Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-31720 Konferenzveröffentlichung Neumann, Isabel; Gado, Sabrina; Käthner, Ivo; Hildebrandt, Lea; Andreatta, Marta Abstracts of the Wuertual Reality XR Meeting 2023 The Wuertual Reality XR Meeting 2023 was initiated to bring together researchers from many fields who use VR/AR/XR. There was a focus on applied XR and social VR. In this conference band, you can find the abstracts of the two keynotes, the 34 posters and poster pitches, the 29 talks and the four workshops. korrigierte Auflage 2023 76 urn:nbn:de:bvb:20-opus-317203 10.25972/OPUS-31720 Institut für Psychologie OPUS4-32231 Konferenzveröffentlichung Förster, Kristina; Grafe, Silke Langran, Elizabeth; Christensen, Peter; Sanson, Jarrod Fostering Teacher Educators' Intercultural Media-Related Competencies Using a Social VR Environment Recent studies suggest that teacher educators require intercultural media-related educational competencies to respond to contemporary and future educational needs. However, necessary professional development concepts, which are aimed at fostering these competencies, are underrepresented in current teacher education research. This study reports on the results of a case study within a Design-Based-Research project aimed at designing, implementing and evaluating a professional development concept to foster teacher educators' intercultural media-related competencies. A remote workshop using a Social VR environment was conducted with a convenience sample of 10 teacher educators. Data collected through a qualitative pre-post survey and a focus group was interpreted through qualitative content analysis. Findings showed intercultural aspects were addressed in several domains as well as an increased ability to evaluate potentials and risks related to interculturally focused teaching and learning with Social VR. 2023 2547-2557 Proceedings of Society for Information Technology & Teacher Education International Conference urn:nbn:de:bvb:20-opus-322310 Institut für Pädagogik OPUS4-31528 Konferenzveröffentlichung Neumann, Isabel; Gado, Sabrina; Käthner, Ivo; Hildebrandt, Lea; Andreatta, Marta Abstracts of the Wuertual Reality XR Meeting 2023 The Wuertual Reality XR Meeting 2023 was initiated to bring together researchers from many fields who use VR/AR/XR. There was a focus on applied XR and social VR. In this conference band, you can find the abstracts of the two keynotes, the 34 posters and poster pitches, the 29 talks and the four workshops. 2023 76 urn:nbn:de:bvb:20-opus-315285 10.25972/OPUS-31528 Institut für Psychologie OPUS4-32019 Konferenzveröffentlichung Abendschein, Robin; Desai, Shital; Astell, Arlene J. Towards Accessibility Guidelines for the Metaverse : A Synthesis of Recommendations for People Living With Dementia Given the growing interest of corporate stakeholders in Metaverse applications, there is a need to understand accessibility of these technologies for marginalized populations such as people living with dementia to ensure inclusive design of Metaverse applications. We assessed the accessibility of extended reality technology for people living with mild cognitive impairment and dementia to develop accessibility guidelines for these technologies. We used four strategies to synthesize evidence for barriers and facilitators of accessibility: (1) Findings from a non-systematic literature review, (2) guidelines from well-researched technology, (3) exploration of selected mixed reality technologies, and (4) observations from four sessions and video data of people living with dementia using mixed reality technologies. We utilized template analysis to develop codes and themes towards accessibility guidelines. Future work can validate our preliminary findings by applying them on video recordings or testing them in experiments. 2023 6 Conference on Human Factors in Computing Systems (CHI’23) : Workshop "Towards an Inclusive and Accessible Metaverse" urn:nbn:de:bvb:20-opus-320199 10.25972/OPUS-32019 Institut Mensch - Computer - Medien OPUS4-24604 Konferenzveröffentlichung Epplée, Rafael; Langbehn, Eike Overlapping Architecture: Implementation of Impossible Spaces in Virtual Reality Games Natural walking in virtual reality games is constrained by the physical boundaries defined by the size of the player's tracking space. Impossible spaces, a redirected walking technique, enlarge the virtual environment by creating overlapping architecture and letting multiple locations occupy the same physical space. Within certain thresholds, this is subtle to the player. In this paper, we present our approach to implement such impossible spaces and describe how we handled challenges like objects with simulated physics or precomputed global illumination. 2021 37-46 urn:nbn:de:bvb:20-opus-246045 Institut für Informatik OPUS4-26057 Konferenzveröffentlichung Förster, Kristina; Grafe, Silke ICT-related Educational Competencies of Teacher Educators from an Intercultural Perspective. A Systematic Analysis of Competency Frameworks Both research and policy indicate the importance of considering ICT-related and intercultural competence development in education together. Teacher educators play a significant role in the development of these related competencies. The aim of this study is to analyze ICT- related competence frameworks addressing teacher educators, focusing on how they incorporate intercultural considerations. We analyze four internationally recognized models—Teacher Educator Technology Competencies (TETCs), DigCompEdu, Jisc Digital Capabilities, and Media Didactica—showing that with the TETCs important steps have been taken to integrate both discourses, while the other frameworks treat aspects related to culture as isolated phenomena. In TETC 8, the global dimension is represented by a specific competency, which is also differentiated into specific areas of competence. This offers a strong starting point for further international discourse, in terms of both the diversification of underlying theoretical concepts and approaches to culturally responsive education. Further research is needed to investigate how professional development can meet the needs of teacher educators in a global context. 2021 1-8 Proceedings of Society for Information Technology & Teacher Education International Conference urn:nbn:de:bvb:20-opus-260577 Institut für Pädagogik OPUS4-26058 Konferenzveröffentlichung Förster, Kristina; Hein, Rebecca; Grafe, Silke; Latoschik, Marc Erich; Wienrich, Carolin Basteans, Theo Fostering Intercultural Competencies in Initial Teacher Education: Implementation of Educational Design Prototypes Using a Social Virtual Reality Environment The combination of globalization and digitalization emphasizes the importance of media-related and intercultural competencies of teacher educators and preservice teachers. This article reports on the initial prototypical implementation of a pedagogical concept to foster such competencies of preservice teachers. The proposed pedagogical concept utilizes a social virtual reality (VR) framework since related work on the characteristics of VR has indicated that this medium is particularly well suited for intercultural professional development processes. The development is integrated into a larger design-based research approach that develops a theory-guided and empirically grounded professional development concept for teacher educators with a special focus on teacher educator technology competencies (TETC8). TETCs provide a suitable competence framework capable of aligning requirements for both media-related and intercultural competencies. In an exploratory study with student teachers, we designed, implemented, and evaluated a pedagogical concept. Reflection reports were qualitatively analyzed to gain insights into factors that facilitate or hinder the implementation of the immersive learning scenario as well as into the participants' evaluation of their learning experience. The results show that our proposed pedagogical concept is particularly suitable for promoting the experience of social presence, agency, and empathy in the group. 2021 95-108 Proceedings of Innovate Learning Summit urn:nbn:de:bvb:20-opus-260586 Institut für Informatik OPUS4-24603 Konferenzveröffentlichung Truman, Samuel; von Mammen, Sebastian Interactive Self-Assembling Agent Ensembles In this paper, we bridge the gap between procedural content generation (PCG) and user-generated content (UGC) by proposing and demonstrating an interactive agent-based model of self-assembling ensembles that can be directed though user input. We motivate these efforts by considering the opportunities technology provides to pursue game designs based on according game design frameworks. We present three different use cases of the proposed model that emphasize its potential to (1) self-assemble into predefined 3D graphical assets, (2) define new structures in the context of virtual environments by self-assembling layers on the surfaces of arbitrary 3D objects, and (3) allow novel structures to self-assemble only considering the model's configuration and no external dependencies. To address the performance restrictions in computer games, we realized the prototypical model implementation by means of an efficient entity component system (ECS). We conclude the paper with an outlook on future steps to further explore novel interactive, dynamic PCG mechanics and to ensure their efficiency. 