19657
2016
eng
141-154
2
171
article
1
--
2016-12-01
--
Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis
Background: There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ T cells (Tregs) and inflammatory T-helper (Th) 17 cells has been suggested. Methods: The study aimed (1) to investigate the phenotypical and functional characteristics of Th17 and Tregs in SSc patients depending on disease manifestation (limited vs. diffuse cutaneous SSc, dcSSc) and activity, and (2) the transcriptional level and methylation status of Th17- and Treg-specific transcription factors. Results: There was a concurrent accumulation of circulating peripheral IL-17-producing CCR6+ Th cells and FoxP3+ Tregs in patients with dcSSc. At the transcriptional level, Th17- and Treg-associated transcription factors were elevated in SSc. A strong association with high circulating Th17 and Tregs was seen with early, active, and severe disease presentation. However, a diminished suppressive function on autologous lymphocytes was found in SSc-derived Tregs. Significant relative hypermethylation was seen at the gene level for RORC1 and RORC2 in SSc, particularly in patients with high inflammatory activity. Conclusions: Besides the high transcriptional activity of T cells, attributed to Treg or Th17 phenotype, in active SSc disease, Tregs may be insufficient to produce high amounts of IL-10 or to control proliferative activity of effector T cells in SSc. Our results suggest a high plasticity of Tregs strongly associated with the Th17 phenotype. Future directions may focus on enhancing Treg functions and stabilization of the Treg phenotype.
International Archives of Allergy and Immunology
1018-2438
1423-0097
10.1159/000450949
27902985
urn:nbn:de:bvb:20-opus-196577
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
swordwue
2020-01-14T14:18:46+00:00
attachment; filename=deposit.zip
c83b8f6f2bd0a0207069c72555c5d60e
International Archives of Allergy and Immunology 2016;171(2):141–154 DOI: 10.1159/000450949
false
true
Deutsches Urheberrecht
Giovanni Almanzar
Matthias Klein
Marc Schmalzing
Deborah Hilligardt
Nady El Hajj
Hermann Kneitz
Vanessa Wild
Andreas Rosenwald
Sandrine Benoit
Henning Hamm
Hans-Peter Tony
Thomas Haaf
Matthias Goebeler
Martina Prelog
eng
uncontrolled
methylation
eng
uncontrolled
systemic sclerosis
eng
uncontrolled
suppression
eng
uncontrolled
Tregs
eng
uncontrolled
Th17
Medizin und Gesundheit
open_access
Kinderklinik und Poliklinik
Pathologisches Institut
Institut für Humangenetik
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Medizinische Klinik und Poliklinik II
Import
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/19657/IAA450949.pdf
13436
2012
eng
463-465
3
87
article
1
2016-06-03
--
--
Flagellate dermatitis caused by shiitake mushrooms
Dermatite flagelada após a ingestão de fungos shiitake
Shiitake (Lentinus edodes) is the second most consumed mushroom in the world. It has long been known in Asian medicine for its anticarcinogenic, antihypertensive and serum cholesterol level reduction properties. Nevertheless, the consumption of raw or not well-cooked mushrooms may cause skin eruptions which usually occur 24 to 48 hours after ingestion and are characterized by linearly arranged pruritic erythematous papules and plaques. We present a 36-year-old patient that developed typical symptoms 24 hours after consumption of shiitake mushrooms and summarize therapeutic options and particularities of this disease.
Shiitake (Lentinus edodes) é o segundo tipo de cogumelo mais consumido no mundo. Suas propriedades terapêuticas antitumorais, anti-hipertensivas e redutoras dos níveis elevados de colesterol são há muito conhecidas pela população asiática. Após ingestão desse cogumelo, cru ou malcozido, podem desenvolver-se lesões eritematosas lineares, pruriginosas, que surgem após 24 ou 48 horas em todo o corpo. Apresentamos um paciente de 36 anos com anamnese e clínica típicos, e comentamos as alternativas terapêuticas e nuances dessa dermatose.
Anais Brasileiros de Dermatologia
10.1590/S0365-05962012000300017
urn:nbn:de:bvb:20-opus-134362
Anais Brasileiros de Dermatologia [online]. 2012, vol.87, n.3, pp.463-465. ISSN 0365-0596. http://dx.doi.org/10.1590/S0365-05962012000300017.
