30080
2022
eng
9
article
1
--
--
--
The 3-triangle method preserves the posterior tibial slope during high tibial valgus osteotomy: first preliminary data using a mathematical model
Purpose
Despite much improved preoperative planning techniques accurate intraoperative assessment of the high tibial valgus osteotomy (HTO) remains challenging and often results in coronal over- and under-corrections as well as unintended changes of the posterior tibial slope. Noyes et al. reported a novel method for accurate intraoperative coronal and sagittal alignment correction based on a three-dimensional mathematical model. This is the first study examining preliminary data via the proposed Noyes approach for accurate intraoperative coronal and sagittal alignment correction during HTO.
Methods
From 2016 to 2020 a total of 24 patients (27 knees) underwent HTO applying the proposed Noyes method (Noyes-Group). Radiographic data was analyzed retrospectively and matched to patients that underwent HTO using the conventional method, i.e., gradual medial opening using a bone spreader under fluoroscopic control (Conventional-Group). All operative procedures were performed by an experienced surgeon at a single orthopaedic university center.
Results
From the preoperative to the postoperative visit no statistically significant changes of the posterior tibial slope were noted in the Noyes-Group compared to a significant increase in the Conventional-Group (p = 0.01). Regarding the axial alignment no significant differences between both groups were observed pre- and postoperatively. The number of over- and under-corrections did not differ significantly between both groups. Linear regression analysis showed a significant correlation of the postoperative medial proximal tibial angle (MPTA) with the position of the weightbearing line on the tibial plateau.
Conclusion
The 3-triangle method by Noyes seems to be a promising approach for preservation of the posterior tibial slope during HTO.
Journal of Experimental Orthopaedics
2197-1153
10.1186/s40634-022-00466-y
urn:nbn:de:bvb:20-opus-300806
@articleWeienberger.2022, author = Weißenberger, Manuel and Wagenbrenner, Mike and Schote, Fritz and Horas, Konstantin and Schäfer, Thomas and Rudert, Maximilian and Barthel, Thomas and Heinz, Tizian and Reppenhagen, Stephan, year = 2022, title = The 3-triangle method preserves the posterior tibial slope during high tibial valgus osteotomy: first preliminary data using a mathematical model, pages = 29, volume = 9, number = 1, issn = 2197-1153, journal = Journal of experimental orthopaedics, doi = 10.1186/s40634-022-00466-y,
md5:543c3617f7e291f64295c961a29646be
2023-01-23T07:16:37+00:00
/tmp/phpNw3NlL
bibtex
63ce3455546207.97235445
Journal of Experimental Orthopaedics (2022) 9:29. https://doi.org/10.1186/s40634-022-00466-y
Manuel Weißenberger
Mike Wagenbrenner
Fritz Schote
Konstantin Horas
Thomas Schäfer
Maximilian Rudert
Thomas Barthel
Tizian Heinz
Stephan Reppenhagen
eng
uncontrolled
knee
eng
uncontrolled
high tibial valgus osteotomy
eng
uncontrolled
axial alignment
eng
uncontrolled
posterior tibial slope
eng
uncontrolled
weight bearing line
eng
uncontrolled
cartilage
eng
uncontrolled
triangle method
eng
uncontrolled
osteoarthritis
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Förderzeitraum 2022
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/30080/s40634-022-00466-y.pdf
23049
2020
eng
8
15
article
1
2021-03-11
--
--
Different types of cartilage neotissue fabricated from collagen hydrogels and mesenchymal stromal cells via SOX9, TGFB1 or BMP2 gene transfer
Objective
As native cartilage consists of different phenotypical zones, this study aims to fabricate different types of neocartilage constructs from collagen hydrogels and human mesenchymal stromal cells (MSCs) genetically modified to express different chondrogenic factors.
Design
Human MSCs derived from bone-marrow of osteoarthritis (OA) hips were genetically modified using adenoviral vectors encoding sex-determining region Y-type high-mobility-group-box (SOX)9,transforming growth factor beta (TGFB) 1or bone morphogenetic protein (BMP) 2cDNA, placed in type I collagen hydrogels and maintained in serum-free chondrogenic media for three weeks. Control constructs contained unmodified MSCs or MSCs expressing GFP. The respective constructs were analyzed histologically, immunohistochemically, biochemically, and by qRT-PCR for chondrogenesis and hypertrophy.
Results
Chondrogenesis in MSCs was consistently and strongly induced in collagen I hydrogels by the transgenesSOX9,TGFB1andBMP2as evidenced by positive staining for proteoglycans, chondroitin-4-sulfate (CS4) and collagen (COL) type II, increased levels of glycosaminoglycan (GAG) synthesis, and expression of mRNAs associated with chondrogenesis. The control groups were entirely non-chondrogenic. The levels of hypertrophy, as judged by expression of alkaline phosphatase (ALP) and COL X on both the protein and mRNA levels revealed different stages of hypertrophy within the chondrogenic groups (BMP2>TGFB1>SOX9).
Conclusions
Different types of neocartilage with varying levels of hypertrophy could be generated from human MSCs in collagen hydrogels by transfer of genes encoding the chondrogenic factorsSOX9,TGFB1andBMP2. This technology may be harnessed for regeneration of specific zones of native cartilage upon damage.
PLoS One
10.1371/journal.pone.0237479
urn:nbn:de:bvb:20-opus-230494
publish
PLoS ONE 2020, 15(8): e0237479. https://doi.org/10.1371/journal.pone.0237479
true
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Manuel Weissenberger
Manuela H. Weissenberger
Mike Wagenbrenner
Tizian Heinz
Jenny Reboredo
Boris M. Holzapfel
Maximilian Rudert
Jürgen Groll
Christopher H. Evans
Andre F. Steinert
eng
uncontrolled
stem cells
eng
uncontrolled
in vitro
eng
uncontrolled
chondrogenic differentiation
eng
uncontrolled
repair
eng
uncontrolled
chondrocytes
eng
uncontrolled
transplantation
eng
uncontrolled
stimulation
eng
uncontrolled
scaffolds
eng
uncontrolled
defects
eng
uncontrolled
therapy
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Lehrstuhl für Tissue Engineering und Regenerative Medizin
Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde
Förderzeitraum 2020
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/23049/pone.0237479.pdf
22926
2020
eng
21
article
1
2021-03-03
--
--
No functional differences in anatomic reconstruction with one vs. two suture anchors after non-simultaneous bilateral distal biceps brachii tendon rupture: a case report and review of the literature
Background
Surgical reattachment of the tendon is still the gold standard for ruptures of the distal biceps brachii tendon. Several fixation techniques have been described in the literature, with suture anchors being one of the most common fixation techniques. Currently, there is no data available on how many anchors are required for a safe and stable refixation. In this case report clinical data of a patient with non-simultaneous bilateral distal biceps tendon ruptures treated with a different number of suture anchors for each side (one vs. two) are demonstrated.
