12667
2012
eng
14
4
article
1
2016-02-03
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Neurovascular pathophysiology in cerebral ischemia, dementia and the ageing brain – current trends in basic, translational and clinical research
The 7th International Symposium on Neuroprotection and Neurorepair was held from May 2nd to May 5th, 2012 in Potsdam, Germany. The symposium, which directly continues the successful Magdeburg meeting series, attracted over 330 colleagues from 29 countries to discuss recent findings and advances in the field. The focus of the 2012 symposium was widened from stroke and traumatic brain injury to neurodegenerative diseases, notably dementia, and more generally the ageing brain. Thereby, emphasis was given on neurovascular aspects of neurodegeneration and stroke including the blood–brain barrier, recent findings regarding the pathomechanism of Alzheimer’s disease, and brain imaging approaches. In addition, neurobiochemical aspects of neuroprotection, the role of astrogliosis, the clinical progress of cell-based approaches as well as translational hurdles and opportunities were discussed in-depth. This review summarizes some of the most stimulating discussions and reports from the meeting.
Experimental & Translational Stroke Medicine
doi:10.1186/2040-7378-4-14
urn:nbn:de:bvb:20-opus-126679
Experimental & Translational Stroke Medicine 2012, 4:14. doi:10.1186/2040-7378-4-14
Johannes Boltze
Christoph Kleinschnitz
Klaus G. Reymann
Georg Reiser
Daniel-Christoph Wagner
Alexander Kranz
Dominik Michalski
eng
uncontrolled
translational research
eng
uncontrolled
small vessel disease
eng
uncontrolled
Alzheimer’s disease
eng
uncontrolled
cerebral ischemia
eng
uncontrolled
neurorepair
eng
uncontrolled
neuroprotection
eng
uncontrolled
vascular dementia
eng
uncontrolled
mitochondria
eng
uncontrolled
astrogliosis
eng
uncontrolled
in vivo imaging
Medizin und Gesundheit
open_access
Neurologische Klinik und Poliklinik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12667/Boltze_2040-7378-4-14.pdf
14408
2015
eng
36
10
article
1
2017-02-08
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Distinct increased outliers among 136 rectal cancer patients assessed by \(\gamma\)H2AX
Background:
In recent years attention has focused on \(\gamma\)H2AX as a very sensitive double strand break indicator. It has been suggested that \(\gamma\)H2AX might be able to predict individual radiosensitivity. Our aim was to study the induction and repair of DNA double strand breaks labelled by \(\gamma\)H2AX in a large cohort.
Methods:
In a prospective study lymphocytes of 136 rectal cancer (RC) patients and 59 healthy individuals were ex vivo irradiated (IR) and initial DNA damage was compared to remaining DNA damage after 2 Gy and 24 hours repair time and preexisting DNA damage in unirradiated lymphocytes. Lymphocytes were immunostained with anti-\(\gamma\)H2AX antibodies and microscopic images with an extended depth of field were acquired. \(\gamma\)H2AX foci counting was performed using a semi-automatic image analysis software.
Results:
Distinct increased values of preexisting and remaining \(\gamma\)H2AX foci in the group of RC patients were found compared to the healthy individuals. Additionally there are clear differences within the groups and there are outliers in about 12% of the RC patients after ex vivo IR.
Conclusions:
The \(\gamma\)H2AX assay has the capability to identify a group of outliers which are most probably patients with increased radiosensitivity having the highest risk of suffering radiotherapy-related late sequelae.
Radiation Oncology
10.1186/s13014-015-0344-5
urn:nbn:de:bvb:20-opus-144085
Radiation Oncology (2015) 10:36. DOI: 10.1186/s13014-015-0344-5
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Jana Kroeber
Barbara Wenger
Manuela Schwegler
Christoph Daniel
Manfred Schmidt
Cholpon S Djuzenova
Bülent Polat
Michael Flentje
Rainer Fietkau
Luitpold V. Distel
eng
uncontrolled
histone H2AX
eng
uncontrolled
blood lymphocytes
eng
uncontrolled
in vivo
eng
uncontrolled
foci
eng
uncontrolled
individual radiosensitivity
eng
uncontrolled
rectal cancer
eng
uncontrolled
radiotherapy
eng
uncontrolled
DNA double strand breaks
eng
uncontrolled
phosphorylation
eng
uncontrolled
neck cancer
eng
uncontrolled
oral mucositis
eng
uncontrolled
DNA damage
eng
uncontrolled
radiosensitivity
eng
uncontrolled
repair
eng
uncontrolled
\(\gamma\)h2ax
Medizin und Gesundheit
open_access
Klinik und Poliklinik für Strahlentherapie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/14408/054_Kroeber_Radiation_Oncology.pdf