12787
1982
eng
50-56
98
article
1
2016-02-24
--
--
Effects of Adenosine on Histamine Release from Human Lung Fragments
The actions of adenosine on histamine release of human lung fragments were investigated. Histamine release was stimulated either with the calcium ionophore A 23187 orwith concanavalin A. Adenosine and its analogue 5'-N-ethylcarboxamidoadenosine alone had no significant effect on basal release or on the release elicited by A 23187 or concanavalin A. However, in the presence of the adenosine receptor antagonist 8-[4-[[[[(2-aminoethyl)amino]-carbonyl] methyloxy]-phenyl]-1,3-dipropylaxanthine (XAC), which itself did not affect the release, adenosine increased the stimulated histamine release. On the other hand, in the presence of the nucleoside transport inhibitor S-(p-nitrobenzyl)-6-thioninosine (NBTI), adenosine caused a reduction in stimulated histamine release. NBTI itself caused a stimulation of release. Thus, a stimulatory effect of adenosine was seen in the presence ofXAC, whereas an inhibitory effect was unmasked by NBTI. From these data it is concluded that adenosine exerts two opposing effects on histamine release in the human lung which neutralize each other: it inhibits release via a si te antagonized by XAC, which presumably represents an A2 adenosine receptor, and it stimulates release via a mechanism that is blocked by NBTI, suggesting that adenosine needs to reach the interior of cells to exert this effect. The slight stimulatory effect of NBTI alone demonstrates that trapping intracellularly formed adenosine inside mast cells leads to sufficient concentrations of adenosine to stimulate histamine release. These findings suggest an important bimodal role of adenosine in regulating histamine release in the human lung.
International Archives of Allergy and Immunology
urn:nbn:de:bvb:20-opus-127877
International Archives of Allergy and Immunology 1982; 98: 50-56
Deutsches Urheberrecht
Ilka Ott
Martin J. Lohse
Karl-Norbert Klotz
Ingolf Vogt-Moykopf
Ulrich Schwabe
eng
uncontrolled
mast cells
eng
uncontrolled
adenosine
eng
uncontrolled
histamine release
eng
uncontrolled
human lung
Pharmakologie, Therapeutik
open_access
Institut für Pharmakologie und Toxikologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12787/X_Klotz_adenosine.pdf
6990
1982
eng
article
1
2013-08-23
--
--
Promotion and regression of neoplasia by testosterone-promoted cell differentiation in Xiphophorus and Girardinus
No abstract available.
8048
urn:nbn:de:bvb:20-opus-86684
In: Carcinogenesis, 1982, 7, S. 427-434
Deutsches Urheberrecht
A. Schartl
Manfred Schartl
F. Anders
deu
swd
Schwertkärpfling
deu
swd
Lebendgebärende Zahnkarpfen
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6990/Schartl_6990.pdf
7099
1982
eng
article
1
2013-08-23
--
--
The expression in eukaryotes of a tyrosine kinase which is reactive with pp60v-src antibodies
All specimens of Eumetazoa and Parazoa, ranging from mammals, birds, teleosts, sharks, lampreys, amphioxus, insects, down to sponges showed the pp60c-src associated kinase activity, indicating that c-src, which is the cellular homologue of the oncogene v-src of Rous sarcoma virus (RSV) is probably present in all multicellular animals. Protozoa and plants did not show pp60c-src: kinase activity.
The degree of c-src expression depends on the taxonomic rank of the Eumetazoa tested, and is organ-specific with nervaus tissues displaying the highest kinase activities. In the central nervous system of mammals and birds we found a high c-src expression, and in that of the lampreys, amphioxus, and insects the lowest. Unexpectedly, total extracts of sponges showed an amount of pp60c-src kinase activity similar to that of brain cell extracts of mammals and birds. These findings suggest that pp60c-src is a phylogenetic old protein that might have evolved together with the multicellular organisation of Metazoa, and that might be of importance in proliferation and differentiation of nontransformed cells.
