12810
2015
eng
doctoralthesis
1
2016-02-28
--
2016-02-18
Valuation Algorithms for Structural Models of Financial Networks
Algorithmen zur Bestimmung von Gleichgewichtslösungen in Finanzsystemen mit Kapitalverflechtung
The thesis focuses on the valuation of firms in a system context where cross-holdings of the firms in liabilities and equities are allowed and, therefore, systemic risk can be modeled on a structural level. A main property of such models is that for the determination of the firm values a pricing equilibrium has to be found. While there exists a small but growing amount of research on the existence and the uniqueness of such price equilibria, the literature is still somewhat inconsistent. An example for this fact is that different authors define the underlying financial system on differing ways. Moreover, only few articles pay intense attention on procedures to find the pricing equilibria. In the existing publications, the provided algorithms mainly reflect the individual authors' particular approach to the problem. Additionally, all existing methods do have the drawback of potentially infinite runtime.
For these reasons, the objects of this thesis are as follows. First, a definition of a financial system is introduced in its most general form in Chapter 2. It is shown that under a fairly mild regularity condition the financial system has a unique existing payment equilibrium. In Chapter 3, some extensions and differing definitions of financial systems that exist in literature are presented and it is shown how these models can be embedded into the general model from the proceeding chapter. Second, an overview of existing valuation algorithms to find the equilibrium is given in Chapter 4, where the existing methods are generalized and their corresponding mathematical properties are highlighted. Third, a complete new class of valuation algorithms is developed in Chapter 4 that includes the additional information whether a firm is in default or solvent under a current payment vector. This results in procedures that are able find the solution of the system in a finite number of iteration steps. In Chapter 5, the developed concepts of Chapter 4 are applied to more general financial systems where more than one seniority level of debt is present. Chapter 6 develops optimal starting vectors for non-finite algorithms and Chapter 7 compares the existing and the new developed algorithms concerning their efficiency in an extensive simulation study covering a wide range of possible settings for financial systems.
Die vorliegende Dissertation hat die Unternehmensbewertung in Finanzsystemen mit Fremd- und Eigenkapitalverflechtung zum Thema. Die zentrale Eigenschaft dieser Modelle ist, dass zur Bestimmung der Firmenwerte eine Gleichgewichtslösung ermittelt werden muss. Die Zahl der Veröffentlichungen mit dem Schwerpunkt des Nachweises von Existenz- und Eindeutigkeitsaussagen der Gleichgewichte steigt zwar stetig an, allerdings ist die Fachliteratur in diesem Bereich teilweise noch sehr inkonsistent. Beispielsweise existieren je nach Autor unterschiedliche Vorgehensweisen, das zugrunde liegende Finanzsystem zu definieren. Darüber hinaus schenken nur wenige Fachartikel der Frage Beachtung, wie die Lösungsgleichgewichte genau bestimmt werden können. Zuletzt weisen die bereits entwickelten Verfahren den Nachteil auf, dass Sie womöglich unendlich viele Iterationsschritte benötigen bis die gesuchte Lösung exakt erreicht wird.
Aus diesen Gründen beinhaltet die vorliegende Dissertation folgende Themen. Im ersten Schritt wird in Kapitel 2 eine möglichst allgemeine Definition eines Finanzsystems eingeführt. Es wird gezeigt dass unter nicht allzu strengen Voraussetzungen die Gleichgewichtslösung dieses Systems eindeutig bestimmt ist. In Kapitel 3 werden in der Fachliteratur zu diesem Thema zu findende Erweiterungen und abweichende Definitionen des Systems vorgestellt und wie diese in das allgemeine Modell aus dem vorherigen Kapitel eingebettet werden können. Danach wird in Kapitel 4 ein Überblick über bereits entwickelte Lösungsverfahren gegeben, wobei die existierenden Prozeduren in ihrem Vorgehen verallgemeinert und deren zugehörige mathematische Eigenschaften aufgezeigt werden. Des weiteren wird im gleichen Kapitel eine komplett neue Klasse von Lösungsverfahren entwickelt, die noch die zusätzliche Information verarbeiten, ob eine Firma für einen gegebenen Zahlungsvektor solvent oder insolvent ist. Als Folge dieses Ansatzes sind diese Algorithmen in der Lage, die exakte Gleichgewichtslösung des Systems in endlich vielen Schritten zu finden. In Kapitel 5 werden die entworfenen Konzepte dann für Finanzsysteme angewendet, in denen mehr als nur eine Schulden-Seniorität berücksichtigt wird. Kapitel 6 leitet optimale Startvektoren der nicht-endlichen Verfahren her und Kapitel 7 vergleicht die bereits existierenden und alle neu entwickelten Lösungsverfahren bezüglich ihrer Laufzeiteffizienz im Rahmen einer ausführlichen Simulationsstudie.
