16476
2016
eng
15
18
article
1
2018-07-17
--
--
Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
Background
BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs).
Methods
We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database.
Results
Among BRCA2 MBCs, grade significantly decreased with increasing age at diagnosis (P = 0.005). Compared with BRCA2 FBCs, BRCA2 MBCs were of significantly higher stage (P for trend = 2 × 10−5) and higher grade (P for trend = 0.005) and were more likely to be oestrogen receptor–positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15–21.80] and progesterone receptor–positive (OR 5.04; 95 % CI 3.17–8.04). With the exception of grade, similar patterns of associations emerged when we compared BRCA1 MBCs and FBCs. BRCA2 MBCs also presented with higher grade than MBCs from the SEER database (P for trend = 4 × 10−12).
Conclusions
On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management.
Breast Cancer Research
10.1186/s13058-016-0671-y
urn:nbn:de:bvb:20-opus-164769
Breast Cancer Research (2016) 18:15
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Valentina Silvestri
Daniel Barrowdale
Anna Marie Mulligan
Susan L. Neuhausen
Stephen Fox
Beth Y. Karlan
Gillian Mitchell
Paul James
Darcy L. Thull
Kristin K. Zorn
Natalie J. Carter
Katherine L. Nathanson
Susan M. Domchek
Timothy R. Rebbeck
Susan J. Ramus
Robert L. Nussbaum
Olufunmilayo I. Olopade
Johanna Rantala
Sook-Yee Yoon
Maria A. Caligo
Laura Spugnesi
Anders Bojesen
Inge Sokilde Pedersen
Mads Thomassen
Uffe Birk Jensen
Amanda Ewart Toland
Leigha Senter
Irene L. Andrulis
Gord Glendon
Peter J. Hulick
Evgeny N. Imyanitov
Mark H. Greene
Phuong L. Mai
Christian F. Singer
Christine Rappaport-Fuerhauser
Gero Kramer
Joseph Vijai
Kenneth Offit
Mark Robson
Anne Lincoln
Lauren Jacobs
Eva Machackova
Lenka Foretova
Marie Navratilova
Petra Vasickova
Fergus J. Couch
Emily Hallberg
Kathryn J. Ruddy
Priyanka Sharma
Sung-Won Kim
Manuel R. Teixeira
Pedro Pinto
Marco Montagna
Laura Matricardi
Adalgeir Arason
Oskar Th Johannsson
Rosa B. Barkardottir
Anna Jakubowska
Jan Lubinski
Angel Izquierdo
Miguel Angel Pujana
Judith Balmaña
Orland Diez
Gabriella Ivady
Janos Papp
Edith Olah
Ava Kwong
Heli Nevanlinna
Kristiina Aittomäki
Pedro Perez Segura
Trinidad Caldes
Tom Van Maerken
Bruce Poppe
Kathleen B. M. Claes
Claudine Isaacs
Camille Elan
Christine Lasset
Dominique Stoppa-Lyonnet
Laure Barjhoux
Muriel Belotti
Alfons Meindl
Andrea Gehrig
Christian Sutter
Christoph Engel
Dieter Niederacher
Doris Steinemann
Eric Hahnen
Karin Kast
Norbert Arnold
Raymonda Varon-Mateeva
Dorothea Wand
Andrew K. Godwin
D. Gareth Evans
Debra Frost
Jo Perkins
Julian Adlard
Louise Izatt
Radka Platte
Ros Eeles
Steve Ellis
Ute Hamann
Judy Garber
Florentia Fostira
George Fountzilas
Barbara Pasini
Giuseppe Giannini
Piera Rizzolo
Antonio Russo
Laura Cortesi
Laura Papi
Liliana Varesco
Domenico Palli
Ines Zanna
Antonella Savarese
Paolo Radice
Siranoush Manoukian
Bernard Peissel
Monica Barile
Bernardo Bonanni
Alessandra Viel
Valeria Pensotti
Stefania Tommasi
Paolo Peterlongo
Jeffrey N. Weitzel
Ana Osorio
Javier Benitez
Lesley McGuffog
Sue Healey
Anne-Marie Gerdes
Bent Ejlertsen
Thomas V. O. Hansen
Linda Steele
