studies on major scientific literature sources and delineate the outcomes of identified studies.},
  language  = {en}
}
@article{FanZebischHornyetal.2020,
  author    = {Fan, Kaiji and Zebisch, Armin and Horny, Kai and Schrama, David and Becker, J{\"u}rgen C.},
  title     = {Highly expressed miR-375 is not an intracellular oncogene in Merkel cell polyomavirus-associated Merkel cell carcinoma},
  series = {Cancers},
  volume    = {12},
  journal   = {Cancers},
  number    = {3},
  issn      = {2072-6694},
  doi       = {10.3390/cancers12030529},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-200678},
  year      = {2020},
  abstract  = {miR-375 is a highly abundant miRNA in Merkel cell carcinoma (MCC). In other cancers, it acts as either a tumor suppressor or oncogene. While free-circulating miR-375 serves as a surrogate marker for tumor burden in patients with advanced MCC, its function within MCC cells has not been established. Nearly complete miR-375 knockdown in MCC cell lines was achieved using antagomiRs via nucleofection. The cell viability, growth characteristics, and morphology were not altered by this knockdown. miR-375 target genes and related signaling pathways were determined using Encyclopedia of RNA Interactomes (ENCORI) revealing Hippo signaling and epithelial to mesenchymal transition (EMT)-related genes likely to be regulated. Therefore, their expression was analyzed by multiplexed qRT-PCR after miR-375 knockdown, demonstrating only a limited change in expression. In summary, highly effective miR-375 knockdown in classical MCC cell lines did not significantly change the cell viability, morphology, or oncogenic signaling pathways. These observations render miR-375 an unlikely intracellular oncogene in MCC cells, thus suggesting that likely functions of miR-375 for the intercellular communication of MCC should be addressed.},
  language  = {en}
}
@article{SchmidtAbinzanoMensingaetal.2020,
  author    = {Schmidt, Stefanie and Abinzano, Florencia and Mensinga, Anneloes and Teßmar, J{\"o}rg and Groll, J{\"u}rgen and Malda, Jos and Levato, Riccardo and Blunk, Torsten},
  title     = {Differential production of cartilage ECM in 3D agarose constructs by equine articular cartilage progenitor cells and mesenchymal stromal cells},
  series = {International Journal of Molecular Sciences},
  volume    = {21},
  journal   = {International Journal of Molecular Sciences},
  number    = {19},
  issn      = {1422-0067},
  doi       = {10.3390/ijms21197071},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-236180},
  year      = {2020},
  abstract  = {Identification of articular cartilage progenitor cells (ACPCs) has opened up new opportunities for cartilage repair. These cells may be used as alternatives for or in combination with mesenchymal stromal cells (MSCs) in cartilage engineering. However, their potential needs to be further investigated, since only a few studies have compared ACPCs and MSCs when cultured in hydrogels. Therefore, in this study, we compared chondrogenic differentiation of equine ACPCs and MSCs in agarose constructs as monocultures and as zonally layered co-cultures under both normoxic and hypoxic conditions. ACPCs and MSCs exhibited distinctly differential production of the cartilaginous extracellular matrix (ECM). For ACPC constructs, markedly higher glycosaminoglycan (GAG) contents were determined by histological and quantitative biochemical evaluation, both in normoxia and hypoxia. Differential GAG production was also reflected in layered co-culture constructs. For both cell types, similar staining for type II collagen was detected. However, distinctly weaker staining for undesired type I collagen was observed in the ACPC constructs. For ACPCs, only very low alkaline phosphatase (ALP) activity, a marker of terminal differentiation, was determined, in stark contrast to what was found for MSCs. This study underscores the potential of ACPCs as a promising cell source for cartilage engineering.},
  language  = {en}
}
@phdthesis{Taigel2020,
  author    = {Taigel, Fabian Michael},
  title     = {Data-driven Operations Management: From Predictive to Prescriptive Analytics},
  doi       = {10.25972/OPUS-20651},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-206514},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2020},
  abstract  = {Autonomous cars and artificial intelligence that beats humans in Jeopardy or Go are glamorous examples of the so-called Second Machine Age that involves the automation of cognitive tasks [Brynjolfsson and McAfee, 2014]. However, the larger impact in terms of increasing the efficiency of industry and the productivity of society might come from computers that improve or take over business decisions by using large amounts of available data. This impact may even exceed that of the First Machine Age, the industrial revolution that started with James Watt's invention of an efficient steam engine in the late eighteenth century. Indeed, the prevalent phrase that calls data "the new oil" indicates the growing awareness of data's importance. However, many companies, especially those in the manufacturing and traditional service industries, still struggle to increase productivity using the vast amounts of data [for Economic Co-operation and Development, 2018]. One reason for this struggle is that companies stick with a traditional way of using data for decision support in operations management that is not well suited to automated decision-making. In traditional inventory and capacity management, some data - typically just historical demand data - is used to estimate a model that makes predictions about uncertain planning parameters, such as customer demand. The planner then has two tasks: to adjust the prediction with respect to additional information that was not part of the data but still might influence demand and to take the remaining uncertainty into account