26584
2022
eng
22
article
1
2022-04-05
--
--
Similar severity of influenza primary and re-infections in pre-school children requiring outpatient treatment due to febrile acute respiratory illness: prospective, multicentre surveillance study (2013-2015)
Background
Influenza virus infections in immunologically naïve children (primary infection) may be more severe than in children with re-infections who are already immunologically primed. We compared frequency and severity of influenza virus primary and re-infections in pre-school children requiring outpatient treatment.
Methods
Influenza-unvaccinated children 1–5 years of age presenting at pediatric practices with febrile acute respiratory infection < 48 h after symptom onset were enrolled in a prospective, cross-sectional, multicenter surveillance study (2013–2015). Influenza types/subtypes were PCR-confirmed from oropharyngeal swabs. Influenza type/subtype-specific IgG antibodies serving as surrogate markers for immunological priming were determined using ELISA/hemagglutination inhibition assays. The acute influenza disease was defined as primary infection/re-infection by the absence/presence of influenza type-specific immunoglobulin G (IgG) and, in a second approach, by the absence/presence of subtype-specific IgG. Socio-demographic and clinical data were also recorded.
Results
Of 217 influenza infections, 178 were due to influenza A (87 [49%] primary infections, 91 [51%] re-infections) and 39 were due to influenza B (38 [97%] primary infections, one [3%] re-infection). Children with “influenza A primary infections” showed fever with respiratory symptoms for a shorter period than children with “influenza A re-infections” (median 3 vs. 4 days; age-adjusted p = 0.03); other disease characteristics were similar. If primary infections and re-infections were defined based on influenza A subtypes, 122 (87%) primary infections (78 “A(H3N2) primary infections”, 44 “A(H1N1)pdm09 primary infections”) and 18 (13%) re-infections could be classified (14 “A(H3N2) re-infections” and 4 “A(H1N1)pdm09 re-infections”). Per subtype, primary infections and re-infections were of similar disease severity. Children with re-infections defined on the subtype level usually had non-protective IgG titers against the subtype of their acute infection (16 of 18; 89%). Some patients infected by one of the influenza A subtypes showed protective IgG titers (≥ 1:40) against the other influenza A subtype (32/140; 23%).
Conclusions
Pre-school children with acute influenza A primary infections and re-infections presented with similar frequency in pediatric practices. Contrary to expectation, severity of acute “influenza A primary infections” and “influenza A re-infections” were similar. Most “influenza A re-infections” defined on the type level turned out to be primary infections when defined based on the subtype. On the subtype level, re-infections were rare and of similar disease severity as primary infections of the same subtype. Subtype level re-infections were usually associated with low IgG levels for the specific subtype of the acute infection, suggesting only short-time humoral immunity induced by previous infection by this subtype. Overall, the results indicated recurring influenza virus infections in this age group and no or only limited heterosubtypic antibody-mediated cross-protection.
BMC Infectious Diseases
10.1186/s12879-021-06988-7
urn:nbn:de:bvb:20-opus-265841
publish
BMC Infectious Diseases (2022) 22:12. https://doi.org/10.1186/s12879-021-06988-7
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Andrea Streng
Christiane Prifert
Benedikt Weissbrich
Andreas Sauerbrei
Andi Krumbholz
Ruprecht Schmid-Ott
Johannes G. Liese
eng
uncontrolled
influenza
eng
uncontrolled
children
eng
uncontrolled
disease severity
eng
uncontrolled
IgG
eng
uncontrolled
immunology
Gynäkologie, Geburtsmedizin, Pädiatrie, Geriatrie
open_access
Kinderklinik und Poliklinik
Institut für Virologie und Immunbiologie
Förderzeitraum 2021
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/26584/s12879-021-06988-7.pdf
19663
2012
eng
293
300
4
223
article
1
--
2012-01-24
--
High-risk human papillomavirus infection in Bowen’s disease of the nail unit: report of three cases and review of the literature
Background: Bowen’s disease (BD) of the nail unit is associated with human papillomavirus (HPV) infection. Objective: This study aimed to investigate the frequency of high-risk HPV infection, gender, age and digital distribution in this condition.
Methods: Biopsy specimens of 3 consecutive cases with periungual BD were investigated for the presence of HPV DNA by in situ hybridization and by polymerase chain reaction (PCR). Furthermore, 74 cases of ungual BD conducted with HPV genotyping as reported in the literature were reviewed.