Yuan Chun Ding
Nadine Tung
Ramunas Janavicius
David E. Goldgar
Saundra S. Buys
Mary B. Daly
Anita Bane
Mary Beth Terry
Esther M. John
Melissa Southey
Douglas F. Easton
Georgia Chenevix-Trench
Antonis C. Antoniou
Laura Ottini
eng
uncontrolled
Male breast cancer
eng
uncontrolled
BRCA1/2
eng
uncontrolled
Pathology
eng
uncontrolled
Histologic grade
eng
uncontrolled
Genotype–phenotype correlations
Induktion
open_access
Institut für Humangenetik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16476/028_Silvestri_BREAST-CANCER-RESEARCH.pdf
11682
2014
eng
e1004256
4
article
SWE-BRCA ; HEBON ; kConFab Investigators
1
2015-07-27
--
--
DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose polymerase), and both BRCA1 and BRCA2. In the present study, we have performed a comprehensive analysis of 18 genes involved in BER using a tagging SNP approach in a large series of BRCA1 and BRCA2 mutation carriers. 144 SNPs were analyzed in a two stage study involving 23,463 carriers from the CIMBA consortium (the Consortium of Investigators of Modifiers of BRCA1 and BRCA2). Eleven SNPs showed evidence of association with breast and/or ovarian cancer at p<0.05 in the combined analysis. Four of the five genes for which strongest evidence of association was observed were DNA glycosylases. The strongest evidence was for rs1466785 in the NEIL2 (endonuclease VIII-like 2) gene (HR: 1.09, 95% CI (1.03-1.16), p = 2.7x10(-3)) for association with breast cancer risk in BRCA2 mutation carriers, and rs2304277 in the OGG1 (8-guanine DNA glycosylase) gene, with ovarian cancer risk in BRCA1 mutation carriers (HR: 1.12 95% CI: 1.03-1.21, p = 4.8x10(-3)). DNA glycosylases involved in the first steps of the BER pathway may be associated with cancer risk in BRCA1/2 mutation carriers and should be more comprehensively studied.
PLOS Genetics
10.1371/journal.pgen.1004256
1553-7404
24698998
urn:nbn:de:bvb:20-opus-116820
PLoS Genetics 10(4): e1004256. doi:10.1371/journal.pgen.1004256
CC 0: Public Domain Dedication
Ana Osorio
Roger L. Milne
Karoline Kuchenbaecker
Tereza Vaclová
Guillermo Pita
Rosario Alonso
Paolo Peterlongo
Ignacio Blanco
Miguel de la Hoya
Mercedes Duran
Orland Diez
Teresa Ramón y Cajal
Irene Konstantopoulou
Christina Martínez-Bouzas
Raquel Andrés Conejero
Penny Soucy
Lesley McGuffog
Daniel Barrowdale
Andrew Lee
Brita Arver
Johanna Rantala
Niklas Loman
Hans Ehrencrona
Olufunmilayo I. Olopade
Mary S. Beattie
Susan M. Domchek
Katherine Nathanson
Timothy R. Rebbeck
Banu K. Arun
Beth Y. Karlan
Christine Walsh
Jenny Lester
Esther M. John
Alice S. Whittemore
Mary B. Daly
Melissa Southey
John Hopper
Mary B. Terry
Saundra S. Buys
Ramunas Janavicius
Cecilia M. Dorfling
Elizabeth J. van Rensburg
Linda Steele
Susan L. Neuhausen
Yuan Chun Ding
Thomas V. O. Hansen
Lars Jønson
Bent Ejlertsen
Anne-Marie Gerdes
Mar Infante
Belén Herráez
Leticia Thais Moreno
Jeffrey N. Weitzel
Josef Herzog
Kisa Weeman
Siranoush Manoukian
Bernard Peissel
Daniela Zaffaroni
Guilietta Scuvera
Bernardo Bonanni
Frederique Mariette
Sara Volorio
Alessandra Viel
Liliana Varesco
Laura Papi
Laura Ottini
Maria Grazia Tibiletti
Paolo Radice
Drakoulis Yannoukakos
Judy Garber
Steve Ellis
Debra Frost
Radka Platte
Elena Fineberg