8047
urn:nbn:de:bvb:20-opus-86208
In: Differentiation, 1982, 23, S. 109-14
Deutsches Urheberrecht
Manfred Schartl
Angelika Barnekow
deu
swd
Protein-Tyrosin-Kinasen
deu
swd
Eukaryoten
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/7099/Schartl_7099.pdf
6112
1982
eng
article
1
2012-08-10
--
--
Differences in central actions of arachidonic acid and prostaglandin F\(_{2\alpha}\) between spontaneously hypertensive and normotensive rats
Prostag1andin F\(_{2\alpha}\) (PGF\(_{2\alpha}\)) is one of the most common metabo1ites of arachidonic acid (M) in rat brain. When administered intracerebroventricularly (i.c.v.) to rats, both AA and PGFal exert dose-related hypertensive, tachycardic and hyperthermic effects. Metabolie alterations in the endogenaus formation of some prostaglandins in the brain-stem of spontaneously hypertensive rats (SHR) have been reported. Therefore the central effects of AA and PGF \(_{2\alpha}\) on blood pressure, heart rate and body temperature were studied both in SHR and nonootensive Wistar rats (NR) under urethane-anaesthesia. The hypertensive effect of AA i.c.v. (0.01-100 \(\mu\)g/rat) was larger in magni tude in SHR than in NR, but there was no significant difference in the M-induced changes of heart rate and body temperature between the groups. Pretreatment of NR wi th soditm1 :meclofenamate (1 mg/rat i.c.v.) antagonised the central effects of M indicating that these effects are not due to M itself but to its conversion to prostaglandins. Unlike the effects of AA, the central hypertensive, tachycardic and hyperthennic responses to PGF\(_{2\alpha}\) (0.5-50 l-lg/rat i.c.v .) were significantly attenuated in SHR. The present results obtained with M are conpatible with the previous assumption that the synthesis of prostaglandins in the brain of SHR might differ from that in NR. The results also demonstrate that the central effects of PGF\(_{2\alpha}\) are reduced in SHR.
urn:nbn:de:bvb:20-opus-63324
6332
Life Sciences (1982) 30, 503-513.
Deutsches Urheberrecht
Anna-Leena Sirén
deu
swd
Neurobiologie
Medizin und Gesundheit
open_access
Neurochirurgische Klinik und Poliklinik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6112/Siren58.pdf
5952
1982
eng
article
1
2012-06-28
--
--
Identification of a fish protein associated with a kinase activity and related to the Rous sarcoma virus transforming protein
No abstract available
urn:nbn:de:bvb:20-opus-61946
6194
In: Cancer Research (1982) 42, 2429-33.
Deutsches Urheberrecht
A. Barnekow
Manfred Schartl
F. Anders
H. Bauer
deu
swd
Physiologische Chemie
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/5952/Schartl62.pdf
5951
1982
eng
article
1
2012-06-28
--
--
Correlations of inheritance and expression between a tumor gene and the cellular homolog of the Rous sarcoma virus-transforming gene in Xiphophorus
No abstract available
urn:nbn:de:bvb:20-opus-61937
6193
In: Cancer Research (1982) 42, 4222-7.
Deutsches Urheberrecht
Manfred Schartl
A. Barnekow
H. Bauer
F. Anders
deu
swd
Physiologische Chemie
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/5951/Schartl61.pdf
5817
1982
eng
article
1
2012-05-02
--
--
The imported preprotein of the proteolipid subunit of the mitochondrial ATP synthase from Neurospora crassa. Molecular cloning and sequencing of the mRNA
No abstract available
urn:nbn:de:bvb:20-opus-62742
6274
In: EMBO Journal (1982) 1(5), 565-571.
Deutsches Urheberrecht
A. Viebrock
A. Perz
Walter Sebald
deu
swd
Biochemie
Biowissenschaften; Biologie
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/5817/Sebald43.pdf
5816
1982
eng
article
1
2012-04-27
--
--
Structure and genetics of the H\(^+\)-conducting F\(_0\) portion of the ATP synthase
The ATP synthase occurs in remarkably conserved form in procaryotic and eucaryotic cells. Thus, our present knowledge of ATP synthase is derived from sturlies of the enzyme from different organisms, each affering specific experimental possibilities. In recent tim es, research on the H\(^+\) -conducting F0 part of the ATP synthase has been greatly stimulated by two developments in the Escherichio coli system. Firstly, the purification and reconstitution of the whole ATP synthase as weil as the proton conductor Fa from E. coli have been achieved. These functionally active preparations are well defined in terms of subunit composition, similar to the thermophilic enzyme from PS-3 studied by Kagawa's group.u Secondly, the genetics and the molecular cloning of the genes of all the F\(_0\) subunits from E. coli yielded information on the function of subunit polypeptides and essential amino acid residues. Furthermore, the amino acid sequence of hydrophobic F\(_0\) subunits, which are difficult to analyze by protein-chemical techniques, could be derived from the nucleotide sequence of the genes. These achievements, which shall be briefly summarized in the next part of this communication, provide the framework to study specific aspects of the structure and function of the F\(_0\) subunits.
urn:nbn:de:bvb:20-opus-62733
6273
Annals of the New York Academy of Sciences (1982) 402, p 28-44.
