5445
1989
eng
review
1
2012-01-12
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Results of animal studies suggest a nonlinear dose-response relationship for benzene effects
Considering the very large industrial usage of benzene, studies in risk assessment aimed at the evaluation of carcinogenic risk at low Ievels of exposure are important. Animal data can offer indications about what could happen in humans and provide more diverse information than epidemiological data with respect to doseresponse consideration. We have considered experiments investigating metabolism, short·term genotoxicity tests, DNA adduct formation, and carcinogenicity long-term tests. According to the different experiments, a Saturation of benzene metabolism and benzene effects in terms of genotoxicity seems evident above 30 to 100 ppm. Below 30 to 60 ppm the initiating effect ofbenzene seems tobe linear fora large intervaJ ofdosages, at least judging from DNA adduct formation. Potentiallack of a promoting effect of benzene (below 10 ppm) could generate a sublinear response at nontox.ic levels of ex.posure. This possibility was suggested by epidemiological data in humans and is not confirmed or excluded by our observations with animals.
urn:nbn:de:bvb:20-opus-60843
6084
In: Environmental health perspectives (1989) 82, 171-6. Review.
Deutsches Urheberrecht
S. Parodi
Werner K. Lutz
A. Colacci
M. Mazzullo
M. Taningher
S. Grilli
deu
swd
Toxikologie
Medizin und Gesundheit
open_access
Institut für Pharmakologie und Toxikologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/5445/Lutz29.pdf
3113
1989
eng
review
1
2009-08-27
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A convenient synthesis of 2,2',6,6'-Tetramethyl-4,4'-bipyridine and its oxidation to 2,2',6,6'-Tetracarboxy-4,4'-bipyridine
No abstract available
urn:nbn:de:bvb:20-opus-32005
3200
In: Synthesis (1989) 552.
Siegfried Hünig
Ingeborg Wehner
Chemie und zugeordnete Wissenschaften
open_access
Institut für Pharmazie und Lebensmittelchemie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/3113/Wehner_Convenient_synthesis_oxidation.pdf