Gareth Evans
Fiona Lalloo
Louise Izatt
Ros Eeles
Julian Adlard
Rosemarie Davidson
Trevor Cole
Diana Eccles
Jackie Cook
Shirley Hodgson
Carole Brewer
Marc Tischkowitz
Fiona Douglas
Mary Porteous
Lucy Side
Lisa Walker
Patrick Morrison
Alan Donaldson
John Kennedy
Claire Foo
Andrew K. Godwin
Rita Katharina Schmutzler
Barbara Wappenschmidt
Kerstin Rhiem
Christoph Engel
Alftons Meindl
Nina Ditsch
Norbert Arnold
Hans Jörg Plendl
Dieter Niederacher
Christian Sutter
Shan Wang-Gohrke
Doris Steinemann
Sabine Preisler-Adams
Karin Kast
Raymonda Varon-Mateeva
Andrea Gehrig
Dominique Stoppa-Lyonnet
Olga M. Sinilnikova
Sylvie Mazoyer
Francesca Damiola
Bruce Poppe
Kathleen Claes
Marion Piedmonte
Kathy Tucker
Floor Backes
Gustavo Rodríguez
Wendy Brewster
Katie Wakeley
Thomas Rutherford
Trinidad Caldés
Heli Nevanlinna
Kristiina Aittomäki
Matti A. Rookus
Theo A. M. van Os
Lizet van der Kolk
J. L. de Lange
Hanne E. J. Meijers-Heijboer
A. H. van der Hout
Christi J. van Asperen
Encarna B. Goméz Garcia
B. Encarna
Nicoline Hoogerbrugge
J. Margriet Collée
Carolien H. M. van Deurzen
Rob B. van der Luijt
Peter Devilee
Edith Olah
Conxi Lázaro
Alex Teulé
Mireia Menéndez
Anna Jakubowska
Cezary Cybulski
Jecek Gronwald
Jan Lubinski
Katarzyna Durda
Katarzyna Jaworska-Bieniek
Oskar Th. Johannsson
Christine Maugard
Marco Montagna
Silvia Tognazzo
Manuel R. Teixeira
Sue Healey
Curtis Olswold
Lucia Guidugli
Noralane Lindor
Susan Slager
Csilla I. Szabo
Joseph Vijai
Mark Robson
Noah Kauff
Liying Zhang
Rohini Rau-Murthy
Anneliese Fink-Retter
Christine F. Singer
Christine Rappaport
Daphne Geschwantler Kaulich
Georg Pfeiler
Muy-Kheng Tea
Andreas Berger
Catherine M. Phelan
Mark H. Greene
Phuong L. Mai
Flavio Lejbkowicz
Irene Andrulis
Anna Marie Mulligan
Gord Glendon
Amanda Ewart Toland
Anders Bojesen
Inge Sokilde Pedersen
Lone Sunde
Mads Thomassen
Torben A. Kruse
Uffe Birk Jensen
Eitan Friedman
Yeal Laitman
Shanie Paluch Shimon
Jaques Simard
Douglas F. Easton
Kenneth Offit
Fergus J. Couch
Georgia Chenevix-Trench
Antonis C. Antoniou
Javier Benitez
eng
uncontrolled
single-nucleotide polymorphisms
eng
uncontrolled
breast cancer
eng
uncontrolled
ovarian cancer
eng
uncontrolled
genetic modifiers
eng
uncontrolled
common variants
eng
uncontrolled
NEIL2
eng
uncontrolled
OGG1
eng
uncontrolled
investigators
eng
uncontrolled
consortium
eng
uncontrolled
damage
Medizin und Gesundheit
open_access
Institut für Humangenetik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/11682/097_Osario_Plos_Genetics.pdf
13044
2012
eng
R33
14
article
CIMBA; SWE-BRCA; HEBON; EMBRACE; GEMO Study Collaborators; kConFab Investigators
1
2016-03-22
--
--
Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers
Introduction: Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B), rs10995190 (ZNF365), rs704010 (ZMIZ1), rs2380205 (10p15), rs614367 (11q13), rs1292011 (12q24), rs10771399 (12p11 near PTHLH) and rs865686 (9q31.2).
Methods: To evaluate whether these single nucleotide polymorphisms (SNPs) are associated with breast cancer risk for BRCA1 and BRCA2 carriers, we genotyped these SNPs in 12,599 BRCA1 and 7,132 BRCA2 mutation carriers and analysed the associations with breast cancer risk within a retrospective likelihood framework.