2021 29-36 Proceedings of the 1st Games Technology Summit urn:nbn:de:bvb:20-opus-246032 Institut für Informatik OPUS4-24577 Konferenzveröffentlichung von Mammen, Sebastian; Klemke, Roland; Lorber, Martin Proceedings of the 1st Games Technology Summit As part of the Clash of Realities International Conference on the Technology and Theory of Digital Games, the Game Technology Summit is a premium venue to bring together experts from academia and industry to disseminate state-of-the-art research on trending technology topics in digital games. In this first iteration of the Game Technology Summit, we specifically paid attention on how the successes in AI in Natural User Interfaces have been impacting the games industry (industry track) and which scientific, state-of-the-art ideas and approaches are currently pursued (scientific track). 2021 vi, 46 978-3-945459-36-2 urn:nbn:de:bvb:20-opus-245776 10.25972/OPUS-24577 Institut für Informatik OPUS4-24584 Konferenzveröffentlichung Klemke, Roland; Sanusi, Khaleel Asyraaf Mat; Rose, Melina Immersive Game Technologies for Innovative Education - A Method for Experimental Interdisciplinary Technology Transfer Immersive, sensor-enabled technologies such as augmented and virtual reality expand the way human beings interact with computers significantly. While these technologies are widely explored in entertainment games, they also offer possibilities for educational use. However,their uptake in education is so far very limited. Within the ImTech4Ed project, we aim at systematically exploring the power of interdisciplinary, international hackathons as a novel method to create immersive educational game prototypes and as a means to transfer these innovative technical prototypes into educational use. To achieve this, we bring together game design and development, where immersive and interactive solutions are designed and developed; computer science, where the technological foundations for immersive technologies and for scalable architectures for these are created; and teacher education, where future teachers are educated. This article reports on the concept and design of these hackathons. 2021 1-8 Proceedings of the 1st Games Technology Summit urn:nbn:de:bvb:20-opus-245843 Institut für Informatik OPUS4-24602 Konferenzveröffentlichung Davies, Richard; Dewell, Nathan; Harvey, Carlo A framework for interactive, autonomous and semantic dialogue generation in games Immersive virtual environments provide users with the opportunity to escape from the real world, but scripted dialogues can disrupt the presence within the world the user is trying to escape within. Both Non-Playable Character (NPC) to Player and NPC to NPC dialogue can be non-natural and the reliance on responding with pre-defined dialogue does not always meet the players emotional expectations or provide responses appropriate to the given context or world states. This paper investigates the application of Artificial Intelligence (AI) and Natural Language Processing to generate dynamic human-like responses within a themed virtual world. Each thematic has been analysed against humangenerated responses for the same seed and demonstrates invariance of rating across a range of model sizes, but shows an effect of theme and the size of the corpus used for fine-tuning the context for the game world. 2021 16-28 Proceedings of the 1st Games Technology Summit urn:nbn:de:bvb:20-opus-246023 Institut für Informatik OPUS4-24601 Konferenzveröffentlichung Sanusi, Khaleel Asyraaf Mat; Klemke, Roland Immersive Multimodal Environments for Psychomotor Skills Training Modern immersive multimodal technologies enable the learners to completely get immersed in various learning situations in a way that feels like experiencing an authentic learning environment. These environments also allow the collection of multimodal data, which can be used with artificial intelligence to further improve the immersion and learning outcomes. The use of artificial intelligence has been widely explored for the interpretation of multimodal data collected from multiple sensors, thus giving insights to support learners' performance by providing personalised feedback. In this paper, we present a conceptual approach for creating immersive learning environments, integrated with multi-sensor setup to help learners improve their psychomotor skills in a remote setting. 2021 9-15 Proceedings of the 1st Games Technology Summit urn:nbn:de:bvb:20-opus-246016 Institut für Informatik OPUS4-17720 Konferenzveröffentlichung Middelhoff, Frederike; Schönbeck, Sebastian; Borgards, Roland; Gersdorf, Catrin Texts, Animals, Environments: Zoopoetics and Ecopoetics Texts, Animals, Environments. Zoopoetics and Ecopoetics probes the multiple links between ecocriticism and animal studies, assessing the relations between animals, environments and poetics. While ecocriticism usually relies on a relational approach to explore phenomena related to the environment or ecology more broadly, animal studies tends to examine individual or species-specific aspects. As a consequence, ecocriticism concentrates on ecopoetical, animal studies on zoopoetical elements and modes of representation in literature (and the arts more generally). Bringing key concepts of ecocriticism and animal studies into dialogue, the volume explores new ways of thinking about and reading texts, animals, and environments - not as separate entities but as part of the same collective. 1. Auflage Freiburg i. Br. Rombach Druck- und Verlagshaus 2019 359 urn:nbn:de:bvb:20-opus-177209 Institut für deutsche Philologie OPUS4-16220 Konferenzveröffentlichung Werner, Rudolf A.; Marcus, Charles; Sheikhbahaei, Sara; Higuchi, Takahiro; Solnes, Lilja B.; Rowe, Steven P.; Buck, Andreas K.; Lapa, Constantin; Javadi, Mehrbod S. Diagnostic Accuracy of Visual Assessment of an Initial DaT-Scan in Comparison to a Fully Automatic Semiquantitative Method No abstract available. 2018 Journal of Nuclear Medicine 59 Supplement No. 1 626 urn:nbn:de:bvb:20-opus-162208 Klinik und Poliklinik für Nuklearmedizin OPUS4-16221 Konferenzveröffentlichung Werner, Rudolf A.; Marcus, Charles; Sheikhbahaei, Sara; Higuchi, Takahiro; Solnes, Lilja B.; Rowe, Steven P.; Buck, Andreas K.; Lapa, Constantin; Javadi, Mehrbod S. The Impact of Ageing on Dopamine Transporter Imaging No abstract available. 2018 Journal of Nuclear Medicine 59 Supplement No 1 1646 urn:nbn:de:bvb:20-opus-162213 Klinik und Poliklinik für Nuklearmedizin OPUS4-16222 Konferenzveröffentlichung Werner, Rudolf A.; Chen, Xinyu; Hirano, Mitsuru; Nose, Naoko; Lapa, Constantin; Javadi, Mehrbod S.; Higuchi, Takahiro The Impact of Ageing on [\(^{11}\)C]meta-Hydroxyephedrine Uptake in the Rat Heart No abstract available. 2018 100 Journal of Nuclear Medicine 59 Supplement No 1 urn:nbn:de:bvb:20-opus-162228 Klinik und Poliklinik für Nuklearmedizin OPUS4-16111 Konferenzveröffentlichung Werner, Rudolf; Kobayashi, Ryohei; Wakabayashi, Hiroshi; Lapa, Constantin; Menke, Andreas; Higuchi, Takahiro Effect of Antidepressants on Radiolabeled Metaiodobenzylguanidine (MIBG) Uptake No abstract available. Oxford University Press 2017 i52-53 European Heart Journal - Cardiovascular Imaging 18 Supplement urn:nbn:de:bvb:20-opus-161116 10.1093/ehjci/jex080 Klinik und Poliklinik für Nuklearmedizin OPUS4-16112 Konferenzveröffentlichung Werner, Rudolf; Wakabayashi, Hiroshi; Jahns, Roland; Ergün, Süleyman; Jahns, Valerie; Higuchi, Takahiro PET-Guided Histological Characterization of Myocardial Infiltrating Cells in a Rat Model of Myocarditis No abstract available. Oxford University Press 2017 i1-i3 European Heart Journal - Cardiovascular Imaging 18 Supplement urn:nbn:de:bvb:20-opus-161127 10.1093/ehjci/jex071 Klinik und Poliklinik für Nuklearmedizin OPUS4-16113 Konferenzveröffentlichung Werner, Rudolf; Chen, Xinyu; Lapa, Constantin; Robinson, Simon; Higuchi, Takahiro Intracellular behavior of the novel sympathetic nerve agent \(^{18}\)F-LMI1195 No abstract available. 2017 1461-1496 Journal of Nuclear Cardiology 24 4 Supplement (2017) Aug urn:nbn:de:bvb:20-opus-161137 10.1007/s12350-017-0984-y Klinik und Poliklinik für Nuklearmedizin OPUS4-16114 Konferenzveröffentlichung Werner, Rudolf; Higuchi, Takahiro; Muegge, Dirk; Javadi, Mehrbod S.; Märkl, Bruno; Aulmann, Christoph; Buck, Andreas K.; Fassnacht, Martin; Lapa, Constantin; Kreissl, Michael C. Predictive value of FDG-PET in patients with advanced medullary thyroid cancer undergoing vandetanib treatment Introduction: The prognosis of medullary thyroid carcinoma (MTC) is poor using common chemotherapeutic approaches. However, during the last years encouraging results of recently introduced tyrosine kinase inhibitors (TKI) such as vandetanib have been published. In this study we aimed to correlate the results of \(^{18}\)F-fluorodeoxyglucose ([\(^{18}\)F]FDG) positron emission tomography (PET) imaging with treatment outcome. Methods: Eighteen patients after thyroidectomy with recurrent/advanced MTC lesions receiving vandetanib (300 mg orally/day) could be analysed. A baseline \(^{18}\)F-FDG PET prior to and a follow-up \(^{18}\)F-FDG PET 3 months after TKI initiation were performed. During follow-up, tumor progression was assessed every 3 months including computed tomography according to RECIST. Progression-free survival (PFS) was correlated with the maximum standardized uptake value of \(^{18}\)F-FDG in lymph nodes (SUV(LN)max) or visceral metastases (SUV(MTS)max) as well as with clinical parameters using ROC analysis. Results: Within median 3.6 years of follow-up, 9 patients showed disease progression at median 8.5 months after TKI initiation. An elevated glucose consumption assessed by baseline \(^{18}\)F-FDG PET (SUV(LN)max > 7.25) could predict a shorter PFS (2 y) with an accuracy of 76.5% (SUV(LN)max <7.25, 4.3 y; p=0.03). Accordingly, preserved tumor metabolism in the follow-up PET (SUV(MTS)max >2.7) also demonstrated an unfavorable prognosis (accuracy, 85.7%). On the other hand, none of the clinical parameters reached significance in response prediction. Conclusions: In patients with advanced and progressive MTC, tumors with higher metabolic activity at baseline are more aggressive and more prone to progression as reflected by a shorter PFS; they should be monitored more closely. Preserved glucose consumption 3 months after treatment initiation was also related to poorer prognosis. 