Results: PCR of biopsy specimens revealed in 2 cases infection with HPV-16 and in 1 case with HPV-73. Additionally, in 1 HPV-16-positive case HPV-31/33 was detected by in situ hybridization. In line, review of the literature demonstrated a clear association of HPV-positive BD with high-risk HPV types. Interestingly, age at diagnosis was significantly lower in women. Whereas in both genders the second to fourth fingers on both hands were commonly diseased, only in men the thumbs were also prominently affected.
Conclusions: Infection with high-risk HPV types is common in BD of the nail unit suggesting the aetiological cause. Therefore, patients and partners should be closely followed up for digital and genital HPV-associated lesions.
Dermatology
1018-8665
1421-9832
10.1159/000335371
22269697
urn:nbn:de:bvb:20-opus-196638
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-14T14:19:28+00:00
attachment; filename=deposit.zip
8a539d947405d9c7b0277a892f38b04a
Dermatology (2012) 223:4, 293-300. https://doi.org/10.1159/000335371
true
true
Deutsches Urheberrecht
Natalie Grundmeier
Henning Hamm
Benedikt Weissbrich
Sabrina Christine Lang
Eva-Bettina Bröcker
Andreas Kerstan
eng
uncontrolled
Nail unit
eng
uncontrolled
Human papillomavirus
eng
uncontrolled
Bowen’s disease, periungual
Medizin und Gesundheit
open_access
Institut für Virologie und Immunbiologie
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19663/DRM335371.pdf
19899
2015
eng
1
4
1
231
article
1
--
2015-05-30
--
Kerinokeratosis papulosa of childhood
Background: Kerinokeratosis papulosa (KP) is considered an extremely rare genodermatosis presenting usually as waxy papules on the trunk in childhood.
Objective: To describe and analyze the clinical, histological and potential etiopathological aspects of KP.
Methods: The dermatoscopic features of a new case of KP of childhood are investigated. The presence of human papillomavirus (HPV) DNA in lesional skin was studied by polymerase chain reaction. Furthermore, all cases of KP of childhood reported so far were reviewed.
Results: As a diagnostic tool, we describe for the first time a dermatoscopic feature, namely a cribriform pattern of KP, in an 11-year-old boy. In addition, we detected HPV (type 57) in his KP lesions.
Conclusions: Dermatoscopic examination might be a useful tool to distinguish KP from other skin lesions, e.g. common warts. The detection of HPV type 57 might hint to an etiological role of HPV for KP.
Dermatology
1018-8665
1421-9832
10.1159/000381539
26044728
urn:nbn:de:bvb:20-opus-198997
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-28T13:22:22+00:00
attachment; filename=deposit.zip
ccfb2d3283226f7198a83753c8fd93a6
Dermatology (2015) 231:1, 1-4. https://doi.org/10.1159/000381539
true
true
Deutsches Urheberrecht
Boris Bauer
Matthias Goebeler
Benedikt Weissbrich
Andreas Kerstan
eng
uncontrolled
Waxy papulosis of childhood
eng
uncontrolled
Human papillomavirus
eng
uncontrolled
EVER1
eng
uncontrolled
EVER2
eng
uncontrolled
Kerinokeratosis papulosa
Medizin und Gesundheit
open_access
Institut für Virologie und Immunbiologie
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19899/DRM381539.pdf
16724
2016
eng
e0148258
2
11
article
1
2018-08-22
--
--
Long-Term Shedding of Influenza Virus, Parainfluenza Virus, Respiratory Syncytial Virus and Nosocomial Epidemiology in Patients with Hematological Disorders
Respiratory viruses are a cause of upper respiratory tract infections (URTI), but can be associated with severe lower respiratory tract infections (LRTI) in immunocompromised patients. The objective of this study was to investigate the genetic variability of influenza virus, parainfluenza virus and respiratory syncytial virus (RSV) and the duration of viral shedding in hematological patients. Nasopharyngeal swabs from hematological patients were screened for influenza, parainfluenza and RSV on admission as well as on development of respiratory symptoms. Consecutive swabs were collected until viral clearance. Out of 672 tested patients, a total of 111 patients (17%) were infected with one of the investigated viral agents: 40 with influenza, 13 with parainfluenza and 64 with RSV; six patients had influenza/RSV or parainfluenza/RSV co-infections. The majority of infected patients (n = 75/111) underwent stem cell transplantation (42 autologous, 48 allogeneic, 15 autologous and allogeneic). LRTI was observed in 48 patients, of whom 15 patients developed severe LRTI, and 13 patients with respiratory tract infection died. Phylogenetic analysis revealed a variety of influenza A(H1N1)pdm09, A(H3N2), influenza B, parainfluenza 3 and RSV A, B viruses. RSV A was detected in 54 patients, RSV B in ten patients. The newly emerging RSV A genotype ON1 predominated in the study cohort and was found in 48 (75%) of 64 RSV-infected patients. Furthermore, two distinct clusters were detected for RSV A genotype ON1, identical RSV G gene sequences in these patients are consistent with nosocomial transmission. Long-term viral shedding for more than 30 days was significantly associated with prior allogeneic transplantation (p = 0.01) and was most pronounced in patients with RSV infection (n = 16) with a median duration of viral shedding for 80 days (range 35–334 days). Long-term shedding of respiratory viruses might be a catalyzer of nosocomial transmission and must be considered for efficient infection control in immunocompromised patients.