Results: Only SNP rs10771399 near PTHLH was associated with breast cancer risk for BRCA1 mutation carriers (per-allele hazard ratio (HR) = 0.87, 95% CI: 0.81 to 0.94, P-trend = 3 x 10\(^{-4}\)). The association was restricted to mutations proven or predicted to lead to absence of protein expression (HR = 0.82, 95% CI: 0.74 to 0.90, P-trend = 3.1 x 10\(^{-5}\), P-difference = 0.03). Four SNPs were associated with the risk of breast cancer for BRCA2 mutation carriers: rs10995190, P-trend = 0.015; rs1011970, P-trend = 0.048; rs865686, 2df P = 0.007; rs1292011 2df P = 0.03. rs10771399 (PTHLH) was predominantly associated with estrogen receptor (ER)-negative breast cancer for BRCA1 mutation carriers (HR = 0.81, 95% CI: 0.74 to 0.90, P-trend = 4 x 10\(^{-5}\)) and there was marginal evidence of association with ER- negative breast cancer for BRCA2 mutation carriers (HR = 0.78, 95% CI: 0.62 to 1.00, P-trend = 0.049).
Conclusions: The present findings, in combination with previously identified modifiers of risk, will ultimately lead to more accurate risk prediction and an improved understanding of the disease etiology in BRCA1 and BRCA2 mutation carriers.
Breast Cancer Research
10.1186/bcr3121
urn:nbn:de:bvb:20-opus-130449
Breast Cancer Research 2012, 14:R33. DOI:10.1186/bcr3121
223175
Antonis C. Antoniou
Karoline B. Kuchenbaecker
Penny Soucy
Jonathan Beesley
Xiaoqing Chen
Lesley McGuffog
Andrew Lee
Daniel Barrowdale
Sue Healey
Olga M. Sinilnikova
Maria A. Caligo
Niklas Loman
Katja Harbst
Annika Lindblom
Brita Arver
Richard Rosenquist
Per Karlsson
Kate Nathanson
Susan Domchek
Tim Rebbeck
Anna Jakubowska
Jan Lubinski
Katarzyna Jaworska
Katarzyna Durda
Elżbieta Zlowowcka-Perłowska
Ana Osorio
Mercedes Durán
Raquel Andrés
Javier Benítez
Ute Hamann
Frans B. Hogervorst
Theo A. van Os
Senno Verhoef
Hanne E. J. Meijers-Heijboer
Juul Wijnen
Encarna B. Gómez Garcia
Marjolijn J. Ligtenberg
Mieke Kriege
Margriet Collée
Margreet G. E. M. Ausems
Jan C. Oosterwijk
Susan Peock
Debra Frost
Steve D. Ellis
Radka Platte
Elena Fineberg
D. Gareth Evans
Fiona Lalloo
Chris Jacobs
Ros Eeles
Julian Adlard
Rosemarie Davidson
Trevor Cole
Jackie Cook
Joan Paterson
Fiona Douglas
Carole Brewer
Shirley Hodgson
Patrick J. Morrison
Lisa Walker
Mark T. Rogers
Alan Donaldson
Huw Dorkins
Andrew K. Godwin
Betsy Bove
Dominique Stoppa-Lyonnet
Claude Houdayer
Bruno Buecher
Antoine de Pauw
Sylvie Mazoyer
Alain Calender
Mélanie Léoné
Brigitte Bressac-de Paillerets
Olivier Caron
Hagay Sobol
Marc Frenay
Fabienne Prieur
Sandra Fert Ferrer
Isabelle Mortemousque
Saundra Buys
Mary Daly
Alexander Miron
Mary Beth Terry
John L. Hopper
Esther M. John
Melissa Southey
David Goldgar
Christian F. Singer
Anneliese Fink-Retter
Tea Muy-Kheng
Daphne Geschwantler Kaulich
Thomas V. O. Hansen
Finn C. Nielsen
Rosa B. Barkardottir
Mia Gaudet
Tomas Kirchhoff
Vijai Joseph
Ana Dutra-Clarke
Kenneth Offit
Marion Piedmonte
Judy Kirk
David Cohn
Jean Hurteau
John Byron
James Fiorica
Amanda E. Toland
Marco Montagna
Cristina Oliani
Evgeny Imyanitov
Claudine Isaacs
Laima Tihomirova
Ignacio Blanco
Conxi Lazaro
Alex Teulé
J. Del Valle
Simon A. Gayther
Kunle Odunsi
Jenny Gross
Beth Y. Karlan
Edith Olah
Soo-Hwang Teo
Patricia A. Ganz
Mary S. Beattie
Cecelia M. Dorfling
Elizabeth Jansen van Rensburg
Orland Diez
Ava Kwong
Rita K. Schmutzler
Barbara Wappenschmidt
Christoph Engel
Alfons Meindl
Nina Ditsch
Norbert Arnold
