14902
2015
eng
191
4
article
1
2017-05-22
--
--
Salmonella - how a metabolic generalist adopts an intracellular lifestyle during infection
The human-pathogenic bacterium Salmonella enterica adjusts and adapts to different environments while attempting colonization. In the course of infection nutrient availabilities change drastically. New techniques, "-omics" data and subsequent integration by systems biology improve our understanding of these changes. We review changes in metabolism focusing on amino acid and carbohydrate metabolism. Furthermore, the adaptation process is associated with the activation of genes of the Salmonella pathogenicity islands (SPIs). Anti-infective strategies have to take these insights into account and include metabolic and other strategies. Salmonella infections will remain a challenge for infection biology.
Frontiers in Cellular and Infection Microbiology
10.3389/fcimb.2014.00191
urn:nbn:de:bvb:20-opus-149029
Frontiers in Cellular and Infection Microbiology 4:191 (2015). DOI: 10.3389/fcimb.2014.00191
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Thomas Dandekar
Astrid Fieselmann
Eva Fischer
Jasmin Popp
Michael Hensel
Janina Noster
eng
uncontrolled
enterica serovar Typhimurium
eng
uncontrolled
bacterial invasion
eng
uncontrolled
mouse model
eng
uncontrolled
defenses
eng
uncontrolled
regulation
eng
uncontrolled
"-omics"
eng
uncontrolled
virulence
eng
uncontrolled
Salmonella-containing vacuole (SCV)
eng
uncontrolled
metabolism
eng
uncontrolled
nitric oxide
Medizin und Gesundheit
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/14902/054_Dandekar_Frontiers_in_Cellular_and_Infection_Microbiology.pdf
12068
2014
eng
191
4
article
1
2015-10-21
--
--
Salmonella—how a metabolic generalist adopts an intracellular lifestyle during infection
The human-pathogenic bacterium Salmonella enterica adjusts and adapts to different environments while attempting colonization. In the course of infection nutrient availabilities change drastically. New techniques, “-omics” data and subsequent integration by systems biology improve our understanding of these changes. We review changes in metabolism focusing on amino acid and carbohydrate metabolism. Furthermore, the adaptation process is associated with the activation of genes of the Salmonella pathogenicity islands (SPIs). Anti-infective strategies have to take these insights into account and include metabolic and other strategies. Salmonella infections will remain a challenge for infection biology.
Frontiers in Cellular and Infection Microbiology
10.3389/fcimb.2014.00191
2235-2988
urn:nbn:de:bvb:20-opus-120686
Frontiers in Cellular and Infection Microbiology 4:191. doi:10.3389/fcimb.2014.00191
Thomas Dandekar
Astrid Fieselmann
Eva Fischer
Jasmin Popp
Michael Hensel
Janina Noster
eng
uncontrolled
regulation
eng
uncontrolled
virulence
eng
uncontrolled
"-omics"
eng
uncontrolled
metabolism
eng
uncontrolled
Salmonella-containing vacuole (SCV)
Medizin und Gesundheit
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12068/114_Dandekar_Frontiers_in_Cellular_and_Infection_Microbiology.pdf