Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-7272 Konferenzveröffentlichung Anders, Fritz; Schartl, Manfred; Barnekow, Angelika Xiphophorus as an in vivo model for studies on oncogenes The capacity of Xiphophorus to develop neoplasia can be formally assigned to a "tumor gene" (Tu), which appears to be a normal part of the genome of all individuals. The wild fish have evolved population-specific and cell type-specific systems of regulatory genes (R) for Tu that protect the fish from neoplasia. Hybridization of members of different wild populations in the laborstory followed by treatment of the hybrids with carcinogens led to disintegration of the R systems permitting excessive expression of Tu and thus resulting in neoplasia. Certain hybrids developed neoplasia even spontaneously. Observations on the genuine phenotypic effect of the derepressed Tu in the early embryo indicated an essential normal function of this oncogene in cell differentiation, proliferation and cell-cell communication. Tu appeared to be indispensable in the genome but may also be present in accessory copics. Recently, c-src, the cellular homolog of the Rous sarcoma virus oncogene v-src, was detected in Xiphophorus. The protein product of c-src, pp60c-src, was identified and then examined by its associated kinase activity. This pp60c-src was found in all individuals tested, but, depending on the genotype, its kinase activity was different. The genetic characters of c-src, such as linkage relations, dosage relations, expression, etc., correspond to those of Tu. From a systematic study which showed that pp60c-src was present in all metazoa tested ranging from mammals down to sponges, we concluded that c-src has evolved with the multicellular organization of animals. Neoplasia of animals and humans is a characteristic closely related to this evolution. Our data showed that small aquariurn fish, besides being used successfully because they are time-, space-, and money-saving systems for carcinogenicity testing, are also highly suitable for basic studies on neoplasia at the populational, morphological, developmental, cell biological, and molecular levels. 1984 urn:nbn:de:bvb:20-opus-86398 Theodor-Boveri-Institut für Biowissenschaften OPUS4-3092 Konferenzveröffentlichung Trendelenburg, M. F.; Franke, Werner W.; Spring, H.; Scheer, Ulrich Ultrastructure of transcription in the nucleoli of the green algae Acetabularia major and A. mediterranea No abstract available 1975 urn:nbn:de:bvb:20-opus-33779 Theodor-Boveri-Institut für Biowissenschaften OPUS4-3612 Konferenzveröffentlichung Scheer, Ulrich; Franke, Werner W. Transcriptional complexes of nucleolar genes No abstract available 1976 urn:nbn:de:bvb:20-opus-41072 Theodor-Boveri-Institut für Biowissenschaften OPUS4-4674 Konferenzveröffentlichung Fiala, Brigitte; Federle, W.; Maschwitz, U.; Azarae, Idris The first myrmecophytic 2-partner-system in the genus Macaranga: The association between Macaranga puncticulata and a Componotus (Colobopsis) in Malaysia No abstract available 1994 urn:nbn:de:bvb:20-opus-55144 Theodor-Boveri-Institut für Biowissenschaften OPUS4-5954 Konferenzveröffentlichung Gotz, R.; Schartl, Manfred The conservation of neurotrophic factors during vertebrate evolution No abstract available 1994 urn:nbn:de:bvb:20-opus-61964 Theodor-Boveri-Institut für Biowissenschaften OPUS4-4658 Konferenzveröffentlichung Fiala, Brigitte; Maschwitz, Ulrich; Tho, Yow Pong The association between Macaranga trees and ants in South-east Asia No abstract available 1991 urn:nbn:de:bvb:20-opus-54752 Theodor-Boveri-Institut für Biowissenschaften OPUS4-3367 Konferenzveröffentlichung Franke, Werner W.; Zentgraf, Hanswalter; Scheer, Ulrich Supranucleosomal and non-nucleosomal chromatin configurations A significant contribution to the understanding of chromatin organization was the d iscovery of the nucleosome as a globular repeating unit of the package of DNA (Hewish and Burgoyne, 1973; Woodcock, 1973; Kornberg, 1974; Olins and Olins, 1974; for review see Oudet et al., 1978 a) . In accord with the original definition and in ag reement with most workers in this field of research we identify a nucleosome as a spheric alor slightly oblate gr anular particle 10-13 nm in diameter, containing about 200 base pairs of DNA and two of each of the four his tones H2a, H2b, H3 and H4. It is this structure in which the bulk of the nuclear chroma tin is organized in most eukaryotic cells, with the exception of the dinofl age llates (Rae and Steele, 1977; dinofl agellate DNA, however, c an be packed into nucleosoma l structures in vitro by addition of the appropriate amounts of histones;the same reference). Although it seems clear from the work reported that condensed and transcriptiona lly inactive chroma tin is contained in nucleosomes as the principle for first order p acking of DNA there are two important questions onto which we are focusing in the present study: ( i ) What is the higher order of p a cking present in - and perhaps typical-of - the condensed sta te of chromatin, and (ii) what is the specific form of arrangement of transcriptionally a ctive chromatin? 1978 urn:nbn:de:bvb:20-opus-39447 Theodor-Boveri-Institut für Biowissenschaften OPUS4-3094 Konferenzveröffentlichung Scheer, Ulrich; Trendelenburg, M. F.; Franke, Werner W. Regulation of transcription of ribosomal RNA genes during amphibian oogenesis No abstract available 1976 urn:nbn:de:bvb:20-opus-33700 Theodor-Boveri-Institut für Biowissenschaften OPUS4-6937 Konferenzveröffentlichung Peter, R. U.; Schartl, Manfred; Anders, F.; Duncker, H.-R. Pigment pattern formation during embryogenesis in Xiphophorus No abstract available. 1985 urn:nbn:de:bvb:20-opus-69370 Theodor-Boveri-Institut für Biowissenschaften OPUS4-6972 Konferenzveröffentlichung Schartl, A.; Schartl, Manfred; Anders, F. Phenotypic conversion of malignant melanoma to benign melanoma and vice versa in Xiphophorus No abstract available. 1981 urn:nbn:de:bvb:20-opus-86662 Theodor-Boveri-Institut für Biowissenschaften