Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-17463 Wissenschaftlicher Artikel Werner, Rudolf A.; Ordonez, Alvaro A.; Sanchez-Bautista, Julian; Marcus, Charles; Lapa, Constantin; Rowe, Steven P.; Pomper, Martin G.; Leal, Jeffrey P.; Lodge, Martin A.; Javadi, Mehrbod S.; Jain, Sanjay K.; Higuchi, Takahiro Novel functional renal PET imaging with 18F-FDS in human subjects The novel PET probe 2-deoxy-2-18F-fluoro-D-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in two human volunteers. 18F-FDS was produced by a simple one-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from 18F-FDG, 18F-FDS is virtually available at any PET facility with radiochemistry infrastructure. 2019 410-411 Clinical Nuclear Medicine 44 5 urn:nbn:de:bvb:20-opus-174634 Klinik und Poliklinik für Nuklearmedizin