Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-14410 Wissenschaftlicher Artikel Sagiv, Jitka Y.; Michaeli, Janna; Assi, Simaan; Mishalian, Inbal; Kisos, Hen; Levy, Liran; Damti, Pazzit; Lumbroso, Delphine; Polyansky, Lola; Sionov, Ronit V.; Ariel, Amiram; Hovav, Avi-Hai; Henke, Erik; Fridlender, Zvi G.; Granot, Zvi Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer Controversy surrounds neutrophil function in cancer because neutrophils were shown to provide both pro-and antitumor functions. We identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflammation but accumulate continuously with cancer progression. LDNs display impaired neutrophil function and immunosuppressive properties, characteristics that are in stark contrast to those of mature, high-density neutrophils (HDNs). LDNs consist of both immature myeloid-derived suppressor cells (MDSCs) and mature cells that are derived from HDNs in a TGF-beta-dependent mechanism. Our findings identify three distinct populations of circulating neutrophils and challenge the concept that mature neutrophils have limited plasticity. Furthermore, our findings provide a mechanistic explanation to mitigate the controversy surrounding neutrophil function in cancer. 2015 562-573 Cell Reports 10 4 urn:nbn:de:bvb:20-opus-144102 10.1016/j.celrep.2014.12.039 Institut für Anatomie und Zellbiologie