PLoS ONE
10.1371/journal.pone.0148258
urn:nbn:de:bvb:20-opus-167243
PLoS ONE 11(2):e0148258 (2016). DOI: 10.1371/journal.pone.0148258
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Nicola Lehners
Julia Tabatabai
Christiane Prifert
Marianne Wedde
Joe Puthenparambil
Benedikt Weissbrich
Barbara Biere
Brunhilde Schweiger
Gerlinde Egerer
Paul Schnitzler
eng
uncontrolled
viral shedding
eng
uncontrolled
influenza virus
eng
uncontrolled
parainfluenza virus
eng
uncontrolled
respiratory syncytial virus
eng
uncontrolled
hematological disorders
Medizin und Gesundheit
open_access
Institut für Virologie und Immunbiologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16724/Lehners_PLoS_ONE.PDF
13442
2012
eng
e40431
7
7
article
1
2016-06-06
--
--
Intrathecal, Polyspecific Antiviral Immune Response in Oligoclonal Band Negative Multiple Sclerosis
Background: Oligoclonal bands (OCB) are detected in the cerebrospinal fluid (CSF) in more than 95% of patients with multiple sclerosis (MS) in the Western hemisphere. Here we evaluated the intrathecal, polyspecific antiviral immune response as a potential diagnostic CSF marker for OCB-negative MS patients.
Methodology/Principal Findings: We tested 46 OCB-negative German patients with paraclinically well defined, definite MS. Sixteen OCB-negative patients with a clear diagnosis of other autoimmune CNS disorders and 37 neurological patients without evidence for autoimmune CNS inflammation served as control groups. Antibodies against measles, rubella, varicella zoster and herpes simplex virus in paired serum and CSF samples were determined by ELISA, and virus-specific immunoglobulin G antibody indices were calculated. An intrathecal antibody synthesis against at least one neurotropic virus was detected in 8 of 26 (31%) patients with relapsing-remitting MS, 8 of 12 (67%) with secondary progressive MS and 5 of 8 (63%) with primary progressive MS, in 3 of 16 (19%) CNS autoimmune and 3 of 37 (8%) non-autoimmune control patients. Antibody synthesis against two or more viruses was found in 11 of 46 (24%) MS patients but in neither of the two control groups. On average, MS patients with a positive antiviral immune response were older and had a longer disease duration than those without.
Conclusion: Determination of the intrathecal, polyspecific antiviral immune response may allow to establish a CSF-supported diagnosis of MS in OCB-negative patients when two or more of the four virus antibody indices are elevated.
PLoS One
10.1371/journal.pone.0040431
urn:nbn:de:bvb:20-opus-134426
PLoS ONE 7(7): e40431. doi:10.1371/journal.pone.0040431
Isabel Brecht
Benedikt Weissbrich
Julia Braun
Klaus Viktor Toyka
Andreas Weishaupt
Mathias Buttmann
eng
uncontrolled
MS
eng
uncontrolled
cerebrospinal fluid
eng
uncontrolled
differential diagnosis
eng
uncontrolled
nervous-system
eng
uncontrolled
criteria
eng
uncontrolled
serum
Medizin und Gesundheit
open_access
Institut für Virologie und Immunbiologie
Neurologische Klinik und Poliklinik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/13442/Brecht_PLoSOne.pdf
14647
2016
eng
e0146678
1
11
article
1
2017-03-31
--
--
Effects of Prednisolone on Disease Progression in Antiretroviral-Untreated HIV Infection: A 2-Year Randomized, Double-Blind Placebo-Controlled Clinical Trial
Background
HIV-disease progression correlates with immune activation. Here we investigated whether corticosteroid treatment can attenuate HIV disease progression in antiretroviral-untreated patients.