and determine a safety buffer based on the underage and overage costs. In the best case, the planner determines the safety buffer based on an optimization model that takes the costs and the distribution of historical forecast errors into account; however, these decisions are usually based on a planner's experience and intuition, rather than on solid data analysis. This two-step approach is referred to as separated estimation and optimization (SEO). With SEO, using more data and better models for making the predictions would improve only the first step, which would still improve decisions but would not automize (and, hence, revolutionize) decision-making. Using SEO is like using a stronger horse to pull the plow: one still has to walk behind. The real potential for increasing productivity lies in moving from predictive to prescriptive approaches, that is, from the two-step SEO approach, which uses predictive models in the estimation step, to a prescriptive approach, which integrates the optimization problem with the estimation of a model that then provides a direct functional relationship between the data and the decision. Following Akcay et al. [2011], we refer to this integrated approach as joint estimation-optimization (JEO). JEO approaches prescribe decisions, so they can automate the decision-making process. Just as the steam engine replaced manual work, JEO approaches replace cognitive work. The overarching objective of this dissertation is to analyze, develop, and evaluate new ways for how data can be used in making planning decisions in operations management to unlock the potential for increasing productivity. In doing so, the thesis comprises five self-contained research articles that forge the bridge from predictive to prescriptive approaches. While the first article focuses on how sensitive data like condition data from machinery can be used to make predictions of spare-parts demand, the remaining articles introduce, analyze, and discuss prescriptive approaches to inventory and capacity management. All five articles consider approach that use machine learning and data in innovative ways to improve current approaches to solving inventory or capacity management problems. The articles show that, by moving from predictive to prescriptive approaches, we can improve data-driven operations management in two ways: by making decisions more accurate and by automating decision-making. Thus, this dissertation provides examples of how digitization and the Second Machine Age can change decision-making in companies to increase efficiency and productivity.},
  subject      = {Maschinelles Lernen},
  language  = {en}
}
@article{MuessigLisinetskayaDewhurstetal.2020,
  author    = {Muessig, Jonas H. and Lisinetskaya, Polina and Dewhurst, Rian D. and Bertermann, R{\"u}diger and Thaler, Melanie and Mitric, Roland and Braunschweig, Holger},
  title     = {Dibortetraiodid (B\(_2\)I\(_4\)) ist im Festk{\"o}rper ein Polymer aus sp3-hybridisiertem Bor},
  series = {Angewandte Chemie},
  volume    = {132},
  journal   = {Angewandte Chemie},
  number    = {14},
  doi       = {10.1002/ange.201913590},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-219653},
  pages     = {5574-5579},
  year      = {2020},
  abstract  = {Anhand der ersten Festk{\"o}rperstrukturen von Dibortetraiodid (B\(_2\)I\(_4\)) wird gezeigt, dass dieses nicht, wie lange angenommen, analog zu den leichteren Dibortetrahalogeniden B\(_2\)F\(_4\), B\(_2\)Cl\(_4\) und B\(_2\)Br\(_4\) in allen Aggregatzust{\"a}nden in Form diskreter Molek{\"u}le mit planaren, dreifach koordinierten Boratomen vorliegt. R{\"o}ntgenstrukturanalysen, Festk{\"o}rper-NMR- und IR-Messungen zeigen, dass B\(_2\)I\(_4\) im Festk{\"o}rper in zwei polymeren Konformeren vorkommt, die tetraedrisch koordinierte Boratome enthalten. Anhand von DFT-Rechnungen werden die IR-Spektren in L{\"o}sung und im Festk{\"o}rper simuliert und mit den experimentellen Daten verglichen.},
  language  = {de}
}
@article{MuessigLisinetskayaDewhurstetal.2020,
  author    = {Muessig, Jonas H. and Lisinetskaya, Polina and Dewhurst, Rian D. and Bertermann, R{\"u}diger and Thaler, Melanie and Mitric, Roland and Braunschweig, Holger},
  title     = {Tetraiododiborane(4) (B\(_2\)I\(_4\)) is a Polymer based on sp\(^3\) Boron in the Solid State},
  series = {Angewandte Chemie International Edition},
  volume    = {59},
  journal   = {Angewandte Chemie International Edition},
  doi       = {10.1002/anie.201913590},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-209428},
  pages     = {5531-5535},
  year      = {2020},
  abstract  = {Herein we present the first solid-state structures of tetraiododiborane(4) (B\(_2\)I\(_4\)), which was long believed to exist in all phases as discrete molecules with planar, tricoordinate boron atoms, like the lighter tetrahalodiboranes(4) B\(_2\)F\(_4\), B\(_2\)Cl\(_4\), and B\(_2\)Br\(_4\). Single-crystal X-ray diffraction, solid-state NMR, and IR measurements indicate that B\(_2\)I\(_4\) in fact exists as two different polymeric forms in the solid state, both of which feature boron atoms in tetrahedral environments. DFT calculations are used to simulate the IR spectra of the solution and solid-state structures, and these are compared with the experimental spectra.},
  language  = {en}
}
@article{PrommersbergerHudecekNerreter2020,
  author    = {Prommersberger, Sabrina and Hudecek, Michael and Nerreter, Thomas},
  title     = {Antibody-Based CAR T Cells Produced by Lentiviral Transduction},
  series = {Current Protocols in Immunology},
  volume    = {128},
  journal   = {Current Protocols in Immunology},
  number    = {1},
  doi       = {10.1002/cpim.93},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-215497},
  year      = {2020},
