19661
2016
eng
129
136
2
232
article
1
--
2016-01-07
--
Juvenile Adamantiades-Behçet disease
Adamantiades-Behçet disease (ABD) is a chronic, multisystemic, recurrent, inflammatory vascular disorder of unknown etiology. Patients with symptoms initially appearing at the age of 16 or less are considered as cases of juvenile-onset ABD (JABD). JABD is relatively rare compared to ABD of adults, and only case reports and case studies have been published regarding this subtype of the disease. Epidemiology, clinical features, diagnosis and treatment of JABD are discussed in this review.
Dermatology
1018-8665
1421-9832
10.1159/000442667
26736030
urn:nbn:de:bvb:20-opus-196616
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-14T14:19:17+00:00
attachment; filename=deposit.zip
3ac1e8ca7ec33bcc6bf15d567ca2b6e6
Dermatology (2016) 232:2, 129-136. https://doi.org/10.1159/000442667
true
true
Deutsches Urheberrecht
Aristeidis G. Vaiopoulos
Meletios A. Kanakis
Violetta Kapsimali
Georgios Vaiopoulos
Phedon G. Kaklamanis
Christos C. Zouboulis
eng
uncontrolled
Aphthae
eng
uncontrolled
Childhood
eng
uncontrolled
Epidemiological study
eng
uncontrolled
Genitoanal region
eng
uncontrolled
Adamantiades-Behçet disease
eng
uncontrolled
Behçet’s disease
eng
uncontrolled
Uveitis
Medizin und Gesundheit
open_access
Pathologisches Institut
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19661/DRM442667.pdf
19670
2016
eng
240-246
4
147
article
1
--
2016-03-10
--
5-Methylcytosine-Rich Heterochromatin in the Indian Muntjac
Two 5-methylcytosine (5-MeC)-rich heterochromatic regions were demonstrated in metaphase chromosomes of the Indian muntjac by indirect immunofluorescence using a monoclonal anti-5-MeC antibody. The metaphases were obtained from diploid and triploid cell lines. A major region is located in the ‘neck' of the 3;X fusion chromosome and can be detected after denaturation of the chromosomal DNA with UV-light irradiation for 1 h. It is located exactly at the border of the X chromosome and the translocated autosome 3. A minor region is found in the centromeric region of the free autosome 3 after denaturing the chromosomal DNA for 3 h or longer. The structure and possible function of the major hypermethylated region as barrier against spreading of the X-inactivation process into the autosome 3 is discussed.
Cytogenetic and Genome Research
1424-8581
1424-859X
10.1159/000444431
26959372
urn:nbn:de:bvb:20-opus-196701
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-14T14:20:05+00:00
attachment; filename=deposit.zip
d5f393b3e4918de1f4c7aaa823107283
Cytogenetic and Genome Research 2015;147(4):240–246. DOI: 10.1159/000444431
false
true
Deutsches Urheberrecht
Michael Schmid
Claus Steinlein
Christian Lomb
Karl Sperling
Heidemarie Neitzel
eng
uncontrolled
heterochromatin
eng
uncontrolled
immunofluorescence
eng
uncontrolled
Indian muntjac
eng
uncontrolled
5-Methylcytosine
Medizin und Gesundheit
open_access
Institut für Humangenetik
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19670/CGR444431.pdf
19901
2016
eng
253-259
4
147
article
1
--
2016-03-18
--
Multicolor Spectral Analyses of Mitotic and Meiotic Mouse Chromosomes Involved in Multiple Robertsonian Translocations. I. The CD/Cremona Hybrid Strain
Multicolor spectral analysis (spectral karyotyping) was applied to mitotic and male diakinetic chromosomes of hybrid mice carrying a unique system of 18 autosomal Robertsonian translocation chromosomes with alternating arm homologies. Only the autosomes 19 and the XY sex chromosomes are excluded from these Robertsonian translocations. The translocations, previously identified by conventional banding analyses, could be verified by spectral karyotyping. Besides the Robertsonian translocations, no other interchromosomal rearrangements were detected. In diakineses of male meiosis, the 18 metacentric Robertsonian translocation chromosomes form a very large meiotic ‘superring'. The predictable, specific order of the chromosomes along this ‘superring' was completely confirmed by multicolor spectral analysis. In the majority of diakineses analyzed, the free autosomal bivalent 19 and the XY sex bivalent form a conspicuous complex which tightly associates with the 12;14 Robertsonian translocation chromosome in the ‘superring'.