2017 169 Journal of Nuclear Medicine 58 no. supplement 1 urn:nbn:de:bvb:20-opus-161147 Klinik und Poliklinik für Nuklearmedizin OPUS4-16116 Konferenzveröffentlichung Werner, Rudolf; Lapa, Constantin; Buck, Andreas; Lassmann, Michael; Hänscheid, Heribert Less is sometimes more - Accurate Dose Mapping after Endoradiotherapy with \(^{177}\)Lu-DOTATATE/-TOC by One-Single Measurement after 96 h No abstract available. Society of Nuclear Medicine and Molecular Imaging 2017 247 Journal of Nuclear Medicine 58 No. Supplement 1 urn:nbn:de:bvb:20-opus-161168 Klinik und Poliklinik für Nuklearmedizin OPUS4-14713 Konferenzveröffentlichung Brill, Michael; Jonsson, Gudberg; Schwab, Frank Research Network on Methodology for the Analysis of Social Interaction. Proceedings of the ninth meeting of MASI. T-pattern analysis supports studies of various aspects of human or animal behavior as well as interaction between human subjects and animal or artificial agents. The following proceedings give an overiew on the application of T-pattern analysis in different research fields like media, gaming, human behaviour, social and organisational interaction as well as sports and health. 2017 978-3-945459-16-4 urn:nbn:de:bvb:20-opus-147135 Institut Mensch - Computer - Medien OPUS4-12158 Konferenzveröffentlichung Högger, Petra; Xiao, Jianbo Abstracts of the International Symposium on Phytochemicals in Medicine and Food The International Symposium on Phytochemicals in Medicine and Food (ISPMF2015), organized by the Phytochemical Society of Europe (PSE) and the Phytochemical Society of Asia (PSA), was held June 26-29, 2015, in Shanghai of China. This was the first time that a PSE meeting has been held in Asia and a PSE-PSA joint symposium provided an opportunity for communication between scientists from Europe and Asia and other continents. ISPMF2015 has been jointly sponsored by Fujian Agriculture and Forestry University, Guizhou Medical University, Shanghai Normal University, Yancheng Institute of Technology, Beijing Normal University, and Fudan University. More than 270 scientists from 48 countries attended this meeting and presented their research and opinions on phytochemistry, phytomedicine and phytoneering. The international organizing committee and scientific advisory board of ISPMF 2015 comprised of outstanding scientists from around the globe. Dr. Jianbo Xiao was the chairman of the International Organizing Committee of ISPMF2015 and moderated the open address on June 26. The organizing committee of ISPMF2015 assembled an exciting and diverse program, featuring 16 sessions including 12 plenary lectures, 20 invited talks, 55 short oral presentations, and more than 130 posters, which were dedicated to creating a podium for exchanging the latest research results in the phytochemicals for food and human health. 2015 urn:nbn:de:bvb:20-opus-121585 Institut für Pharmazie und Lebensmittelchemie OPUS4-11127 Konferenzveröffentlichung Flanders, Julia; Jannidis, Fotis Knowledge Organization and Data Modeling in the Humanities Based on the results of a 3-day workshop at the Brown University (2012) this white paper tries to sum up important topics and problems which came up in the presentations and discussions and to outline some general aspects of data modeling in digital humanities. Starting with an attempt to define data modeling it introduces distinctions like curation-driven vs. research-driven for a more general description of data modeling. The second part discusses specific problems and challenges of data modeling in the Humanities, while the third part outlines practical aspects, like the creation of data models or their evaluation. 2015 urn:nbn:de:bvb:20-opus-111270 Institut für deutsche Philologie OPUS4-11449 Konferenzveröffentlichung Ali, Qasim; Montenegro, Sergio A Simple Approach to Quadrocopter Formation Flying Test Setup for Education and Development A simple test setup has been developed at Institute of Aerospace Information Technology, University of Würzburg, Germany to realize basic functionalities for formation flight of quadrocopters. The test environment is planned to be utilized for developing and validating the algorithms for formation flying capability in real environment as well as for education purpose. An already existing test bed for single quadrocopter was extended with necessary inter-communication and distributed control mechanism to test the algorithms for formation flights in 2 degrees of freedom (roll / pitch). This study encompasses the domain of communication, control engineering and embedded systems programming. Bluetooth protocol has been used for inter-communication between two quadrocopters. A simple approach of PID control in combination with Kalman filter has been exploited. MATLAB Instrument Control Toolbox has been used for data display, plotting and analysis. Plots can be drawn in real-time and received information can also be stored in the form of files for later use and analysis. The test setup has been developed indigenously and at considerably low cost. Emphasis has been placed on simplicity to facilitate students learning process. Several lessons have been learnt during the course of development of this setup. Proposed setup is quite flexible that can be modified as per changing requirements. International Academy of Technology, Education and Development (IATED) 2015 8 INTED2015 Proceedings 978-84-606-5763-7 2776 2784 urn:nbn:de:bvb:20-opus-114495 Institut für Informatik OPUS4-10611 Konferenzveröffentlichung Kuhn, Dieter Emperor Huizong's (r. 1100-1126): Short-lived Earthly Paradise Zhao Ji (1082-1135), better known as Emperor Huizong (r. 1100-1126) of the Southern Song Dynasty (960-1127) gained a reputation as supreme perfectionist as artist, art collector and connoisseur, a ruler devoted to the faith of Daoism, squandering a fortune on building palaces and halls and on landscape gardening. A famous example of his costly 'folie de grandeur' is the Sacred Northeast Mountain Peak Genyue, a gigantic rock garden in the northeast part of the Old City of the capital Kaifeng. The garden is described in sources such as the Huayanggong jishi (Description of the Florescent Solitary Palace) by the Buddhist monk Zu Xiu from 1127 and Zhang Hao's (ca. 1180-1250) Genyue ji (Record of the Northeast Marchmount). The project in search of auspicious blessing started in 1118, having originated in the emperor's conviction that the Daoist Immortals would descend to this exquisite paradise situated in the centre of the world, his capital. In his conviction the landscape garden that exceeded nature's beauty would prolong and glorify his rule for ten thousand years. The Genyue was completed in January 1123, and thus became part of Emperor Huizong's Divine Empyrean Daoist ideology of statecraft. Contrary to all auspicious symbolism, the Song's emblematic demonstrations of power, and the necessity to meet political expectations, Emperor Huizong proved incapable of finding a solution to the disastrous situation at the northern frontier with Jin troupes moving onto his capital. Completed in 1123 the Genyue Marchmount was destroyed in the cold winter of 1126/1127 by the inhabitants of Kaifeng in their desperate struggle for survival in their besieged town. 2014 22 urn:nbn:de:bvb:20-opus-106115 Institut für Kulturwissenschaften Ost- und Südasiens OPUS4-9740 Konferenzveröffentlichung Schwab, Frank; Carolus, Astrid; Brill, Michael; Hennighausen, Christine Media Psychology - "Media Research: Yesterday, Today, and Tomorrow" Proceedings of the 8th Conference of the Media Psychology Division of the German Psychological Society The proceedings of the 8th Conference of the Media Psychology Division of the German Psychological Society hosted by the University of Wuerzburg from the 4th until the 6th of September 2013 contains the abstracts of the conference participants. Following the motto of the conference "Media Research: Yesterday, Today, and Tomorrow" a large number of media-psychological topics was dealt with. Amongst others, participants presented their research on interactive learning, emotions, virtual agents and avatars, gaming, scientific communication, politics, motion pictures and entertainment, social media, methods, and persuasions. 2013 105 978-3-923959-93-8 urn:nbn:de:bvb:20-opus-97403 10.25972/OPUS-9740 Institut Mensch - Computer - Medien OPUS4-6116 Konferenzveröffentlichung Fetzer, Anita; Weizman, Elda; Reber, Elisabeth Follow-ups across discourse domains: A cross-cultural exploration of their forms and functions The edited volume documents the proceedings of the ESF workshop "Follow-ups across discourse domains: a cross-cultural exploration of their forms and functions". It examines the forms and functions of the dialogue act of a follow-up, viz. accepting or challenging a prior communicative act, in political discourse across spoken and written dialogic genres. Specifically, it considers (1) the discourse domains of political interviews, editorials, op-eds and discussion forums, (2) their sequential organization as regards the status of initial (or 1st order) follow-up, a follow-up of a prior follow-up (2nd order follow-up), or nth-order follow-up, and (3) their discursive realization as regards degrees of indirectness and responsiveness which are conceptualized as a continuum along the lines of degrees of explicitness and degrees of responsiveness. The chapters come from the fields of linguistics, discourse analysis, socio-pragmatics, communication, political science and psychology, examining the heterogeneous field of political discourse and its manifestation in diverse discourse genres with respect to evasiveness, indirectness and redundancy in mediated political discourse, professional discourse, discourse identity and doing politics, to name but the most prominent questions. 