16112
2017
eng
i1-i3
Supplement
18
conferenceobject
Oxford University Press
1
2018-04-25
--
--
PET-Guided Histological Characterization of Myocardial Infiltrating Cells in a Rat Model of Myocarditis
No abstract available.
European Heart Journal - Cardiovascular Imaging
2047-2404
10.1093/ehjci/jex071
urn:nbn:de:bvb:20-opus-161127
This is a pre-copyedited, author-produced version of an article accepted for publication in European Heart Journal Cardiovascular Imaging following peer review. The version of record . Eur Heart J Cardiovasc Imaging. ISSN: 2047-2404. Supplement, vol. 18, i1-i3, May 2017 is available online at: 10.1093/ehjci/jex071.
European Heart Journal - Cardiovascular Imaging, Volume 18, Issue suppl_1, May 2017, Pages i1–i3, https://doi.org/10.1093/ehjci/jex071
701983
Johns Hopkins School of Medicine, Baltimore, MD, U.S.
Deutsches Urheberrecht
Rudolf Werner
Hiroshi Wakabayashi
Roland Jahns
Süleyman Ergün
Valerie Jahns
Takahiro Higuchi
deu
swd
Myokarditis
eng
uncontrolled
positron emission tomography
eng
uncontrolled
myocarditis
eng
uncontrolled
PET
eng
uncontrolled
18F-FDG
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Nuklearmedizin
Institut für Pharmakologie und Toxikologie
Institut für Anatomie und Zellbiologie
Medizinische Klinik und Poliklinik I
OpenAIRE
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16112/Werner_Rudolf_Myocarditis.pdf
7277
1990
eng
conferenceobject
1
2013-08-21
--
--
Interaction of HIV-1 and HHV-6
No abstract available.
8023
urn:nbn:de:bvb:20-opus-86415
In: Progress in aids research in the Federal Republic of Germany / ed. Marianna Schauzu. - München: MMV, Medizin-Verl., 1990. - S. 24-30. - ISBN 3-8208-1140-0
Deutsches Urheberrecht
Andreas Schwinn
Axel Rethwilm
Stefan Esers
Bettina Borisch
Volker ter Meulen
deu
swd
HIV
deu
swd
Herpesviren
Medizin und Gesundheit
open_access
Institut für Pharmakologie und Toxikologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/7277/Rethwilm_7277.pdf
6833
1978
eng
conferenceobject
1
2013-11-06
--
--
Extrapolation of carcinogenicity data to low doses with a dose-response study of the binding of benzo(a)pyrene to rat liver DNA
The binding of tritiated benzo(a)pyrene (BP) to liver DNA of 25 adult male rats (SIV 50) has been determined 50 h after a single intraperitoneal injection of doses between 40 ug/kg and 4; mg/kg. The dose-response relations~ ip is linear up to i mg/kg, shows a sigmoid step towards 2 mg/kg and a shallow linear. slope above that value. TlJe 0 bserved bin ding ranges from 1.7 to 180 nmoles BP per mole DNA phosphate. The non-linearity between 1 and 2 mg/kg could be explained 0):1 the basis of an induction of metabolizing enzymes. A pure1y mathematical extrapolation of therumour incidence from a carcinogenic dose (1 x 40mg/kg for a 20% hepatoma incidence in newborn mice) to human exposure levels (aboilt 0.1 ug/kg per day) would never have followed a step like the on~ found in our experiments. Our dose-effect study therefore shows how carcinogenitity data could be extrapolated in a biologically founded way to low doses.
urn:nbn:de:bvb:20-opus-80157
8015
In: Toxieological Aspects of Food Safety : proc. of the European Society of Toxicology ; meeting held in Copenhagen, June 19 - 22, 1977 / Hrsg.: Leonard, B. - Berlin : Springer, 1978. - [Archives of toxicology / Supplement] ; 1 - ISBN: 3-540-08646-3, p. 369-71.