Cytogenetic and Genome Research
1424-8581
1424-859X
10.1159/000444597
26987048
urn:nbn:de:bvb:20-opus-199013
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-28T13:22:30+00:00
attachment; filename=deposit.zip
96d96ab5dc3383a535a66772b1a94a9e
Cytogenetic and Genome Research 2015;147(4):253–259. DOI: 10.1159/000444597
false
true
Deutsches Urheberrecht
Michael Schmid
Claus Steinlein
Heinz Winking
eng
uncontrolled
meiotic ‘superring’
eng
uncontrolled
mouse
eng
uncontrolled
Robertsonian translocation chromosomes
eng
uncontrolled
spectral karyotyping
Medizin und Gesundheit
open_access
Institut für Humangenetik
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19901/CGR444597.pdf
19671
2016
eng
169-178
2-3
147
article
1
--
2016-02-20
--
Hypermethylated Chromosome Regions in Nine Fish Species with Heteromorphic Sex Chromosomes
Sites and amounts of 5-methylcytosine (5-MeC)-rich chromosome regions were detected in the karyotypes of 9 Brazilian species of Characiformes fishes by indirect immunofluorescence using a monoclonal anti-5-MeC antibody. These species, belonging to the genera Leporinus, Triportheus and Hoplias, are characterized by highly differentiated and heteromorphic ZW and XY sex chromosomes. In all species, the hypermethylated regions are confined to constitutive heterochromatin. The number and chromosome locations of hypermethylated heterochromatic regions in the karyotypes are constant and species-specific. Generally, heterochromatic regions that are darkly stained by the C-banding technique are distinctly hypermethylated, but several of the brightly fluorescing hypermethylated regions merely exhibit moderate or faint C-banding. The ZW and XY sex chromosomes of all 9 analyzed species also show species-specific heterochromatin hypermethylation patterns. The analysis of 5-MeC-rich chromosome regions contributes valuable data for comparative cytogenetics of closely related species and highlights the dynamic process of differentiation operating in the repetitive DNA fraction of sex chromosomes.
Cytogenetic and Genome Research
1424-8581
1424-859X
10.1159/000444067
26895457
urn:nbn:de:bvb:20-opus-196710
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-14T14:20:10+00:00
attachment; filename=deposit.zip
02c8862777a97db9a5e1d868b3079b80
Cytogenetic and Genome Research 2015;147(2-3):169–178. DOI: 10.1159/000444067
false
true
Deutsches Urheberrecht
Michael Schmid
Claus Steinlein
Cassia F. Yano
Marcelo B. Cioffi
eng
uncontrolled
heterochromatin
eng
uncontrolled
heteromorphic sex chromosomes
eng
uncontrolled
hypermethylation
eng
uncontrolled
immunofluorescence
eng
uncontrolled
5-Methylcytosine
eng
uncontrolled
fish
Medizin und Gesundheit
open_access
Institut für Humangenetik
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19671/CGR444067.pdf
19902
2016
eng
35-43
1
148
article
1
--
2016-04-30
--
Chromosome Banding in Amphibia. XXXIII. Demonstration of 5-Methylcytosine-Rich Heterochromatin in Anura
An experimental approach using monoclonal anti-5-methylcytosine (5-MeC) antibodies and indirect immunofluorescence was elaborated for detecting 5-MeC-rich chromosome regions in anuran chromosomes. This technique was applied to mitotic metaphases of 6 neotropical frog species belonging to 6 genera and 4 families. The hypermethylation patterns were compared with a variety of banding patterns obtained by conventional banding techniques. The hypermethylated DNA sequences are species-specific and located exclusively in constitutive heterochromatin. They are found in centromeric, pericentromeric, telomeric, and interstitial positions of the chromosomes and adjacent to nucleolus organizer regions. 5-MeC-rich DNA sequences can be embedded both in AT- and GC-rich repetitive DNA. The experimental parameters that have major influence on the reproducibility and quality of the anti-5-MeC antibody labeling are discussed.