Simone Heidemann
Dieter Niederacher
Sabine Preisler-Adams
Dorothea Gadzicki
Raymonda Varon-Mateeva
Helmut Deissler
Andrea Gehrig
Christian Sutter
Karin Kast
Britta Fiebig
Dieter Schäfer
Trinidad Caldes
Miguel de la Hoya
Heli Nevanlinna
Taru A. Muranen
Bernard Lespérance
Amanda B. Spurdle
Susan L. Neuhausen
Yuan C. Ding
Xianshu Wang
Zachary Fredericksen
Vernon S. Pankratz
Noralane M. Lindor
Paulo Peterlongo
Siranoush Manoukian
Bernard Peissel
Daniela Zaffaroni
Bernardo Bonanni
Loris Bernard
Riccardo Dolcetti
Laura Papi
Laura Ottini
Paolo Radice
Mark H. Greene
Jennifer T. Loud
Irene L. Andrulis
Hilmi Ozcelik
Anna Marie Mulligan
Gord Glendon
Mads Thomassen
Anne-Marie Gerdes
Uffe B. Jensen
Anne-Bine Skytte
Torben A. Kruse
Georgia Chenevix-Trench
Fergus J. Couch
Jacques Simard
Douglas F. Easton
eng
uncontrolled
investigators
eng
uncontrolled
genetic modifiers
eng
uncontrolled
mammographic density
eng
uncontrolled
susceptibility loci
eng
uncontrolled
ovarian cancer
eng
uncontrolled
hormone-related protein
eng
uncontrolled
genome-wide association
eng
uncontrolled
tumor subtypes
eng
uncontrolled
alleles
eng
uncontrolled
consortium
Menschliche Anatomie, Zytologie, Histologie
open_access
Institut für Humangenetik
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/13044/Antoniou_A10.1186-Fbcr3121.pdf
14545
2015
eng
61
17
article
1
2017-03-07
--
--
An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers
Introduction:
Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals with different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. In the present study, we tested the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers.
Methods:
We genotyped 22,214 (11,421 affected, 10,793 unaffected) mutation carriers belonging to the Consortium of Investigators of Modifiers of BRCA1/2 for 129 mitochondrial polymorphisms using the iCOGS array. Haplogroup inference and association detection were performed using a phylogenetic approach. ALTree was applied to explore the reference mitochondrial evolutionary tree and detect subclades enriched in affected or unaffected individuals.
Results:
We discovered that subclade T1a1 was depleted in affected BRCA2 mutation carriers compared with the rest of clade T (hazard ratio (HR) = 0.55; 95% confidence interval (CI), 0.34 to 0.88; P = 0.01). Compared with the most frequent haplogroup in the general population (that is, H and T clades), the T1a1 haplogroup has a HR of 0.62 (95% CI, 0.40 to 0.95; P = 0.03). We also identified three potential susceptibility loci, including G13708A/rs28359178, which has demonstrated an inverse association with familial breast cancer risk.
Conclusions:
This study illustrates how original approaches such as the phylogeny-based method we used can empower classical molecular epidemiological studies aimed at identifying association or risk modification effects.
Breast Cancer Research
10.1186/s13058-015-0567-2
urn:nbn:de:bvb:20-opus-145458
Breast Cancer Research (2015) 17:61. DOI: 10.1186/s13058-015-0567-2
223175
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Sophie Blein
Claire Bardel
Vincent Danjean
Lesley McGuffog
Sue Healay
Daniel Barrowdale
Andrew Lee
Joe Dennis
Karoline B. Kuchenbaecker
Penny Soucy
Mary Beth Terry
Wendy K. Chung
David E. Goldgar
Saundra S. Buys
Ramunas Janavicius
Laima Tihomirova
Nadine Tung
Cecilia M. Dorfling
Elizabeth J. van Rensburg
Susan L. Neuhausen