  abstract  = {One promising approach to treat hematologic malignancies is the usage of patient-derived CAR T cells. There are continuous efforts to improve the function of these cells, to optimize their receptor, and to use them for the treatment of additional types of cancer and especially solid tumors. In this protocol, an easy and reliable approach for CAR T cell generation is described. T cells are first isolated from peripheral blood (here: leukoreduction system chambers) and afterwards activated for one day with anti-CD3/CD28 Dynabeads. The gene transfer is performed by lentiviral transduction and gene transfer rate can be verified by flowcytometric analysis. Six days after transduction, the stimulatory Dynabeads are removed. T cells are cultured in interleukin-2 conditioned medium for several days for expansion. There is an option to expand CAR T cells further by co-incubation with irradiated, antigen-expressing feeder cell lines. The CAR T cells are ready to use after 10 (without feeder cell expansion) to 24 days (with feeder cell expansion).},
  language  = {en}
}
@unpublished{TitovHumeniukMitric2020,
  author    = {Titov, Evgenii and Humeniuk, Alexander and Mitric, Roland},
  title     = {Comparison of moving and fixed basis sets for nonadiabatic quantum dynamics at conical intersections},
  series = {Chemical Physics},
  journal   = {Chemical Physics},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-198699},
  year      = {2020},
  abstract  = {We assess the performance of two different types of basis sets for nonadiabatic quantum dynamics at conical intersections. The basis sets of both types are generated using Ehrenfest trajectories of nuclear coherent states. These trajectories can either serve as a moving (time-dependent) basis or be employed to sample a fixed (time-independent) basis. We demonstrate on the example of two-state two-dimensional and three-state five-dimensional models that both basis set types can yield highly accurate results for population transfer at intersections, as compared with reference quantum dynamics. The details of wave packet evolutions are discussed for the case of the two-dimensional model. The fixed basis is found to be superior to the moving one in reproducing true nonlocal spreading and maintaining correct shape of the wave packet upon time evolution. Moreover, for the models considered, the fixed basis set outperforms the moving one in terms of computational efficiency.},
  language  = {en}
}
@unpublished{BrychHaendel2020,
  author    = {Brych, Mareike and H{\"a}ndel, Barbara},
  title     = {Disentangling top-down and bottom-up influences on blinks in the visual and auditory domain},
  series = {International Journal of Psychophysiology},
  journal   = {International Journal of Psychophysiology},
  issn      = {1872-7697},
  doi       = {10.1016/j.ijpsycho.2020.11.002},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-246590},
  year      = {2020},
  abstract  = {Sensory input as well as cognitive factors can drive the modulation of blinking. Our aim was to dissociate sensory driven bottom-up from cognitive top-down influences on blinking behavior and compare these influences between the auditory and the visual domain. Using an oddball paradigm, we found a significant pre-stimulus decrease in blink probability for visual input compared to auditory input. Sensory input further led to an early post-stimulus blink increase in both modalities if a task demanded attention to the input. Only visual input caused a pronounced early increase without a task. In case of a target or the omission of a stimulus (as compared to standard input), an additional late increase in blink rate was found in the auditory and visual domain. This suggests that blink modulation must be based on the interpretation of the input, but does not need any sensory input at all to occur. Our results show a complex modulation of blinking based on top-down factors such as prediction and attention in addition to sensory-based influences. The magnitude of the modulation is mainly influenced by general attentional demands, while the latency of this modulation allows to dissociate general from specific top-down influences that are independent of the sensory domain.},
  language  = {en}
}
@article{MeierKaehlerBergenetal.2020,
  author    = {Meier, Sandra M. and K{\"a}hler, Anna K. and Bergen, Sarah E. and Sullivan, Patrick F. and Hultman, Christina M. and Mattheisen, Manuel},
  title     = {Chronicity and Sex Affect Genetic Risk Prediction in Schizophrenia},
  series = {Frontiers in Psychiatry},
  volume    = {11},
  journal   = {Frontiers in Psychiatry},
  issn      = {1664-0640},
  doi       = {10.3389/fpsyt.2020.00313},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-205677},
  year      = {2020},
  abstract  = {Schizophrenia (SCZ) is a severe mental disorder with immense personal and societal costs; identifying individuals at risk is therefore of utmost importance. Genomic risk profile scores (GRPS) have been shown to significantly predict cases-control status. Making use of a large-population based sample from Sweden, we replicate a previous finding demonstrating that the GRPS is strongly associated with admission frequency and chronicity of SCZ. Furthermore, we were able to show a substantial gap in prediction accuracy between males and females. In sum, our results indicate that prediction accuracy by GRPS depends on clinical and demographic characteristics.},
  language  = {en}
}
@article{BiereKranzMaturaetal.2020,
  author    = {Biere, Silvia and Kranz, Thorsten M. and Matura, Silke and Petrova, Kristiyana and Streit, Fabian and Chiocchetti, Andreas G. and Grimm, Oliver and Brum, Murielle and Brunkhorst-Kanaan, Natalie and Oertel, Viola and Malyshau, Aliaksandr and Pfennig, Andrea and Bauer, Michael and Schulze, Thomas G. and Kittel-Schneider, Sarah and Reif, Andreas},
  title     = {Risk Stratification for Bipolar Disorder Using Polygenic Risk Scores Among Young High-Risk Adults},
  series = {Frontiers in Psychiatry},
  volume    = {11},