Cytogenetic and Genome Research
1424-8581
1424-859X
10.1159/000446141
27160320
urn:nbn:de:bvb:20-opus-199022
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-28T13:22:35+00:00
attachment; filename=deposit.zip
8ea1ccd58dc2f2e6668014303672db52
Cytogenetic and Genome Research 2016;148(1):35–43. DOI: 10.1159/000446141
false
true
Deutsches Urheberrecht
Michael Schmid
Claus Steinlein
eng
uncontrolled
Anura
eng
uncontrolled
heterochromatin
eng
uncontrolled
hypermethylated DNA
eng
uncontrolled
immunofluorescence
eng
uncontrolled
5-Methylcytosine
Medizin und Gesundheit
open_access
Institut für Humangenetik
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19902/CGR446141.pdf
19669
2016
eng
211-226
2-3
148
article
1
--
2016-05-28
--
Chromosome Banding in Amphibia. XXXIV. Intrachromosomal Telomeric DNA Sequences in Anura
The mitotic chromosomes of 4 anuran species were examined by various classical banding techniques and by fluorescence in situ hybridization using a (TTAGGG)\(_n\) repeat. Large intrachromosomal telomeric sequences (ITSs) were demonstrated in differing numbers and chromosome locations. A detailed comparison of the present results with numerous published and unpublished data allowed a consistent classification of the various categories of large ITSs present in the genomes of anurans and other vertebrates. The classification takes into consideration the total numbers of large ITSs in the karyotypes, their chromosomal locations and their specific distribution patterns. A new category of large ITSs was recognized to exist in anuran species. It consists of large clusters of ITSs located in euchromatic chromosome segments, which is in clear contrast to the large ITSs in heterochromatic chromosome regions known in vertebrates. The origin of the different categories of large ITSs in heterochromatic and euchromatic chromosome regions, their mode of distribution in the karyotypes and evolutionary fixation in the genomes, as well as their cytological detection are discussed.
Cytogenetic and Genome Research
1424-8581
1424-859X
10.1159/000446298
27233250
urn:nbn:de:bvb:20-opus-196693
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-14T14:20:01+00:00
attachment; filename=deposit.zip
1b6594bb5077bff51e0cb359b41a3d90
Cytogenetic and Genome Research 2016;148(2-3):211–226. DOI: 10.1159/000446298
false
true
Deutsches Urheberrecht
Michael Schmid
Claus Steinlein
eng
uncontrolled
heterochromatin
eng
uncontrolled
intrachromosomal telomeric sequences
eng
uncontrolled
Anura
eng
uncontrolled
euchromatin
eng
uncontrolled
evolutionary fixation
Medizin und Gesundheit
open_access
Institut für Humangenetik
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19669/CGR446298.pdf
19657
2016
eng
141-154
2
171
article
1
--
2016-12-01
--
Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis
Background: There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ T cells (Tregs) and inflammatory T-helper (Th) 17 cells has been suggested. Methods: The study aimed (1) to investigate the phenotypical and functional characteristics of Th17 and Tregs in SSc patients depending on disease manifestation (limited vs. diffuse cutaneous SSc, dcSSc) and activity, and (2) the transcriptional level and methylation status of Th17- and Treg-specific transcription factors. Results: There was a concurrent accumulation of circulating peripheral IL-17-producing CCR6+ Th cells and FoxP3+ Tregs in patients with dcSSc. At the transcriptional level, Th17- and Treg-associated transcription factors were elevated in SSc. A strong association with high circulating Th17 and Tregs was seen with early, active, and severe disease presentation. However, a diminished suppressive function on autologous lymphocytes was found in SSc-derived Tregs. Significant relative hypermethylation was seen at the gene level for RORC1 and RORC2 in SSc, particularly in patients with high inflammatory activity. Conclusions: Besides the high transcriptional activity of T cells, attributed to Treg or Th17 phenotype, in active SSc disease, Tregs may be insufficient to produce high amounts of IL-10 or to control proliferative activity of effector T cells in SSc. Our results suggest a high plasticity of Tregs strongly associated with the Th17 phenotype. Future directions may focus on enhancing Treg functions and stabilization of the Treg phenotype.