Case presentation
A 47-year-old factory worker suffered a rupture of the distal biceps tendon on both arms following two different occasions. The left side was fixed using a single suture anchor, while refixation on the right side was performed with two anchors. The patient was prospectively followed for one year. Functional outcome was assessed using the Andrews Carson Score (ACS), the Oxford Elbow Score (OES), and the Disabilities of Arm, Shoulder and Hand (DASH) Score after six, twelve, 24 and 48 weeks. Furthermore, an isokinetic strength measurement for flexion strength was performed after 24 and 48 weeks. After 48 weeks the patient presented with excellent functional outcome scores and no follow-up complications. During the follow-up period, no differences in the functional scores nor in the isokinetic flexion strength measurement could be detected. Furthermore, no radiological complications (like heterotopic ossifications) could be detected in the postoperative radiographs after one year.
Conclusions
Anatomic reattachment of the distal biceps tendon is a successful operative treatment option for distal biceps tendon ruptures. Suture anchor fixation remains one of the most common techniques, as it allows fast surgery and provides good results with respect to range of motion (ROM) and functional scoring according to the current literature. However, the number of anchors required for a stable fixation remains unclear. As indicated by our presented case, we hypothesize, that there are no significant differences between a one-point or a two-point fixation. In the presented case report, no intraindividual differences between the usage of one versus two suture anchors were evident in the short-term follow-up.
BMC Musculoskeletal Disorders
10.1186/s12891-020-03304-3
urn:nbn:de:bvb:20-opus-229266
publish
BMC Musculoskeletal Disorders (2020) 21:270 https://doi.org/10.1186/s12891-020-03304-3
true
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Manuel Weissenberger
Tizian Heinz
Kilian Rueckl
Maximilian Rudert
Alexander Klug
Reinhard Hoffmann
Kay Schmidt-Horlohé
eng
uncontrolled
Non-simultaneous bilateral distal biceps tendon rupture
eng
uncontrolled
Distal biceps tendon repair
eng
uncontrolled
Anatomic reattachment
eng
uncontrolled
Suture anchor
eng
uncontrolled
Case report
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Förderzeitraum 2020
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/22926/12891_2020_Article_3304.pdf
26233
2022
eng
4
12
article
1
--
2022-02-21
--
Mesenchymal stromal cells (MSCs) isolated from various tissues of the human arthritic knee joint possess similar multipotent differentiation potential
(1) Background: The mesenchymal stromal cells (MSCs) of different tissue origins are applied in cell-based chondrogenic regeneration. However, there is a lack of comparability determining the most suitable cell source for the tissue engineering (TE) of cartilage. The purpose of this study was to compare the in vitro chondrogenic potential of MSC-like cells from different tissue sources (bone marrow, meniscus, anterior cruciate ligament, synovial membrane, and the infrapatellar fat pad removed during total knee arthroplasty (TKA)) and define which cell source is best suited for cartilage regeneration. (2) Methods: MSC-like cells were isolated from five donors and expanded using adherent monolayer cultures. Differentiation was induced by culture media containing specific growth factors. Transforming growth factor (TGF)-ß1 was used as the growth factor for chondrogenic differentiation. Osteogenesis and adipogenesis were induced in monolayer cultures for 27 days, while pellet cell cultures were used for chondrogenesis for 21 days. Control cultures were maintained under the same conditions. After, the differentiation period samples were analyzed, using histological and immunohistochemical staining, as well as molecularbiological analysis by RT-PCR, to assess the expression of specific marker genes. (3) Results: Plastic-adherent growth and in vitro trilineage differentiation capacity of all isolated cells were proven. Flow cytometry revealed the clear co-expression of surface markers CD44, CD73, CD90, and CD105 on all isolated cells. Adipogenesis was validated through the formation of lipid droplets, while osteogenesis was proven by the formation of calcium deposits within differentiated cell cultures. The formation of proteoglycans was observed during chondrogenesis in pellet cultures, with immunohistochemical staining revealing an increased relative gene expression of collagen type II. RT-PCR proved an elevated expression of specific marker genes after successful differentiation, with no significant differences regarding different cell source of native tissue. (4) Conclusions: Irrespective of the cell source of native tissue, all MSC-like cells showed multipotent differentiation potential in vitro. The multipotent differentiation capacity did not differ significantly, and chondrogenic differentiation was proven in all pellet cultures. Therefore, cell suitability for cell-based cartilage therapies and tissue engineering is given for various tissue origins that are routinely removed during total knee arthroplasty (TKA). This study might provide essential information for the clinical tool of cell harvesting, leading to more flexibility in cell availability.