urn:nbn:de:bvb:20-opus-128108
X 126970
Deutsches Urheberrecht mit Print on Demand
Johannes Hain
deu
swd
Risikomanagement
deu
swd
Finanzmathematik
eng
uncontrolled
Financial Networks
eng
uncontrolled
Counterparty Risk
eng
uncontrolled
Numerical Asset Valuation
eng
uncontrolled
Systemic Risk
eng
uncontrolled
Structrual Model
deu
uncontrolled
Unternehmensbewertung
deu
uncontrolled
Kapitalverflechtung
deu
uncontrolled
Finanzielle Netzwerke
deu
uncontrolled
Systemisches Risiko
Mathematik
open_access
Institut für Mathematik
Universität Würzburg
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12810/Hain_Johannes_Networks.pdf
14926
2015
eng
753-761
93
article
1
2017-05-24
--
--
Trabeculectomy versus canaloplasty (TVC study) in the treatment of patients with open-angle glaucoma: a prospective randomized clinical trial
Purpose: To compare the outcomes of canaloplasty and trabeculectomy in open-angle glaucoma.
Methods: This prospective, randomized clinical trial included 62 patients who randomly received trabeculectomy (n = 32) or canaloplasty (n = 30) and were followed up prospectively for 2 years. Primary endpoint was complete (without medication) and qualified success (with or without medication) defined as an intraocular pressure (IOP) of ≤18 mmHg (definition 1) or IOP ≤21 mmHg and ≥20% IOP reduction (definition 2), IOP ≥5 mmHg, no vision loss and no further glaucoma surgery. Secondary endpoints were the absolute IOP reduction, visual acuity, medication, complications and second surgeries.
Results: Surgical treatment significantly reduced IOP in both groups (p < 0.001). Complete success was achieved in 74.2% and 39.1% (definition 1, p = 0.01), and 67.7% and 39.1% (definition 2, p = 0.04) after 2 years in the trabeculectomy and canaloplasty group, respectively. Mean absolute IOP reduction was 10.8 ± 6.9 mmHg in the trabeculectomy and 9.3 ± 5.7 mmHg in the canaloplasty group after 2 years (p = 0.47). Mean IOP was 11.5 ± 3.4 mmHg in the trabeculectomy and 14.4 ± 4.2 mmHg in the canaloplasty group after 2 years. Following trabeculectomy, complications were more frequent including hypotony (37.5%), choroidal detachment (12.5%) and elevated IOP (25.0%).
Conclusions: Trabeculectomy is associated with a stronger IOP reduction and less need for medication at the cost of a higher rate of complications. If target pressure is attainable by moderate IOP reduction, canaloplasty may be considered for its relative ease of postoperative care and lack of complications.
Acta Ophthalmologica
10.1111/aos.12722
urn:nbn:de:bvb:20-opus-149263
Acta Ophthalmologica 2015, 93, 753-761. DOI: 10.1111/aos.12722
CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International
Juliane Matlach
Christine Dhillon
Johannes Hain
Günther Schlunck
Franz Grehn
Thomas Klink
eng
uncontrolled
months follow-up
eng
uncontrolled
surgical outcomes
eng
uncontrolled
mitomycin C
eng
uncontrolled
canaloplasty
eng
uncontrolled
open-angle glaucoma
eng
uncontrolled
trabeculectomy
eng
uncontrolled
glaucoma surgery
eng
uncontrolled
series
eng
uncontrolled
phacocanaloplasty
eng
uncontrolled
phacotrabeculectomy
eng
uncontrolled
canal surgery
eng
uncontrolled
cataract surgery
eng
uncontrolled
flexible microcatheter
eng
uncontrolled
circumferential viscodilation
Medizin und Gesundheit
open_access
Institut für Mathematik
Augenklinik und Poliklinik
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/14926/070_Matlach_Acta_Ophthalmologica.pdf
9680
2013
eng
article
1
--
--
--
Single venom-based immunotherapy effectively protects patients with double positive tests to honey bee and Vespula venom
Background
Referring to individuals with reactivity to honey bee and Vespula venom in diagnostic tests, the umbrella terms “double sensitization” or “double positivity” cover patients with true clinical double allergy and those allergic to a single venom with asymptomatic sensitization to the other. There is no international consensus on whether immunotherapy regimens should generally include both venoms in double sensitized patients.
