17462
2019
eng
preprint
1
2018-12-29
--
--
Novel Structured Reporting Systems for Theranostic Radiotracers
Standardized reporting is more and more routinely implemented in clinical practice and such structured reports have a major impact on a large variety of medical fields, e.g. laboratory medicine, pathology, and, recently, radiology. Notably, the field of nuclear medicine is constantly evolving, as novel radiotracers for numerous clinical applications are developed. Thus, framework systems for standardized reporting in this field may a) increase clinical acceptance of new radiotracers, b) allow for inter- and intra-center comparisons for quality assurance, and c) may be used in (global) multi-center studies to ensure comparable results and enable efficient data abstraction. In the last two years, several standardized framework systems for positron emission tomography (PET) radiotracers with potential theranostic applications have been proposed. These include systems for prostate-specific membrane antigen (PSMA)-targeted PET agents for the diagnosis and treatment of prostate cancer (PCa) and somatostatin receptor (SSTR)-targeted PET agents for the diagnosis and treatment of neuroendocrine neoplasias. In the present review, those standardized framework systems for PSMA- and SSTR-targeted PET will be briefly introduced followed by an overview of their advantages and limitations. In addition, potential applications will be defined, approaches to validate such concepts will be proposed, and future perspectives will be discussed.
Journal of Nuclear Medicine
0161-5505
10.2967/jnumed.118.223537
urn:nbn:de:bvb:20-opus-174629
This research was originally published in JNM. Authors: Rudolf A. Werner, Ralph A. Bundschuh, Lena Bundschuh, Stefano Fanti, Mehrbod S. Javadi, Takahiro Higuchi, A. Weich, Kenneth J. Pienta, Andreas K. Buck, Martin G. Pomper, Michael A. Gorin, Ken Herrmann, Constantin Lapa, Steven P. Rowe. Novel Structured Reporting Systems for Theranostic Radiotracers. J Nucl Med May 1, 2019 vol. 60 no. 5 577-584 © SNMMI.
Johns Hopkins School of Medicine
701983
Journal of Nuclear Medicine May 1, 2019, vol. 60, no. 5, 577-584. doi: 10.2967/jnumed.118.223537
false
true
Deutsches Urheberrecht
Rudolf A. Werner
Ralph A. Bundschuh
Lena Bundschuh
Stefano Fanti
Mehrbod S. Javadi
Takahiro Higuchi
A. Weich
Kenneth J. Pienta
Andreas K. Buck
Martin G. Pomper
Michael A. Gorin
Ken Herrmann
Constantin Lapa
Steven P. Rowe
eng
uncontrolled
standardized reporting
deu
swd
Positronen-Emissions-Tomografie
eng
uncontrolled
prostate cancer
eng
uncontrolled
neuroendocrine neoplasia
eng
uncontrolled
68Ga-DOTATATE
eng
uncontrolled
68Ga-DOTATOC
eng
uncontrolled
68Ga-DOTANOC
eng
uncontrolled
somatostatin receptor
eng
uncontrolled
SSTR
eng
uncontrolled
prostate-specific membrane antigen
eng
uncontrolled
PSMA
eng
uncontrolled
RADS
eng
uncontrolled
PSMA-RADS
eng
uncontrolled
SSTR-RADS
eng
uncontrolled
MI-RADS
eng
uncontrolled
PROMISE
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Medizinische Klinik und Poliklinik II
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/17462/Werner_Novel_Structured_Reporting_JNM_accepted_version.pdf
16778
2018
eng
preprint
1
2018-08-31
--
--
Interobserver Agreement for the Standardized Reporting System PSMA-RADS 1.0 on \(^{18}\)F-DCFPyL PET/CT Imaging
Objectives: Recently, the standardized reporting and data system for prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) imaging studies, termed PSMA-RADS version 1.0, was introduced. We aimed to determine the interobserver agreement for applying PSMA-RADS to imaging interpretation of 18F-DCFPyL PET examinations in a prospective setting mimicking the typical clinical work-flow at a prostate cancer referral center.
Methods: Four readers (two experienced readers (ER, > 3 years of PSMA-targeted PET interpretation experience) and two inexperienced readers (IR, < 1 year of experience)), who had all read the initial publication on PSMA-RADS 1.0, assessed 50 18F-DCFPyL PET/computed tomography (CT) studies independently. Per scan, a maximum of 5 target lesions were selected by the observers and a PSMA-RADS score for every target lesion was recorded. No specific pre-existing conditions were placed on the selection of the target lesions, although PSMA-RADS 1.0 suggests that readers focus on the most highly avid or largest lesions. An overall scan impression based on PSMA-RADS was indicated and interobserver agreement rates on a target lesion-based, on an organ-based, and on an overall PSMA-RADS score-based level were computed.
Results: The number of target lesions identified by each observer were as follows: ER 1, 123; ER 2, 134; IR 1, 123; and IR 2, 120. Among those selected target lesions, 125 were chosen by at least two individual observers (all four readers selected the same target lesion in 58/125 (46.4%) instances, three readers in 40/125 (32%) and two observers in 27/125 (21.6%) instances). The interobserver agreement for PSMA-RADS scoring among identical target lesions was good (intraclass correlation coefficient (ICC) for four, three and two identical target lesions, ≥0.60, respectively). For lymph nodes, an excellent interobserver agreement was derived (ICC=0.79). The interobserver agreement for an overall scan impression based on PSMA-RADS was also excellent (ICC=0.84), with a significant difference for ER (ICC=0.97) vs. IR (ICC=0.74, P=0.005).
Conclusions: PSMA-RADS demonstrates a high concordance rate in this study, even among readers with different levels of experience. This suggests that PSMA-RADS can be effectively used for communication with clinicians and can be implemented in the collection of data for large prospective trials.
Journal of Nuclear Medicine
0161-5505
10.2967/jnumed.118.217588
urn:nbn:de:bvb:20-opus-167788
This research was originally published in JNM. Rudolf A. Werner, Ralph A. Bundschuh, Lena Bundschuh, Mehrbod S. Javadi, Jeffrey P. Leal, Takahiro Higuchi, Kenneth J. Pienta, Andreas K. Buck, Martin G. Pomper, Michael A. Gorin, Constantin Lapa and Steven P. Rowe. Interobserver Agreement for the Standardized Reporting System PSMA-RADS 1.0 on 18F-DCFPyL PET/CT Imaging. J Nucl Med 2018;59:1857-1864 © SNMMI.
Johns Hopkins School of Medicine
701983
Journal of Nuclear Medicine, 2018 vol. 59 no. 12, 1857-1864 , doi:10.2967/jnumed.118.217588
Deutsches Urheberrecht
Rudolf A. Werner
Ralph A. Bundschuh
Lena Bundschuh
Mehrbod S. Javadi
Jeffrey P. Leal
Takahiro Higuchi
Kenneth J. Pienta
Andreas K. Buck
Martin G. Pomper
Michael A. Gorin
Constantin Lapa
Steven P. Rowe
eng
uncontrolled
18F-DCFPyL
deu
swd
Positronen-Emissions-Tomografie
eng
uncontrolled
PSMA-RADS
eng
uncontrolled
interreader
eng
uncontrolled
interobserver
eng
uncontrolled
PSMA
eng
uncontrolled
prostate cancer
eng
uncontrolled
RADS
eng
uncontrolled
reporting and data system
eng
uncontrolled
PET
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16778/Rudolf_Werner_PSMA_RADS_2018_JNM_accepted_version.pdf