@article{LutzSchlatter1978,
  author    = {Lutz, Werner K. and Schlatter, C.},
  title     = {A closed inhalation system for pharmacokinetic and metabolism studies of volatile compounds with small laboratory animals},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-80145},
  year      = {1978},
  abstract  = {In the inhalation system described an animal can be kept in the same atmosphere of a 2-liter desiccator for up to 24 h. The expired carbon dioxide is adsorbed with soda lime and the resulting reduced pressure is balanced by a supply of oxygen also used for the inflow of the chemical to be investigated. Urine and faeces can be collected ~eparately and the system allows a periodical control of the concentration of the chemical by sampling the air with needle and syringe.},
  subject      = {Toxikologie},
  language  = {en}
}
@inproceedings{LutzSchlatter1978,
  author    = {Lutz, Werner K. and Schlatter, C.},
  title     = {Extrapolation of carcinogenicity data to low doses with a dose-response study of the binding of benzo(a)pyrene to rat liver DNA},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-80157},
  year      = {1978},
  abstract  = {The binding of tritiated benzo(a)pyrene (BP) to liver DNA of 25 adult male rats (SIV 50) has been determined 50 h after a single intraperitoneal injection of doses between 40 ug/kg and 4; mg/kg. The dose-response relations~ ip is linear up to i mg/kg, shows a sigmoid step towards 2 mg/kg and a shallow linear. slope above that value. TlJe 0 bserved bin ding ranges from 1.7 to 180 nmoles BP per mole DNA phosphate. The non-linearity between 1 and 2 mg/kg could be explained 0):1 the basis of an induction of metabolizing enzymes. A pure1y mathematical extrapolation of therumour incidence from a carcinogenic dose (1 x 40mg/kg for a 20\% hepatoma incidence in newborn mice) to human exposure levels (aboilt 0.1 ug/kg per day) would never have followed a step like the on~ found in our experiments. Our dose-effect study therefore shows how carcinogenitity data could be extrapolated in a biologically founded way to low doses.},
  subject      = {Toxikologie},
  language  = {en}
}
@article{LutzSchlatter1977,
  author    = {Lutz, Werner K. and Schlatter, C.},
  title     = {Saccharin does not bind to DNA of liver or bladder in the rat [Short Communication]},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61194},
  year      = {1977},
  abstract  = {No abstract available},
  subject      = {Toxikologie},
  language  = {en}
}
@article{LutzSchlatter1977,
  author    = {Lutz, Werner K. and Schlatter, C.},
  title     = {Mechanism of the carcinogenic action of benzene: irreversible binding to rat liver DNA},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61208},
  year      = {1977},
  abstract  = {No abstract available},
  subject      = {Toxikologie},
  language  = {en}
}
@article{LutzWinklerDunitz1971,
  author    = {Lutz, Werner K. and Winkler, F. K. and Dunitz, J. D.},
  title     = {Crystal structure of the antibiotic monensin similarities and differences betweeen free acid and metal complex},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61228},
  year      = {1971},
  abstract  = {The structure of monensin, C36H620 11 , has been deterrnined by X-ray analysis of its crystalline monohydrate (orthorhombic, a = 15.15, b = 23.61, c = 10.65 A, Z = 4, space group P212121). Phases were assigned by direct methods, malring use of the 'tangent formula'. Although the conformation of the free acid resembles that of the silver salt in being cyclic, there are differences in the hydrogen bonding pattern. These featurcs are discussed in relation to the cornplexation of metal ions by m.onensin.},
  subject      = {Toxikologie},
  language  = {en}
}
@article{LutzFruehSimon1971,
  author    = {Lutz, Werner K. and Fr{\"u}h, P. U. and Simon, W.},
  title     = {Microcalorimetric determination of ΔH0, ΔG0 and ΔS0 for the interaction of the carrier antibiotics nigericin and monensin with sodium and potassium ions},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61218},
  year      = {1971},
  abstract  = {The thermodynainic parameters ΔH0, ΔG0 and ΔS0 - and thereby the equilibrium constants - for the complexation of the carrier antibiotics nigericin and monensin with sodium and potassium ions in methanol at 25°C have been determined by microcalorimetry. Tbc results are discussed in terms of the nature of the interaction between ligands and cations.},
  subject      = {Toxikologie},
  language  = {en}
}
@article{LutzWipfSimon1970,
  author    = {Lutz, Werner K. and Wipf, H. K. and Simon, W.},
  title     = {Alkalikationen-Spezifit{\"a}t und Tr{\"a}ger-Eigenschaftender Antibiotica Nigerfein und Monensin},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61233},
  year      = {1970},
  abstract  = {It is shown by means of IR. spectroscopic methodsthat nigericin and monensin bave a cyclic conformation similar to that of their silver salts. Camplex fonnation constants with sodium and potassium ions follow the selectivity order determined by EMF. measurements on liquid membranes: nigericin: K\(^+\) >Rb\(^+\)> Na\(^+\)> Cs\(^+\) >Li\(^+\); monensin: Na\(^+\)> K\(^+\) >Li\(^+\)> Rb\(^+\)> Cs\(^+\). Transport experiments show that nigericin and monensin facilitate the diffusion of potassium ions across model membranes, although in electrolytic transport experiments the permeability is not affected.},
  subject      = {Toxikologie},
  language  = {de}
}