@article{IsaiasBrumbergPozzietal.2020,
  author    = {Isaias, Ioannis U. and Brumberg, Joachim and Pozzi, Nicol{\´o} G. and Palmisano, Chiara and Canessa, Andrea and Marotta, Giogio and Volkmann, Jens and Pezzoli, Gianni},
  title     = {Brain metabolic alterations herald falls in patients with Parkinson's disease},
  series = {Annals of Clinical and Translational Neurology},
  volume    = {7},
  journal   = {Annals of Clinical and Translational Neurology},
  number    = {4},
  doi       = {10.1002/acn3.51013},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-235982},
  pages     = {579-583},
  year      = {2020},
  abstract  = {Pathophysiological understanding of gait and balance disorders in Parkinson's disease is insufficient and late recognition of fall risk limits efficacious followup to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased metabolic activity in the cerebellum, in parkinsonian patients 6-8 months before their first fall episode. Falls in Parkinson's disease may arise from altered cortical processing of body spatial orientation, possibly predicted by abnormal cortical metabolism.},
  language  = {en}
}