12622
2012
eng
2759-2767
9
32
article
1
2016-01-29
--
--
Impact of patient and disease characteristics on therapeutic success during adalimumab treatment of patients with rheumatoid arthritis: data from a German
The objective of this study was to use data from a noninterventional study to evaluate the effectiveness of adalimumab in rheumatoid arthritis (RA) patients during routine clinical practice and to explore the potential impact of patient and disease characteristics in response to adalimumab therapy. A total of 2,625 RA patients with specified data at baseline (prior to initiating adalimumab treatment) and 12 months entered this study between April 2003 and March 2009. We evaluated response to adalimumab therapy and conducted stepwise regression and subgroup analyses of factors influencing therapeutic response. During the 1-year adalimumab treatment period, disease activity decreased from a baseline mean disease activity score-28 joints (DAS28) of 5.9–3.9, while functional capacity improved from 59.0 to 68.4 Funktionsfragebogen Hannover (FFbH) percentage points. In multivariate regression models, high baseline DAS28 was the strongest positive predictor for decrease in disease activity, and high baseline functional capacity was associated with reduced gains in functional capacity. Male gender was a positive predictor of therapeutic response for both disease activity and functional capacity, while older age and multiple previous biologics were associated with a reduced therapeutic response. Subset analyses provided further support for the impact of baseline DAS28, FFbH, and prior biologic therapy on therapeutic response during treatment. We conclude that treatment with adalimumab leads to decreased disease activity and improved function during routine clinical practice. Patients with high disease activity and low functional capacity are particularly benefitted by adalimumab therapy.
Rheumatology International
10.1007/s00296-011-2033-5
urn:nbn:de:bvb:20-opus-126220
Rheumatology International (2012) 32:2759–2767 DOI 10.1007/s00296-011-2033-5
Stefan Kleinert
Hans-Peter Tony
Andreas Krause
Martin Feuchtenberger
Siegfried Wassenberg
Constanze Richter
Ekkehard Röther
Wolfgang Spieler
Holger Gnann
Bianca M. Wittig
eng
uncontrolled
antirheumatic agents
eng
uncontrolled
adalimumab
eng
uncontrolled
rheumatoid arthritis
eng
uncontrolled
treatment outcome
eng
uncontrolled
regression analysis
Medizin und Gesundheit
open_access
Medizinische Klinik und Poliklinik II
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12622/296_2011_Article_2033.pdf
12511
2012
eng
2759-2767
9
32
article
1
2016-01-25
--
--
Impact of patient and disease characteristics on therapeutic success during adalimumab treatment of patients with rheumatoid arthritis: data from a German noninterventional observational study
The objective of this study was to use data from a noninterventional study to evaluate the effectiveness of adalimumab in rheumatoid arthritis (RA) patients during routine clinical practice and to explore the potential impact of patient and disease characteristics in response to adalimumab therapy. A total of 2,625 RA patients with specified data at baseline (prior to initiating adalimumab treatment) and 12 months entered this study between April 2003 and March 2009. We evaluated response to adalimumab therapy and conducted stepwise regression and subgroup analyses of factors influencing therapeutic response. During the 1-year adalimumab treatment period, disease activity decreased from a baseline mean disease activity score-28 joints (DAS28) of 5.9–3.9, while functional capacity improved from 59.0 to 68.4 Funktionsfragebogen Hannover (FFbH) percentage points. In multivariate regression models, high baseline DAS28 was the strongest positive predictor for decrease in disease activity, and high baseline functional capacity was associated with reduced gains in functional capacity. Male gender was a positive predictor of therapeutic response for both disease activity and functional capacity, while older age and multiple previous biologics were associated with a reduced therapeutic response. Subset analyses provided further support for the impact of baseline DAS28, FFbH, and prior biologic therapy on therapeutic response during treatment. We conclude that treatment with adalimumab leads to decreased disease activity and improved function during routine clinical practice. Patients with high disease activity and low functional capacity are particularly benefitted by adalimumab therapy.
Rheumatology International
10.1007/s00296-011-2033-5
urn:nbn:de:bvb:20-opus-125118
Rheumatology International (2012) 32:2759–2767 DOI 10.1007/s00296-011-2033-5
Stefan Kleinert
Hans-Peter Tony
Andreas Krause
Martin Feuchtenberger
Siegfried Wassenberg
Constanze Richter
Ekkehard Räther
Wolfgang Spieler
Holger Gnann
Bianca M. Wittig
eng
uncontrolled
antirheumatic agents
eng
uncontrolled
arthritis
eng
uncontrolled
adalimumab
eng
uncontrolled
rheumatoid
eng
uncontrolled
treatment outcome
eng
uncontrolled
regression analysis
Krankheiten
open_access
Medizinische Klinik und Poliklinik II
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12511/Kleinert_2Fs00296-011-2033-5.pdf