6974
1994
eng
conferenceobject
1
2013-08-23
--
--
Molecular approaches to study the genetic regulation of the fish reproductive system
No abstract available.
8051
urn:nbn:de:bvb:20-opus-86679
In: Perspectives in Comparative Endocrinology / ed.: K. G. Davy. - Ottawa: Natl. Res. Council of Canada, 1994. - S. 343-351. - ISBN 0-660-15551-6
Deutsches Urheberrecht
Martin P. Schreibman
Manfred Schartl
Klaus D. Kallman
Lucia Magliulo-Cepriano
deu
swd
Fische
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6974/Schartl_6974.pdf
6972
1981
eng
conferenceobject
1
2013-08-23
--
--
Phenotypic conversion of malignant melanoma to benign melanoma and vice versa in Xiphophorus
No abstract available.
8049
urn:nbn:de:bvb:20-opus-86662
In: Phenotypic expression in pigment cells : pigment cell 1981 ; proceedings of the XIth International Pigment Cell Conference, Sendai, Japan, 1980 / ed. by Makoto Seiji. - [Tokyo] : Univ. of Tokyo Press, [1981]. - S. 507-514. - ISBN 0-86008-293-8
Deutsches Urheberrecht
A. Schartl
Manfred Schartl
F. Anders
deu
swd
Schwertkärpfling
deu
swd
Krebs <Medizin>
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6972/Schartl_6972.pdf
7273
1981
eng
conferenceobject
1
2013-09-03
--
--
Environmental and hereditary factors in the causation of neoplasia, based on studies of the Xiphophorus fish melanoma system
Neoplasia in Xiphophorus can be classified into: a) a Jarge group triggered by carcinogens; b) a large group triggered by promoters; and c) a small group that develops "spontaneously" according to Mendelian Jaw. The process leading to susceptibility for neoplasia is represented by the disintegration of gene systems that normally protect the fish from neoplasia. Interpopulational arid interracial hybridization is the most effective process that Ieads to disintegration of the protective gene systems. Environmental factors may complete disintegration in somatic cells and thus may trigger neoplasia. The applications of the findings on Xiphophorus to humans are discussed.
8074
urn:nbn:de:bvb:20-opus-86402
In: Phenotypic Expression in Pigment Cells: Pigment Cell / ed. Makoto Seiji. - [Tokyo]: Univ. of Tokyo Press, 1981. - S. 491-499. - ISBN: 0-86008-293-8
Deutsches Urheberrecht
F. Anders
E. Scholl
Manfred Schartl
deu
swd
Schwertkärpfling
deu
swd
Gen
deu
swd
Umweltfaktor
deu
swd
Tumor
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/7273/Schartl_7273.pdf
7272
1984
eng
conferenceobject
1
2013-09-03
--
--
Xiphophorus as an in vivo model for studies on oncogenes
The capacity of Xiphophorus to develop neoplasia can be formally assigned to a "tumor gene" (Tu), which appears to be a normal part of the genome of all individuals. The wild fish have evolved population-specific and cell type-specific systems of regulatory genes (R) for Tu that protect the fish from neoplasia. Hybridization of members of different wild populations in the laborstory followed by treatment of the hybrids with carcinogens led to disintegration of the R systems permitting excessive expression of Tu and thus resulting in neoplasia. Certain hybrids developed neoplasia even spontaneously. Observations on the genuine phenotypic effect of the derepressed Tu in the early embryo indicated an essential normal function of this oncogene in cell differentiation, proliferation and cell-cell communication. Tu appeared to be indispensable in the genome but may also be present in accessory copics. Recently, c-src, the cellular homolog of the Rous sarcoma virus oncogene v-src, was detected in Xiphophorus. The protein product of c-src, pp60c-src, was identified and then examined by its associated kinase activity. This pp60c-src was found in all individuals tested, but, depending on the genotype, its kinase activity was different. The genetic characters of c-src, such as linkage relations, dosage relations, expression, etc., correspond to those of Tu. From a systematic study which showed that pp60c-src was present in all metazoa tested ranging from mammals down to sponges, we concluded that c-src has evolved with the multicellular organization of animals. Neoplasia of animals and humans is a characteristic closely related to this evolution. Our data showed that small aquariurn fish, besides being used successfully because they are time-, space-, and money-saving systems for carcinogenicity testing, are also highly suitable for basic studies on neoplasia at the populational, morphological, developmental, cell biological, and molecular levels.
8073
urn:nbn:de:bvb:20-opus-86398
In: Use of small fish species in carcinogenity testing / ed. Karen L. Hoover. - Bethesda, Md: US Dep. of Health and Human Services, Public Health Service, National Institutes of Health; 1984. - S. 97-109. - (National Cancer Institute <Bethesda, Md.>: Monographs ; 65)
Deutsches Urheberrecht
Fritz Anders
Manfred Schartl
Angelika Barnekow
deu
swd
Schwertkärpfling
deu
swd
In vivo
deu
swd
Onkogen
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/7272/Schartl_7272.pdf
6937
1985
eng
conferenceobject
1
2013-08-22
--
--
Pigment pattern formation during embryogenesis in Xiphophorus
No abstract available.
