Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Abteilungen OPUS4-13379 Wissenschaftlicher Artikel Schmitt, Jana; Keller, Andreas; Nourkami-Tutdibi, Nasenien; Heisel, Sabrina; Habel, Nunja; Leidinger, Petra; Ludwig, Nicole; Gessler, Manfred; Graf, Norbert; Berthold, Frank; Lenhof, Hans-Peter; Meese, Eckart Autoantibody Signature Differentiates Wilms Tumor Patients from Neuroblastoma Patients Several studies report autoantibody signatures in cancer. The majority of these studies analyzed adult tumors and compared the seroreactivity pattern of tumor patients with the pattern in healthy controls. Here, we compared the autoimmune response in patients with neuroblastoma and patients with Wilms tumor representing two different childhood tumors. We were able to differentiate untreated neuroblastoma patients from untreated Wilms tumor patients with an accuracy of 86.8%, a sensitivity of 87.0% and a specificity of 86.7%. The separation of treated neuroblastoma patients from treated Wilms tumor patients' yielded comparable results with an accuracy of 83.8%. We furthermore identified the antigens that contribute most to the differentiation between both tumor types. The analysis of these antigens revealed that neuroblastoma was considerably more immunogenic than Wilms tumor. The reported antigens have not been found to be relevant for comparative analyses between other tumors and controls. In summary, neuroblastoma appears as a highly immunogenic tumor as demonstrated by the extended number of antigens that separate this tumor from Wilms tumor. 2011 e28951 PLoS ONE 6 12 urn:nbn:de:bvb:20-opus-133794 10.1371/journal.pone.0028951 Theodor-Boveri-Institut für Biowissenschaften