Applied Sciences
2076-3417
10.3390/app12042239
urn:nbn:de:bvb:20-opus-262334
2022-03-28T07:41:50+00:00
sword
swordwue
attachment; filename=deposit.zip
debf0dc4c2a84affdfe54ba84679840b
Applied Sciences (2022) 12:4, 2239. https://doi.org/10.3390/app12042239
IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen
Bernhard-Heine-Centrum für Bewegungsforschung
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Mike Wagenbrenner
Konrad Poker
Tizian Heinz
Marietta Herrmann
Konstantin Horas
Regina Ebert
Susanne Mayer-Wagner
Boris M. Holzapfel
Maximilian Rudert
Andre F. Steinert
Manuel Weißenberger
eng
uncontrolled
knee joint
eng
uncontrolled
MSCs
eng
uncontrolled
cellular origin
eng
uncontrolled
cartilage regeneration
eng
uncontrolled
tissue engineering
eng
uncontrolled
cell-based therapies
eng
uncontrolled
osteoarthritis
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Import
Förderzeitraum 2022
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/26233/applsci-12-02239.pdf
25017
2021
eng
4
7
article
1
--
2021-11-16
--
Combinations of hydrogels and mesenchymal stromal cells (MSCs) for cartilage tissue engineering — a review of the literature
Cartilage offers limited regenerative capacity. Cell-based approaches have emerged as a promising alternative in the treatment of cartilage defects and osteoarthritis. Due to their easy accessibility, abundancy, and chondrogenic potential mesenchymal stromal cells (MSCs) offer an attractive cell source. MSCs are often combined with natural or synthetic hydrogels providing tunable biocompatibility, biodegradability, and enhanced cell functionality. In this review, we focused on the different advantages and disadvantages of various natural, synthetic, and modified hydrogels. We examined the different combinations of MSC-subpopulations and hydrogels used for cartilage engineering in preclinical and clinical studies and reviewed the effects of added growth factors or gene transfer on chondrogenesis in MSC-laden hydrogels. The aim of this review is to add to the understanding of the disadvantages and advantages of various combinations of MSC-subpopulations, growth factors, gene transfers, and hydrogels in cartilage engineering.
Gels
2310-2861
10.3390/gels7040217
urn:nbn:de:bvb:20-opus-250177
2021-12-01T17:38:19+00:00
sword
swordwue
attachment; filename=deposit.zip
a5635a465eb5a4c8528683f11eb91f44
Gels (2021) 7:4, 217. https://doi.org/10.3390/gels7040217
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Mike Wagenbrenner
Susanne Mayer-Wagner
Maximilian Rudert
Boris Michael Holzapfel
Manuel Weissenberger
eng
uncontrolled
hydrogels
eng
uncontrolled
osteoarthritis
eng
uncontrolled
cartilage defects
eng
uncontrolled
MSCs
eng
uncontrolled
cartilage regeneration
eng
uncontrolled
tissue engineering
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/25017/gels-07-00217-v4.pdf
22949
2020
eng
1
21
article
1
2021-03-04
--
--
The human arthritic hip joint is a source of mesenchymal stromal cells (MSCs) with extensive multipotent differentiation potential
Background
While multiple in vitro studies examined mesenchymal stromal cells (MSCs) derived from bone marrow or hyaline cartilage, there is little to no data about the presence of MSCs in the joint capsule or the ligamentum capitis femoris (LCF) of the hip joint. Therefore, this in vitro study examined the presence and differentiation potential of MSCs isolated from the bone marrow, arthritic hyaline cartilage, the LCF and full-thickness samples of the anterior joint capsule of the hip joint.
Methods
MSCs were isolated and multiplied in adherent monolayer cell cultures. Osteogenesis and adipogenesis were induced in monolayer cell cultures for 21 days using a differentiation medium containing specific growth factors, while chondrogenesis in the presence of TGF-ss1 was performed using pellet-culture for 27 days. Control cultures were maintained for comparison over the same duration of time. The differentiation process was analyzed using histological and immunohistochemical stainings as well as semiquantitative RT-PCR for measuring the mean expression levels of tissue-specific genes.
Results
This in vitro research showed that the isolated cells from all four donor tissues grew plastic-adherent and showed similar adipogenic and osteogenic differentiation capacity as proven by the histological detection of lipid droplets or deposits of extracellular calcium and collagen type I. After 27 days of chondrogenesis proteoglycans accumulated in the differentiated MSC-pellets from all donor tissues. Immunohistochemical staining revealed vast amounts of collagen type II in all differentiated MSC-pellets, except for those from the LCF. Interestingly, all differentiated MSCs still showed a clear increase in mean expression of adipogenic, osteogenic and chondrogenic marker genes. In addition, the examination of an exemplary selected donor sample revealed that cells from all four donor tissues were clearly positive for the surface markers CD44, CD73, CD90 and CD105 by flow cytometric analysis.
Conclusions
This study proved the presence of MSC-like cells in all four examined donor tissues of the hip joint. No significant differences were observed during osteogenic or adipogenic differentiation depending on the source of MSCs used. Further research is necessary to fully determine the tripotent differentiation potential of cells isolated from the LCF and capsule tissue of the hip joint.
BMC Musculoskeletal Disorders
10.1186/s12891-020-03340-z
urn:nbn:de:bvb:20-opus-229497
publish
BMC Musculoskeletal Disorders (2020) 21:297 https://doi.org/10.1186/s12891-020-03340-z
true
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Mike Wagenbrenner
Tizian Heinz
Konstantin Horas
Axel Jakuscheit
Jörg Arnholdt
Marietta Hermann
Maximilian Rudert
Boris M. Holzapfel
Andre F. Steinert
Manuel Weißenberger
eng
uncontrolled
Hip joint
eng
uncontrolled
Osteoarthritis
eng
uncontrolled
MSCs
eng
uncontrolled
Cartilage regeneration
eng
uncontrolled
Tissue engineering
eng
uncontrolled
Ligamentum capitis femoris
eng
uncontrolled
Joint capsule
eng
uncontrolled
Bone marrow
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Förderzeitraum 2020
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/22949/s12891-020-03340-z.pdf
21941
2020
eng
12
9
article
1
--
2020-11-29
--
Impact of Tranexamic Acid on Chondrocytes and Osteogenically Differentiated Human Mesenchymal Stromal Cells (hMSCs) In Vitro
The topical application of tranexamic acid (TXA) helps to prevent post-operative blood loss in total joint replacements. Despite these findings, the effects on articular and periarticular tissues remain unclear. Therefore, this in vitro study examined the effects of varying exposure times and concentrations of TXA on proliferation rates, gene expression and differentiation capacity of chondrocytes and human mesenchymal stromal cells (hMSCs), which underwent osteogenic differentiation. Chondrocytes and hMSCs were isolated and multiplied in monolayer cell cultures. Osteogenic differentiation of hMSCs was induced for 21 days using a differentiation medium containing specific growth factors. Cell proliferation was analyzed using ATP assays. Effects of TXA on cell morphology were examined via light microscopy and histological staining, while expression levels of tissue-specific genes were measured using semiquantitative RT-PCR. After treatment with 50 mg/mL of TXA, a decrease in cell proliferation rates was observed. Furthermore, treatment with concentrations of 20 mg/mL of TXA for at least 48 h led to a visible detachment of chondrocytes. TXA treatment with 50 mg/mL for at least 24 h led to a decrease in the expression of specific marker genes in chondrocytes and osteogenically differentiated hMSCs. No significant effects were observed for concentrations beyond 20 mg/mL of TXA combined with exposure times of less than 24 h. This might therefore represent a safe limit for topical application in vivo. Further research regarding in vivo conditions and effects on hMSC functionality are necessary to fully determine the effects of TXA on articular and periarticular tissues.