8043
urn:nbn:de:bvb:20-opus-69370
In: Biological, Molecular and Clinical Aspects of Pigmentation : proceedings of the XIIth Internat. Pigment Cell Conference, Gießen, Federal Republic of Germany Pigment cell nineteen hundred and eighty-five / ed. by Joseph T. Bagnara. - [Tokyo]: Univ. of Tokyo Pr., 1985. - S. 291-302. - ISBN 4-13-068114-1
Deutsches Urheberrecht
R. U. Peter
Manfred Schartl
F. Anders
H.-R. Duncker
deu
swd
Schwertkärpfling
deu
swd
Embryonalentwicklung
deu
swd
Pigmentmuster
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6937/Schartl_6937.pdf
7097
1985
eng
conferenceobject
1
2013-08-23
--
--
An ultrastructural study of melanoma in Xiphophorus
Melanotic melanoma (MM) of Xiphophorus (Teleostei: Poeciliidae) was studied by conventional preparations and freeze-etch preparations for electron microscopy. MM of Xiphophorus exhibits tightly packed pigment cells with prominent dendritic processes and interdigitations of their plasma membranes. The most impressive feature of MM cells is the occurrence of Iarge lobulated nuclei with numerous nuclear pores and some nuclear pockets. Abundant spheroidal or ellipsoidal melanosomes (diameter 200-650 nm) and vesicular structures are distributed throughout the cellular dendrites, whereas the perinucJear cytoplasm is free of melanosomes.
A further characteristic feature of melanoma cells in fish is the occurrence of melanosome complexes (i.e., "compound melanosomes"). These melanosome complexes consist of a few to numerous melanosomes, which are enveloped by a separate rnembrane. Pinocytotic vesicles couJd be demonstrated with distinct differences in frequency and distribution patterns, indicating differences in the metabolic activities of the cells in the same melanoma. Intercellular junctions are lacking in the MM cells.
The conventional TEM technique showed clear advantages in the demonstration of intemal architecture of organelles, whereas FE bad considerable potential in respect to the visualization of membrane surface specializations.
8045
urn:nbn:de:bvb:20-opus-70978
In: Biological, Molecular and Clinical Aspects of Pigmentation : proceedings of the XIIth Internat. Pigment Cell Conference, Gießen, Federal Republic of Germany Pigment cell nineteen hundred and eighty-five / ed. by Joseph T. Bagnara. - [Tokyo]: Univ. of Tokyo Pr., 1985. - S. 457-464. - ISBN 4-13-068114-1
Deutsches Urheberrecht
Rüdiger Riehl
Manfred Schartl
Fritz Anders
deu
swd
Schwertkärpfling
deu
swd
Krebs <Medizin>
deu
swd
Ultrastruktur
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/7097/Schartl_7097.pdf
7268
1988
eng
conferenceobject
1
2013-09-03
--
--
Molecular aspects of melanoma formation in Xiphophorus
No abstract available.
8069
urn:nbn:de:bvb:20-opus-72689
In: Advances in pigment cell research : proceedings of symposia and lectures from the 13. Internat. Pigment Cell Conference held in Tucson, Arizona, Oct. 5 - 9, 1986 / ed. by. Joseph T. Bagnara. - New York: Liss, 1988. - S. 283-296. - (Progress in clinical and biological research ; 256). - ISBN 0-8451-5106-1
Deutsches Urheberrecht
Manfred Schartl
Winfried Mäueler
Friedrich Raulf
Scott M. Robertson
deu
swd
Schwertkärpfling
deu
swd
Krebs <Medizin>
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/7268/Schartl_7268.pdf
7274
1981
eng
conferenceobject
1
2013-09-03
--
--
Evaluation of environmental and hereditary factors in carcinogenesis, based on studies in Xiphophorus
Neoplasia in Xiphophorus can be classified into a) a large group that is triggered by carcinogens; b) a large group triggered by promoters; c) a small group that develops "spontaneously" following interpopulational and interracial hybridizations; and d) a small group that develops "spontaneously" following germ line mutation. The process leading to susceptibility for neoplasia is represented by the disintegration of gene systems that normally protect the fish from neoplasia. Hybridization is the most effective process that leads to disintegration of the protection gene systems. Environmental factors may complete disintegration and thus may trigger neoplasia. It is discussed whether the findings on Xiphophorus may also apply to humans.
8075
urn:nbn:de:bvb:20-opus-72741
In: Phyletic Approaches to Cancer / ed. by. Clyde J. Dawe. - Tokyo: Japan Scientific Soc. Press, 1981. - S. 289-309. - (Proceedings of the international symposium of the Princess Takamatsu Cancer Research Fund ; 11)
Deutsches Urheberrecht
F. Anders
Manfred Schartl
E. Scholl
deu
swd
Schwertkärpfling
deu
swd
Gen
deu
swd
Umweltfaktor
deu
swd
Carcinogenese
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/7274/Schartl_7274.pdf
5954
1994
eng
conferenceobject
1
2012-06-28
--
--
The conservation of neurotrophic factors during vertebrate evolution
No abstract available
urn:nbn:de:bvb:20-opus-61964
6196
In: Comparative Biochemistry and Physiology / Part C: Pharmacology, Toxicology and Endocrinology (1994) 108, 1-10.
Deutsches Urheberrecht
R. Gotz
Manfred Schartl
deu
swd
Physiologische Chemie
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/5954/Schartl66.pdf