International Archives of Allergy and Immunology
1018-2438
1423-0097
10.1159/000450949
27902985
urn:nbn:de:bvb:20-opus-196577
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-14T14:18:46+00:00
attachment; filename=deposit.zip
c83b8f6f2bd0a0207069c72555c5d60e
International Archives of Allergy and Immunology 2016;171(2):141–154 DOI: 10.1159/000450949
false
true
Deutsches Urheberrecht
Giovanni Almanzar
Matthias Klein
Marc Schmalzing
Deborah Hilligardt
Nady El Hajj
Hermann Kneitz
Vanessa Wild
Andreas Rosenwald
Sandrine Benoit
Henning Hamm
Hans-Peter Tony
Thomas Haaf
Matthias Goebeler
Martina Prelog
eng
uncontrolled
methylation
eng
uncontrolled
systemic sclerosis
eng
uncontrolled
suppression
eng
uncontrolled
Tregs
eng
uncontrolled
Th17
Medizin und Gesundheit
open_access
Kinderklinik und Poliklinik
Pathologisches Institut
Institut für Humangenetik
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Medizinische Klinik und Poliklinik II
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19657/IAA450949.pdf
19912
2016
eng
212-222
4
21
article
1
--
2016-06-29
--
Multicenter Clinical Trial of Vibroplasty Couplers to Treat Mixed/Conductive Hearing Loss: First Results
Objective: To evaluate the safety and effectiveness of round window (RW), oval window (OW), CliP and Bell couplers for use with an active middle ear implant. Methods: This is a multicenter, long-term, prospective trial with consecutive enrollment, involving 6 university hospitals in Germany. Bone conduction, air conduction, implant-aided warble-tone thresholds and Freiburger monosyllable word recognition scores were compared with unaided preimplantation results in 28 moderate-to-profound hearing-impaired patients after 12 months of follow-up. All patients had previously undergone failed reconstruction surgeries (up to 5 or more). In a subset of patients, additional speech tests at 12 months postoperatively were used to compare the aided with the unaided condition after implantation with the processor switched off. An established quality-of-life questionnaire for hearing aids was used to determine patient satisfaction. Results: Postoperative bone conduction remained stable. Mean functional gain for all couplers was 37 dB HL (RW = 42 dB, OW = 35 dB, Bell = 38 dB, CliP = 27 dB). The mean postoperative Freiburger monosyllable score was 71% at 65 dB SPL. The postimplantation mean SRT<sub>50</sub> (speech reception in quiet for 50% understanding of words in sentences) improved on average by 23 dB over unaided testing and signal-to-noise ratios also improved in all patients. The International Outcome Inventory for Hearing Aids (IOI-HA)quality-of-life questionnaire was scored very positively by all patients. Conclusion: A significant improvement was seen with all couplers, and patients were satisfied with the device at 12 months postoperatively. These results demonstrate that an active implant is an advantage in achieving good hearing benefit in patients with prior failed reconstruction surgery.
Audiology and Neurotology
1420-3030
1421-9700
10.1159/000444616
27351868
urn:nbn:de:bvb:20-opus-199129
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-28T13:23:24+00:00
attachment; filename=deposit.zip
f14ec486cf7a2c20039ecb8a3c9c2e65
Audiology and Neurotology 2016;21(4):212–222. DOI: 10.1159/000444616
false
true
Deutsches Urheberrecht
Thomas Zahnert
Hubert Löwenheim
Dirk Beutner
Rudolf Hagen
Arneborg Ernst
Hans-Wilhelm Pau
Thorsten Zehlicke
Hilke Kühne
Natascha Friese
Anke Tropitzsch
Jan-Christoffer Lüers
Robert Mlynski
Ingo Todt
Karl-Bernd Hüttenbrink
eng
uncontrolled
conductive hearing loss
eng
uncontrolled
mixed hearing loss
eng
uncontrolled
vibroplasty
eng
uncontrolled
couplers
eng
uncontrolled
middle ear implant
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, plastische und ästhetische Operationen
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19912/AUD444616.pdf
19679
2016
eng
187-198
3-4
41
article
Giant Intracranial Aneurysm Study Group
1
--
2016-01-15
--
Outcome of Surgical or Endovascular Treatment of Giant Intracranial Aneurysms, with Emphasis on Age, Aneurysm Location, and Unruptured Aneuryms - A Systematic Review and Meta-Analysis