Journal of Clinical Medicine
2077-0383
10.3390/jcm9123880
urn:nbn:de:bvb:20-opus-219410
2020-12-18T18:38:59+00:00
sword
swordwue
attachment; filename=deposit.zip
38fe330686e1bc63730263ef9ba044c6
Journal of Clinical Medicine 2020, 9(12), 3880; https://doi.org/10.3390/jcm9123880
true
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Mike Wagenbrenner
Tizian Heinz
Konstantin Horas
Axel Jakuscheit
Joerg Arnholdt
Susanne Mayer-Wagner
Maximilian Rudert
Boris M. Holzapfel
Manuel Weißenberger
eng
uncontrolled
tranexamic acid
eng
uncontrolled
hMSCs
eng
uncontrolled
chondrocytes
eng
uncontrolled
osteoarthritis
eng
uncontrolled
toxicity
eng
uncontrolled
differentiation capacity
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Import
Förderzeitraum 2020
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/21941/jcm-09-03880.pdf
23651
2021
eng
4
11
article
1
--
2021-04-08
--
Custom Made Monoflange Acetabular Components for the Treatment of Paprosky Type III Defects
Purpose: Patient-specific, flanged acetabular components are used for the treatment of Paprosky type III defects during revision total hip arthroplasty (THA). This monocentric retrospective cohort study analyzes the outcome of patients treated with custom made monoflanged acetabular components (CMACs) with intra- and extramedullary iliac fixation. Methods: 14 patients were included who underwent revision THA with CMACs for the treatment of Paprosky type III defects. Mechanism of THA failure was infection in 4 and aseptic loosening in 10 patients. Seven patients underwent no previous revision, the other seven patients underwent three or more previous revisions. Results: At a mean follow-up of 35.4 months (14–94), the revision rate of the implant was 28.3%. Additionally, one perioperative dislocation and one superficial wound infection occurred. At one year postoperatively, we found a significant improvement of the Western Ontario and McMaster Universities Arthritis Index (WOMAC) score (p = 0.015). Postoperative radiographic analysis revealed good hip joint reconstruction with a mean leg length discrepancy of 3 mm (−8–20), a mean lateralization of the horizontal hip center of rotation of 8 mm (−8–35), and a mean proximalization of the vertical hip center of rotation of 6 mm (13–26). Radiolucency lines were present in 30%. Conclusion: CMACs can be considered an option for the treatment of acetabular bone loss in revision THA. Iliac intra- and extramedullary fixation allows soft tissue-adjusted hip joint reconstruction and improves hip function. However, failure rates are high, with periprosthetic infection being the main threat to successful outcome.
Journal of Personalized Medicine
2075-4426
10.3390/jpm11040283
urn:nbn:de:bvb:20-opus-236513
2021-05-03T10:37:43+00:00
sword
swordwue
attachment; filename=deposit.zip
a0e964376d4f6cf198962274d41c5412
Journal of Personalized Medicine 2021, 11(4), 283; https://doi.org/10.3390/jpm11040283
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Sebastian Philipp von Hertzberg-Boelch
Mike Wagenbrenner
Jörg Arnholdt
Stephan Frenzel
Boris Michael Holzapfel
Maximilian Rudert
eng
uncontrolled
patient specific implant
eng
uncontrolled
custom made implant
eng
uncontrolled
revision hip
eng
uncontrolled
Paprosky
eng
uncontrolled
pelvic discontinuity
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Import
Förderzeitraum 2021
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/23651/jpm-11-00283.pdf
28170
2022
eng
8
10
article
1
--
2022-07-29
--
PMMA bone cement: antibiotic elution and mechanical properties in the context of clinical use
This literature review discusses the use of antibiotic loaded polymethylmethacrylate bone cements in arthroplasty. The clinically relevant differences that have to be considered when antibiotic loaded bone cements (ALBC) are used either for long-term implant fixation or as spacers for the treatment of periprosthetic joint infections are outlined. In this context, in vitro findings for antibiotic elution and material properties are summarized and transferred to clinical use.
Biomedicines
2227-9059
10.3390/biomedicines10081830
urn:nbn:de:bvb:20-opus-281708
2022-08-03T11:34:38+00:00
sword
swordwue
attachment; filename=deposit.zip
e30c0b077a1bbe6ab146fa1ff6c697b4
Biomedicines (2022) 10:8, 1830. doi:10.3390/biomedicines10081830
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Sebastian Philipp von Hertzberg-Boelch
Martin Luedemann
Maximilian Rudert
Andre F. Steinert
eng
uncontrolled
spacer
eng
uncontrolled
bone cement
eng
uncontrolled
PMMA
eng
uncontrolled
polymethylmethacrylate
eng
uncontrolled
periprosthetic infection
eng
uncontrolled
antibiotic elution
Chirurgie und verwandte medizinische Fachrichtungen
open_access
Lehrstuhl für Orthopädie
Import
Förderzeitraum 2022
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/28170/biomedicines-10-01830.pdf
32466
2023
eng
713-733
3
19
article
1
--
--
--
Enhancement of immunosuppressive activity of mesenchymal stromal cells by platelet-derived factors is accompanied by apoptotic priming
The pro-inflammatory phase of bone healing, initiated by platelet activation and eventually hematoma formation, impacts bone marrow mesenchymal stromal cells (MSCs) in unknown ways. Here, we created platelet-rich plasma (PRP) hydrogels to study how platelet-derived factors modulate functional properties of encapsulated MSCs in comparison to a non-inflammatory fibrin (FBR) hydrogel environment. MSCs were isolated from human bone marrow, while PRP was collected from pooled apheresis thrombocyte concentrates and used for hydrogel preparation. After their encapsulation in hydrogels for 72 h, retrieved MSCs were analyzed for immunomodulatory activities, apoptosis, stem cell properties, senescence, CD9\(^+\), CD63\(^+\) and CD81\(^+\) extracellular vesicle (EV) release, and metabolism-related changes. PRP-hydrogels stimulated immunosuppressive functions of MSCs, along with their upregulated susceptibility to cell death in communication with PBMCs and augmented caspase 3/7 activity. We found impaired clonal growth and cell cycle progression, and more pronounced β-galactosidase activity as well as accumulation of LC3-II-positive vacuoles in PRP-MSCs. Stimuli derived from PRP-hydrogels upregulated AKT and reduced mTOR phosphorylation in MSCs, which suggests an initiation of survival-related processes. Our results showed that PRP-hydrogels might represent a metabolically stressful environment, inducing acidification of MSCs, reducing polarization of the mitochondrial membrane and increasing lipid accumulation. These features were not detected in FBR-MSCs, which showed reduced CD63\(^+\) and CD81\(^+\) EV production and maintained clonogenicity. Our data revealed that PRP-derived hematoma components cause metabolic adaptation of MSCs followed by increased immune regulatory functions. For the first time, we showed that PRP stimuli represent a survival challenge and “apoptotic priming” that are detrimental for stem cell-like growth of MSCs and important for their therapeutic consideration.
