23560
2020
eng
1669–1670
48
article
1
2021-04-26
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Pitfalls in PSMA-PET/CT: Intensive bone-marrow uptake in a case with polycythaemia vera
No abstract available.
European Journal of Nuclear Medicine and Molecular Imaging
1619-7070
10.1007/s00259-020-05072-7
urn:nbn:de:bvb:20-opus-235608
publish
European Journal of Nuclear Medicine and Molecular Imaging 48, 1669–1670 (2021). https://doi.org/10.1007/s00259-020-05072-7
true
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Philipp E. Hartrampf
Bernhard Petritsch
Andreas K. Buck
Sebastian E. Serfling
eng
uncontrolled
bone-marrow
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik)
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/23560/Hartrampf2021_Article_PitfallsInPSMA-PETCTIntensiveB.pdf
12220
2013
eng
471-481
5
article
1
2015-11-19
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Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes
We used a novel approach of cytostatically induced leucocyte depletion and subsequent reconstitution with leucocytes deprived of classical \((inflammatory/Gr1^{hi})\) or non-classical \((resident/Gr1^{lo})\) monocytes to dissect their differential role in atheroprogression under high-fat diet (HFD). Apolipoprotein E-deficient \((Apoe^{-/-})\) mice lacking classical but not non-classical monocytes displayed reduced lesion size and macrophage and apoptotic cell content. Conversely, HFD induced a selective expansion of classical monocytes in blood and bone marrow. Increased CXCL1 levels accompanied by higher expression of its receptor CXCR2 on classical monocytes and inhibition of monocytosis by CXCL1-neutralization indicated a preferential role for the CXCL1/CXCR2 axis in mobilizing classical monocytes during hypercholesterolemia. Studies correlating circulating and lesional classical monocytes in gene-deficient \(Apoe^{-/-}\) mice, adoptive transfer of gene-deficient cells and pharmacological modulation during intravital microscopy of the carotid artery revealed a crucial function of CCR1 and CCR5 but not CCR2 or \(CX_3CR1\) in classical monocyte recruitment to atherosclerotic vessels. Collectively, these data establish the impact of classical monocytes on atheroprogression, identify a sequential role of CXCL1 in their mobilization and CCR1/CCR5 in their recruitment.
EMBO Molecular Medicine
10.1002/emmm.201201717
1757-4676
urn:nbn:de:bvb:20-opus-122204
EMBO Molecular Medicine (2013) 5, 471–481. DOI 10.1002/emmm.201201717
Oliver Soehnlein
Maik Drechsler
Yvonne Döring
Dirk Lievens
Helene Hartwig
Klaus Kemmerich
Almudena Ortega-Gómez
Manuela Mandl
Santosh Vijayan
Delia Projahn
Christoph D. Garlichs
Rory R. Koenen
Mihail Hristov
Esther Lutgens
Alma Zernecke
Christian Weber
eng
uncontrolled
hypercholeterolemia
eng
uncontrolled
CCR2
eng
uncontrolled
atherosclerosis
eng
uncontrolled
chemokine
eng
uncontrolled
accumulation
eng
uncontrolled
subsets
eng
uncontrolled
inflammatory sites
eng
uncontrolled
fractalkine
eng
uncontrolled
marcophages
eng
uncontrolled
mobilization
eng
uncontrolled
monocyte
eng
uncontrolled
recruitment
eng
uncontrolled
bone-marrow
eng
uncontrolled
atheriosclerotic lesions
eng
uncontrolled
hyperlipedemic mice
Medizin und Gesundheit
open_access
Rudolf-Virchow-Zentrum
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12220/025_Soehnlein_Embo_Molecular_Medicine.pdf
11759
2014
eng
14
12
article
1
2015-08-10
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Autologous mesenchymal stem cell therapy for progressive supranuclear palsy: translation into a phase I controlled, randomized clinical study
Background: Progressive Supranuclear Palsy (PSP) is a sporadic and progressive neurodegenerative disease which belongs to the family of tauopathies and involves both cortical and subcortical structures. No effective therapy is to date available.
Methods/design: Autologous bone marrow (BM) mesenchymal stem cells (MSC) from patients affected by different type of parkinsonisms have shown their ability to improve the dopaminergic function in preclinical and clinical models. It is also possible to isolate and expand MSC from the BM of PSP patients with the same proliferation rate and immuphenotypic profile as MSC from healthy donors. BM MSC can be efficiently delivered to the affected brain regions of PSP patients where they can exert their beneficial effects through different mechanisms including the secretion of neurotrophic factors. Here we propose a randomized, placebo-controlled, double-blind phase I clinical trial in patients affected by PSP with MSC delivered via intra-arterial injection.
Discussion: To our knowledge, this is the first clinical trial to be applied in a no-option parkinsonism that aims to test the safety and to exploit the properties of autologous mesenchymal stem cells in reducing disease progression. The study has been designed to test the safety of this " first-in-man" approach and to preliminarily explore its efficacy by excluding the placebo effect.
Trial registration: NCT01824121
Journal of Translational Medicine
10.1186/1479-5876-12-14
24438512
urn:nbn:de:bvb:20-opus-117594
Journal of Translational Medicine 2014 12:14. doi:10.1186/1479-5876-12-14
Rosaria Giordano
Margherita Canesi
Maurizio Isalberti
Ioannis Ugo Isaias
Tiziana Montemurro
Mariele Viganò
Elisa Montelatici
Valentina Boldrin
Riccardo Benti
Agostino Cortelezzi
Nicola Fracchiolla
Lorenza Lazzari
Gianni Pezzoli
eng
uncontrolled
Parkinson's disease
eng
uncontrolled
cellular therapy
eng
uncontrolled
deep brain-stimulation
eng
uncontrolled
bone-marrow
eng
uncontrolled
transplantation
eng
uncontrolled
receptor tyrosine kinase
eng
uncontrolled
Richardson-Olszewski-Syndrome
eng
uncontrolled
multiple system atrophy
eng
uncontrolled
advanced therapy medicinal products
eng
uncontrolled
mesenchymal stem and stromal cells
eng
uncontrolled
progressive supranuclear palsy
eng
uncontrolled
treatment options
eng
uncontrolled
adrenal medulla
eng
uncontrolled
stromal cells
Medizin und Gesundheit
open_access
Neurologische Klinik und Poliklinik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/11759/133_Giordano_JOURNAL_OF_TRANSLATIONAL_MEDICINE.pdf