  journal   = {Frontiers in Psychiatry},
  doi       = {10.3389/fpsyt.2020.552532},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214976},
  year      = {2020},
  abstract  = {Objective: Identifying high-risk groups with an increased genetic liability for bipolar disorder (BD) will provide insights into the etiology of BD and contribute to early detection of BD. We used the BD polygenic risk score (PRS) derived from BD genome-wide association studies (GWAS) to explore how such genetic risk manifests in young, high-risk adults. We postulated that BD-PRS would be associated with risk factors for BD. Methods: A final sample of 185 young, high-risk German adults (aged 18-35 years) were grouped into three risk groups and compared to a healthy control group (n = 1,100). The risk groups comprised 117 cases with attention deficit hyperactivity disorder (ADHD), 45 with major depressive disorder (MDD), and 23 help-seeking adults with early recognition symptoms [ER: positive family history for BD, (sub)threshold affective symptomatology and/or mood swings, sleeping disorder]. BD-PRS was computed for each participant. Logistic regression models (controlling for sex, age, and the first five ancestry principal components) were used to assess associations of BD-PRS and the high-risk phenotypes. Results: We observed an association between BD-PRS and combined risk group status (OR = 1.48, p < 0.001), ADHD diagnosis (OR = 1.32, p = 0.009), MDD diagnosis (OR = 1.96, p < 0.001), and ER group status (OR = 1.7, p = 0.025; not significant after correction for multiple testing) compared to healthy controls. Conclusions: In the present study, increased genetic risk for BD was a significant predictor for MDD and ADHD status, but not for ER. These findings support an underlying shared risk for both MDD and BD as well as ADHD and BD. Improving our understanding of the underlying genetic architecture of these phenotypes may aid in early identification and risk stratification.},
  language  = {en}
}
@article{BittorfBergmannMerlinetal.2020,
  author    = {Bittorf, Patrick and Bergmann, Thorsten and Merlin, Simone and Olgasi, Chistina and Pullig, Oliver and Sanzenbacher, Ralf and Zierau, Martin and Walles, Heike and Follenzi, Antonia and Braspenning, Joris},
  title     = {Regulatory-Compliant Validation of a Highly Sensitive qPCR for Biodistribution Assessment of Hemophilia A Patient Cells},
  series = {Molecular Therapy - Methods \& Clinical Development},
  volume    = {18},
  journal   = {Molecular Therapy - Methods \& Clinical Development},
  doi       = {10.1016/j.omtm.2020.05.029},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-230284},
  pages     = {176-188},
  year      = {2020},
  abstract  = {The investigation of the biodistribution profile of a cell-based medicinal product is a pivotal prerequisite to allow a factual benefit-risk assessment within the non-clinical to clinical translation in product development. Here, a qPCR-based method to determine the amount of human DNA in mouse DNA was validated according to the guidelines of the European Medicines Agency and the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. Furthermore, a preclinical worst-case scenario study was performed in which this method was applied to investigate the biodistribution of 2 x 10\(^6\) intravenously administered, genetically modified, blood outgrowth endothelial cells from hemophilia A patients after 24 h and 7 days. The validation of the qPCR method demonstrated high accuracy, precision, and linearity for the concentration interval of 1:1 x 10\(^3\) to 1:1 x 10\(^6\) human to mouse DNA. The application of this method in the biodistribution study resulted in the detection of human genomes in four out of the eight investigated organs after 24 h. After 7 days, no human DNA was detected in the eight organs analyzed. This biodistribution study provides mandatory data on the toxicokinetic safety profile of an actual candidate cell-based medicinal product. The extensive evaluation of the required validation parameters confirms the applicability of the qPCR method for non-clinical biodistribution studies.},
  language  = {en}
}
@article{MetzenmacherVaraljaiHegeduesetal.2020,
  author    = {Metzenmacher, Martin and V{\´a}raljai, Ren{\´a}ta and Heged{\"u}s, Balazs and Cima, Igor and Forster, Jan and Schramm, Alexander and Scheffler, Bj{\"o}rn and Horn, Peter A. and Klein, Christoph A. and Szarvas, Tibor and Reis, Hennig and Bielefeld, Nicola and Roesch, Alexander and Aigner, Clemens and Kunzmann, Volker and Wiesweg, Marcel and Siveke, Jens T. and Schuler, Martin and Lueong, Smiths S.},
  title     = {Plasma Next Generation Sequencing and Droplet Digital-qPCR-Based Quantification of Circulating Cell-Free RNA for Noninvasive Early Detection of Cancer},
  series = {Cancers},
  volume    = {12},
  journal   = {Cancers},
  number    = {2},
  issn      = {2072-6694},
  doi       = {10.3390/cancers12020353},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-200553},
  year      = {2020},
  abstract  = {Early detection of cancer holds high promise for reducing cancer-related mortality. Detection of circulating tumor-specific nucleic acids holds promise, but sensitivity and specificity issues remain with current technology. We studied cell-free RNA (cfRNA) in patients with non-small cell lung cancer (NSCLC; n = 56 stage IV, n = 39 stages I-III), pancreatic cancer (PDAC, n = 20 stage III), malignant melanoma (MM, n = 12 stage III-IV), urothelial bladder cancer (UBC, n = 22 stage II and IV), and 65 healthy controls by means of next generation sequencing (NGS) and real-time droplet digital PCR (RT-ddPCR). We identified 192 overlapping upregulated transcripts in NSCLC and PDAC by NGS, more than 90\% of which were noncoding. Previously reported transcripts (e.g., HOTAIRM1) were identified. Plasma cfRNA transcript levels of POU6F2-AS2 discriminated NSCLC from healthy donors (AUC = 0.82 and 0.76 for stages IV and I-III, respectively) and significantly associated (p = 0.017) with the established tumor marker Cyfra 21-1. cfRNA yield and POU6F2-AS transcript abundance discriminated PDAC patients from healthy donors (AUC = 1.0). POU6F2-AS2 transcript was significantly higher in MM (p = 0.044). In summary, our findings support further validation of cfRNA detection by RT-ddPCR as a biomarker for early detection of solid cancers.},