Objective
We investigated the long-term outcome of single venom-based immunotherapy with regard to potential risk factors for treatment failure and specifically compared the risk of relapse in mono sensitized and double sensitized patients.
Methods
Re-sting data were obtained from 635 patients who had completed at least 3 years of immunotherapy between 1988 and 2008. The adequate venom for immunotherapy was selected using an algorithm based on clinical details and the results of diagnostic tests.
Results
Of 635 patients, 351 (55.3%) were double sensitized to both venoms. The overall re-exposure rate to Hymenoptera stings during and after immunotherapy was 62.4%; the relapse rate was 7.1% (6.0% in mono sensitized, 7.8% in double sensitized patients). Recurring anaphylaxis was statistically less severe than the index sting reaction (P = 0.004). Double sensitization was not significantly related to relapsing anaphylaxis (P = 0.56), but there was a tendency towards an increased risk of relapse in a subgroup of patients with equal reactivity to both venoms in diagnostic tests (P = 0.15).
Conclusions
Single venom-based immunotherapy over 3 to 5 years effectively and long-lastingly protects the vast majority of both mono sensitized and double sensitized Hymenoptera venom allergic patients. Double venom immunotherapy is indicated in clinically double allergic patients reporting systemic reactions to stings of both Hymenoptera and in those with equal reactivity to both venoms in diagnostic tests who have not reliably identified the culprit stinging insect.
Allergy, Asthma & Clinical Immunology
10.1186/1710-1492-9-33
http://www.aacijournal.com/content/9/1/33
urn:nbn:de:bvb:20-opus-96808
In: Allergy, Asthma & Clinical Immunology (2013) 9: 33, doi:10.1186/1710-1492-9-33
Johanna Stoevesandt
Bernd Hofmann
Johannes Hain
Andreas Kerstan
Axel Trautmann
eng
uncontrolled
Anaphylaxis
eng
uncontrolled
Double sensitization
eng
uncontrolled
Field sting
eng
uncontrolled
Honey bee
eng
uncontrolled
Hymenoptera venom
eng
uncontrolled
Immunotherapy
eng
uncontrolled
Relapse
eng
uncontrolled
Risk factor
eng
uncontrolled
Treatment failure
eng
uncontrolled
Vespula
Medizin und Gesundheit
open_access
Institut für Mathematik
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Förderzeitraum 2013
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/9680/Stoevesandt_1710-1492-9-33.pdf
11039
2014
eng
article
1
2015-02-26
--
--
Non-steroidal anti-inflammatory drug hypersensitivity: association with elevated basal serum tryptase?
Background
It is hypothesized that because of higher mast cell numbers and mediator release, mastocytosis predisposes patients for systemic immediate-type hypersensitivity reactions to certain drugs including non-steroidal anti-inflammatory drugs (NSAID).
Objective
To clarify whether patients with NSAID hypersensitivity show increased basal serum tryptase levels as sign for underlying mast cell disease.
Methods
As part of our allergy work-up, basal serum tryptase levels were determined in all patients with a diagnosis of NSAID hypersensitivity and the severity of the reaction was graded. Patients with confirmed IgE-mediated hymenoptera venom allergy served as a comparison group.
