@article{SteigerwaldTimmermannKuehnetal.2018,
  author    = {Steigerwald, Frank and Timmermann, Lars and K{\"u}hn, Andrea and Schnitzler, Alfons and Reich, Martin M. and Kirsch, Anna Dalal and Barbe, Michael Thomas and Visser-Vandewalle, Veerle and H{\"u}bl, Julius and van Riesen, Christoph and Groiss, Stefan Jun and Moldovan, Alexia-Sabine and Lin, Sherry and Carcieri, Stephen and Manola, Ljubomir and Volkmann, Jens},
  title     = {Pulse duration settings in subthalamic stimulation for Parkinson's disease},
  series = {Movement Disorders},
  volume    = {33},
  journal   = {Movement Disorders},
  doi       = {10.1002/mds.27238},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-239402},
  pages     = {165-169},
  year      = {2018},
  abstract  = {Background Stimulation parameters in deep brain stimulation (DBS) of the subthalamic nucleus for Parkinson's disease (PD) are rarely tested in double-blind conditions. Evidence-based recommendations on optimal stimulator settings are needed. Results from the CUSTOM-DBS study are reported, comparing 2 pulse durations. Methods A total of 15 patients were programmed using a pulse width of 30 µs (test) or 60 µs (control). Efficacy and side-effect thresholds and unified PD rating scale (UPDRS) III were measured in meds-off (primary outcome). The therapeutic window was the difference between patients' efficacy and side effect thresholds. Results The therapeutic window was significantly larger at 30 µs than 60 µs (P = ·0009) and the efficacy (UPDRS III score) was noninferior (P = .00008). Interpretation Subthalamic neurostimulation at 30 µs versus 60 µs pulse width is equally effective on PD motor signs, is more energy efficient, and has less likelihood of stimulation-related side effects. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.},
  language  = {en}
}
@article{ArlottiPalmisanoMinafraetal.2019,
  author    = {Arlotti, Mattia and Palmisano, Chiara and Minafra, Brigida and Todisco, Massimiliano and Pacchetti, Claudio and Canessa, Andrea and Pozzi, Nicol{\´o} G. and Cilia, Roberto and Prenassi, Marco and Marceglia, Sara and Priori, Alberto and Rampini, Paolo and Barbieri, Sergio and Servello, Domenico and Volkmann, Jens and Pezzoli, Gianni and Isaias, Ioannis U.},
  title     = {Monitoring subthalamic oscillations for 24 hours in a freely moving Parkinson's disease patient},
  series = {Movement Disorders},
  volume    = {34},
  journal   = {Movement Disorders},
  doi       = {10.1002/mds.27657},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-221249},
  pages     = {757-759},
  year      = {2019},
  abstract  = {No abstract available},
  language  = {en}
}
@article{ZeinerPreusseGolebiewskaetal.2019,
  author    = {Zeiner, Pia S. and Preusse, Corinna and Golebiewska, Anna and Zinke, Jenny and Iriondo, Ane and Muller, Arnaud and Kaoma, Tony and Filipski, Katharina and M{\"u}ller-Eschner, Monika and Bernatz, Simon and Blank, Anna-Eva and Baumgarten, Peter and Ilina, Elena and Grote, Anne and Hansmann, Martin L. and Verhoff, Marcel A. and Franz, Kea and Feuerhake, Friedrich and Steinbach, Joachim P. and Wischhusen, J{\"o}rg and Stenzel, Werner and Niclou, Simone P. and Harter, Patrick N. and Mittelbronn, Michel},
  title     = {Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas},
  series = {Brain Pathology},
  volume    = {29},
  journal   = {Brain Pathology},
  doi       = {10.1111/bpa.12690},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-233897},
  pages     = {513-529},
  year      = {2019},
  abstract  = {While the central nervous system is considered an immunoprivileged site and brain tumors display immunosuppressive features, both innate and adaptive immune responses affect glioblastoma (GBM) growth and treatment resistance. However, the impact of the major immune cell population in gliomas, represented by glioma-associated microglia/macrophages (GAMs), on patients' clinical course is still unclear. Thus, we aimed at assessing the immunohistochemical expression of selected microglia and macrophage markers in 344 gliomas (including gliomas from WHO grade I-IV). Furthermore, we analyzed a cohort of 241 IDH1R132H-non-mutant GBM patients for association of GAM subtypes and patient overall survival. Phenotypical properties of GAMs, isolated from high-grade astrocytomas by CD11b-based magnetic cell sorting, were analyzed by immunocytochemistry, mRNA microarray, qRT-PCR and bioinformatic analyses. A higher amount of CD68-, CD163- and CD206-positive GAMs in the vital tumor core was associated with beneficial patient survival. The mRNA expression profile of GAMs displayed an upregulation of factors that are considered as pro-inflammatory M1 (eg, CCL2, CCL3L3, CCL4, PTGS2) and anti-inflammatory M2 polarization markers (eg, MRC1, LGMN, CD163, IL10, MSR1), the latter rather being associated with phagocytic functions in the GBM microenvironment. In summary, we present evidence that human GBMs contain mixed M1/M2-like polarized GAMs and that the levels of different GAM subpopulations in the tumor core are positively associated with overall survival of patients with IDH1R132H-non-mutant GBMs.},
  language  = {en}
}
@article{IngendohTsakmakidisMikolaiWinkeletal.2019,
  author    = {Ingendoh-Tsakmakidis, Alexandra and Mikolai, Carina and Winkel, Andreas and Szafrański, Szymon P. and Flak, Christine S. and Rossi, Angela and Walles, Heike and Stiesch, Meike},
  title     = {Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model},
  series = {Cellular Microbiology},
  volume    = {21},
  journal   = {Cellular Microbiology},
  doi       = {10.1111/cmi.13078},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-323077},
  year      = {2019},