  language  = {en}
}
@article{ZieglerAlmosMcNeilletal.2020,
  author    = {Ziegler, Georg C. and Almos, Peter and McNeill, Rhiannon V. and Jansch, Charline and Lesch, Klaus-Peter},
  title     = {Cellular effects and clinical implications of SLC2A3 copy number variation},
  series = {Journal of Cellular Physiology},
  volume    = {235},
  journal   = {Journal of Cellular Physiology},
  number    = {12},
  doi       = {10.1002/jcp.29753},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218009},
  pages     = {9021 -- 9036},
  year      = {2020},
  abstract  = {SLC2A3 encodes the predominantly neuronal glucose transporter 3 (GLUT3), which facilitates diffusion of glucose across plasma membranes. The human brain depends on a steady glucose supply for ATP generation, which consequently fuels critical biochemical processes, such as axonal transport and neurotransmitter release. Besides its role in the central nervous system, GLUT3 is also expressed in nonneural organs, such as the heart and white blood cells, where it is equally involved in energy metabolism. In cancer cells, GLUT3 overexpression contributes to the Warburg effect by answering the cell's increased glycolytic demands. The SLC2A3 gene locus at chromosome 12p13.31 is unstable and prone to non-allelic homologous recombination events, generating multiple copy number variants (CNVs) of SLC2A3 which account for alterations in SLC2A3 expression. Recent associations of SLC2A3 CNVs with different clinical phenotypes warrant investigation of the potential influence of these structural variants on pathomechanisms of neuropsychiatric, cardiovascular, and immune diseases. In this review, we accumulate and discuss the evidence how SLC2A3 gene dosage may exert diverse protective or detrimental effects depending on the pathological condition. Cellular states which lead to increased energetic demand, such as organ development, proliferation, and cellular degeneration, appear particularly susceptible to alterations in SLC2A3 copy number. We conclude that better understanding of the impact of SLC2A3 variation on disease etiology may potentially provide novel therapeutic approaches specifically targeting this GLUT.},
  language  = {en}
}
@article{SchmidtWernerArrowsmithetal.2020,
  author    = {Schmidt, Uwe and Werner, Luis and Arrowsmith, Merle and Deissenberger, Andrea and Hermann, Alexander and Hofmann, Alexander and Ullrich, Stefan and Mattock, James D. and Vargas, Alfredo and Braunschweig, Holger},
  title     = {Trans-selektive Dihydroborierung eines cis-Diborens durch Insertion: Synthese eines linearen sp\(^3\)-sp\(^2\)-sp\(^3\)-Triborans und anschließende Kationisierung},
  series = {Angewandte Chemie},
  volume    = {132},
  journal   = {Angewandte Chemie},
  number    = {1},
  doi       = {10.1002/ange.201911645},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-219713},
  pages     = {333-337},
  year      = {2020},
  abstract  = {Die Reaktion zwischen Aryl- und Amino(dihydro)boranen und Dibora[2]ferrocenophan 1 f{\"u}hrt zur Bildung von 1,3-trans-Dihydrotriboranen durch formale Hydrierung und Insertion eines Borylens in die B=B Doppelbindung. Die Aryltriboran-Derivate unterliegen einer reversiblen Photoisomerisierung zugunsten eines cis-1,2-μ-H-3-Hydrotriborans, w{\"a}hrend eine Hydridabstraktion zu kationischen Triboranen f{\"u}hrt, welche die ersten doppelt basenstabilisierten B\(_3\)H\(_4\)\(^+\)-Analoga darstellen.},
  language  = {de}
}
@article{SchmidtWernerArrowsmithetal.2020,
  author    = {Schmidt, Uwe and Werner, Luis and Arrowsmith, Merle and Deissenberger, Andrea and Hermann, Alexander and Hofmann, Alexander and Ullrich, Stefan and Mattock, James D. and Vargas, Alfredo and Braunschweig, Holger},
  title     = {trans-Selective Insertional Dihydroboration of a cis-Diborene: Synthesis of Linear sp\(^3\)-sp\(^2\)-sp\(^3\)-Triboranes and Subsequent Cationization},
  series = {Angewandte Chemie International Edition},
  volume    = {59},
  journal   = {Angewandte Chemie International Edition},
  number    = {1},
  doi       = {10.1002/anie.201911645},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-208090},
  pages     = {325-329},
  year      = {2020},
  abstract  = {The reaction of aryl- and amino(dihydro)boranes with dibora[2]ferrocenophane 1 leads to the formation 1,3-trans -dihydrotriboranes by formal hydrogenation and insertion of a borylene unit into the B=B bond. The aryltriborane derivatives undergo reversible photoisomerization to the cis -1,2-μ-H-3-hydrotriboranes, while hydride abstraction affords cationic triboranes, which represent the first doubly base-stabilized B3H4\(^+\) analogues.},
  language  = {en}
}
@article{HermannFantuzziArrowsmithetal.2020,
  author    = {Hermann, Alexander and Fantuzzi, Felipe and Arrowsmith, Merle and Zorn, Theresa and Krummenacher, Ivo and Ritschel, Benedikt and Radacki, Krzysztof and Engels, Bernd and Braunschweig, Holger},
  title     = {Oxidation, Coordination, and Nickel-Mediated Deconstruction of a Highly Electron-Rich Diboron Analogue of 1,3,5-Hexatriene},
  series = {Angewandte Chemie, International Edition},
  volume    = {59},
  journal   = {Angewandte Chemie, International Edition},
  number    = {36},
  doi       = {10.1002/anie.202006131},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-240652},
  pages     = {15717-15725},
  year      = {2020},