Stem Cell Reviews and Reports
10.1007/s12015-022-10471-4
urn:nbn:de:bvb:20-opus-324669
@articleTrivanovic.2023, author = Trivanovic, Drenka and Volkmann, Noah and Stoeckl, Magdalena and Tertel, Tobias and Rudert, Maximilian and Giebel, Bernd and Herrmann, Marietta, year = 2023, title = Enhancement of Immunosuppressive Activity of Mesenchymal Stromal Cells by Platelet-Derived Factors is Accompanied by Apoptotic Priming, pages = 713–733, volume = 19, number = 3, journal = Stem cell reviews and reports, doi = 10.1007/s12015-022-10471-4
md5:9b69cc18cb23f88b9b87fe5aaf5cd34c
2023-08-12T10:40:49+00:00
/tmp/phpCXFgQK
bibtex
64d761b160e546.99157456
Stem Cell Reviews and Reports (2023) 19:3, 713-733. DOI: 10.1007/s12015-022-10471-4
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Drenka Trivanovic
Noah Volkmann
Magdalena Stoeckl
Tobias Tertel
Maximilian Rudert
Bernd Giebel
Marietta Herrmann
eng
uncontrolled
hematoma
eng
uncontrolled
platelet-rich plasma
eng
uncontrolled
fibrin
eng
uncontrolled
mesenchymal stromal cells
eng
uncontrolled
immunomodulation
eng
uncontrolled
apoptosis
eng
uncontrolled
autophagy
eng
uncontrolled
senescence
eng
uncontrolled
extracellular vesicles
eng
uncontrolled
metabolism
Chirurgie und verwandte medizinische Fachrichtungen
open_access
Lehrstuhl für Orthopädie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/32466/s12015-022-10471-4.pdf
26528
2022
deu
246–250
3
51
article
1
--
--
--
Insuffizienzfraktur der Klavikula nach Implantation einer inversen Schulterendoprothese
Wir stellen den seltenen Fall einer Insuffizienzfraktur der Klavikula nach Implantation einer inversen Schulterendoprothese (RSA) vor. Als Ursache solcher Frakturen wird eine vermehrte Zugbelastung durch den Musculus deltoideus nach RSA diskutiert. In den wenigen verfügbaren Fallberichten zeigten die betroffenen Patienten deutliche Funktionseinschränkungen. Die Versorgung erfolgte im vorliegenden Fall mit Plattenosteosynthese. Trotz intraoperativ gutem Korrekturergebnis kam es im Verlauf ohne Trauma zum Osteosyntheseversagen mit weiterer Dislokation der Fraktur.
Der Orthopäde
10.1007/s00132-021-04205-6
urn:nbn:de:bvb:20-opus-265286
publish
Der Orthopäde 2022, 51(3):246–250. DOI: 10.1007/s00132-021-04205-6
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Laura Elisa Streck
Lothar Seefried
Franca Genest
Thomas Reichel
Maximilian Rudert
Kilian Rueckl
deu
uncontrolled
Schulterendoprothetik
deu
uncontrolled
Glenohumeralgelenk
deu
uncontrolled
Osteoporose
deu
uncontrolled
Osteosynthese
deu
uncontrolled
Fraktur
deu
uncontrolled
postoperative Komplikationen
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/26528/Streck_Kasuistiken.pdf
30079
2022
eng
23
article
1
--
--
--
The role of synovial fluid aspiration in shoulder joint infections
Background
Joint aspiration with analysis of synovial fluid white blood cell count (WBC) and microbiological culture is a widely established aspect in the diagnosis of shoulder joint infections (SJI). In case of a two stage revision for SJI, joint aspiration before re−/implantation of a total shoulder arthroplasty (TSA) was used to rule out persistent infection for years but its value is under debate. Shoulder specific data on all aspects is rare. The current study aims to answer the following research questions: Does joint aspiration have an insufficient predictive value in the diagnosis of SJI in (1) initial workup and (2) before definite arthroplasty with polymethylmethacrylate (PMMA)-Spacer in place?
Methods
This retrospective evaluation investigates 35 patients that were treated for SJI with a two staged implantation of a TSA after debridement and implantation of an PMMA-Spacer. Joint aspirations were performed preoperatively (PA) and before re−/implantation of the prosthesis while spacer was in place (interstage aspiration, IA). Samples were taken for microbiological culture and analysis of WBC. Sensitivity and specificity were calculated with reference to intraoperative microbiological samples. Receiver Operating Characteristic (ROC), Area-Under-Curve analysis (AUC) and calculation of the Youden index were performed to find optimum cut-off for WBC.