2012 urn:nbn:de:bvb:20-opus-71656 Institut für Anglistik und Amerikanistik OPUS4-5182 Konferenzveröffentlichung Scheuermann, Manuela Effective or multilateral? The UN-EU partnership in military crisis management For the EU "effective multilateralism" in, with and within international organisations is the foundation of a system of global governance, so is laid down in the ESS. Therefore the term is used to label the EU's activities in the UN-family and to characterise the relations with the UN in the wider context of global governance. It is the political argument for the EU's commitment in military crisis management, side by side with UN peacekeepers. The UN in turn speaks of multilateralism to call for the EU's loyalty and partnership. Both organisations build their partnership on the common normative ground of multilateralism. The paper questions these rhetorical denominations critically. It goes beyond the political declarations to analyse the degree and quality of "effective multilateralism" in reality in and with international organisations, using the example of UN-EU-relations in military crisis management. The theoretical approach of multilateralism serves as the starting point of the analysis and theoretical basis of the paper (Chapter 1). The special EU-touch in "effective multilateralism" in comparison to the "UN-touch" is subject of Chapter 2. This analysis is necessary due to the meanwhile inflationary use of the term "effective multilateralism" in almost every CSFP context. Are the institutional steps to a partnership in crisis management as well as the operational collaboration in DR Congo (2003/2006/2009) and Chad/CAR (2008/2009) in line with "multilateralism"? is the question that is answered in the paper (Chapter 3). 2011 urn:nbn:de:bvb:20-opus-65565 Institut für Politikwissenschaft und Soziologie OPUS4-10167 Konferenzveröffentlichung Förstner, Konrad; Hagedorn, Gregor; Koltzenburg, Claudia; Kubke, Fabiana; Mietchen, Daniel Collaborative platforms for streamlining workflows in Open Science Despite the internet's dynamic and collaborative nature, scientists continue to produce grant proposals, lab notebooks, data files, conclusions etc. that stay in static formats or are not published online and therefore not always easily accessible to the interested public. Because of limited adoption of tools that seamlessly integrate all aspects of a research project (conception, data generation, data evaluation, peerreviewing and publishing of conclusions), much effort is later spent on reproducing or reformatting individual entities before they can be repurposed independently or as parts of articles. We propose that workflows - performed both individually and collaboratively - could potentially become more efficient if all steps of the research cycle were coherently represented online and the underlying data were formatted, annotated and licensed for reuse. Such a system would accelerate the process of taking projects from conception to publication stages and allow for continuous updating of the data sets and their interpretation as well as their integration into other independent projects. A major advantage of such work ows is the increased transparency, both with respect to the scientific process as to the contribution of each participant. The latter point is important from a perspective of motivation, as it enables the allocation of reputation, which creates incentives for scientists to contribute to projects. Such work ow platforms offering possibilities to fine-tune the accessibility of their content could gradually pave the path from the current static mode of research presentation into a more coherent practice of open science. 2011 Proceedings of the 6th Open Knowledge Conference urn:nbn:de:bvb:20-opus-101678 Institut für Molekulare Infektionsbiologie OPUS4-5522 Konferenzveröffentlichung Schmitz, Barbara War, violence and Tyrannicide in the Book of Judith No abstract available 2010 urn:nbn:de:bvb:20-opus-67058 Institut für Biblische Theologie OPUS4-4700 Konferenzveröffentlichung Schlosser, Daniel; Jarschel, Michael; Duelli, Michael; Hoßfeld, Tobias; Hoffmann, Klaus; Hoffmann, Marco; Morper, Hans Jochen; Jurca, Dan; Khan, Ashiq A Use Case Driven Approach to Network Virtualization In today's Internet, services are very different in their requirements on the underlying transport network. In the future, this diversity will increase and it will be more difficult to accommodate all services in a single network. A possible approach to cope with this diversity within future networks is the introduction of support for running isolated networks for different services on top of a single shared physical substrate. This would also enable easy network management and ensure an economically sound operation. End-customers will readily adopt this approach as it enables new and innovative services without being expensive. In order to arrive at a concept that enables this kind of network, it needs to be designed around and constantly checked against realistic use cases. In this contribution, we present three use cases for future networks. We describe functional blocks of a virtual network architecture, which are necessary to support these use cases within the network. Furthermore, we discuss the interfaces needed between the functional blocks and consider standardization issues that arise in order to achieve a global consistent control and management structure of virtual networks. 2010 urn:nbn:de:bvb:20-opus-55611 Institut für Informatik OPUS4-5954 Konferenzveröffentlichung Gotz, R.; Schartl, Manfred The conservation of neurotrophic factors during vertebrate evolution No abstract available 1994 urn:nbn:de:bvb:20-opus-61964 Theodor-Boveri-Institut für Biowissenschaften OPUS4-4165 Konferenzveröffentlichung Heiser, A.; Ulrichs, Karin; Müller-Ruchholtz, W. Enzyme Kinetics of Commercial Collagenases and their Influence on Porcine Islet Isolation No abstract available 1994 urn:nbn:de:bvb:20-opus-45488 Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) OPUS4-4674 Konferenzveröffentlichung Fiala, Brigitte; Federle, W.; Maschwitz, U.; Azarae, Idris The first myrmecophytic 2-partner-system in the genus Macaranga: The association between Macaranga puncticulata and a Componotus (Colobopsis) in Malaysia No abstract available 1994 urn:nbn:de:bvb:20-opus-55144 Theodor-Boveri-Institut für Biowissenschaften OPUS4-4186 Konferenzveröffentlichung Heiser, A.; Ulrichs, Karin; Müller-Ruchholtz, W. Enzyme Activities in Commercial Collagenase Preparations and Their Kinetics During Islet Isolation Procedure No abstract available 1994 urn:nbn:de:bvb:20-opus-45633 Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) OPUS4-3909 Konferenzveröffentlichung Marohn, Frank On testing the exponential and Gumbel distribution No abstract available 1994 urn:nbn:de:bvb:20-opus-45804 Institut für Mathematik OPUS4-3373 Konferenzveröffentlichung Dabauvalle, M.-C.; Wilken, N.; Ewald, A.; Kuhbier, A.; Senécal, J.-L.; Scheer, Ulrich Nuclear pore complex structure analyzed by immunogold EM with human autoantibodies No abstract available 1994 urn:nbn:de:bvb:20-opus-39439 Theodor-Boveri-Institut für Biowissenschaften OPUS4-3187 Konferenzveröffentlichung Boege, P.; Schäfer, H.; Shanjia, Xu; Xinzhang, Wu; Einfeldt, S.; Becker, Charles R.; Hommel, D.; Geick, R. Improved conductivity-measurement of semiconductor epitaxial layers by means of the contactless microwave method Measurements and calculations of the scattering-characteristics of stratified lossy dielectric blocks completely filling a waveguide cross section are presented. The method is used for contactless conductivity measurements of MBE-grown II-VI semiconductor layers. 1994 urn:nbn:de:bvb:20-opus-37763 Physikalisches Institut OPUS4-6974 Konferenzveröffentlichung Schreibman, Martin P.; Schartl, Manfred; Kallman, Klaus D.; Magliulo-Cepriano, Lucia Molecular approaches to study the genetic regulation of the fish reproductive system No abstract available. 1994 urn:nbn:de:bvb:20-opus-86679 Theodor-Boveri-Institut für Biowissenschaften OPUS4-4683 Konferenzveröffentlichung Fiala, Brigitte; Rabenstein, R.; Maschwitz, Ulrich Ant-attracting plant-structures: Food bodies of SE Asian Vitaceae No abstract available 1994 urn:nbn:de:bvb:20-opus-55177 Theodor-Boveri-Institut für Biowissenschaften OPUS4-4819 Konferenzveröffentlichung Sponholz, Barbara Holocene fulgurite formation in the southern Central Sahara (Niger) Fulgurites (= natural glasses formed by lightning strikes to the ground) are indicators of thunderstorms (e.g. Julien 1901). The distribution pattern of fulgurites in the study area (Grand Erg de Bilma and Erg de Tenere between 11.5°E and 16.5° and 18.5°N) shows decreasing fulgurite concentration from south to north. The fulgurite sites are concentrated in the area of fossil dune complexes, where they occur topographically above palaeolimnic deposits in mid-slope position of interdune depressions. 