  abstract  = {The reductive coupling of an N-heterocyclic carbene (NHC) stabilized (dibromo)vinylborane yields a 1,2-divinyl- diborene, which, although isoelectronic to a 1,3,5-triene, displays no extended p conjugation because of twisting of the C\(_2\)B\(_2\)C\(_2\) chain. While this divinyldiborene coordinates to copper(I) and platinum(0) in an η\(^2\)-B\(_2\) and η\(^4\)-C\(_2\)B\(_2\) fashion, respectively, it undergoes a complex rearrangement to an η\(^4\)-1,3-diborete upon complexation with nickel(0).},
  language  = {en}
}
@article{ScheitlLangeHoebartner2020,
  author    = {Scheitl, Carolin P. M. and Lange, Sandra and H{\"o}bartner, Claudia},
  title     = {New deoxyribozymes for the native ligation of RNA},
  series = {Molecules},
  volume    = {25},
  journal   = {Molecules},
  number    = {16},
  doi       = {https://doi.org/10.3390/molecules25163650},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-210405},
  year      = {2020},
  abstract  = {Deoxyribozymes (DNAzymes) are small, synthetic, single-stranded DNAs capable of catalysing chemical reactions, including RNA ligation. Herein, we report a novel class of RNA ligase deoxyribozymes that utilize 5'-adenylated RNA (5'-AppRNA) as the donor substrate, mimicking the activated intermediates of protein-catalyzed RNA ligation. Four new DNAzymes were identified by in vitro selection from an N40 random DNA library and were shown to catalyze the intermolecular linear RNA-RNA ligation via the formation of a native 3'-5'-phosphodiester linkage. The catalytic activity is distinct from previously described RNA-ligating deoxyribozymes. Kinetic analyses revealed the optimal incubation conditions for high ligation yields and demonstrated a broad RNA substrate scope. Together with the smooth synthetic accessibility of 5'-adenylated RNAs, the new DNA enzymes are promising tools for the protein-free synthesis of long RNAs, for example containing precious modified nucleotides or fluorescent labels for biochemical and biophysical investigations.},
  language  = {en}
}
@article{MaghamiDeyLenzetal.2020,
  author    = {Maghami, Mohammad Ghaem and Dey, Surjendu and Lenz, Ann-Kathrin and H{\"o}bartner, Claudia},
  title     = {Repurpsing Antiviral Drugs for Orthogonal RNA-Catalyzed Labeling},
  series = {Angewandte Chemie, International Edition},
  volume    = {59},
  journal   = {Angewandte Chemie, International Edition},
  doi       = {10.1002/anie.202001300},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-205552},
  pages     = {9335-9339},
  year      = {2020},
  abstract  = {In vitro selected ribozymes are promising tools for site-specific labeling of RNA. Previously known nucleic acid catalysts attached fluorescently labeled adenosine or guanosine derivatives through 2',5'-branched phosphodiester bonds to the RNA of interest. Herein, we report new ribozymes that use orthogonal substrates, derived from the antiviral drug tenofovir, and attach bioorthogonal functional groups, as well as affinity handles and fluorescent reporter units through a hydrolytically more stable phosphonate ester linkage. The tenofovir transferase ribozymes were identified by in vitro selection and are orthogonal to nucleotide transferase ribozymes. As genetically encodable functional RNAs, these ribozymes may be developed for potential cellular applications. The orthogonal ribozymes addressed desired target sites in large RNAs in vitro, as shown by fluorescent labeling of E. coli 16S and 23S RNAs in total cellular RNA.},
  language  = {en}
}
@article{LiaqatStillerMicheletal.2020,
  author    = {Liaqat, Anam and Stiller, Carina and Michel, Manuela and Sednev, Maksim V. and H{\"o}bartner, Claudia},
  title     = {N\(^6\)-Isopentenyladenosine in RNA Determines the Cleavage Site of Endonuclease Deoxyribozymes},
  series = {Angewandte Chemie International Edition},
  journal   = {Angewandte Chemie International Edition},
  edition   = {Early View},
  doi       = {10.1002/ange.202006218},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-212121},
  year      = {2020},
  abstract  = {RNA-cleaving deoxyribozymes can serve as selective sensors and catalysts to examine the modification state of RNA. However, site-specific endonuclease deoxyribozymes that selectively cleave posttranscriptionally modified RNA are extremely rare and their specificity over unmodified RNA is low. In this study, we report that the native tRNA modification N\(^6\)-isopentenyladenosine (i\(^6\)A) strongly enhances the specificity and has the power to reconfigure the active site of an RNA-cleaving deoxyribozyme. Using in vitro selection, we identified a DNA enzyme that cleaves i\(^6\)A-modified RNA at least 2500-fold faster than unmodified RNA. Another deoxyribozyme shows unique and unprecedented behaviour by shifting its cleavage site in the presence of the i\(^6\)A RNA modification. Together with deoxyribozymes that are strongly inhibited by i\(^6\)A, these results highlight intricate ways of modulating the catalytic activity of DNA by posttranscriptional RNA modifications.},
  language  = {en}
}
@article{HirschPachnerFischeretal.2020,
  author    = {Hirsch, Florian and Pachner, Kai and Fischer, Ingo and Issler, Kevin and Petersen, Jens and Mitric, Roland and Bakels, Sjors and Rijs, Anouk M.},
  title     = {Do Xylylenes Isomerize in Pyrolysis?},
  series = {ChemPhysChem},
  volume    = {21},
  journal   = {ChemPhysChem},
  number    = {14},
  doi       = {10.1002/cphc.202000317},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218316},
  pages     = {1515 -- 1518},
  year      = {2020},
  abstract  = {We report infrared spectra of xylylene isomers in the gas phase, using free electron laser (FEL) radiation. All xylylenes were generated by flash pyrolysis. The IR spectra were obtained by monitoring the ion dip signal, using a IR/UV double resonance scheme. A gas phase IR spectrum of para-xylylene  was recorded, whereas ortho- and meta-xylylene were found to partially rearrange to benzocyclobutene and styrene. Computations of the UV oscillator strength  for all molecules were carried out and provde an explanation for the observation of the isomerization products.},