  abstract  = {The impact of oral commensal and pathogenic bacteria on peri-implant mucosa is not well understood, despite the high prevalence of peri-implant infections. Hence, we investigated responses of the peri-implant mucosa to Streptococcus oralis or Aggregatibacter actinomycetemcomitans biofilms using a novel in vitro peri-implant mucosa-biofilm model. Our 3D model combined three components, organotypic oral mucosa, implant material, and oral biofilm, with structural assembly close to native situation. S. oralis induced a protective stress response in the peri-implant mucosa through upregulation of heat shock protein (HSP70) genes. Attenuated inflammatory response was indicated by reduced cytokine levels of interleukin-6 (IL-6), interleukin-8 (CXCL8), and monocyte chemoattractant protein-1 (CCL2). The inflammatory balance was preserved through increased levels of tumor necrosis factor-alpha (TNF-α). A. actinomycetemcomitans induced downregulation of genes important for cell survival and host inflammatory response. The reduced cytokine levels of chemokine ligand 1 (CXCL1), CXCL8, and CCL2 also indicated a diminished inflammatory response. The induced immune balance by S. oralis may support oral health, whereas the reduced inflammatory response to A. actinomycetemcomitans may provide colonisation advantage and facilitate later tissue invasion. The comprehensive characterisation of peri-implant mucosa-biofilm interactions using our 3D model can provide new knowledge to improve strategies for prevention and therapy of peri-implant disease.},
  language  = {en}
}
@article{MazonLaroucheStLouisetal.2018,
  author    = {Mazon, Melody and Larouche, Val{\´e}rie and St-Louis, Maryse and Schindler, Detlev and Carreau, Madeleine},
  title     = {Elevated blood levels of Dickkopf-1 are associated with acute infections},
  series = {Immunity, Inflammation and Disease},
  volume    = {6},
  journal   = {Immunity, Inflammation and Disease},
  doi       = {10.1002/iid3.232},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-222171},
  pages     = {428-434},
  year      = {2018},
  abstract  = {Introduction Dickkopf-1 (DKK1) is a soluble protein and antagonist of the Wnt/β-catenin signaling pathway. DKK1 is found elevated in serum from patients affected with various types of cancers and in some instances, it is considered a diagnostic and prognostic biomarker. Elevated serum levels of DKK1 have also been detected in animal models of chronic inflammatory diseases. Previous work from our laboratory has demonstrated upregulation of DKK1 in cells and mouse models of the bone marrow failure (BMF) and cancer-prone disease Fanconi anemia (FA). The present study aimed to investigate whether DKK1 blood levels in patients are associated with FA or inflammatory responses to acute infections. Methods Plasma samples were collected from 58 children admitted to the Centre M{\`e}re-Enfant Soleil du Centre Hospitalier de Qu{\´e}bec-Universit{\´e} Laval with signs of acute infections. Blood plasma specimens were also collected from healthy blood donors at the H{\´e}ma-Qu{\´e}bec blood donor clinic. Plasmas from patients diagnosed with FA were also included in the study. DKK1 levels in blood plasmas were assessed by standard ELISA. Results Patients with acute infections showed dramatically high levels of DKK1 (6072 ± 518 pg/ml) in their blood compared to healthy blood donors (1726 ± 95 pg/ml). No correlations were found between DKK1 levels and C reactive protein (CRP) concentration, platelet numbers, or white blood cell counts. Patients with FA showed higher DKK1 plasma levels (3419 ± 147.5 pg/ml) than healthy blood donors (1726 ± 95 pg/ml) but significantly lower than patients with acute infections. Conclusion These findings suggest that blood DKK1 is elevated in response to infections and perhaps to inflammatory responses.},
  language  = {en}
}
@article{VanAsscheFicklFranciscoetal.2018,
  author    = {Van Assche, Nele and Fickl, Stefan and Francisco, Helena and Gurzawska, Katarzyna and Milinkovic, Iva and Navarro, Jose M. and Torsello, Ferruccio and Thoma, Daniel S.},
  title     = {Guidelines for development of Implant Dentistry in the next 10 years regarding innovation, education, certification, and associations},
  series = {Clinical Oral Implants Research},
  volume    = {29},
  journal   = {Clinical Oral Implants Research},
  doi       = {10.1111/clr.13154},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-232150},
  pages     = {568-575},
  year      = {2018},
  abstract  = {Background During the third Summer Camp of European Association of Osseointegration (EAO), 40 junior representatives from various European societies and associations were brought together to discuss and explore the following topics in Implant Dentistry in the next 10 years: (I) certification, (II) societies and associations, (III) continuing education, and (IV) innovations. Aims The aims of all working groups were to identify and outline the present situation in the area of the selected topic and to propose improvements and innovations to be implemented in the following 10 years. Materials and methods Four different groups were assigned randomly to one of the four working units. The method to discuss the selected topics was World Caf{\`e}. The summaries of four topics were then given to all participants for peer review. Results and conclusions All four groups presented the conclusions and guidelines accordingly: (I) The recognition for Implant Dentistry and accreditation of training programs would lead to an improvement of the quality of care to the benefit of the patients; (II) Dental associations and societies have to continuously improve communication to meet needs of dental students, professionals, and patients (III) European Dental Board should be installed and become responsible for continue dental education; (IV) dental engineering, peri-implant diseases, and digital workflow in dentistry currently have limited tools that do not guarantee predictable results.},
  language  = {en}
}