1993 urn:nbn:de:bvb:20-opus-56584 Institut für Geographie OPUS4-4183 Konferenzveröffentlichung Hedke, K.; Eckstein, V.; May, G.; Kaden, J.; Müller-Ruchholtz, W.; Ulrichs, Karin Production of Xenophile Antibodies (XA) in Type I Diabetic Patients is Strongly Influenced by Diabetes and/or Dialysis No abstract available 1993 urn:nbn:de:bvb:20-opus-45642 Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) OPUS4-4184 Konferenzveröffentlichung Ulrichs, Karin; Eckstein, V.; Korsgren, O.; Müller-Ruchholtz, W. Expression of Porcine Pancreatic Islet Antigens Varies and Determines Binding of Human Natural Xenophile Antibodies (NXA) No abstract available 1993 urn:nbn:de:bvb:20-opus-45655 Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) OPUS4-4185 Konferenzveröffentlichung Wang, HY; Ulrichs, Karin; Müller-Ruchholtz, W. Down-Regulation of Xenophile Antibodies by Specific Immunosuppressive Protocols to Facilitate Xenogeneic Organ Transplantation No abstract available 1993 urn:nbn:de:bvb:20-opus-45669 Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) OPUS4-2564 Konferenzveröffentlichung Dandekar, Thomas; Argos, P. Genetic algorithms as a new tool to study protein stability No abstract available 1993 urn:nbn:de:bvb:20-opus-29990 Theodor-Boveri-Institut für Biowissenschaften OPUS4-3050 Konferenzveröffentlichung Zillober, Christian Sequential convex programming in theory and praxis In this paper, convex approximation methods, suclt as CONLIN, the method of moving asymptotes (MMA) and a stabilized version of MMA (Sequential Convex Programming), are discussed with respect to their convergence behaviour. In an extensive numerical study they are :finally compared with other well-known optimization methods at 72 examples of sizing problems. 1993 urn:nbn:de:bvb:20-opus-35513 Institut für Mathematik OPUS4-6985 Konferenzveröffentlichung Krüger, Hans-Peter; Gold, Rainer; Hüppe, A. Coergisms between drugs and alcohol - a psychopharmacological review No abstract available. 1993 urn:nbn:de:bvb:20-opus-69850 Institut für Psychologie (bis Sept. 2007) OPUS4-7207 Konferenzveröffentlichung Kreuzer, H.; Henjes-Kunst, F.; Seidel, E.; Schüssler, Ulrich; Bühn, B. Ar-Ar spectra on minerals from KTB and related medium-pressure units No abstract available. 1993 urn:nbn:de:bvb:20-opus-86731 Institut für Mineralogie und Kristallstrukturlehre OPUS4-7101 Konferenzveröffentlichung Krüger, Hans-Peter Interaction - toward a precise understanding of a scientific term No abstract available. 1993 urn:nbn:de:bvb:20-opus-87088 Institut für Psychologie (bis Sept. 2007) OPUS4-6984 Konferenzveröffentlichung Krüger, Hans-Peter Effects of low alcohol dosages: A review of the literature No abstract available. 1993 urn:nbn:de:bvb:20-opus-69843 Institut für Psychologie (bis Sept. 2007) OPUS4-4166 Konferenzveröffentlichung Heiser, A.; Ulrichs, Karin; Eckstein, V.; Müller-Ruchholtz, W. Xenogeneic Cellular Response of Human Lymphocytes Against Porcine Lymphocytes and Isolated Pancreatic Islets no abstract available 1992 urn:nbn:de:bvb:20-opus-45479 Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) OPUS4-4182 Konferenzveröffentlichung Heiser, A.; Ulrichs, Karin; Eckstein, V.; Müller-Ruchholtz, W. The Human Cell Mediated Response to Xenogeneic (Porcine) Transplantation Antigen Depends on the Stimulator Cell Compartment No abstract available 1992 urn:nbn:de:bvb:20-opus-45670 Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) OPUS4-3190 Konferenzveröffentlichung Bicknell-Tassius, R. N.; Scholl, S.; Becker, Charles R.; Landwehr, G. High magnetic field transport in II-VI heterostructures In the present work we report the results of magneto-transport measurements on some Hg-based li-VI semiconductor epitaxiallayers grown by molecular beam epitaxy. The transport measurement were carried out at temperatures in the range 0.4 - 4.2 K in magnetic fields up to 10.0 T. Further, we point out the necessity of using multicarrier models for data interpretation and show finally some Shubnikov-de-Haas results on sampies with high mobility carners. 1992 urn:nbn:de:bvb:20-opus-37797 Physikalisches Institut OPUS4-7138 Konferenzveröffentlichung Schneider, Wolfgang; Näslund, Jan Carol Cognitive prerequisites of reading and spelling: A longitudinal approach No abstract available. 1992 urn:nbn:de:bvb:20-opus-71388 Institut für Psychologie (bis Sept. 2007) OPUS4-7135 Konferenzveröffentlichung Schneider, Wolfgang The "what" and "how" of development: Really two separate research agendas? No abstract available. 1992 urn:nbn:de:bvb:20-opus-86630 Institut für Psychologie (bis Sept. 2007) OPUS4-3297 Konferenzveröffentlichung Vollmer, Heinz C.; Ferstl, Roman; Ellgring, Johann Heinrich Individualized behavior therapy for drug addicts No abstract available 1992 urn:nbn:de:bvb:20-opus-33817 Institut für Psychologie (bis Sept. 2007) OPUS4-4380 Konferenzveröffentlichung Vollmer, H. C.; Ellgring, Johann Heinrich; Ferstl, R. Prediction of premature termination of therapy in the treatment of drug addicts No abstract available 1992 urn:nbn:de:bvb:20-opus-50274 Institut für Psychologie (bis Sept. 2007) OPUS4-4377 Konferenzveröffentlichung Ellgring, Johann Heinrich; Vollmer, Heinz C. Changes of personality and depression during treatment of drug addicts In accordance with various other studies. the present longitudinal study gave no clues for specific personality variables or traits 01' drug addicts. Personality factors did not allow a valid prediction of the kind 01' th~apy termination. nor were there clear deviations from the norm. Analyzed as a group. the addicts showed only minor changes that appeared over the course of treatment. These results correspond to data reported on alcohol dependency (cf. Wanke 1987). A more differentiated picture is gained when stable and changeable components of personality and analyzed separately. Changeable components are of special relevance for treatment. From the current study these were characteristics of action regulation, that is, activation and impulse control, social interaction, and somatic reactions (sleep disorders, bodily reactions to drug deprivation). For relapse prevention, attention should be given to stable, persistent, problematic components. Persistent suicidal ideas turned out to be one such aspect. Like the differentiation between state and trait anxiety, stable and variable components could also be separated for other domains of personality when they are used to describe the course of treatment. How can personality concepts and instruments for assessment be utilized for treatment? The claim of therapists to predict the outcome of a treatment may be realized for only a delimited period of time. Especially at such critical points as shortly before relapse, a firm prediction might be possible only rarely (Wanke 1987). Lack of predictability could be a warning which, however, can be verified only afterward. According to the current results, one benefit of personality concepts could be to specify targets of change on an individual basis and thus clarify effects of therapeutic interventions. Personality concepts can help patients to better understand their problems and to recognize changes as weil as persistent areas of vulnerability. 1992 urn:nbn:de:bvb:20-opus-50287 Institut für Psychologie (bis Sept. 2007) OPUS4-4222 Konferenzveröffentlichung Eckstein, V.; Ulrichs, Karin; Meincke, G.; Mülller-Ruchholtz, W. Transplantation of Diabetic Patients With Xenogeneic Pancreatic Islets Has to Consider Natural Xenophile Antibodies (NXA) In Patients Sera As a Major Obstacle to Success No abstract available 1991 urn:nbn:de:bvb:20-opus-45707 Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) OPUS4-4223 Konferenzveröffentlichung Winoto-Morbach, S.; Ulrichs, Karin; Müller-Ruchholtz, W. New Developments in Biodegradable Microspheres For Magnetic Separation Techniques No abstract available 1991 urn:nbn:de:bvb:20-opus-45712 Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) OPUS4-4224 Konferenzveröffentlichung Kaitschick, J.; Ulrichs, K.; Müller-Ruchholtz, W. The New Immunosuppressant Leflunomide Appears To Be a Potent Inhibitor of Humoral Xeno Sensitization No abstract available 1991 urn:nbn:de:bvb:20-opus-45727 Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) OPUS4-4181 Konferenzveröffentlichung Ulrichs, Karin; Euler, HH; Müller-Ruchholtz, W. A Clinically Successful Protocol to Suppress Autoantibody Production in SLE Patients Is Analyzed For Its Efficacy To Inhibit Natural Xenophile Antibodies (NXA) No abstract available 1991 urn:nbn:de:bvb:20-opus-45693 Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) OPUS4-3324 Konferenzveröffentlichung Schüssler, Ulrich; Okrusch, Martin; Seidel, Eberhard; Kreuzer, Hans; Raschka, Helmut Pre- to early Variscan magmatism in the Bohemian Massif No abstract available 1990 urn:nbn:de:bvb:20-opus-39171 Institut für Mineralogie und Kristallstrukturlehre OPUS4-7278 Konferenzveröffentlichung Mori, Kazuyasu; Rethwilm, Axel; Schwinn, Andreas; Horak, Ivan Replication of human immunodeficiency virus type 1 in human t-cells expressing antisense RNA No abstract available. 1990 urn:nbn:de:bvb:20-opus-86426 Institut für Virologie und Immunbiologie OPUS4-7279 Konferenzveröffentlichung Rethwilm, Axel; Baunach, Gerald; Mori, Kazuyasu; ter Meulen, Volker Transactivation of HIV by human spumaretrovirus To study the activation of HIV by human spumaretrovirus (HSRV) the long terminal repeats (LTRs) of HSRV, HIVl and HIV2 were examined with respect to their ability to function as transcriptional promoters in virus infected and uninfected cells. Transient transfections using plasmids in which the L TRs of the three viruses were coupled to the bacterial chloramphenicol acetyltransferase (CA T) gene revealed (i) the level of cat gene expression directed by the HSRV LTR was markedly increased in HSRV infected cells compared to uninfected cells, (ii) cat gene expression driven by the HIV1 LTR, but not by the HIV2 LTR could be enhanced upon HSRV infection, whereas (iii) neither in HIV1 nor in HIV2 infected cells an effect on HSRV LTR driven cat geneexpression was detected. 