Deutsches Urheberrecht
Werner K. Lutz
C. Schlatter
deu
swd
Toxikologie
Medizin und Gesundheit
open_access
Institut für Pharmakologie und Toxikologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6833/Lutz76.pdf
6797
1984
eng
conferenceobject
1
2013-10-08
--
--
Structural characteristics of compounds that can be activated to chemically reactive metabolites: use for a prediction of a carcinogenic potential
Many mutagens and carcinogens act via covalent interaction of metabolic intermediates with DNA in the target cell. This report groups those structural elements which are often found to form the basis for a metabolism to such chemically reactive metabolites. ~mpounds which are chemically reactive per se and which do not require metabolic activation form group 1. Group 2 compri~es of olefins and aromatic hydrocarbons where the oxidation via an epoxide can be responsible for the generation of reactive species. Aromatic amines, hydrazines, and nitrosamirres form group 3 requiring an oxidation of a nitrogen atom or of a carbon atom in alpha position to a nitrosated amine. Group 4 compounds are halogenated hydrocarbons which can either give rise to radicals or can form an ·olefin (group 2) upon dehydrohalogenation. Group 5 compounds depend upon some preceding enzymatic activity either not available in the target cell or acting on positions in the molecule which are not directly involved in the subsequent formation of electrophilic atoms. Examples for each group are taken from the "List of Chemieals and Irrdustrial Processes Associated with Cancer in Humans" as compiled by the International Agency for the Research on Cancer, and it is shown that 91% of the organic carcinogens would have been detected on the basis of structural elements characteristic for group 1-5. As opposed to this very high sensitivity, the specificity ( the true negative fraction) of using this approach as a short-term test for carcinogenicity is shown to be bad because detoxification pathways have so far not been taken into account. These competing processes are so complex, however, that either only very extensive knowledge about pharmacokinetics, stability, and reactivity will be required or that in vivo systems have to be used to predict, on a quantitative basis, the darnage expected on the DNA. DNA-binding experiments in vivo are presented with benzene and toluene to demonstrate one possible way for an experimental assessment and it is shown that the detoxification reaction at the methyl group available only in toluene gives rise to a reduction by at least a factor of forty for the binding to rat liver DNA. This quantitative approach available with DNA-binding tests in vivo, also allows evaluation as to whether reactive metabolites and their DNA binding are always the most important single activities contributing to the overall carcinogenicity of a chemical. With the example of the livertumor inducing hexachlorocyclohexane isomers it is shown that situations will be found where reactive metabolites are formed and DNA binding in vivo is measurable but where this activity cannot be the decisive mode of carcinogenic action. It is concluded that the lack of structural elements known to become potentially reactive does not guarantee the lack of a carcinogenic potential.
urn:nbn:de:bvb:20-opus-80105
8010
In: Disease, metabolism and reproduction in the toxic response to drugs and other chemicals : proceedings of the Europ. Soc. of Toxicology meeting held in Rome, March 28 - 30, 1983. - Berlin [u.a.], Springer, 1984. - (Archives of toxicology / Supplement) ; 7. - ISBN: 3-540-12452-7; p.194-207
Deutsches Urheberrecht
Werner K. Lutz
deu
swd
Toxikologie
eng
uncontrolled
Structureactivity relationship
eng
uncontrolled
Reactive intermediates
eng
uncontrolled
Metabolic activation
eng
uncontrolled
DNA Binding
eng
uncontrolled
Covalent binding index
eng
uncontrolled
Carcinogens
eng
uncontrolled
Benzene
Medizin und Gesundheit
open_access
Institut für Pharmakologie und Toxikologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6797/Lutz54.pdf
6796
1987
eng
conferenceobject
1
2013-10-08
--
--
Quantitative evaluation of DNA-binding data in vivo for low-dose extrapolations
no abstract available
urn:nbn:de:bvb:20-opus-80079
8007
In: Mechanisms and Models in Toxicology : proc. of the Europ. Soc. of Toxicology ; meeting held in Harrogate, May 27 - 29, 1986. - Berlin [u.a.], Springer, 1987. - (Archives of toxicology / Suppl.) ; 11, p. 66-74.
Deutsches Urheberrecht
Werner K. Lutz
deu
swd
Toxikologie
Medizin und Gesundheit
open_access
Institut für Pharmakologie und Toxikologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6796/Lutz39.pdf
6795
1987
eng
conferenceobject
1
2013-10-08
--
--
Sensitivity of DNA and nucleotides to oxidation by permanganate and hydrogen peroxide
no abstract available
urn:nbn:de:bvb:20-opus-80062
8006
In: Mechanisms and Models in Toxicology : proc. of the Europ. Soc. of Toxicology ; meeting held in Harrogate, May 27 - 29, 1986. - Berlin [u.a.], Springer, 1987. - (Archives of toxicology / Suppl.) ; 11, p. 84-88.
Deutsches Urheberrecht
P. Sagelsdorff
Werner K. Lutz
deu
swd
Toxikologie
Medizin und Gesundheit
open_access
Institut für Pharmakologie und Toxikologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/6795/Lutz38.pdf