16222
2018
eng
100
Supplement No 1
59
conferenceobject
1
2018-05-27
--
--
The Impact of Ageing on [\(^{11}\)C]meta-Hydroxyephedrine Uptake in the Rat Heart
No abstract available.
Journal of Nuclear Medicine
0161-5505
http://jnm.snmjournals.org/content/59/supplement_1/100.abstract
urn:nbn:de:bvb:20-opus-162228
Johns Hopkins School of Medicine
Journal of Nuclear Medicine May 1, 2018 vol. 59 no. supplement 1 100
701983
Deutsches Urheberrecht
Rudolf A. Werner
Xinyu Chen
Mitsuru Hirano
Naoko Nose
Constantin Lapa
Mehrbod S. Javadi
Takahiro Higuchi
deu
swd
Positronen-Emissions-Tomografie
eng
uncontrolled
moycardial sympathetic innervation
deu
uncontrolled
Positronen-Emissions-Tomografie
eng
uncontrolled
positron emission tomography
eng
uncontrolled
PET
eng
uncontrolled
11C-HED
eng
uncontrolled
hydroxyephedrine
eng
uncontrolled
ageing
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16222/Werner_Rudolf_11C-HED_JNM_Kongressbeitrag_accepted_version.pdf
16114
2017
eng
169
no. supplement 1
58
conferenceobject
1
2018-04-25
--
--
Predictive value of FDG-PET in patients with advanced medullary thyroid cancer undergoing vandetanib treatment
Introduction: The prognosis of medullary thyroid carcinoma (MTC) is poor using common chemotherapeutic approaches. However, during the last years encouraging results of recently introduced tyrosine kinase inhibitors (TKI) such as vandetanib have been published. In this study we aimed to correlate the results of \(^{18}\)F-fluorodeoxyglucose ([\(^{18}\)F]FDG) positron emission tomography (PET) imaging with treatment outcome.
Methods: Eighteen patients after thyroidectomy with recurrent/advanced MTC lesions receiving vandetanib (300 mg orally/day) could be analysed. A baseline \(^{18}\)F-FDG PET prior to and a follow-up \(^{18}\)F-FDG PET 3 months after TKI initiation were performed. During follow-up, tumor progression was assessed every 3 months including computed tomography according to RECIST. Progression-free survival (PFS) was correlated with the maximum standardized uptake value of \(^{18}\)F-FDG in lymph nodes (SUV(LN)max) or visceral metastases (SUV(MTS)max) as well as with clinical parameters using ROC analysis.
Results: Within median 3.6 years of follow-up, 9 patients showed disease progression at median 8.5 months after TKI initiation. An elevated glucose consumption assessed by baseline \(^{18}\)F-FDG PET (SUV(LN)max > 7.25) could predict a shorter PFS (2 y) with an accuracy of 76.5% (SUV(LN)max <7.25, 4.3 y; p=0.03). Accordingly, preserved tumor metabolism in the follow-up PET (SUV(MTS)max >2.7) also demonstrated an unfavorable prognosis (accuracy, 85.7%). On the other hand, none of the clinical parameters reached significance in response prediction.
Conclusions: In patients with advanced and progressive MTC, tumors with higher metabolic activity at baseline are more aggressive and more prone to progression as reflected by a shorter PFS; they should be monitored more closely. Preserved glucose consumption 3 months after treatment initiation was also related to poorer prognosis.
Journal of Nuclear Medicine
0161-5505
http://jnm.snmjournals.org/content/58/supplement_1/169
urn:nbn:de:bvb:20-opus-161147
This research was originally published in JNM.
Rudolf A. Werner, Takahiro Higuchi, Dirk O. Muegge, Mehrbod S. Javadi, B. Märkl, C. Aulmann, Andreas K. Buck, Martin Fassnacht, Constantin Lapa, Michael C. Kreissl.