1990 urn:nbn:de:bvb:20-opus-86436 Institut für Virologie und Immunbiologie OPUS4-7277 Konferenzveröffentlichung Schwinn, Andreas; Rethwilm, Axel; Esers, Stefan; Borisch, Bettina; ter Meulen, Volker Interaction of HIV-1 and HHV-6 No abstract available. 1990 urn:nbn:de:bvb:20-opus-86415 Institut für Pharmakologie und Toxikologie OPUS4-3978 Konferenzveröffentlichung Mahsberg, Dieter Brood care and family cohesion in the tropical scorpion Pandinus imperator (Koch) (Scorpiones: Scorpionidae) Pandinus imperator is a forest dweller of tropical West Africa. In the field, lobserved aggregations of up to 15 individuals. In the laboratory, mixed age groups of related and also unrelated animals lived jointly in terraria rarely showing within-group aggression or cannibalism. Brood-caring behavior of the mother influenced growth rate and survival probability of the young. With birth, mothers became very aggressive. To study family cohesion in Pandinus, experiments with family groups were conducted. Siblings aggregated around their mother. In choice experiments with two family groups, mothers were placed in enclosures that only the young were able to enter or to leave. Second instars significantly preferred the enclosure containing their own mother. Aggression among unrelated young of the same age was not observed. Feeding experiments studied the possible advantages of long-Iasting group living with regard to enhanced success in prey capture and its effect on growth of the young. Even groups of second instars were unable to subdue large prey on their own. Sibling groups with their mother removed suffered high mortality due to starvation and cannibalism compared to groups with mothers present. Here, young grew significantly faster: they shared the prey that only the mother was able to kill and dismember. Pandinus imperator has to be considered an intermediate subsocial scorpion. 1990 urn:nbn:de:bvb:20-opus-45776 Theodor-Boveri-Institut für Biowissenschaften OPUS4-6940 Konferenzveröffentlichung Schneider, Wolfgang; Körkel, Joachim; Weinert, Franz E. Expert knowledge, general abilities, and text processing No abstract available. 1990 urn:nbn:de:bvb:20-opus-87175 Institut für Psychologie (bis Sept. 2007) OPUS4-6960 Konferenzveröffentlichung Schneider, Wolfgang; Weinert, Franz E. The role of knowledge, strategies, and aptitudes in cognitive Performance: Concluding Comments No abstract available. 1990 urn:nbn:de:bvb:20-opus-87190 Institut für Psychologie (bis Sept. 2007) OPUS4-7093 Konferenzveröffentlichung Schneider, Wolfgang; Weinert, Franz E. The role of knowledge, strategies, and aptitudes in cognitive performance : concluding comments No abstract available. 1990 urn:nbn:de:bvb:20-opus-86554 Institut für Psychologie (bis Sept. 2007) OPUS4-4951 Konferenzveröffentlichung Bossert, Sabine; Meiler, Caroline; Laessle, Reinhold; Ellgring, Heiner; Pirke, Karl-Martin Responses to visual perception of food in eating disorders No abstract available 1989 urn:nbn:de:bvb:20-opus-58762 Institut für Psychologie OPUS4-2652 Konferenzveröffentlichung Hodgson, Barbara; Reusch, Wolfgang; Kjöllerström, Bengt; Velarde, Manuel Non-Formal Education No abstract available 1989 urn:nbn:de:bvb:20-opus-30620 Physikalisches Institut OPUS4-2873 Konferenzveröffentlichung Deger, H.; Reusch, Wolfgang; Luchner, K. Microscopic Observation of Crystal Growth and Phase Transitions No abstract available 1989 urn:nbn:de:bvb:20-opus-33001 Physikalisches Institut OPUS4-7120 Konferenzveröffentlichung Schneider, Wolfgang Problems of longitudinal studies with young children: Practical, conceptual, and methodological issues No abstract available. 1989 urn:nbn:de:bvb:20-opus-86521 Institut für Psychologie (bis Sept. 2007) OPUS4-7119 Konferenzveröffentlichung Schneider, Wolfgang; Weinert, Franz E. Universal trends and individual differences in memory development No abstract available. 1989 urn:nbn:de:bvb:20-opus-86518 Institut für Psychologie (bis Sept. 2007) OPUS4-3318 Konferenzveröffentlichung Seidel, E.; Kreuzer, H.; Schüssler, Ulrich; Okrusch, M.; Lenz, K.-L.; Raschka, H. K-Ar geochronology of the East-Bavarian basement No abstract available 1988 urn:nbn:de:bvb:20-opus-38874 Institut für Mineralogie und Kristallstrukturlehre OPUS4-3319 Konferenzveröffentlichung Schüssler, Ulrich; Okrusch, M.; Richter, P.; Seidel, E. Geochemistry of metabasites and element mobility No abstract available 1988 urn:nbn:de:bvb:20-opus-38880 Institut für Mineralogie und Kristallstrukturlehre OPUS4-2872 Konferenzveröffentlichung Kreuzer, Hans; Vejnar, Zdenek; Schüssler, Ulrich; Okrusch, Martin; Seidel, Eberhard K-Ar dating in the Teplá-Domazlice zone at the western margin of the Bohemian Massif K-Ar dating on hornblendes and micas from the Tepla Domazlice zone revealed a pattern of dates which significantly deviates from the mid-Carboniferous to early Permian one that is found in the adjacent low-pressure metamorphic Moldanubian and Saxothuringian. Especially for the Marianske Lazne metabasic complex, confirming early Czech determinations, the dates resemble the early Devonian pattern determined for the Munchberg Gneiss Massif and the Erbendorf-Vohenstrau zone of northeastern Bavaria. This supports the idea that all three units are remnants of a huge' complex which suffered a metamorphic overprint under medium-pressure conditions, probably in the early Devonian. Strong rejuvenation is found in the southern part of the Tepla-Domazlice zone by which micas and even two hornblendes were reset to mid-Carboniferous ages. According to the geological setting, part of the apparently preDevonian dates may be explained by inherited argon from earlier metamorphic and magmatic events, e.g. the high-pressure metamorphism documented in eciogitic relics. However, excess argon, caused by the mid-Carboniferous overprint cannot be excluded. 1988 urn:nbn:de:bvb:20-opus-31106 Institut für Mineralogie und Kristallstrukturlehre OPUS4-7191 Konferenzveröffentlichung Maurer, B.; Bannert, H.; Rethwilm, Axel; Darai, B.; Flügel, R. M. Characterization of the env gene and of two novel coding regions of the human spumaretrovirus Recombinant clones harboring retroviral DNA were established. The nucleotide sequence of the central and 3' region of the genome of the human spumaretrovirus was determined. The 5' end of the deduced protein sequence was homologaus to the endonuclease domain of retroviral reverse transcriptases. A small intergenic region is followed by a lang open reading frame of 985 aminoacid residues that according to its genomic location and structural features is a typical retroviral env gene. Surprisingly, the postenv region contains two open reading frames that encodes two novel retroviral genes, termed bel-l and bel-2. The 3' LTR is 963 nucleotides lang and contains the signal sequences characteristic for transcriptional regulation of retrovirus genomes. 1988 urn:nbn:de:bvb:20-opus-86334 Institut für Virologie und Immunbiologie OPUS4-7210 Konferenzveröffentlichung Kreuzer, Hans; Vejnar, Zdenek; Schüssler, Ulrich; Okrusch, Martin; Seidel, Eberhard K-Ar dating of the last metamorphic events in different tectonic units of the western margin of the Bohemian Massif K-Ar dating on hornblendes and micas from the TepläDomazlice zone revealed a pattern of dates which significantly deviates from the mid-Carboniferous to early Permian one that is found in the adjacent low-pressure metamorphic Moldanubian and Saxothuringian. Especially for the Mariänske Läzne metabasic complex, confirming early Czech determinations, the dates resemble the early Devonian pattern determined for the Münchberg Gneiss Massif and the Erbendorf-Vohenstrauß zone of northeastern Bavaria. This supports the idea that all three units are remnants of a huge complex which suffered a metamorphic overprint under medium-pressure conditions, probably in the early Devonian. Streng rejuvenation is found in the southern part of the Teplä-Domailice zone by which micas and even two hornblendes were reset to mid-Carboniferous ages. According to the geological setting, part of the apparently preDevonian dates may be explained by inherited argon from earlier metamorphic and magmatic events, e.g. the high-pressure metamorphism documented in eclogitic relics. However, excess argon, caused by the mid-Carboniferous overprint cannot be excluded. 1988 urn:nbn:de:bvb:20-opus-87527 Institut für Mineralogie und Kristallstrukturlehre OPUS4-7214 Konferenzveröffentlichung Schüssler, Ulrich; Vejnar, Z.; Okrusch, M.; Rose, S.; Seidel, E. Geochemistry of Metabasites and gabbroic rocks from the Tepla-Domazlice zone Various amphibolites, metagabbros and eclogitic relics of the Mariänske Läzne complex, and amphibolites from the Cernä Hora Massif exhibit an uniform geochemical character which compares weil with modern mid-ocean ridge basalts. Geochemically these metabasites are similar to the amphibolites of the Myto area and to schistose, partly striped amphibolites of the neighbouring Tirschenreuth-Mähring Zone and the Erbendorf-Vohenstrauss Zone (Bavaria). Greenschists and amphibolites from the Domazlice metamorphic complex show an alkaline-basaltic tendency conforming to modern within-plate basalts or basalts from anomalaus midocean ridge segments. In their chemical character, these metabasites compare weil with the flaseramphibolites of the Erbendorf-Vohenstrauss Zone. Fine-grained amphibolites in the Warzenrieth area and (gabbro-) amphibolites in the Blätterberg-Hoher Bogen area show normal MORB character. The metamorphosed gabbroic rocks in the southern part of the Neukirchen-Kdyne (meta-) igneous complex are subalkaline - tholeiitic and exhibit a magmatic differentiation trend. They differ from the neighbouring amphibolites by generally lower contents of incompatible elements. 