Methods
Double-blind, placebo-controlled randomized clinical trial including 326 HIV-patients in a resource-limited setting in Tanzania (clinicaltrials.gov NCT01299948). Inclusion criteria were a CD4 count above 300 cells/μl, the absence of AIDS-defining symptoms and an ART-naïve therapy status. Study participants received 5 mg prednisolone per day or placebo for 2 years. Primary endpoint was time to progression to an AIDS-defining condition or to a CD4-count below 200 cells/μl.
Results
No significant change in progression towards the primary endpoint was observed in the intent-to-treat (ITT) analysis (19 cases with prednisolone versus 28 cases with placebo, p = 0.1407). In a per-protocol (PP)-analysis, 13 versus 24 study participants progressed to the primary study endpoint (p = 0.0741). Secondary endpoints: Prednisolone-treatment decreased immune activation (sCD14, suPAR, CD38/HLA-DR/CD8+) and increased CD4-counts (+77.42 ± 5.70 cells/μl compared to -37.42 ± 10.77 cells/μl under placebo, p < 0.0001). Treatment with prednisolone was associated with a 3.2-fold increase in HIV viral load (p < 0.0001). In a post-hoc analysis stratifying for sex, females treated with prednisolone progressed significantly slower to the primary study endpoint than females treated with placebo (ITT-analysis: 11 versus 21 cases, p = 0.0567; PP-analysis: 5 versus 18 cases, p = 0.0051): No changes in disease progression were observed in men.
Conclusions
This study could not detect any significant effects of prednisolone on disease progression in antiretroviral-untreated HIV infection within the intent-to-treat population. However, significant effects were observed on CD4 counts, immune activation and HIV viral load. This study contributes to a better understanding of the role of immune activation in the pathogenesis of HIV infection.
PLoS One
10.1371/journal.pone.0146678
urn:nbn:de:bvb:20-opus-146479
PLoS ONE 11(1): e0146678. doi:10.1371/journal.pone.0146678
Christa Kasang
Samuel Kalluvya
Charles Majinge
Gilbert Kongola
Mathias Mlewa
Irene Massawe
Rogatus Kabyemera
Kinanga Magambo
Albrecht Ulmer
Hartwig Klinker
Eva Gschmack
Anne Horn
Eleni Koutsilieri
Wolfgang Preiser
Daniela Hofmann
Johannes Hain
Andreas Müller
Lars Dölken
Benedikt Weissbrich
Axel Rethwilm
August Stich
Carsten Scheller
eng
uncontrolled
HIV
eng
uncontrolled
immune activation
eng
uncontrolled
viral load
eng
uncontrolled
drug adherence
eng
uncontrolled
viral replication
eng
uncontrolled
AIDS
eng
uncontrolled
HIV infections
eng
uncontrolled
highly-active antiretroviral therapy
Medizin und Gesundheit
open_access
Institut für Mathematik
Institut für Virologie und Immunbiologie
Medizinische Klinik und Poliklinik II
Förderzeitraum 2016
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/14647/054_Scheller_journal.pone.0146678.pdf
13798
2011
eng
e23091
8
6
article
1
2016-08-29
--
--
HIV Drug Resistance (HIVDR) in Antiretroviral Therapy-Naïve Patients in Tanzania Not Eligible for WHO Threshold HIVDR Survey Is Dramatically High
Background
The World Health Organization (WHO) has recommended guidelines for a HIV drug resistance (HIVDR) survey for resource-limited countries. Eligibility criteria for patients include age below 25 years in order to focus on the prevalence of transmitted HIVDR (tHIVDR) in newly-infected individuals. Most of the participating sites across Africa have so far reported tHIVDR prevalences of below 5%. In this study we investigated whether the rate of HIVDR in patients <25 years is representative for HIVDR in the rest of the therapy-naïve population.