Results
Out of 284 patients with NSAID hypersensitivity, 26 were identified with basal serum tryptase > 10.0 ng/mL (9.2%). In contrast, significantly (P = .004) more hymenoptera venom allergic patients had elevated tryptase > 10.0 ng/mL (83 out of 484; 17.1%). Basal tryptase > 20.0 ng/mL was indicative for severe anaphylaxis only in venom allergic subjects (29 patients; 4x grade 2 and 25x grade 3 anaphylaxis), but not in NSAID hypersensitive patients (6 patients; 4x grade 1, 2x grade 2).
Conclusions
In contrast to hymenoptera venom allergy, NSAID hypersensitivity do not seem to be associated with elevated basal serum tryptase levels and levels > 20 ng/mL were not related to increased severity of the clinical reaction. This suggests that mastocytosis patients may be treated with NSAID without special precautions.
10.1186/1710-1492-10-19
urn:nbn:de:bvb:20-opus-110399
In: Allergy, Asthma & Clinical Immunology 2014, 10:19. doi:10.1186/1710-1492-10-19
Axel Trautmann
Cornelia S. Seitz
Knut Brockow
Johannes Hain
eng
uncontrolled
Anaphylaxis
eng
uncontrolled
Non-steroidal anti-inflammatory drug
eng
uncontrolled
Mastocytosis
eng
uncontrolled
Drug allergy
eng
uncontrolled
Drug reaction
eng
uncontrolled
Pseudo-allergy
Medizin und Gesundheit
open_access
Institut für Mathematik
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie
Förderzeitraum 2014
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/11039/058_Trautmann_AllergyAsthma.pdf
13238
2013
eng
1411-1419
120
article
1
2016-04-18
--
--
Increases in CSF dopamine in HIV patients are due to the dopamine transporter 10/10-repeat allele which is more frequent in HIV-infected individuals
Dysfunction of dopaminergic neurotransmission has been implicated in HIV infection. We showed previously increased dopamine (DA) levels in CSF of therapy-naïve HIV patients and an inverse correlation between CSF DA and CD4 counts in the periphery, suggesting adverse effects of high levels of DA on HIV infection. In the current study including a total of 167 HIV-positive and negative donors from Germany and South Africa (SA), we investigated the mechanistic background for the increase of CSF DA in HIV individuals. Interestingly, we found that the DAT 10/10-repeat allele is present more frequently within HIV individuals than in uninfected subjects. Logistic regression analysis adjusted for gender and ethnicity showed an odds ratio for HIV infection in DAT 10/10 allele carriers of 3.93 (95 % CI 1.72–8.96; p = 0.001, Fishers exact test). 42.6 % HIV-infected patients harbored the DAT 10/10 allele compared to only 10.5 % uninfected DAT 10/10 carriers in SA (odds ratio 6.31), whereas 68.1 versus 40.9 %, respectively, in Germany (odds ratio 3.08). Subjects homozygous for the 10-repeat allele had higher amounts of CSF DA and reduced DAT mRNA expression but similar disease severity compared with those carrying other DAT genotypes. These intriguing and novel findings show the mutual interaction between DA and HIV, suggesting caution in the interpretation of CNS DA alterations in HIV infection solely as a secondary phenomenon to the virus and open the door for larger studies investigating consequences of the DAT functional polymorphism on HIV epidemiology and progression of disease.
Journal of Neural Transmission
10.1007/s00702-013-1086-x
urn:nbn:de:bvb:20-opus-132385
Journal of Neural Transmission (2013) 120:1411–1419 DOI 10.1007/s00702-013-1086-x
Anne Horn
Carsten Scheller
Stefan du Plessis
Gabriele Arendt
Thorsten Nolting
John Joska
Sieghart Sopper
Matthias Maschke
Mark Obermann
Ingo W. Husstedt
Johannes Hain
Tongai Maponga
Peter Riederer
Eleni Koutsilieri
eng
uncontrolled
HIV
eng
uncontrolled
HAND
eng
uncontrolled
dopamine
eng
uncontrolled
DAT
eng
uncontrolled
polymorphism
eng
uncontrolled
CSF
Krankheiten
open_access
Institut für Mathematik
Institut für Virologie und Immunbiologie
Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/13238/153_Horn_Journal_of_Neural_Transmission.pdf
14647
2016
eng
e0146678
1
11
article
1
2017-03-31
--
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Effects of Prednisolone on Disease Progression in Antiretroviral-Untreated HIV Infection: A 2-Year Randomized, Double-Blind Placebo-Controlled Clinical Trial
Background
HIV-disease progression correlates with immune activation. Here we investigated whether corticosteroid treatment can attenuate HIV disease progression in antiretroviral-untreated patients.