Lidia Marilia Poppe
Diana Anders
Hermann Kneitz
Eva-Bettina Bröcker
Sandrine Benoit
por
uncontrolled
bleomicina
por
uncontrolled
shiitake-dermatite
eng
uncontrolled
bleomycin
eng
uncontrolled
flagellate dermatitis
eng
uncontrolled
shiitake dermatitis
eng
uncontrolled
shiitake mushrooms
por
uncontrolled
dermatite flagelada
por
uncontrolled
fungos shiitake
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/13436/Poppe_v87n3a17.pdf
22507
2018
eng
1788, 1-8
9
article
1
2021-02-18
--
--
The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts
IgG3 is the IgG subclass with the strongest effector functions among all four IgG subclasses and the highest degree of allelic variability among all constant immunoglobulin genes. Due to its genetic position, IgG3 is often the first isotype an antibody switches to before IgG1 or IgG4. Compared with the other IgG subclasses, it has a reduced half-life which is probably connected to a decreased affinity to the neonatal Fc receptor (FcRn). However, a few allelic variants harbor an amino acid replacement of His435 to Arg that reverts the half-life of the resulting IgG3 to the same level as the other IgG subclasses. Because of its functional impact, we hypothesized that the p.Arg435His variation could be associated with susceptibility to autoantibody-mediated diseases like pemphigus vulgaris (PV) and bullous pemphigoid (BP). Using a set of samples from German, Turkish, Egyptian, and Iranian patients and controls, we were able to demonstrate a genetic association of the p.Arg435His variation with PV risk, but not with BP risk. Our results suggest a hitherto unknown role for the function of IgG3 in the pathogenesis of PV.
frontiers in Immunology
10.3389/fimmu.2018.01788
urn:nbn:de:bvb:20-opus-225073
publish
Front. Immunol. 9:1788.
true
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Andreas Recke
Sarah Konitzer
Susanne Lemcke
Miriam Freitag
Nele Maxi Sommer
Mohammad Abdelhady
Mahsa M. Amoli
Sandrine Benoit
Farha El-Chennawy
Mohammad Eldarouti
Rüdiger Eming
Regine Gläser
Claudia Günther
Eva Hadaschik
Bernhard Homey
Wolfgang Lieb
Wiebke K. Peitsch
Claudia Pföhler
Reza M. Robati
Marjan Saeedi
Miklós Sárdy
Michael Sticherling
Soner Uzun
Margitta Worm
Detlef Zillikens
Saleh Ibrahim
Gestur Vidarsson
Enno Schmidt
eng
uncontrolled
immunology
eng
uncontrolled
dermatology
eng
uncontrolled
autoantibodies
eng
uncontrolled
allotype
eng
uncontrolled
pemphigus
deu
swd
Diagnose
eng
uncontrolled
pemphigoid
eng
uncontrolled
half-life
eng
uncontrolled
functional genetics
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/22507/The_p.Arg435His_Variation.pdf
31839
2022
eng
798
805
6
20
article
1
--
--
--
Comorbid diseases among bullous pemphigoid patients in Germany: new insights from a case-control study
Background and objectives
Bullous pemphigoid (BP) is associated with neuropsychiatric disorders. Other comorbid diseases are discussed controversially. We evaluated the prevalence of comorbidity in BP patients in a representative area of Germany.
Patients and methods
Medical files of all BP patients treated at the Department of Dermatology, University Hospital Würzburg, Germany, between June 2002 and May 2013 were retrospectively reviewed. Bullous pemphigoid was diagnosed based on established criteria. For each patient, two controls were individually matched. Records were evaluated for age, sex, laboratory values, concomitant medication and comorbidity. Conditional logistic regression, multivariable regression analysis and complex regression models were performed to compare results.
Results
300 BP patients were identified and compared to 583 controls. Bullous pemphigoid was associated with neuropsychiatric disorders as well as laboratory abnormalities including leukocytosis and eosinophilia. Importantly, a highly significant association of BP with anemia (OR 2.127; 95 % CI 1.532–2.953) and renal impairment (OR 2.218; 95 % CI 1.643–2.993) was identified. No association was found with malignancy and arterial hypertension.
Conclusions
Our data revealed an increased frequency of anemia and renal impairment in BP patients. In accordance with previous studies the strong association for neuropsychiatric disorders was confirmed (p < 0.0005).