Methods and Findings
HIVDR was determined in 88 sequentially enrolled ART-naïve patients from Mwanza, Tanzania (mean age 35.4 years). Twenty patients were aged <25 years and 68 patients were aged 25–63 years. The frequency of HIVDR in the study population was 14.8% (95%; CI 0.072–0.223) and independent of NVP-resistance induced by prevention of mother-to-child transmission programs. Patients >25 years had a significantly higher HIVDR frequency than younger patients (19.1%; 95% CI 0.095–0.28) versus 0%, P = 0.0344). In 2 out of the 16 patients with HIVDR we found traces of antiretrovirals (ARVs) in plasma.
Conclusions
ART-naïve patients aged over 25 years exhibited significantly higher HIVDR than younger patients. Detection of traces of ARVs in individuals with HIVDR suggests that besides transmission, undisclosed misuse of ARVs may constitute a significant factor in the generation of the observed high HIVDR rate. The current WHO tHIVDR survey that is solely focused on the transmission of HIVDR and that excludes patients over 25 years of age may therefore result in substantial underestimation of the prevalence of HIVDR in the therapy-naïve population. Similar studies should be performed also in other areas to test whether the so far reported optimistic picture of low HIVDR prevalence in young individuals is really representative for the rest of the ART-naïve HIV-infected population.
PLoS One
10.1371/journal.pone.0023091
urn:nbn:de:bvb:20-opus-137988
PLoS ONE 6(8): e23091. doi:10.1371/journal.pone.0023091
Christa Kasang
Samuel Kalluvya
Charles Majinge
August Stich
Jochen Bodem
Gilbert Kongola
Graeme B. Jacobs
Mathias Mlewa
Miriam Mildner
Irina Hensel
Anne Horn
Wolfgang Preiser
Gert van Zyl
Hartwig Klinker
Eleni Koutsilieri
Axel Rethwilm
Carsten Scheller
Benedikt Weissbrich
eng
uncontrolled
Tanzania
eng
uncontrolled
antimicrobial resistance
eng
uncontrolled
antiretroviral therapy
eng
uncontrolled
HIV
eng
uncontrolled
sequence databases
eng
uncontrolled
mutation databases
eng
uncontrolled
antiretrovirals
eng
uncontrolled
HIV diagnosis and management
Medizin und Gesundheit
open_access
Institut für Virologie und Immunbiologie
Missionsärztliche Klinik
Medizinische Klinik und Poliklinik I
Förderzeitraum 2011
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/13798/Kasang_journal.pone.0023091.pdf
13008
2013
eng
e68909
7
8
article
1
2016-03-16
--
--
Epidemiology of Subacute Sclerosing Panencephalitis (SSPE) in Germany from 2003 to 2009: A Risk Estimation
Subacute sclerosing panencephalitis (SSPE) is a fatal long-term complication of measles infection. We performed an estimation of the total number of SSPE cases in Germany for the period 2003 to 2009 and calculated the risk of SSPE after an acute measles infection. SSPE cases were collected from the Surveillance Unit for Rare Paediatric Diseases in Germany and the Institute of Virology and Immunobiology at the University of Würzburg. The total number of SSPE cases was estimated by capture-recapture analysis. For the period 2003 to 2009, 31 children with SSPE who were treated at German hospitals were identified. The capture-recapture estimate was 39 cases (95% confidence interval: 29.2–48.0). The risk of developing SSPE for children contracting measles infection below 5 years of age was calculated as 1∶1700 to 1∶3300. This risk is in the same order of magnitude as the risk of a fatal acute measles infection.
PLoS ONE
10.1371/journal.pone.0068909
urn:nbn:de:bvb:20-opus-130089
PLoS ONE 8(7): e68909. doi:10.1371/journal.pone.0068909
Katharina Schönberger
Maria-Sabine Ludwig
Manfred Wildner
Benedikt Weissbrich
eng
uncontrolled
Germany
eng
uncontrolled
pediatric infections
eng
uncontrolled
age groups
eng
uncontrolled
measels virus
eng
uncontrolled
German people
eng
uncontrolled
measles
eng
uncontrolled
pediatrics
eng
uncontrolled
vaccination and immunization
Medizin und Gesundheit
open_access
Institut für Virologie und Immunbiologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/13008/095_Epidemiology of Subacute Sclerosing Panencephalitis.pdf
12904
2013
eng
1029-1030
6
19
article
1
2016-03-08
--
--
Novel Respiratory Syncytial Virus A Genotype, Germany, 2011-2012
No abstract available.