  language  = {en}
}
@article{AppeltshauserBrunderHeiniusetal.2020,
  author    = {Appeltshauser, Luise and Brunder, Anna-Michelle and Heinius, Annika and K{\"o}rtv{\´e}lyessy, Peter and Wandinger, Klaus-Peter and Junker, Ralf and Villmann, Carmen and Sommer, Claudia and Leypoldt, Frank and Doppler, Kathrin},
  title     = {Antiparanodal antibodies and IgG subclasses in acute autoimmune neuropathy},
  series = {Neurology: Neuroimmunology \& Neuroinflammation},
  volume    = {7},
  journal   = {Neurology: Neuroimmunology \& Neuroinflammation},
  number    = {5},
  doi       = {10.1212/NXI.0000000000000817},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-230079},
  year      = {2020},
  abstract  = {Objective To determine whether IgG subclasses of antiparanodal autoantibodies are related to disease course and treatment response in acute- to subacute-onset neuropathies, we retrospectively screened 161 baseline serum/CSF samples and 66 follow-up serum/CSF samples. Methods We used ELISA and immunofluorescence assays to detect antiparanodal IgG and their subclasses and titers in serum/CSF of patients with Guillain-Barre syndrome (GBS), recurrent GBS (R-GBS), Miller-Fisher syndrome, and acute- to subacute-onset chronic inflammatory demyelinating polyradiculoneuropathy (A-CIDP). We evaluated clinical data retrospectively. Results We detected antiparanodal autoantibodies with a prevalence of 4.3\% (7/161), more often in A-CIDP (4/23, 17.4\%) compared with GBS (3/114, 2.6\%). Longitudinal subclass analysis in the patients with GBS revealed IgG2/3 autoantibodies against Caspr-1 and against anti-contactin-1/Caspr-1, which disappeared at remission. At disease onset, patients with A-CIDP had IgG2/3 anti-Caspr-1 and anti-contactin-1/Caspr-1 or IgG4 anti-contactin-1 antibodies, IgG3 being associated with good response to IV immunoglobulins (IVIg). In the chronic phase of disease, IgG subclass of one patient with A-CIDP switched from IgG3 to IgG4. Conclusion Our data (1) confirm and extend previous observations that antiparanodal IgG2/3 but not IgG4 antibodies can occur in acute-onset neuropathies manifesting as monophasic GBS, (2) suggest association of IgG3 to a favorable response to IVIg, and (3) lend support to the hypothesis that in some patients, an IgG subclass switch from IgG3 to IgG4 may be the correlate of a secondary progressive or relapsing course following a GBS-like onset.},
  language  = {en}
}
@article{WhisnantJuergesHennigetal.2020,
  author    = {Whisnant, Adam W. and J{\"u}rges, Christopher S. and Hennig, Thomas and Wyler, Emanuel and Prusty, Bhupesh and Rutkowski, Andrzej J. and L'hernault, Anne and Djakovic, Lara and G{\"o}bel, Margarete and D{\"o}ring, Kristina and Menegatti, Jennifer and Antrobus, Robin and Matheson, Nicholas J. and K{\"u}nzig, Florian W. H. and Mastrobuoni, Guido and Bielow, Chris and Kempa, Stefan and Liang, Chunguang and Dandekar, Thomas and Zimmer, Ralf and Landthaler, Markus and Gr{\"a}sser, Friedrich and Lehner, Paul J. and Friedel, Caroline C. and Erhard, Florian and D{\"o}lken, Lars},
  title     = {Integrative functional genomics decodes herpes simplex virus 1},
  series = {Nature Communications},
  volume    = {11},
  journal   = {Nature Communications},
  doi       = {10.1038/s41467-020-15992-5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-229884},
  year      = {2020},
  abstract  = {The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been intensively studied for decades. Here, we unravel the complete viral transcriptome and translatome during lytic infection with base-pair resolution by computational integration of multi-omics data. We identify a total of 201 transcripts and 284 ORFs including all known and 46 novel large ORFs. This includes a so far unknown ORF in the locus deleted in the FDA-approved oncolytic virus Imlygic. Multiple transcript isoforms expressed from individual gene loci explain translation of the vast majority of ORFs as well as N-terminal extensions (NTEs) and truncations. We show that NTEs with non-canonical start codons govern the subcellular protein localization and packaging of key viral regulators and structural proteins. We extend the current nomenclature to include all viral gene products and provide a genome browser that visualizes all the obtained data from whole genome to single-nucleotide resolution. Here, using computational integration of multi-omics data, the authors provide a detailed transcriptome and translatome of herpes simplex virus 1 (HSV-1), including previously unidentified ORFs and N-terminal extensions. The study also provides a HSV-1 genome browser and should be a valuable resource for further research.},
  language  = {en}
}
@article{HuangWangDewhurstetal.2020,
  author    = {Huang, Zhenguo and Wang, Suning and Dewhurst, Rian D. and Ignat'ev, Nikolai V. and Finze, Maik and Braunschweig, Holger},
  title     = {Boron: Its Role in Energy-Related Processes and Applications},
  series = {Angewandte Chemie International Edition},
  volume    = {59},
  journal   = {Angewandte Chemie International Edition},
  number    = {23},
  doi       = {10.1002/anie.201911108},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-218514},
  pages     = {8800 -- 8816},
  year      = {2020},