Background: Designing treatment strategies for unruptured giant intracranial aneurysms (GIA) is difficult as evidence of large clinical trials is lacking. We examined the outcome following surgical or endovascular GIA treatment focusing on patient age, GIA location and unruptured GIA. Methods: Medline and Embase were searched for studies reporting on GIA treatment outcome published after January 2000. We calculated the proportion of good outcome (PGO) for all included GIA and for unruptured GIA by meta-analysis using a random effects model. Results: We included 54 studies containing 64 study populations with 1,269 GIA at a median follow-up time (FU-T) of 26.4 months (95% CI 10.8-42.0). PGO was 80.9% (77.4-84.4) in the analysis of all GIA compared to 81.2% (75.3-86.1) in the separate analysis of unruptured GIA. For each year added to patient age, PGO decreased by 0.8%, both for all GIA and unruptured GIA. For all GIA, surgical treatment resulted in a PGO of 80.3% (95% CI 76.0-84.6) compared to 84.2% (78.5-89.8, p = 0.27) after endovascular treatment. In unruptured GIA, PGO was 79.7% (95% CI 71.5-87.8) after surgical treatment and 84.9% (79.1-90.7, p = 0.54) after endovascular treatment. PGO was lower in high quality studies and in studies presenting aggregate instead of individual patient data. In unruptured GIA, the OR for good treatment outcome was 5.2 (95% CI 2.0-13.0) at the internal carotid artery compared to 0.1 (0.1-0.3, p < 0.1) in the posterior circulation. Patient sex, FU-T and prevalence of ruptured GIA were not associated with PGO. Conclusions: We found that the chances of good outcome after surgical or endovascular GIA treatment mainly depend on patient age and aneurysm location rather than on the type of treatment conducted. Our analysis may inform future research on GIA.
Cerebrovascular Diseases
1015-9770
1421-9786
10.1159/000443485
26764969
urn:nbn:de:bvb:20-opus-196792
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-14T14:20:52+00:00
attachment; filename=deposit.zip
e8041c725cd3433d8e4b1e577ed43b9b
Cerebrovascular Diseases 2016;41(3-4):187–198. DOI: 10.1159/000443485
Deutsches Urheberrecht
Julius Dengler
Nicolai Maldaner
Sven Gläsker
Matthias Endres
Martin Wagner
Uwe Malzahn
Peter U. Heuschmann
Peter Vajkoczy
eng
uncontrolled
surgical aneurysm treatment
eng
uncontrolled
giant intracranial aneurysm
eng
uncontrolled
endovascular treatment
Medizin und Gesundheit
open_access
Institut für Klinische Epidemiologie und Biometrie
Import
Deutsches Zentrum für Herzinsuffizienz (DZHI)
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19679/CED443485.pdf
24245
2016
eng
10
workingpaper
0
2021-07-30
--
--
The Prospects of Cloud Gaming: Do the Benefits Outweigh the Costs?
In recent years, cloud gaming has become a popular research topic and has claimed many benefits in the commercial domain over conventional gaming. While, cloud gaming platforms have frequently failed in the past, they have received a new impetus over the last years that brought it to the edge of commercial breakthrough. The fragility of the cloud gaming market may be caused by the high investment costs, offered pricing models or competition from existing "à la carte" platforms. This paper aims at investigating the costs and benefits of both platform types through a twofold approach. We first take on the perspective of the customers, and investigate several cloud gaming platforms and their pricing models in comparison to the costs of other gaming platforms. Then, we explore engagement metrics in order to assess the enjoyment of playing the offered games. Lastly, coming from the perspective of the service providers, we aim to identify challenges in cost-effectively operating a large-scale cloud gaming service while maintaining high QoE values. Our analysis provides initial, yet still comprehensive reasons and models for the prospects of cloud gaming in a highly competitive market.
urn:nbn:de:bvb:20-opus-242452
Originally written in 2016, but never published.
publish
false
true
CC BY-SA: Creative-Commons-Lizenz: Namensnennung, Weitergabe unter gleichen Bedingungen 4.0 International
Florian Metzger
Albert Rafetseder
Svenja Schröder
Patrick Zwickl
deu
swd
Cloud Computing
deu
swd
Videospiel
deu
swd
Kosten-Nutzen-Analyse
eng
uncontrolled
Cloud Gaming
eng
uncontrolled
Video Game QoS
eng
uncontrolled
Cost-benefit analysis
Informatik, Informationswissenschaft, allgemeine Werke
open_access
Institut für Informatik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/24245/Metzger_Prospects_Cloud_Gaming_2016.pdf