1988 urn:nbn:de:bvb:20-opus-87511 Institut für Mineralogie und Kristallstrukturlehre OPUS4-7268 Konferenzveröffentlichung Schartl, Manfred; Mäueler, Winfried; Raulf, Friedrich; Robertson, Scott M. Molecular aspects of melanoma formation in Xiphophorus No abstract available. 1988 urn:nbn:de:bvb:20-opus-72689 Theodor-Boveri-Institut für Biowissenschaften OPUS4-4417 Konferenzveröffentlichung Kurtz, Beth; Schneider, Wolfgang; Borkowski, John G.; Carr, Martha; Turner, Lisa A. Sources of memory and metamemory development: Societal, parental, and educational influences This project had two goals: (1) to examine the impact of strategy training on memory performance in German and American children, and (2) to search for environmental correlates of individual differences in cognitive processes. Following pretesting, 437 children were divided into training and control groups, with the former receiving training in clustering strategies. Trained children showed sizable strategy maintenance and transfer effects two weeks and six months later. Parents and teachers completed questionnaires about the teaching of strategies and their attributional beliefs about children's academic successes and failures. The differences in strategie behavior and attributions of German and American children were due, in part, to differences in strategy-enriched environments. 1988 urn:nbn:de:bvb:20-opus-50524 Institut für Psychologie (bis Sept. 2007) OPUS4-3316 Konferenzveröffentlichung Schüssler, Ulrich; Okrusch, M.; Richter, P. Amphibolites of the KTB target area Oberpfalz, Bavaria No abstract available 1987 urn:nbn:de:bvb:20-opus-38866 Institut für Mineralogie und Kristallstrukturlehre OPUS4-3416 Konferenzveröffentlichung Moch, Thomas; Hoschützky, Heinz; Hacker, Jörg; Krönke, Klaus-D.; Jann, Klaus Isolation and characterization of the \(\alpha\)-Sialyl-\(\beta\) 2-3-Galactosyl (S)-Specific Adhesin fimbriated Escherichia coli The \(\alpha\)-Sialyl-\(\beta\) 2-3-Galactosyl-specific adhesin (S adhesin) was isolated from cells of a recombinant Escherichia coli K-12 strain expressing the S-flmbrial adhesin complex. A crude cell extract was partiaUy dissociated into fimbriae and an adhesin-enriched fraction by heating to 7O°C. From the latter, adhesin was purified to apparent homogeneity (by fast protein liquid chromatography, immunoblot, and NaDodSO\(_4\)/PAGE) by differential ammonium sulfate precipitation, dissociation in 8 M guanidine hydrochloride, and high-resolution anion-exchange chromatography in 8 M urea. The purified adhesin formed an aggregate of M\(_r\)\(\approx\)10\(^6\) that was made up of one type of 12-kDa polypeptide (fimbrillin is 16.5 kDa). It had pI value of 4.7 (fimbriae has a pI value of 6). Adhesin and fimbrillin had different amino add compositions. The purified adhesins agglutinated human and bovine erythrocytes with the same speclfkity as the whole bacteria; purified fimbriae were not adhesive. Monoclonal anti-adhesin and anti-fimbriae antibodies were obtained. Monoclonal antiadhesin, but none of the anti-fimbriae, antibodies inhibited the agglutination of erythrocytes. The anti-adhesive antibodies were used in immuno-gold electron microscopy to localize adhesin exclusively on the fimbriae, with a possible preference to their tips. 1987 urn:nbn:de:bvb:20-opus-40330 Institut für Molekulare Infektionsbiologie OPUS4-6795 Konferenzveröffentlichung Sagelsdorff, P.; Lutz, Werner K. Sensitivity of DNA and nucleotides to oxidation by permanganate and hydrogen peroxide no abstract available 1987 urn:nbn:de:bvb:20-opus-80062 Institut für Pharmakologie und Toxikologie OPUS4-6796 Konferenzveröffentlichung Lutz, Werner K. Quantitative evaluation of DNA-binding data in vivo for low-dose extrapolations no abstract available 1987 urn:nbn:de:bvb:20-opus-80079 Institut für Pharmakologie und Toxikologie OPUS4-7097 Konferenzveröffentlichung Riehl, Rüdiger; Schartl, Manfred; Anders, Fritz An ultrastructural study of melanoma in Xiphophorus Melanotic melanoma (MM) of Xiphophorus (Teleostei: Poeciliidae) was studied by conventional preparations and freeze-etch preparations for electron microscopy. MM of Xiphophorus exhibits tightly packed pigment cells with prominent dendritic processes and interdigitations of their plasma membranes. The most impressive feature of MM cells is the occurrence of Iarge lobulated nuclei with numerous nuclear pores and some nuclear pockets. Abundant spheroidal or ellipsoidal melanosomes (diameter 200-650 nm) and vesicular structures are distributed throughout the cellular dendrites, whereas the perinucJear cytoplasm is free of melanosomes. A further characteristic feature of melanoma cells in fish is the occurrence of melanosome complexes (i.e., "compound melanosomes"). These melanosome complexes consist of a few to numerous melanosomes, which are enveloped by a separate rnembrane. Pinocytotic vesicles couJd be demonstrated with distinct differences in frequency and distribution patterns, indicating differences in the metabolic activities of the cells in the same melanoma. Intercellular junctions are lacking in the MM cells. The conventional TEM technique showed clear advantages in the demonstration of intemal architecture of organelles, whereas FE bad considerable potential in respect to the visualization of membrane surface specializations. 1985 urn:nbn:de:bvb:20-opus-70978 Theodor-Boveri-Institut für Biowissenschaften OPUS4-6937 Konferenzveröffentlichung Peter, R. U.; Schartl, Manfred; Anders, F.; Duncker, H.-R. Pigment pattern formation during embryogenesis in Xiphophorus No abstract available. 1985 urn:nbn:de:bvb:20-opus-69370 Theodor-Boveri-Institut für Biowissenschaften OPUS4-3073 Konferenzveröffentlichung Scheer, Ulrich; Rose, Kathleen M. Localization of RNA polymerase I in interphase cells and mitotic chromosomes by light and electron microscopic immunocytochemistry Rabbit antibodies to RNA polymerase I from a rat hepatoma have been used to localize the enzyme in a variety of cells at the light and electron microscopic level. In interphase cells the immunofluorescence pattern indicated that polymerase I is contained exclusively within the nucleolus. That this fluorescence, which appeared punctated rather than uniform, represented transcriptional complexes of RNA polymerase I and rRNA genes was suggested by the observation that it was enhanced in regenerating liver and in a hepatoma and was markedly diminished in cells treated with actinomycin D. Electron microscopic immunolocalization using gold-coupled second antibodies showed that transcribed rRNA genes are located in, and probably confined to, the fibrillar centers of the nucleolus. In contrast, the surrounding dense fibrillar component, previously thought to be the site of nascent prerRNA, did not contain detectable amounts of polymerase I. During mitosis, polymerase I molecules were detected by immunofluorescence microscopy at the chromosomal nucleolus organizer region, indicating that a considerable quantity of the enzyme remains bound to the rRNA genes. From this we conclude that rRNA genes loaded with polymerase I molecules are transmitted from one cell generation to the next one and that factors other than the polymerase itself are involved in the modulation of transcription of DNA containing rRNA genes during the cell cycle. 1984 urn:nbn:de:bvb:20-opus-33223 Theodor-Boveri-Institut für Biowissenschaften OPUS4-6797 Konferenzveröffentlichung Lutz, Werner K. Structural characteristics of compounds that can be activated to chemically reactive metabolites: use for a prediction of a carcinogenic potential Many mutagens and carcinogens act via covalent interaction of metabolic intermediates with DNA in the target cell. This report groups those structural elements which are often found to form the basis for a metabolism to such chemically reactive metabolites. ~mpounds which are chemically reactive per se and which do not require metabolic activation form group 1. Group 2 compri~es of olefins and aromatic hydrocarbons where the oxidation via an epoxide can be responsible for the generation of reactive species. Aromatic amines, hydrazines, and nitrosamirres form group 3 requiring an oxidation of a nitrogen atom or of a carbon atom in alpha position to a nitrosated amine. Group 4 compounds are halogenated hydrocarbons which can either give rise to radicals or can form an ·olefin (group 2) upon dehydrohalogenation. Group 5 compounds depend upon some preceding enzymatic activity either not available in the target cell or acting on positions in the molecule which are not directly involved in the subsequent formation of electrophilic atoms. Examples for each group are taken from the "List of Chemieals and Irrdustrial Processes Associated with Cancer in Humans" as compiled by the International Agency for the Research on Cancer, and it is shown that 91% of the organic carcinogens would have been detected on the basis of structural elements characteristic for group 1-5. As opposed to this very high sensitivity, the specificity ( the true negative fraction) of using this approach as a short-term test for carcinogenicity is shown to be bad because detoxification pathways have so far not been taken into account. These competing processes are so complex, however, that either only very extensive knowledge about pharmacokinetics, stability, and reactivity will be required or that in vivo systems have to be used to predict, on a quantitative basis, the darnage expected on the DNA. DNA-binding experiments in vivo are presented with benzene and toluene to demonstrate one possible way for an experimental assessment and it is shown that the detoxification reaction at the methyl group available only in toluene gives rise to a reduction by at least a factor of forty for the binding to rat liver DNA. This quantitative approach available with DNA-binding tests in vivo, also allows evaluation as to whether reactive metabolites and their DNA binding are always the most important single activities contributing to the overall carcinogenicity of a chemical. With the example of the livertumor inducing hexachlorocyclohexane isomers it is shown that situations will be found where reactive metabolites are formed and DNA binding in vivo is measurable but where this activity cannot be the decisive mode of carcinogenic action. It is concluded that the lack of structural elements known to become potentially reactive does not guarantee the lack of a carcinogenic potential. 