16500
2016
eng
e19686
5
article
1
2018-07-20
--
--
Stereotyped responses of Drosophila peptidergic neuronal ensemble depend on downstream neuromodulators
Neuropeptides play a key role in the regulation of behaviors and physiological responses including alertness, social recognition, and hunger, yet, their mechanism of action is poorly understood. Here, we focus on the endocrine control ecdysis behavior, which is used by arthropods to shed their cuticle at the end of every molt. Ecdysis is triggered by ETH (Ecdysis triggering hormone), and we show that the response of peptidergic neurons that produce CCAP (crustacean cardioactive peptide), which are key targets of ETH and control the onset of ecdysis behavior, depends fundamentally on the actions of neuropeptides produced by other direct targets of ETH and released in a broad paracrine manner within the CNS; by autocrine influences from the CCAP neurons themselves; and by inhibitory actions mediated by GABA. Our findings provide insights into how this critical insect behavior is controlled and general principles for understanding how neuropeptides organize neuronal activity and behaviors.
eLife
10.7554/eLife.19686
urn:nbn:de:bvb:20-opus-165003
eLife 2016;5:e19686
false
true
Wilson Mena
Sören Diegelmann
Christian Wegener
John Ewer
eng
uncontrolled
neuropeptides
Biowissenschaften; Biologie
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/16500/041_Mena_ELIFE.pdf
17083
2017
eng
15563
8
article
1
2018-10-31
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--
Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila
Animal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology and behaviour. Despite its importance for optimal performance and health, the mechanism of clock coordination is poorly understood. Here we dissect the pathway through which the circadian clock of Drosophila imposes daily rhythmicity to the pattern of adult emergence. Rhythmicity depends on the coupling between the brain clock and a peripheral clock in the prothoracic gland (PG), which produces the steroid hormone, ecdysone. Time information from the central clock is transmitted via the neuropeptide, sNPF, to non-clock neurons that produce the neuropeptide, PTTH. These secretory neurons then forward time information to the PG clock. We also show that the central clock exerts a dominant role on the peripheral clock. This use of two coupled clocks could serve as a paradigm to understand how daily steroid hormone rhythms are generated in animals.
Nature Communications
10.1038/ncomms15563
28555616
urn:nbn:de:bvb:20-opus-170831
Nature Communications 2017, 8:15563. DOI: 10.1038/ncomms15563
false
true
CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International
Mareike Selcho
Carola Millán
Angelina Palacios-Muñoz
Franziska Ruf
Lilian Ubillo
Jiangtian Chen
Gregor Bergmann
Chihiro Ito
Valeria Silva
Christian Wegener
John Ewer
eng
uncontrolled
circadian clock
eng
uncontrolled
Drosophila
eng
uncontrolled
neuropeptide pathway
eng
uncontrolled
peripheral clocks
eng
uncontrolled
central clocks
Biowissenschaften; Biologie
open_access
Theodor-Boveri-Institut für Biowissenschaften
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/17083/068_Selcho_NATURE-COMMUNICATIONS.pdf