Predictive value of FDG-PET in patients with advanced medullary thyroid cancer undergoing vandetanib treatment. J Nucl Med. May 1, 2017; vol. 58 no. supplement 1:169. © SNMMI.
Johns Hopkins School of Medicine, Baltimore, MD, U.S.
Hospital Augsburg, Augsburg, Germany
Journal of Nuclear Medicine May 1, 2017 vol. 58 no. supplement 1 169
701983
Deutsches Urheberrecht
Rudolf Werner
Takahiro Higuchi
Dirk Muegge
Mehrbod S. Javadi
Bruno Märkl
Christoph Aulmann
Andreas K. Buck
Martin Fassnacht
Constantin Lapa
Michael C. Kreissl
eng
uncontrolled
18F-FDG
eng
uncontrolled
vandetanib
eng
uncontrolled
TKI
eng
uncontrolled
PET
eng
uncontrolled
positron emission tomography
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Medizinische Klinik und Poliklinik I
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16114/Werner_Rudolf_Vandetanib_Kongressbeitrag_accepted_version.pdf
16113
2017
eng
1461-1496
4 Supplement (2017) Aug
24
conferenceobject
1
2018-04-25
--
--
Intracellular behavior of the novel sympathetic nerve agent \(^{18}\)F-LMI1195
No abstract available.
Journal of Nuclear Cardiology
10.1007/s12350-017-0984-y
1071-3581
urn:nbn:de:bvb:20-opus-161137
This is a post-peer-review, pre-copyedit version of an article published in J Nucl Cardiol. ISSN: 1071-3581. Supplement (2017) Aug;24;4: 1461-1496. The final authenticated version is available online at: http://dx.doi.org/10.1007/s12350-017-0984-y
Johns Hopkins University School of Medicine, Baltimore, MD, U.S.
Journal of Nuclear Cardiology August 2017, Volume 24, Issue 4, Supplement, pp 1461–1496. doi:10.1007/s12350-017-0984-y
701983
Deutsches Urheberrecht
Rudolf Werner
Xinyu Chen
Constantin Lapa
Simon Robinson
Takahiro Higuchi
deu
swd
Herz
eng
uncontrolled
PET
eng
uncontrolled
sympathetic nerve
eng
uncontrolled
autonomic nervous system
eng
uncontrolled
18F-LMI1195
eng
uncontrolled
positron emission tomography
eng
uncontrolled
heart
eng
uncontrolled
cardiac
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16113/Werner_Rudolf_18F-LMI1195.edited.pdf
16112
2017
eng
i1-i3
Supplement
18
conferenceobject
Oxford University Press
1
2018-04-25
--
--
PET-Guided Histological Characterization of Myocardial Infiltrating Cells in a Rat Model of Myocarditis
No abstract available.
European Heart Journal - Cardiovascular Imaging
2047-2404
10.1093/ehjci/jex071
urn:nbn:de:bvb:20-opus-161127
This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal Cardiovascular Imaging following peer review. The version of record . Eur Heart J Cardiovasc Imaging. ISSN: 2047-2404. Supplement, vol. 18, i1-i3, May 2017 is available online at: 10.1093/ehjci/jex071.
European Heart Journal - Cardiovascular Imaging, Volume 18, Issue suppl_1, May 2017, Pages i1–i3, https://doi.org/10.1093/ehjci/jex071
701983
Johns Hopkins School of Medicine, Baltimore, MD, U.S.
Deutsches Urheberrecht
Rudolf Werner
Hiroshi Wakabayashi
Roland Jahns
Süleyman Ergün
Valerie Jahns
Takahiro Higuchi
deu
swd
Myokarditis
eng
uncontrolled
positron emission tomography
eng
uncontrolled
myocarditis
eng
uncontrolled
PET
eng
uncontrolled
18F-FDG
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Institut für Pharmakologie und Toxikologie
Institut für Anatomie und Zellbiologie
Medizinische Klinik und Poliklinik I
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16112/Werner_Rudolf_Myocarditis.pdf