Journal der Deutschen Dermatologischen Gesellschaft
10.1111/ddg.14738
urn:nbn:de:bvb:20-opus-318395
@articleMartin.2022, author = Martin, Eva and Mauer, Isabell and Malzahn, Uwe and Heuschmann, Peter Ulrich and Goebeler, Matthias and Benoit, Sandrine, year = 2022, title = Comorbid diseases among bullous pemphigoid patients in Germany: new insights from a case-control study, pages = 798–805, volume = 20, number = 6, journal = Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, doi = 10.1111/ddg.14738,
md5:c13d312f8fdd006d4b43312bf62dab6d
2023-06-06T13:36:06+00:00
/tmp/php1lzkKJ
bibtex
647f364608ee77.52690593
Journal der Deutschen Dermatologischen Gesellschaft 2022, 20(6):798-805. DOI: 10.1111/ddg.14738
false
true
CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell 4.0 International
Eva Martin
Isabell Mauer
Uwe Malzahn
Peter Ulrich Heuschmann
Matthias Goebeler
Sandrine Benoit
eng
uncontrolled
bullous pemphigoid
eng
uncontrolled
comorbid diseases
eng
uncontrolled
Germany
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Institut für Klinische Epidemiologie und Biometrie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/31839/Martin_JDDG.pdf
14918
2015
eng
596-599
95
article
1
2017-05-24
--
--
Mepacrine in recalcitrant cutaneous lupus erythematosus: old-fashioned or still useful?
Treatment of recalcitrant cutaneous lupus erythematosus (CLE) is challenging. In situations where conventional treatment approaches fail mepacrine - an antimalarial/antiinfiammatory drug that has fallen into oblivion in the last decades might still be a promising option. We retrospectively analysed medical records of 10 patients with refractory CLE that were treated with mepacrine (100-200 mg/day) as mono- or combination therapy for various time intervals between 2001 and 2013 at the University Hospital Wurzburg. Mepacrine was generally well tolerated. Side effects were mild and usually resolved after reduction or cessation. Over 50% of the patients experienced amelioration of their symptoms despite a previously recalcitrant clinical course. Altogether, our data demonstrate that mepacrine still remains a useful and effective therapeutic option for otherwise treatment-resistant CLE.
Acta Dermato-Venereologica
10.2340/00015555-2031
urn:nbn:de:bvb:20-opus-149181
Acta Dermato-Venereologica 2015; 95: 596–599. DOI: 10.2340/00015555-2031
CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell 4.0 International
Sandrine Benoit
Matthias Goebeler
eng
uncontrolled
classification
eng
uncontrolled
therapy
eng
uncontrolled
cutaneous lupus erythematosus
eng
uncontrolled
quinacrine
eng
uncontrolled
mepacrine
eng
uncontrolled
smoking
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/14918/063_Benoit_Acta_Dermato_Venereologica.pdf
17619
2018
eng
660-666
98
article
1
2019-02-08
--
--
Structured diagnostic approach and risk assessment in mucous membrane pemphigoid with oesophageal involvement
Oesophageal involvement in mucous membrane pemphigoid is considered rare, but it may be underdiagnosed. To assess the incidence of oesophageal involvement in a group of patients with newly diagnosed mucous membrane pemphigoid we retrospectively analysed the medical records of 30 consecutive patients with mucous membrane pemphigoid diagnosed between 2006 and 2016 at the Department of Dermatology, University Hospital Würzburg. Twenty-one patients (70%) reported symptoms indicative of oesophageal mucous membrane pemphigoid. Twelve patients (40%) underwent oesophagogastroduodenoscopy, and oesophageal pathology compatible with mucous membrane pemphigoid was endoscopically found in 9 cases (30%). In all patients indirect and direct immunofluorescence were performed. Patients with and without oesophageal involvement did not differ with regard to the results of indirect immunofluorescence on salt-split human skin and monkey oesophagus. Study results demonstrate the necessity of a standardized diagnostic work-up, including adequate tissue samples for direct immunofluorescence, to prevent underdiagnosis of oesophageal mucous membrane pemphigoid.
Acta Dermato-Venereologica
10.2340/00015555-2938
urn:nbn:de:bvb:20-opus-176191
Acta Dermato-Venereologica 2018; 98; 660-666. DOI: 10.2340/00015555-2938
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Sandrine Benoit
Michael Scheurlen
Matthias Goebeler
Johanna Stoevesandt
eng
uncontrolled
cicatricial pemphigoid
eng
uncontrolled
mucous membrane pemphigoid
eng
uncontrolled
oesophagogastroduodenoscopy
eng
uncontrolled
laminin 332
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Medizinische Klinik und Poliklinik II
Förderzeitraum 2018
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/17619/Benoit_Acta_Dermatovenereologica.pdf