7193
1991
eng
article
1
2013-08-22
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Transcriptional activation of the melanoma inducing Xmrk oncogene in Xiphophorus
The melanoma inducing locus of Xiphophorus encodes a tumorigenic version of a novel putative receptor tyrosine kinase (Xmrk). To elucidate the mechanism of oncogenic activation of Xmrk, we compared the structure and expression of two oncogenic loci with the corresponding proto-oncogene. Only minor structural alterations were found to be specific for the oncogenic Xmrk genes. Marked overexpression of the oncogene transcripts in melanoma, which are approximately 1 kb shorter than the proto-oncogene transcript, correlates with the malignancy of the tumors. The tumor transcripts are derived from an alternative transcription start site that is used only in the oncogenic loci. Thus, oncogenic activation of the melanoma inducing Xmrk gene appears primarily to be due to novel transcriptional control and overexpression.
8033
urn:nbn:de:bvb:20-opus-87584
In: Oncogene, 1991, 6, S. 73-80
Deutsches Urheberrecht
Dieter Adam
Winfried Maueler
Manfred Schartl
deu
swd
Schwertkärpfling
deu
swd
Onkogen
deu
swd
Melanom
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/7193/Schartl_7193.pdf
7264
1993
eng
article
1
2013-09-03
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Oncogenes and melanoma formation in Xiphoporus (Teleostei: Poeciliidae)
In Xiphophorus melanoma formation has been attributed by classical genetic findings to the overexpression of a cellular oncogene (Tu) due to elimination of the corresponding regulatory gene locus in hybrids. We have attempted to elucidate this phenomenon on the molecular biological level. Studies on the structure and expression of known proto-oncogenes revealed that several of these genes, especially the c-src gene of Xiphophorus, may act as effectors in establishing the neoplastic phenotype of the melanoma cells . However, these genes appear more to participate in secondary steps of tumorigenesis. Another gene, being termed Xmrk, which represents obviously a so far unknown proto-oncogene but with a cons iderably high similarity to the epidermal growth-factorreceptor gene, was mapped to the Tu-containing region of the chromosome. This gene shows features with respect to its structure and expression that seem to justify it to be regarded as a candidate for a gene involved in the primary processes leading to neoplastic transformation of pigment cells in Xiphophorus.
8065
urn:nbn:de:bvb:20-opus-87149
In: Trends in Ichthyology (GSF-Bericht 92,7), 1993, S. 79-92
Deutsches Urheberrecht
Manfred Schartl
J. Wittbrodt
W. Mäueler
F. Raulf
D. Adam
G. Hannig
A. Telling
F. Storch
S. Andexinger
S. M. Robertson
deu
swd
Schwertkärpfling
deu
swd
Onkogen
deu
swd
Melanom
Chemie und zugeordnete Wissenschaften
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/7264/Schartl_7264.pdf