Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-12830 Wissenschaftlicher Artikel Tacke, Reinhold; Linoh, Haryanto; Stumpf, Burghard; Abraham, Wolf-Rainer; Kieslich, Klaus; Ernst, Ludger Mikrobiologische Umwandlung von Silicium-Verbindungen: Enantioselektive Reduktion von Acetessigsäure-(trimethylsilylalkyl)estern und deren Carba-Analoga The trimethylsilylalkyl acetoacetates 1 b and 2 b as well as their carba analogues 1 a and 2 a have been reduced microbiologically by Kloeckera corticis (ATCC 20109), leading to the corresponding ( + )-3(S)-hydroxybutanoates 3b, 4b, 3a, and 4a. The enantiomeric purity was found to be 80% (3a, 3b, 4b) and 65% (4a), respectively. The reduction of lb and 2b is - to our knowledge - the first example for a controlled microbiological transformation of organosilicon substrates. 1983 616-620 Zeitschrift für Naturforschung B 38 5 urn:nbn:de:bvb:20-opus-128304 Institut für Anorganische Chemie OPUS4-12840 Wissenschaftlicher Artikel Tacke, Reinhold; Linoh, Haryanto; Attar-Bashi, Moayad T.; Sheldrick, William S.; Ernst, Ludger; Niedner, Roland; Frohnecke, Joachim Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction analysis (8a- 8e) and IR NMR spectroscopy (8a- 8f), respectively. The muscle relaxing properties of 8a- 8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 Å model" for neuromuscular blocking agents. 1982 1461-1471 Zeitschrift für Naturforschung B 37 11 urn:nbn:de:bvb:20-opus-128402 Institut für Anorganische Chemie