Emerging Infectious Diseases
10.3201/eid1906.121582
urn:nbn:de:bvb:20-opus-129041
Public Domain (Source: http://wwwnc.cdc.gov/eid/page/copyright-and-disclaimers)
Emerging Infectious Diseases Vol. 19, No. 6, June 2013. doi:10.3201/eid1906.121582
Christiane Prifert
Andrea Streng
Christine D. Krempl
Johannes Liese
Benedikt Weissbrich
Medizin und Gesundheit
open_access
Institut für Virologie und Immunbiologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12904/029_Novel Respiratory Syncytial Virus A Genotype.pdf
12528
2015
eng
573
15
article
Bavarian PICU Study Group on Influenza and Other Viral ARI
1
2016-01-25
--
--
Continued high incidence of children with severe influenza A(H1N1)pdm09 admitted to paediatric intensive care units in Germany during the first three post-pandemic influenza seasons, 2010/11–2012/13
Background
Previous influenza surveillance at paediatric intensive care units (PICUs) in Germany indicated increased incidence of PICU admissions for the pandemic influenza subtype A(H1N1)pdm09. We investigated incidence and clinical characteristics of influenza in children admitted to PICUs during the first three post-pandemic influenza seasons, using active screening.
Methods
We conducted a prospective surveillance study in 24 PICUs in Bavaria (Germany) from October 2010 to September 2013. Influenza cases among children between 1 month and 16 years of age admitted to these PICUs with acute respiratory infection were confirmed by PCR analysis of respiratory secretions.
Results
A total of 24/7/20 influenza-associated PICU admissions were recorded in the post-pandemic seasons 1/2/3; incidence estimates per 100,000 children were 1.72/0.76/1.80, respectively. Of all 51 patients, 80 % had influenza A, including 65 % with A(H1N1)pdm09. Influenza A(H1N1)pdm09 was almost absent in season 2 (incidence 0.11), but dominated PICU admissions in seasons 1 (incidence 1.35) and 3 (incidence 1.17). Clinical data was available for 47 influenza patients; median age was 4.8 years (IQR 1.6–11.0). The most frequent diagnoses were influenza-associated pneumonia (62 %), bronchitis/bronchiolitis (32 %), secondary bacterial pneumonia (26 %), and ARDS (21 %). Thirty-six patients (77 %) had underlying medical conditions. Median duration of PICU stay was 3 days (IQR 1–11). Forty-seven per cent of patients received mechanical ventilation, and one patient (2 %) extracorporeal membrane oxygenation; 19 % were treated with oseltamivir. Five children (11 %) had pulmonary sequelae. Five children (11 %) died; all had underlying chronic conditions and were infected with A(H1N1)pdm09. In season 3, patients with A(H1N1)pdm09 were younger than in season 1 (p = 0.020), were diagnosed more often with bronchitis/bronchiolitis (p = 0.004), and were admitted to a PICU later after the onset of influenza symptoms (p = 0.041).
Conclusions
Active screening showed a continued high incidence of A(H1N1)pdm09-associated PICU admissions in the post-pandemic seasons 1 and 3, and indicated possible underestimation of incidence in previous German studies. The age shift of severe A(H1N1)pdm09 towards younger children may be explained by increasing immunity in the older paediatric population. The high proportion of patients with underlying chronic conditions indicates the importance of consistent implementation of the current influenza vaccination recommendations for risk groups in Germany.
BMC Infectious Diseases
10.1186/s12879-015-1293-1
urn:nbn:de:bvb:20-opus-125280
BMC Infectious Diseases (2015) 15:573. DOI 10.1186/s12879-015-1293-1
Andrea Streng
Christiane Prifert
Benedikt Weissbrich
Johannes G. Liese
eng
uncontrolled
post-pandemic
eng
uncontrolled
intensive care
eng
uncontrolled
children
eng
uncontrolled
influenza
Medizin und Gesundheit
open_access
Kinderklinik und Poliklinik
Förderzeitraum 2015
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12528/Streng_10.1186_s12879-015-1293-1.pdf