1984 urn:nbn:de:bvb:20-opus-80105 Institut für Pharmakologie und Toxikologie OPUS4-7272 Konferenzveröffentlichung Anders, Fritz; Schartl, Manfred; Barnekow, Angelika Xiphophorus as an in vivo model for studies on oncogenes The capacity of Xiphophorus to develop neoplasia can be formally assigned to a "tumor gene" (Tu), which appears to be a normal part of the genome of all individuals. The wild fish have evolved population-specific and cell type-specific systems of regulatory genes (R) for Tu that protect the fish from neoplasia. Hybridization of members of different wild populations in the laborstory followed by treatment of the hybrids with carcinogens led to disintegration of the R systems permitting excessive expression of Tu and thus resulting in neoplasia. Certain hybrids developed neoplasia even spontaneously. Observations on the genuine phenotypic effect of the derepressed Tu in the early embryo indicated an essential normal function of this oncogene in cell differentiation, proliferation and cell-cell communication. Tu appeared to be indispensable in the genome but may also be present in accessory copics. Recently, c-src, the cellular homolog of the Rous sarcoma virus oncogene v-src, was detected in Xiphophorus. The protein product of c-src, pp60c-src, was identified and then examined by its associated kinase activity. This pp60c-src was found in all individuals tested, but, depending on the genotype, its kinase activity was different. The genetic characters of c-src, such as linkage relations, dosage relations, expression, etc., correspond to those of Tu. From a systematic study which showed that pp60c-src was present in all metazoa tested ranging from mammals down to sponges, we concluded that c-src has evolved with the multicellular organization of animals. Neoplasia of animals and humans is a characteristic closely related to this evolution. Our data showed that small aquariurn fish, besides being used successfully because they are time-, space-, and money-saving systems for carcinogenicity testing, are also highly suitable for basic studies on neoplasia at the populational, morphological, developmental, cell biological, and molecular levels. 1984 urn:nbn:de:bvb:20-opus-86398 Theodor-Boveri-Institut für Biowissenschaften OPUS4-3368 Konferenzveröffentlichung Scheer, Ulrich Electron microscopic analysis of chromatin and gene expression No abstract available 1982 urn:nbn:de:bvb:20-opus-39456 Theodor-Boveri-Institut für Biowissenschaften OPUS4-6972 Konferenzveröffentlichung Schartl, A.; Schartl, Manfred; Anders, F. Phenotypic conversion of malignant melanoma to benign melanoma and vice versa in Xiphophorus No abstract available. 1981 urn:nbn:de:bvb:20-opus-86662 Theodor-Boveri-Institut für Biowissenschaften OPUS4-7273 Konferenzveröffentlichung Anders, F.; Scholl, E.; Schartl, Manfred Environmental and hereditary factors in the causation of neoplasia, based on studies of the Xiphophorus fish melanoma system Neoplasia in Xiphophorus can be classified into: a) a Jarge group triggered by carcinogens; b) a large group triggered by promoters; and c) a small group that develops "spontaneously" according to Mendelian Jaw. The process leading to susceptibility for neoplasia is represented by the disintegration of gene systems that normally protect the fish from neoplasia. Interpopulational arid interracial hybridization is the most effective process that Ieads to disintegration of the protective gene systems. Environmental factors may complete disintegration in somatic cells and thus may trigger neoplasia. The applications of the findings on Xiphophorus to humans are discussed. 1981 urn:nbn:de:bvb:20-opus-86402 Theodor-Boveri-Institut für Biowissenschaften OPUS4-7274 Konferenzveröffentlichung Anders, F.; Schartl, Manfred; Scholl, E. Evaluation of environmental and hereditary factors in carcinogenesis, based on studies in Xiphophorus Neoplasia in Xiphophorus can be classified into a) a large group that is triggered by carcinogens; b) a large group triggered by promoters; c) a small group that develops "spontaneously" following interpopulational and interracial hybridizations; and d) a small group that develops "spontaneously" following germ line mutation. The process leading to susceptibility for neoplasia is represented by the disintegration of gene systems that normally protect the fish from neoplasia. Hybridization is the most effective process that leads to disintegration of the protection gene systems. Environmental factors may complete disintegration and thus may trigger neoplasia. It is discussed whether the findings on Xiphophorus may also apply to humans. 1981 urn:nbn:de:bvb:20-opus-72741 Theodor-Boveri-Institut für Biowissenschaften OPUS4-6818 Konferenzveröffentlichung Viviani, A.; Lutz, Werner K. Modulation of the in vivo covalent binding of the carcinogen benzo(a)pyrene to rat liver DNA by selective induction of microsomal and nuclear aryl hydrocarbon hydroxylase activity The influence of microsomal (mAHH) and nuclear (nAHH) aryl hydrocarbon hydroxylase activity on the covalent binding of t:titiated benzo(a)pyrene to rat liver DNA was evaluated in vivo. Induction ofmAHH was obtained after phenobarbitone treatment (180% of control), which increased DNA binding to 210%, but left the nAHH unchanged. mAHH and nAHH were slightly indilced with dieldrin (130% and 120%), but the binding remairred unchanged. The increasing effect of mAHlt as weil as the possibly decreasing effect of nAHH induction on the binding became obvious when the data of 11 individual rats were used to solve the equation Binding = aX(mAHH) + bX(nAHH) + c. Multiple linear regression analysis resulted in positive values for a and c, a negative value for b, and a multiple correlation coefficient R = 0.82. An influence of other enzymes involved in the metabolism of benzo(a)pyrene cannot be excluded. The Study shows clearly that the binding of a foreign compound to DNA in vivo is not only dependent on microsomal enzyme activities but also on nuclear activities even if the latter are considerably lower than those of mic'rosomes. 1979 urn:nbn:de:bvb:20-opus-80132 Institut für Anatomie und Zellbiologie OPUS4-3367 Konferenzveröffentlichung Franke, Werner W.; Zentgraf, Hanswalter; Scheer, Ulrich Supranucleosomal and non-nucleosomal chromatin configurations A significant contribution to the understanding of chromatin organization was the d iscovery of the nucleosome as a globular repeating unit of the package of DNA (Hewish and Burgoyne, 1973; Woodcock, 1973; Kornberg, 1974; Olins and Olins, 1974; for review see Oudet et al., 1978 a) . In accord with the original definition and in ag reement with most workers in this field of research we identify a nucleosome as a spheric alor slightly oblate gr anular particle 10-13 nm in diameter, containing about 200 base pairs of DNA and two of each of the four his tones H2a, H2b, H3 and H4. It is this structure in which the bulk of the nuclear chroma tin is organized in most eukaryotic cells, with the exception of the dinofl age llates (Rae and Steele, 1977; dinofl agellate DNA, however, c an be packed into nucleosoma l structures in vitro by addition of the appropriate amounts of histones;the same reference). Although it seems clear from the work reported that condensed and transcriptiona lly inactive chroma tin is contained in nucleosomes as the principle for first order p acking of DNA there are two important questions onto which we are focusing in the present study: ( i ) What is the higher order of p a cking present in - and perhaps typical-of - the condensed sta te of chromatin, and (ii) what is the specific form of arrangement of transcriptionally a ctive chromatin? 1978 urn:nbn:de:bvb:20-opus-39447 Theodor-Boveri-Institut für Biowissenschaften OPUS4-6833 Konferenzveröffentlichung Lutz, Werner K.; Schlatter, C. Extrapolation of carcinogenicity data to low doses with a dose-response study of the binding of benzo(a)pyrene to rat liver DNA The binding of tritiated benzo(a)pyrene (BP) to liver DNA of 25 adult male rats (SIV 50) has been determined 50 h after a single intraperitoneal injection of doses between 40 ug/kg and 4; mg/kg. The dose-response relations~ ip is linear up to i mg/kg, shows a sigmoid step towards 2 mg/kg and a shallow linear. slope above that value. TlJe 0 bserved bin ding ranges from 1.7 to 180 nmoles BP per mole DNA phosphate. The non-linearity between 1 and 2 mg/kg could be explained 0):1 the basis of an induction of metabolizing enzymes. A pure1y mathematical extrapolation of therumour incidence from a carcinogenic dose (1 x 40mg/kg for a 20% hepatoma incidence in newborn mice) to human exposure levels (aboilt 0.1 ug/kg per day) would never have followed a step like the on~ found in our experiments. Our dose-effect study therefore shows how carcinogenitity data could be extrapolated in a biologically founded way to low doses. 1978 urn:nbn:de:bvb:20-opus-80157 Institut für Pharmakologie und Toxikologie