Results
The sensitivity of microbiological cultures from PA was 58.3% and the specificity was 88.9%. The mean WBC was 27,800 leucocytes/mm3 (range 400-96,300). The maximum Youden index (0.857) was a cut-off of 2600 leucocytes/mm3 with a sensitivity of 85.7% and a specificity of 100.0%. The sensitivity and specificity of IA were 0.0% and 88.5%, respectively.
Conclusions
Preoperative aspiration is likely to miss Cutibacteria spp. and CoNS and cannot rule out infection for sure. However, we recommend it for its advantages of targeted antibiotic therapy in case of germ identification. Empiric antibiotic therapy should cover Cutibacteria and CoNS even if aspiration showed negative microbiological cultures. In contrast, the diagnostic value of interstage aspiration does not qualify for its routine use.
BMC Musculoskeletal Disorders
10.1186/s12891-022-05285-x
urn:nbn:de:bvb:20-opus-300795
@articleStreck.2022, author = Streck, Laura Elisa and Forster, Johannes and von Hertzberg-Boelch, Sebastian Philipp and Reichel, Thomas and Rudert, Maximilian and Rueckl, Kilian, year = 2022, title = The role of synovial fluid aspiration in shoulder joint infections, pages = 390, volume = 23, number = 1, journal = BMC musculoskeletal disorders, doi = 10.1186/s12891-022-05285-x,
md5:b7e9e5d3d7aeaccab1c6ca8c339d6223
2023-01-23T07:16:37+00:00
/tmp/phpNw3NlL
bibtex
63ce3455546207.97235445
BMC Musculoskeletal Disorders (2022) 23:390. doi:10.1186/s12891-022-05285-x
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Laura Elisa Streck
Johannes Forster
Sebastian Philipp von Hertzberg-Boelch
Thomas Reichel
Maximilian Rudert
Kilian Rueckl
eng
uncontrolled
revision arthroplasty
eng
uncontrolled
periprosthetic joint infection
eng
uncontrolled
white blood cell count
eng
uncontrolled
septic
eng
uncontrolled
microbiological culture
eng
uncontrolled
interstage aspiration
Medizin und Gesundheit
open_access
Institut für Hygiene und Mikrobiologie
Lehrstuhl für Orthopädie
Förderzeitraum 2022
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/30079/s12891-022-05285-x.pdf
26634
2021
eng
1121-1124
5
45
article
1
--
--
--
Bibliometrics of orthopaedic articles published by authors of Germanophone countries
No abstract available.
International Orthopaedics
10.1007/s00264-021-05052-y
urn:nbn:de:bvb:20-opus-266343
publish
International Orthopaedics 2021, 45(5):1121-1124. DOI: 10.1007/s00264-021-05052-y
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Ioannis Stratos
Marius M. Scarlat
Maximilian Rudert
eng
uncontrolled
scientific publications
eng
uncontrolled
orthopaedics
eng
uncontrolled
germanophone
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/26634/Stratos_International.pdf
26635
2022
eng
733-739
4
46
article
1
--
--
--
German surgeons' technical preferences for performing total hip arthroplasties: a survey from the National Endoprosthesis Society
Purpose
The goal of our study was to conduct an online survey that highlights patterns of practice during total hip arthroplasty (THA).
Methods
The survey was conducted in June and August 2020. Three hundred thirteen members of the German Society for Endoprosthesis participated in the survey.
Results
The anterolateral approach is by far the most popular approach used for primary total hip arthroplasty, followed by the anterior approach during minimally invasive (55% for the anterolateral and 29% for the anterior) and regular surgery (52% for the anterolateral and 20% for the anterior). Two-thirds of the orthopaedic surgeons do not use drainages during THA. Moreover, 80% of the survey participants routinely apply tranexamic acid during surgery. Surgeons who perform minimally invasive surgery for THA use more frequently fast-track-concepts for post-operative rehabilitation. According to the interviewees, the application of fast-track-concepts leads to reduced periods of hospital stay after THA.
Conclusion
Our data demonstrate that patterns of practice during THA in Germany are in line with the evidence provided by current literature. This study can be seen as a stimulus to conduct similar surveys in other countries in order to promote minimally invasive surgery for THA.
International Orthopaedics
10.1007/s00264-021-05188-x
urn:nbn:de:bvb:20-opus-266350
publish
International Orthopaedics 2022, 46(4):733-739. DOI: 10.1007/s00264-021-05188-x
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Ioannis Stratos
Karl-Dieter Heller
Maximilian Rudert
eng
uncontrolled
tranexamic acid
eng
uncontrolled
total hip arthroplasty
eng
uncontrolled
approach
eng
uncontrolled
fast-track-concepts
eng
uncontrolled
minimally invasive surgery
eng
uncontrolled
drain
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/26635/Stratos_Orthopaedics.pdf
6511
2012
eng
article
1
2013-03-27
--
--
Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells
Introduction: To date, no single most-appropriate factor or delivery method has been identified for the purpose of mesenchymal stem cell (MSC)-based treatment of cartilage injury. Therefore, in this study we tested whether gene delivery of the growth factor Indian hedgehog (IHH) was able to induce chondrogenesis in human primary MSCs, and whether it was possible by such an approach to modulate the appearance of chondrogenic hypertrophy in pellet cultures in vitro. Methods: First-generation adenoviral vectors encoding the cDNA of the human IHH gene were created by cre-lox recombination and used alone or in combination with adenoviral vectors, bone morphogenetic protein-2 (Ad.BMP- 2), or transforming growth factor beta-1 (Ad.TGF-b1) to transduce human bone-marrow derived MSCs at 5 × 102 infectious particles/cell. Thereafter, 3 × 105 cells were seeded into aggregates and cultured for 3 weeks in serumfree medium, with untransduced or marker gene transduced cultures as controls. Transgene expressions were determined by ELISA, and aggregates were analysed histologically, immunohistochemically, biochemically and by RT-PCR for chondrogenesis and hypertrophy. Results: IHH, TGF-b1 and BMP-2 genes were equipotent inducers of chondrogenesis in primary MSCs, as evidenced by strong staining for proteoglycans, collagen type II, increased levels of glycosaminoglycan synthesis, and expression of mRNAs associated with chondrogenesis. IHH-modified aggregates, alone or in combination, also showed a tendency to progress towards hypertrophy, as judged by the expression of alkaline phosphatase and stainings for collagen type X and Annexin 5. Conclusion: As this study provides evidence for chondrogenic induction of MSC aggregates in vitro via IHH gene delivery, this technology may be efficiently employed for generating cartilaginous repair tissues in vivo.