Yuan Chun Ding
Anne-Marie Gerdes
Bent Ejlertsen
Finn C. Nielsen
Thomas V. O. Hansen
Ana Osorio
Javier Benitez
Raquel Andreas Conejero
Ena Segota
Jeffrey N. Weitzel
Margo Thelander
Paolo Peterlongo
Paolo Radice
Valeria Pensotti
Riccardo Dolcetti
Bernardo Bonanni
Bernard Peissel
Daniela Zaffaroni
Giulietta Scuvera
Siranoush Manoukian
Liliana Varesco
Gabriele L. Capone
Laura Papi
Laura Ottini
Drakoulis Yannoukakos
Irene Konstantopoulou
Judy Garber
Ute Hamann
Alan Donaldson
Angela Brady
Carole Brewer
Claire Foo
D. Gareth Evans
Debra Frost
Diana Eccles
Fiona Douglas
Jackie Cook
Julian Adlard
Julian Barwell
Lisa Walker
Louise Izatt
Lucy E. Side
M. John Kennedy
Marc Tischkowitz
Mark T. Rogers
Mary E. Porteous
Patrick J. Morrison
Radka Platte
Ros Eeles
Rosemarie Davidson
Shirley Hodgson
Trevor Cole
Andrew K Godwin
Claudine Isaacs
Kathleen Claes
Kim De Leeneer
Alfons Meindl
Andrea Gehrig
Barbara Wappenschmidt
Christian Sutter
Christoph Engel
Dieter Niederacher
Doris Steinemann
Hansjoerg Plendl
Karin Kast
Kerstin Rhiem
Nina Ditsch
Norbert Arnold
Raymonda Varon-Mateeva
Rita K. Schmutzler
Sabine Preisler-Adams
Nadja Bogdanova Markov
Shan Wang-Gohrke
Antoine de Pauw
Cedrick Lefol
Christine Lasset
Dominique Leroux
Etienne Rouleau
Francesca Damiola
Helene Dreyfus
Laure Barjhoux
Lisa Golmard
Nancy Uhrhammer
Valerie Bonadona
Valerie Sornin
Yves-Jean Bignon
Jonathan Carter
Linda Van Le
Marion Piedmonte
Paul A. DiSilvestro
Miguel de la Hoya
Trinidad Caldes
Heli Nevanlinna
Kristiina Aittomäki
Agnes Jager
Ans M. W. van den Ouweland
Carolien M. Kets
Cora M. Aalfs
Flora E. van Leeuwen
Frans B. L. Hogervorst
Hanne E. J. Meijers-Heijboer
Jan C. Oosterwijk
Kees E. P. van Roozendaal
Matti A. Rookus
Peter Devilee
Rob B. van der Luijt
Edith Olah
Orland Diez
Alex Teule
Conxi Lazaro
Ignacio Blanco
Jesus Del Valle
Anna Jakubowska
Grzegorz Sukiennicki
Jacek Gronwald
Amanda B. Spurdle
William Foulkes
Curtis Olswold
Noralene M. Lindor
Vernon S. Pankratz
Csilla I. Szabo
Anne Lincoln
Lauren Jacobs
Marina Corines
Mark Robson
Joseph Vijai
Andreas Berger
Anneliese Fink-Retter
Christian F. Singer
Christine Rappaport
Daphne Geschwantler Kaulich
Georg Pfeiler
Muy-Kheng Tea
Mark H. Greene
Phuong L. Mai
Gad Rennert
Evgeny N. Imyanitov
Anna Marie Mulligan
Gord Glendon
Irene L. Andrulis
Andrine Tchatchou
Amanda Ewart Toland
Inge Sokilde Pedersen
Mads Thomassen
Torben A. Kruse
Uffe Birk Jensen
Maria A. Caligo
Eitan Friedman
Jamal Zidan
Yael Laitman
Annika Lindblom
Beatrice Melin
Brita Arver
Niklas Loman
Richard Rosenquist
Olufunmilayo I. Olopade
Robert L. Nussbaum
Susan J. Ramus
Katherine L. Nathanson
Susan M. Domchek
Timothy R. Rebbeck
Banu K. Arun
Gillian Mitchell
Bethy Y. Karlan
Jenny Lester
Sandra Orsulic
Dominique Stoppa-Lyonnet
Gilles Thomas
Jacques Simard
Fergus J. Couch
Kenenth Offit
Douglas F. Easton
Georgia Chenevix-Trench
Antonis C. Antoniou
Sylvie Mazoyer
Catherine M. Phelan
Olga M. Sinilnikova
David G. Cox
eng
uncontrolled
single-nucleotide polymorphisms
eng
uncontrolled
genetic modifiers
eng
uncontrolled
oxidative stress
eng
uncontrolled
consortium
eng
uncontrolled
multiple diseases
eng
uncontrolled
DNA
eng
uncontrolled
haplogroups
eng
uncontrolled
susceptibility
eng
uncontrolled
Ovarian
eng
uncontrolled
variants
Krankheiten
open_access
Institut für Humangenetik
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/14545/012_Blein_BREAST-CANCER-RESEARCH.pdf