  abstract  = {Boron's unique position in the Periodic Table, that is, at the apex of the line separating metals and nonmetals, makes it highly versatile in chemical reactions and applications. Contemporary demand for renewable and clean energy as well as energy-efficient products has seen boron playing key roles in energy-related research, such as 1) activating and synthesizing energy-rich small molecules, 2) storing chemical and electrical energy, and 3) converting electrical energy into light. These applications are fundamentally associated with boron's unique characteristics, such as its electron-deficiency and the availability of an unoccupied p orbital, which allow the formation of a myriad of compounds with a wide range of chemical and physical properties. For example, boron's ability to achieve a full octet of electrons with four covalent bonds and a negative charge has led to the synthesis of a wide variety of borate anions of high chemical and electrochemical stability—in particular, weakly coordinating anions. This Review summarizes recent advances in the study of boron compounds for energy-related processes and applications.},
  language  = {en}
}
@article{GrabenhenrichTrendelenburgBellachetal.2020,
  author    = {Grabenhenrich, Linus and Trendelenburg, Val{\´e}rie and Bellach, Johanna and Y{\"u}rek, Song{\"u}l and Reich, Andreas and Fiandor, Ana and Rivero, Daniela and Sigurdardottir, Sigurveig and Clausen, Michael and Papadopoulos, Nikolaos G. and Xepapadaki, Paraskevi and Sprikkelman, Aline B. and Dontje, Bianca and Roberts, Graham and Grimshaw, Kate and Kowalski, Marek L. and Kurowski, Marcin and Dubakiene, Ruta and Rudzeviciene, Odilija and Fern{\´a}ndez-Rivas, Montserrat and Couch, Philip and Versteeg, Serge A. and van Ree, Ronald and Mills, Clare and Keil, Thomas and Beyer, Kirsten},
  title     = {Frequency of food allergy in school-aged children in eight European countries—The EuroPrevall-iFAAM birth cohort},
  series = {Allergy},
  volume    = {75},
  journal   = {Allergy},
  number    = {9},
  doi       = {10.1111/all.14290},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214746},
  pages     = {2294 -- 2308},
  year      = {2020},
  abstract  = {Background The prevalence of food allergy (FA) among European school children is poorly defined. Estimates have commonly been based on parent-reported symptoms. We aimed to estimate the frequency of FA and sensitization against food allergens in primary school children in eight European countries. Methods A follow-up assessment at age 6-10 years of a multicentre European birth cohort based was undertaken using an online parental questionnaire, clinical visits including structured interviews and skin prick tests (SPT). Children with suspected FA were scheduled for double-blind, placebo-controlled oral food challenges (DBPCFC). Results A total of 6105 children participated in this school-age follow-up (57.8\% of 10 563 recruited at birth). For 982 of 6069 children (16.2\%), parents reported adverse reactions after food consumption in the online questionnaire. Of 2288 children with parental face-to-face interviews and/or skin prick testing, 238 (10.4\%) were eligible for a DBPCFC. Sixty-three foods were challenge-tested in 46 children. Twenty food challenges were positive in 17 children, including seven to hazelnut and three to peanut. Another seventy-one children were estimated to suffer FA among those who were eligible but refused DBPCFC. This yielded prevalence estimates for FA in school age between 1.4\% (88 related to all 6105 participants of this follow-up) and 3.8\% (88 related to 2289 with completed eligibility assessment). Interpretation In primary school children in eight European countries, the prevalence of FA was lower than expected even though parents of this cohort have become especially aware of allergic reactions to food. There was moderate variation between centres hampering valid regional comparisons.},
  language  = {en}
}
@article{CaoChenHaendel2020,
  author    = {Cao, Liyu and Chen, Xinyu and Haendel, Barbara F.},
  title     = {Overground Walking Decreases Alpha Activity and Entrains Eye Movements in Humans},
  series = {Frontiers in Human Neuroscience},
  volume    = {14},
  journal   = {Frontiers in Human Neuroscience},
  issn      = {1662-5161},
  doi       = {10.3389/fnhum.2020.561755},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-219872},
  year      = {2020},
  abstract  = {Experiments in animal models have shown that running increases neuronal activity in early visual areas in light as well as in darkness. This suggests that visual processing is influenced by locomotion independent of visual input. Combining mobile electroencephalography, motion- and eye-tracking, we investigated the influence of overground free walking on cortical alpha activity (~10 Hz) and eye movements in healthy humans. Alpha activity has been considered a valuable marker of inhibition of sensory processing and shown to negatively correlate with neuronal firing rates. We found that walking led to a decrease in alpha activity over occipital cortex compared to standing. This decrease was present during walking in darkness as well as during light. Importantly, eye movements could not explain the change in alpha activity. Nevertheless, we found that walking and eye related movements were linked. While the blink rate increased with increasing walking speed independent of light or darkness, saccade rate was only significantly linked to walking speed in the light. Pupil size, on the other hand, was larger during darkness than during light, but only showed a modulation by walking in darkness. Analyzing the effect of walking with respect to the stride cycle, we further found that blinks and saccades preferentially occurred during the double support phase of walking. Alpha power, as shown previously, was lower during the swing phase than during the double support phase. We however could exclude the possibility that the alpha modulation was introduced by a walking movement induced change in electrode impedance. Overall, our work indicates that the human visual system is influenced by the current locomotion state of the body. This influence affects eye movement pattern as well as neuronal activity in sensory areas and might form part of an implicit strategy to optimally extract sensory information during locomotion.},
  language  = {en}
}