12840
1982
deu
1461-1471
11
37
article
1
2016-03-01
--
--
Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III
Sila-Pharmaca, 26th Communication [1] Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, III
The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction analysis (8a- 8e) and IR NMR spectroscopy (8a- 8f), respectively. The muscle relaxing properties of 8a- 8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 Å model" for neuromuscular blocking agents.
Zeitschrift für Naturforschung B
urn:nbn:de:bvb:20-opus-128402
Zeitschrift für Naturforschung B 37, 1461- 1471 (1982)
Deutsches Urheberrecht
Reinhold Tacke
Haryanto Linoh
Moayad T. Attar-Bashi
William S. Sheldrick
Ludger Ernst
Roland Niedner
Joachim Frohnecke
eng
uncontrolled
structure-activity relationships
eng
uncontrolled
X-ray
eng
uncontrolled
curare-lik activity
eng
uncontrolled
silicon compounds
eng
uncontrolled
conformational anaylses
Anorganische Chemie
open_access
Institut für Anorganische Chemie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12840/X_Tacke_Silicium-Verbindungen.pdf
12830
1983
deu
616-620
5
38
article
1
2016-03-01
--
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Mikrobiologische Umwandlung von Silicium-Verbindungen: Enantioselektive Reduktion von Acetessigsäure-(trimethylsilylalkyl)estern und deren Carba-Analoga
Microbiological Transformation of Silicon Compounds: Enantioselective Reduction of Trimethylsilylalkyl Acetoacetates and their Carba-Analogues
The trimethylsilylalkyl acetoacetates 1 b and 2 b as well as their carba analogues 1 a and 2 a have been reduced microbiologically by Kloeckera corticis (ATCC 20109), leading to the corresponding ( + )-3(S)-hydroxybutanoates 3b, 4b, 3a, and 4a. The enantiomeric purity was found to be 80% (3a, 3b, 4b) and 65% (4a), respectively. The reduction of lb and 2b is - to our knowledge - the first example for a controlled microbiological transformation of organosilicon substrates.
Zeitschrift für Naturforschung B
urn:nbn:de:bvb:20-opus-128304
Zeitschrift für Naturforschung B. Band 38, Heft 5, Seiten 616–620
Deutsches Urheberrecht
Reinhold Tacke
Haryanto Linoh
Burghard Stumpf
Wolf-Rainer Abraham
Klaus Kieslich
Ludger Ernst
eng
uncontrolled
enantioselective reduction
eng
uncontrolled
microbiological transformation
eng
uncontrolled
silicon compounds
Anorganische Chemie
open_access
Institut für Anorganische Chemie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12830/X_Tacke_Mikrobiologische-Umwandlung.pdf