Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-16560 Wissenschaftlicher Artikel Werner, Rudolf; Wakabayashi, Hiroshi; Bauer, Jochen; Schütz, Claudia; Zechmeister, Christina; Hayakawa, Nobuyuki; Javadi, Mehrbod S.; Lapa, Constantin; Jahns, Roland; Ergün, Süleyman; Jahns, Valerie; Higuchi, Takahiro Longitudinal \(^{18}\)F-FDG PET imaging in a Rat Model of Autoimmune Myocarditis Aims: Although mortality rate is very high, diagnosis of acute myocarditis remains challenging with conventional tests. We aimed to elucidate the potential role of longitudinal 2-Deoxy-2-\(^{18}\)F-fluoro-D-glucose (\(^{18}\)F-FDG) positron emission tomography (PET) inflammation monitoring in a rat model of experimental autoimmune myocarditis. Methods and results: Autoimmune myocarditis was induced in Lewis rats by immunizing with porcine cardiac myosin emulsified in complete Freund's adjuvant. Time course of disease was assessed by longitudinal \(^{18}\)F-FDG PET imaging. A correlative analysis between in- and ex vivo \(^{18}\)F-FDG signalling and macrophage infiltration using CD68 staining was conducted. Finally, immunohistochemistry analysis of the cell-adhesion markers CD34 and CD44 was performed at different disease stages determined by longitudinal \(^{18}\)F-FDG PET imaging. After immunization, myocarditis rats revealed a temporal increase in 18F-FDG uptake (peaked at week 3), which was followed by a rapid decline thereafter. Localization of CD68 positive cells was well correlated with in vivo \(^{18}\)F-FDG PET signalling (R\(^2\) = 0.92) as well as with ex vivo 18F-FDG autoradiography (R\(^2\) = 0.9, P < 0.001, respectively). CD44 positivity was primarily observed at tissue samples obtained at acute phase (i.e. at peak 18F-FDG uptake), while CD34-positive staining areas were predominantly identified in samples harvested at both sub-acute and chronic phases (i.e. at \(^{18}\)F-FDG decrease). Conclusion: \(^{18}\)F-FDG PET imaging can provide non-invasive serial monitoring of cardiac inflammation in a rat model of acute myocarditis. 2018 1-8 European Heart Journal Cardiovascular Imaging urn:nbn:de:bvb:20-opus-165601 10.1093/ehjci/jey119 Klinik und Poliklinik für Nuklearmedizin OPUS4-16112 Konferenzveröffentlichung Werner, Rudolf; Wakabayashi, Hiroshi; Jahns, Roland; Ergün, Süleyman; Jahns, Valerie; Higuchi, Takahiro PET-Guided Histological Characterization of Myocardial Infiltrating Cells in a Rat Model of Myocarditis No abstract available. Oxford University Press 2017 i1-i3 European Heart Journal - Cardiovascular Imaging 18 Supplement urn:nbn:de:bvb:20-opus-161127 10.1093/ehjci/jex071 Klinik und Poliklinik für Nuklearmedizin