Deutsches Urheberrecht
Walter Sebald
P. Friedl
H. U. Schairer
J. Hoppe
deu
swd
Biochemie
Biowissenschaften; Biologie
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/5816/Sebald42.pdf
5815
1982
eng
article
1
2012-04-27
--
--
Topological and functional aspects of the proton conductor, F\(_0\), of the Escherichia coli ATP-synthase
The isolated H\(^+\) conductor, F\(_0\) , of the Escherichia co1i ATP-synthase consists of three subunits, a, b, and c. H\(^+\) -permeable liposomes can be reconstit~ted with F\(_0\) and lipids; addition of F\(_1\)-ATPase reconstitutes a functional ATP-synthase. Mutants with altered or misslng F\(_0\) subunits are defective in H\(^+\) conduction. Thus, all three subunits are necessary for the expression of H\(^+\) conduction. The subunits a and b contain binding sites for F\(_1\)• Computer calculations, cross-links, membrane-permeating photo-reactive labels, and proteases were used to develop tentative structural models for the individual F\(_0\) subunits.
urn:nbn:de:bvb:20-opus-62721
6272
Bioscience Reports (1982 Aug) 2(8) 631-9.
Deutsches Urheberrecht
H. U. Schairer
J. Hoppe
Walter Sebald
P. Friedl
deu
swd
Biochemie
Biowissenschaften; Biologie
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/5815/Sebald41.pdf
5492
1982
eng
article
1
2012-01-26
--
--
Covalent binding of diethylstilbestrol to DNA in rat and hamster liver and kidney [Short Communication]
No abstract available
urn:nbn:de:bvb:20-opus-61066
6106
In: Chemico-Biological Interactions (1982) 42, 2, 251-7.
Deutsches Urheberrecht
Werner K. Lutz
W. Jaggi
C. Schlatter
deu
swd
Toxikologie
eng
uncontrolled
Carcinogenesis
eng
uncontrolled
Covalent binding index - Diethylstilbestrol
eng
uncontrolled
DNA binching
eng
uncontrolled
Estrogen
eng
uncontrolled
Hormone
Medizin und Gesundheit
open_access
Institut für Pharmakologie und Toxikologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/5492/Lutz60.pdf
5019
1982
eng
article
1
2011-08-24
--
--
Tricyclo[5.1.0.0\(^{2,8}\)]octa-3,5-diene (Octavalene)
No abstract available
urn:nbn:de:bvb:20-opus-58124
5812
In: Journal of the American Chemical Society (1982) 104, 16, 4494-4496.
Deutsches Urheberrecht
Manfred Christl
R. Lang
deu
swd
Organische Chemie
Chemie und zugeordnete Wissenschaften
open_access
Institut für Organische Chemie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/5019/Christl40.pdf
4593
1982
eng
article
1
2011-01-20
--
--
Central cardiovascular and thermal effects of prostaglandin D2 in rats
Prostaglandin D2 (PGD2) is the most common prostaglandin type of tile rat brain. Recently a neurornodulator role for PGD2 has been suggested. In the present work the central cardiovascular and thermal effects of PGDz were studied in urethane-anaesthetised rats. Mlen adrndnistered at the doses of 0.001-10 ~g/rat into the lateral cerebral ventricle(i.c.v.), PGD2 slightly increased the blood pressure, heart rate and body ternpera~ ure. The highest dose caused also an initial hypotensive effect. Upon lntravenous injections PGD2 (0.1-10 ~g/rat) initially decreased and then weakly increased the blood pressure but had only negligible effects on heart rate and body temperature. Central pretreatment with sodium meclofenamate or indomethacin (1 mg/rat i.c.v.) antagonised effectively all the recorded central effects of PGD2. The central cardiovascular and thermal effects of PGD2 were much weaker than those obtained earlier with other prostaglandins, such as PGF2alpha and PGE2.. Therefore, in spite of its abundance in the brain PGD2 may not be very important for the central cardiovascular and thermal regulation in the rat.
urn:nbn:de:bvb:20-opus-48658
4865
In: Prostaglandins Leukotrienes and Medicine (1982) 8, 349-359.