Methods
Double-blind, placebo-controlled randomized clinical trial including 326 HIV-patients in a resource-limited setting in Tanzania (clinicaltrials.gov NCT01299948). Inclusion criteria were a CD4 count above 300 cells/μl, the absence of AIDS-defining symptoms and an ART-naïve therapy status. Study participants received 5 mg prednisolone per day or placebo for 2 years. Primary endpoint was time to progression to an AIDS-defining condition or to a CD4-count below 200 cells/μl.
Results
No significant change in progression towards the primary endpoint was observed in the intent-to-treat (ITT) analysis (19 cases with prednisolone versus 28 cases with placebo, p = 0.1407). In a per-protocol (PP)-analysis, 13 versus 24 study participants progressed to the primary study endpoint (p = 0.0741). Secondary endpoints: Prednisolone-treatment decreased immune activation (sCD14, suPAR, CD38/HLA-DR/CD8+) and increased CD4-counts (+77.42 ± 5.70 cells/μl compared to -37.42 ± 10.77 cells/μl under placebo, p < 0.0001). Treatment with prednisolone was associated with a 3.2-fold increase in HIV viral load (p < 0.0001). In a post-hoc analysis stratifying for sex, females treated with prednisolone progressed significantly slower to the primary study endpoint than females treated with placebo (ITT-analysis: 11 versus 21 cases, p = 0.0567; PP-analysis: 5 versus 18 cases, p = 0.0051): No changes in disease progression were observed in men.
Conclusions
This study could not detect any significant effects of prednisolone on disease progression in antiretroviral-untreated HIV infection within the intent-to-treat population. However, significant effects were observed on CD4 counts, immune activation and HIV viral load. This study contributes to a better understanding of the role of immune activation in the pathogenesis of HIV infection.
PLoS One
10.1371/journal.pone.0146678
urn:nbn:de:bvb:20-opus-146479
PLoS ONE 11(1): e0146678. doi:10.1371/journal.pone.0146678
Christa Kasang
Samuel Kalluvya
Charles Majinge
Gilbert Kongola
Mathias Mlewa
Irene Massawe
Rogatus Kabyemera
Kinanga Magambo
Albrecht Ulmer
Hartwig Klinker
Eva Gschmack
Anne Horn
Eleni Koutsilieri
Wolfgang Preiser
Daniela Hofmann
Johannes Hain
Andreas Müller
Lars Dölken
Benedikt Weissbrich
Axel Rethwilm
August Stich
Carsten Scheller
eng
uncontrolled
HIV
eng
uncontrolled
immune activation
eng
uncontrolled
viral load
eng
uncontrolled
drug adherence
eng
uncontrolled
viral replication
eng
uncontrolled
AIDS
eng
uncontrolled
HIV infections
eng
uncontrolled
highly-active antiretroviral therapy
Medizin und Gesundheit
open_access
Institut für Mathematik
Institut für Virologie und Immunbiologie
Medizinische Klinik und Poliklinik II
Förderzeitraum 2016
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/14647/054_Scheller_journal.pone.0146678.pdf
12497
2015
eng
25
10
article
1
2016-01-22
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Different duration strategies of perioperative antibiotic prophylaxis in adult patients undergoing cardiac surgery: an observational study
Background
All international guidelines recommend perioperative antibiotic prophylaxis (PAB) should be routinely administered to patients undergoing cardiac surgery. However, the duration of PAB is heterogeneous and controversial.
Methods
Between 01.01.2011 and 31.12.2011, 1096 consecutive cardiac surgery patients were assigned to one of two groups receiving PAB with a second-generation cephalosporin for either 56 h (group I) or 32 h (group II). Patients’ characteristics, intraoperative data, and the in-hospital follow-up were analysed. Primary endpoint was the incidence of surgical site infection (deep and superficial sternal wound-, and vein harvesting site infection; DSWI/SSWI/VHSI). Secondary endpoints were the incidence of respiratory-, and urinary tract infection, as well as the mortality rate.