urn:nbn:de:bvb:20-opus-75425
7542
In: Arthritis Research & Therapy (2012) 14:R168, doi:10.1186/ar3921
Andre F. Steinert
Manuel Weissenberger
Manuela Kunz
Fabian Gilbert
Steven C. Ghivizzani
Sascha Goebel
Franz Jakob
Ulrich Nöth
Maximilian Rudert
deu
swd
Medizin
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Förderzeitraum 2012
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6511/034_ar3921.pdf
31274
2022
eng
2
12
article
1
--
--
--
The impact of total knee replacement with a customized cruciate-retaining implant design on patient-reported and functional outcomes
Purpose: To treat patients with tricompartimental knee osteoarthritis (OA), a customized cruciate-retaining total knee arthroplasty (CCR-TKA) system can be used, including both individualized instrumentation and implants. The objective of this monocentric cohort study was to analyze patient-reported and functional outcomes in a series of patients implanted with the second generation of this customized implant. Methods: At our arthroplasty center, we prospectively recruited a cohort of patients with tricompartmental gonarthrosis to be treated with total knee replacement (TKA) using a customized cruciate-retaining (CCR) implant design. Inclusion criteria for patients comprised the presence of intact posterior cruciate and collateral ligaments and a knee deformity that was restricted to <15° varus, valgus, or flexion contracture. Patients were assessed for their range of motion (ROM), Knee Society Score (KSS), Western Ontario and McMaster University osteoarthritis index (WOMAC), and short form (SF)-12 physical and mental scores, preoperatively, at 3 and 6 months, as well as at 1, 2, 3, and 5 years of follow-up (FU) postoperatively. Results: The average age of the patient population was 64 years (range: 40–81), the average BMI was 31 (range: 23–42), and in total, 28 female and 45 male patients were included. Implant survivorship was 97.5% (one septic loosening) at an average follow-up of 2.5 years. The KSS knee and function scores improved significantly (p < 0.001) from, respectively, 41 and 53 at the pre-operative visit, to 92 and 86, respectively, at the 5-year post-operative time point. The SF-12 Physical and Mental scores significantly (p < 0.001) improved from the pre-operative values of 28 and 50, to 50 and 53 at the 5-year FU, respectively. Patients experienced significant improvements in their overall knee range of motion, from 106° at the preoperative visit to 122°, on average, 5 years postoperatively. The total WOMAC score significantly (p < 0.001) improved from 49.1 preoperatively to 11.4 postoperatively at 5-year FU. Conclusions: Although there was no comparison to other implants within this study, patients reported high overall satisfaction and improvement in functional outcomes within the first year from surgery, which continued over the following years. These mid-term results are excellent compared with those reported in the current literature. Comparative long-term studies with this device are needed. Level of evidence 3b (individual case–control study).
Journal of Personalized Medicine
2075-4426
10.3390/jpm12020194
urn:nbn:de:bvb:20-opus-312746
@articleSteinert.2022, author = Steinert, Andre F. and Schröder, Lennart and Sefrin, Lukas and Janßen, Björn and Arnholdt, Jörg and Rudert, Maximilian, year = 2022, title = The Impact of Total Knee Replacement with a Customized Cruciate-Retaining Implant Design on Patient-Reported and Functional Outcomes, volume = 12, number = 2, issn = 2075-4426, journal = Journal of personalized medicine, doi = 10.3390/jpm12020194,
md5:d108efe5113ba96aea0ab7a808d9556e
2023-04-21T12:22:44+00:00
/tmp/phpy5hrTj
bibtex
64428014384fc3.42619485
Journal of Personalized Medicine (2022) 12:2, 194. doi:10.3390/jpm12020194
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Andre F. Steinert
Lennart Schröder
Lukas Sefrin
Björn Janßen
Jörg Arnholdt
Maximilian Rudert
eng
uncontrolled
patient-specific
eng
uncontrolled
custom-made implant
eng
uncontrolled
total knee arthroplasty
eng
uncontrolled
TKA
eng
uncontrolled
knee replacement
eng
uncontrolled
tricompartmental knee osteoarthritis
eng
uncontrolled
iTotal
Chirurgie und verwandte medizinische Fachrichtungen
open_access
Lehrstuhl für Orthopädie
Förderzeitraum 2022
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/31274/jpm-12-00194-v2.pdf
11034
2014
eng
article
1
2015-02-26
--
--
"Symptomatic loosening of a total knee arthroplasty caused by a tibial chondrosarcoma – a case report"
Premature implant loosening following total knee arthroplasty (TKA) can have several causes. In this article we report on a rare case of a 74 year old male patient suffering tibial component loosening 14 month after primary TKA. The patient did neither have any malignancies nor joint arthroplasty before. Upon clinical examination the range of motion in the diseased knee was painfully restricted to 80° of knee flexion, with the patient increasingly suffering sleeping and resting pain, and also at weight bearing. In standard radiographs, loosening of the TKA due to a large osteolysis at the tibial component was evident. Local computed tomography (CT) of the right knee revealed loosening of the tibial component due to a presumably malign bone tumor. For determination of the final diagnosis a representative biopsy of the tumor was taken by open surgery prior to the tumor resection. Histopathologic evaluation of the biopsy revealed a periprosthetic myxoid chondrosarcoma of the proximal tibia. Pre-operative staging examination included CT scans of lung and abdomen, as well as a bone scintigraphy which revealed no signs of tumor metastasis in the body. Surgical management comprised wide tumor resection and implantation of a hinged tumor knee arthroplasty with replacements of the distal femur and proximal tibia, as well as a patella tendon replacement using a synthetic ligament. Revision surgery was necessary twice due to impaired wound healing and critical soft tissue coverage, and treatment included a gastrocnemius muscle flap with skin mesh graft covering. Unfortunately long-term follow-up examinations could not be obtained, as the patient deceased due to an alveolitis during rehabilitation. In summary, the specifics of this rare case of aseptic TKA loosening, and the unusual circumstances of chondrosarcoma diagnosis and treatment are informative for those providing surgical treatment of similar cases.