Deutsches Urheberrecht
Anna-Leena Sirén
deu
swd
Medizin
Medizin und Gesundheit
open_access
Neurochirurgische Klinik und Poliklinik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/4593/Siren_Central_cardiovascular_thermal.pdf
4590
1982
eng
article
1
2011-01-20
--
--
Central cardiovascular and thermal effects of Prostaglandin E2 in rats
Prostaglandin E2 (PGE2) increased the blood pressure, heart rate and body temperature, when administered at the doses ofO.OOI-IO,ug into the lateral cerebral ventricle (i.c.v.) of the urethane-anesthetised rat. The highest dose of 10 ,ug/rat induced a strong initial hypotensive effect. lntravenously (i.v.), PGE2 at the doses of 0.01-10 ,ug/rat caused a biphasic blood pressure response with dose-related initial decreases followed by slight increases in blood pressure. The heart rate and body temperature were slightly increased by i.v. administrations of PGE2 . The highest i.v. dose of 10 ,ug/rat initially decreased also the heart rate. Central pretreatment with indomethacin ( I mg/rat i.c.v.) partly antagonised all of the recorded central effects of PGE2 , while sodium meclofenamate (I mg/rat i.c. v.) abolished the hypertensive response to i.c. v. administered PGE2 but failed to significantly affect the PGE2-induced rises of heart rate and body temperature. The results support the previous suggestions that PGE2 may participate in the central cardiovascular and thermoregulatory contro!. The results also suggest that indomethacin and sodium meclofenamate antagonize the effects of exogenous prostaglandins. Since sodium meclofenamate, unlike indomethacin, affected preferentially the hypertensive response to centrally administered PGE2 , there may be differences in the sites and/or modes of action between these drugs.
urn:nbn:de:bvb:20-opus-47960
4796
In: Acta physiologica Scandinavica (1982) 116, 229-234.
Deutsches Urheberrecht
Anna-Leena Sirén
deu
swd
Physiologie
Medizin und Gesundheit
open_access
Neurochirurgische Klinik und Poliklinik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/4590/Siren_effects_Prostaglandin.pdf
4439
1982
eng
article
1
2010-12-02
--
--
Synthesis and molecular structure of C\(_5\)H\(_5\)(P-/-Pr\(_3\))Pd(η\(^1\), η\(^3\)-C\(_3\)H\(_4\))Pd(P-/-Pr\(_3\))Br: a compound formed through insertion of allene into a metal-metal bond\(^1\)
No abstract available
urn:nbn:de:bvb:20-opus-46592
4659
Organometallics (1982) 1, 3, S. 496 - 499.
Deutsches Urheberrecht
A. Kuehn
Christian Burschka
H. Werner
deu
swd
Chemie
Chemie und zugeordnete Wissenschaften
open_access
Institut für Anorganische Chemie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/4439/Burschka_Reactivity_metal_35.pdf
4248
1982
eng
article
1
2010-09-16
--
--
Lymphoid tissue transplantation in rats leads to a GVHR, inducing a specific T-cell mediated autoreactivity against MHC-antigens
No abstract available
urn:nbn:de:bvb:20-opus-45420
4542
In: Advances in experimental medicine and biology (1982) 149, 591-597.
Deutsches Urheberrecht
Karin Ulrichs
E. Deltz
A. Thiede
W. Müller-Ruchholtz
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I)
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/4248/Ulrichs_Lymphoid_Tissue.pdf
4087
1982
eng
article
1
2010-07-13
--
--
Cloning vectors derived from plasmids and phage of Bacillus
No abstract available
urn:nbn:de:bvb:20-opus-47014
4701
In: Current Topics in Microbiology and Immunology (1982) 96, 1-17
Deutsches Urheberrecht
Jürgen Kreft
Colin Hughes
Biowissenschaften; Biologie
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/4087/Kreft_Phage_Bacillus.pdf
3931
1982
eng
article
1
2010-04-29
--
--
Tranquillizer effects in an experimental analog of group psychotherapy
In an experimental analog of verbal examinations, the call-up situation, the effects of two dosages of a tranquillizing agent (lopirazepam) are compared to placebo treatment. 72 male and female, healthy, young volunteers have been randomly assigned to 12 groups of 6 subjects each. Pulse frequency and performance were registered. The results indicated differential drug effects which were interpreted according to the hypotheses of "differential effects of social stressors". If a situation was highly challenging for a subject, the application of a tranquillizer in an adequately high dosage enabled him to perform well in spite of or because of strong increases in pulse frequency.
urn:nbn:de:bvb:20-opus-41316
4131
In: International pharmacopsychiatry (1982) 17, S. 303 - 313.