Results
615/1096 patients (56,1%) were enrolled (group I: n = 283 versus group II: n = 332). There were no significant differences with regard to patient characteristics, comorbidities, and procedure-related variables. No statistically significant differences were demonstrated concerning primary and secondary endpoints. The incidence of DSWI/SSWI/VHSI were 4/283 (1,4%), 5/283 (1,7%), and 1/283 (0,3%) in group I versus 6/332 (1,8%), 9/332 (2,7%), and 3/332 (0,9%) in group II (p = 0,76/0,59/0,63). In univariate analyses female gender, age, peripheral arterial obstructive disease, operating-time, ICU-duration, transfusion, and respiratory insufficiency were determinants for nosocomial infections (all ≤ 0,05). Subgroup analyses of these high-risk patients did not show any differences between the two regimes (all ≥ 0,05).
Conclusions
Reducing the duration of PAB from 56 h to 32 h in adult cardiac surgery patients was not associated with an increase of nosocomial infection rate, but contributes to reduce antibiotic resistance and health care costs.
Journal of Cardiothoracic Surgery
10.1186/s13019-015-0225-x
urn:nbn:de:bvb:20-opus-124977
Journal of Cardiothoracic Surgery (2015) 10:25 DOI 10.1186/s13019-015-0225-x
Khaled Hamouda
Mehmet Oezkur
Bhanu Sinha
Johannes Hain
Hannah Menkel
Marcus Leistner
Rainer Leyh
Christoph Schimmer
eng
uncontrolled
nosocomial infection
eng
uncontrolled
cardiac surgery
eng
uncontrolled
antibiotic prophylaxis
Chirurgie und verwandte medizinische Fachrichtungen
open_access
Institut für Informatik
Klinik und Poliklinik für Thorax-, Herz- u. Thorakale Gefäßchirurgie
Förderzeitraum 2015
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/12497/Schimmer_s13019-015-0225-x.pdf
9673
2013
eng
article
1
--
--
--
Chlamydia trachomatis Infection Induces Replication of Latent HHV-6
Human herpesvirus-6 (HHV-6) exists in latent form either as a nuclear episome or integrated into human chromosomes in more than 90% of healthy individuals without causing clinical symptoms. Immunosuppression and stress conditions can reactivate HHV-6 replication, associated with clinical complications and even death. We have previously shown that co-infection of Chlamydia trachomatis and HHV-6 promotes chlamydial persistence and increases viral uptake in an in vitro cell culture model. Here we investigated C. trachomatis-induced HHV-6 activation in cell lines and fresh blood samples from patients having Chromosomally integrated HHV-6 (CiHHV-6). We observed activation of latent HHV-6 DNA replication in CiHHV-6 cell lines and fresh blood cells without formation of viral particles. Interestingly, we detected HHV-6 DNA in blood as well as cervical swabs from C. trachomatis-infected women. Low virus titers correlated with high C. trachomatis load and vice versa, demonstrating a potentially significant interaction of these pathogens in blood cells and in the cervix of infected patients. Our data suggest a thus far underestimated interference of HHV-6 and C. trachomatis with a likely impact on the disease outcome as consequence of co-infection.
PLoS ONE
10.1371/journal.pone.0061400
urn:nbn:de:bvb:20-opus-96731
In: PLoS ONE (2013) 8: 4, doi:10.1371/journal.pone.0061400
Thomas Rudel
Bhupesh K. Prusty
Christine Siegl
Petra Hauck
Johannes Hain
Suvi J. Korhonen
Eija Hiltunen-Back
Mirja Poulakkainen
eng
uncontrolled
blood
eng
uncontrolled
chlamydia
eng
uncontrolled
chlamydia infection
eng
uncontrolled
chlamydia trachomatis
eng
uncontrolled
DNA replication
eng
uncontrolled
macrophages
eng
uncontrolled
polymerase chain reaction
eng
uncontrolled
viral load
Medizin und Gesundheit
open_access
Institut für Mathematik
Theodor-Boveri-Institut für Biowissenschaften
Förderzeitraum 2013
Universität Würzburg
https://opus.bibliothek.uni-wuerzburg.de/files/9673/Rudel_journal.pone.0061400.pdf