10.1186/2193-1801-3-308
urn:nbn:de:bvb:20-opus-110341
In: SpringerPlus 2014, 3:308. doi:10.1186/2193-1801-3-308
Andre F. Steinert
Maximilian Rudert
Jakob T. Sieker
eng
uncontrolled
Total knee arthroplasty
eng
uncontrolled
Bone tumor
eng
uncontrolled
Chondrosarcoma
eng
uncontrolled
Aseptic loosening
Medizin und Gesundheit
open_access
Lehrstuhl für Orthopädie
Förderzeitraum 2014
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/11034/045_Steinert_Springer.pdf
29737
2022
eng
21
11
article
1
--
2022-11-03
--
Bone metastases of diverse primary origin frequently express the VDR (vitamin D receptor) and CYP24A1
Active vitamin D (1,25(OH)2D3) is known to exert direct anti-cancer actions on various malignant tissues through binding to the vitamin D receptor (VDR). These effects have been demonstrated in breast, prostate, renal and thyroid cancers, which all have a high propensity to metastasise to bone. In addition, there is evidence that vitamin D catabolism via 24-hydroxylase (CYP24A1) is altered in tumour cells, thus, reducing local active vitamin D levels in cancer cells. The aim of this study was to assess VDR and CYP24A1 expression in various types of bone metastases by using immunohistochemistry. Overall, a high total VDR protein expression was detected in 59% of cases (39/66). There was a non-significant trend of high-grade tumours towards the low nuclear VDR expression (p = 0.07). Notably, patients with further distant metastases had a reduced nuclear VDR expression (p = 0.03). Furthermore, a high CYP24A1 expression was detected in 59% (39/66) of bone metastases. There was a significant positive correlation between nuclear VDR and CYP24A1 expression (p = 0.001). Collectively, the VDR and CYP24A1 were widely expressed in a multitude of bone metastases, pointing to a potential role of vitamin D signalling in cancer progression. This is of high clinical relevance, as vitamin D deficiency is frequent in patients with bone metastases.
Journal of Clinical Medicine
2077-0383
10.3390/jcm11216537
urn:nbn:de:bvb:20-opus-297377
2022-12-15T14:04:08+00:00
sword
swordwue
attachment; filename=deposit.zip
9eb898034c57f4a5ffe79f23b25909dc
Journal of Clinical Medicine (2022) 11:21, 6537. https://doi.org/10.3390/jcm11216537
Lehrstuhl für Regeneration Muskuloskelettaler Gewebe
IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen
Muskuloskelettales Centrum Würzburg (MCW)
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Jonas Seiler
Regina Ebert
Maximilian Rudert
Marietta Herrmann
Ellen Leich
Manuela Weißenberger
Konstantin Horas
eng
uncontrolled
vitamin D receptor
eng
uncontrolled
VDR
eng
uncontrolled
CYP24A1
eng
uncontrolled
bone metastasis
eng
uncontrolled
vitamin D
Medizin und Gesundheit
open_access
Pathologisches Institut
Lehrstuhl für Orthopädie
Import
Comprehensive Cancer Center Mainfranken
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/29737/jcm-11-06537-v2.pdf
14603
2016
eng
57
17
article
1
2017-03-22
--
--
The Wuerzburg procedure: the tensor fasciae latae perforator is a reliable anatomical landmark to clearly identify the Hueter interval when using the minimally-invasive direct anterior approach to the hip joint
Background
The key for successful delivery in minimally-invasive hip replacement lies in the exact knowledge about the surgical anatomy. The minimally-invasive direct anterior approach to the hip joint makes it necessary to clearly identify the tensor fasciae latae muscle in order to enter the Hueter interval without damaging the lateral femoral cutaneous nerve. However, due to the inherently restricted overview in minimally-invasive surgery, this can be difficult even for experienced surgeons.
Methods and Surgical Technique
In this technical note, we demonstrate for the first time how to use the tensor fasciae latae perforator as anatomical landmark to reliably identify the tensor fasciae latae muscle in orthopaedic surgery. Such perforators are used for flaps in plastic surgery as they are constant and can be found at the lateral third of the tensor fasciae latae muscle in a direct line from the anterior superior iliac spine.
Conclusion
As demonstrated in this article, a simple knowledge transfer between surgical disciplines can minimize the complication rate associated with minimally-invasive hip replacement.
BMC Musculoskeletal Disorders
10.1186/s12891-016-0908-z
urn:nbn:de:bvb:20-opus-146031
BMC Musculoskeletal Disorders (2016) 17:57 DOI 10.1186/s12891-016-0908-z
Maximilian Rudert
Konstantin Horas
Maik Hoberg
Andre Steinert
Dominik Emanuel Holzapfel
Stefan Hübner
Boris Michael Holzapfel
eng
uncontrolled
anatomical landmark
eng
uncontrolled
direct anterior approach
eng
uncontrolled
Hueter interval
eng
uncontrolled
minimally-invasive
eng
uncontrolled
hip replacement
eng
uncontrolled
perforator
Chirurgie und verwandte medizinische Fachrichtungen
open_access
Institut für Anatomie und Zellbiologie
Lehrstuhl für Orthopädie
Förderzeitraum 2016
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/14603/027_Rudert_art_10.1186_s12891-016-0908-z.pdf
13357
2011
eng
553
33
108
article
1
2016-05-13
--
--
Adjuvant Radiotherapy
No abstract available.
Deutsches Ärzteblatt International
10.3238/arztebl.2011.0553a
urn:nbn:de:bvb:20-opus-133571
Deutsches Ärzteblatt International 2011; 108(33), 553. DOI: 10.3238/arztebl.2011.0553a
false
true
Deutsches Urheberrecht
Maximilian Rudert
Boris Michael Holzapfel
Michael Jakubietz
eng
uncontrolled
Soft-tissue sarcoma
Chirurgie und verwandte medizinische Fachrichtungen
open_access
Lehrstuhl für Orthopädie
Klinik und Poliklinik für Unfall-, Hand-, Plastische und Wiederherstellungschirurgie (Chirurgische Klinik II)
Universität Würzburg