Hans-Peter Krüger
Ralf Kohnen
eng
uncontrolled
Tranquillizer
eng
uncontrolled
Social stress situations
eng
uncontrolled
Group dynamics
eng
uncontrolled
Healthy subjects
eng
uncontrolled
Differential effects of stressors
eng
uncontrolled
Anxiolysis
eng
uncontrolled
Telemetry Activation
Psychologie
open_access
Institut für Psychologie (bis Sept. 2007)
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/3931/Krueger_Tranquillizer_group.pdf
3839
1982
eng
article
1
2010-04-01
--
--
Tranquillizer effects in an experimental analog of verbal examinations
In an experimental analog of verbal examinations, the call-up situation, the effects of two dosages of a tranquillizing agent (lopirazepam) are compared to placebo treatment. 72 male and female, healthy, young volunteers have been randomly assigned to 12 groups of 6 subjects each. Pulse frequency and performance were registered. The results indicated differential drug effects which were interpreted according to the hypotheses of "differential effects of social stressors". If a situation was highly challenging for a subject, the application of a tranquillizer in an adequately high dosage enabled him to perform well in spite of or because of strong increases in pulse frequency.
urn:nbn:de:bvb:20-opus-41617
4161
In : International Pharmacopsychiatry (1982) 17, S. 293 - 302.
Ralf Kohnen
Hans-Peter Krüger
eng
uncontrolled
Tranquillizer
eng
uncontrolled
Social stress
eng
uncontrolled
Examination
eng
uncontrolled
Healthy subjects
eng
uncontrolled
Differential effects of stressors
eng
uncontrolled
Telemetry
eng
uncontrolled
Activation
Psychologie
open_access
Institut für Psychologie (bis Sept. 2007)
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/3839/Krueger_Tranquillizer_verbal.pdf
3682
1982
eng
article
1
2010-02-17
--
--
A novel type of chromatin organization in lampbrush chromosomes of Pleurodeles waltlii: visualization of clusters of tandemly repeated, very short transcriptional units
A novel chromatin configuration is described in lampbrush chromosomes of Pleurodeles waltlii oocytes which is different from transcriptionally inactive chromatin as weil as from the various forms of transcribed chromatin hitherto described. This novel type of chromatin is not arranged in Christmas tree-Iike configurations of densely packed lateral ribonucleoprotein (RNP) fibriIs but is characterized by a periodic alternating pattern of thick and thin regions which occur in clusters 01 some 10,000 repeats. Each thickened unit with an average length of 45 nm contains two c10sely spaced particles, the putative RNA polymerases, and each thickened unit is separated from the next one by a beaded chromatin spacer with a length of about 80 nm. This chromatin spacer contains on average two particles of approximately 14 nm in diameter, assumed to be nucleosomes. The thickened regions are interpreted to represent short transcriptional units containing approximately 130 base pairs of DNA which are separated from each other by nontranscribed spacers of 240-400 base pairs of DNA. The possibility is discussed that these transcriptional units represent 5S rRNA or tRNA genes.
urn:nbn:de:bvb:20-opus-41087
4108
In: Biology of the cell (1982) 44, 213 - 220.
Ulrich Scheer
eng
uncontrolled
Lampbrush chromosomes
eng
uncontrolled
Amphibian oocytes
eng
uncontrolled
Transcription units
eng
uncontrolled
Electron microscopy
Biowissenschaften; Biologie
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/3682/Scheer_Novel_type_chromatin.pdf
3598
1982
eng
bookpart
1
2010-01-25
--
--
Morphology of nucleolar chromatin in electron microscopic spread preparations
No abstract available
urn:nbn:de:bvb:20-opus-41155
4115
In: The Cell Nucleus / Hrsg.: Busch, Harris. - New York [u.a.], Acad. Press. - ISBN: 0-12-147610-3, 0-12-147609-X, Vol. XI, 1982, S. 143 - 176.
Ulrich Scheer
Hanswalter Zentgraf
Biowissenschaften; Biologie
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/3598/Scheer_Morphology_microscopic_spread.pdf